[Efficacy of anti-neuraminidase drugs application during and after an influenza pandemic].
Identifieur interne : 000A03 ( PubMed/Curation ); précédent : 000A02; suivant : 000A04[Efficacy of anti-neuraminidase drugs application during and after an influenza pandemic].
Auteurs : N V Breslav ; E S Shevchenko ; D D Abramov ; A G Prilipov ; M M Zhuravleva ; T A Oskerko ; L V Kolobukhina ; L N Merkulova ; M Iu Shchelkanov ; E I Burtseva ; D K L'VovSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Animaux, Antienzymes (administration et posologie), Chiens, Femelle, Grippe humaine (enzymologie), Grippe humaine (génétique), Grippe humaine (épidémiologie), Humains, Lignée cellulaire, Mâle, Oséltamivir (administration et posologie), Pandémies, Russie, Résistance virale aux médicaments (), Résistance virale aux médicaments (génétique), Sialidase (antagonistes et inhibiteurs), Sialidase (génétique), Sous-type H1N1 du virus de la grippe A (enzymologie), Sous-type H1N1 du virus de la grippe A (génétique), Études rétrospectives.
- MESH :
- administration et posologie : Antienzymes, Oséltamivir.
- antagonistes et inhibiteurs : Sialidase.
- enzymologie : Grippe humaine, Sous-type H1N1 du virus de la grippe A.
- génétique : Grippe humaine, Résistance virale aux médicaments, Sialidase, Sous-type H1N1 du virus de la grippe A.
- épidémiologie : Grippe humaine.
- Animaux, Chiens, Femelle, Humains, Lignée cellulaire, Mâle, Pandémies, Russie, Résistance virale aux médicaments, Études rétrospectives.
English descriptors
- KwdEn :
- Animals, Cell Line, Dogs, Drug Resistance, Viral (drug effects), Drug Resistance, Viral (genetics), Enzyme Inhibitors (administration & dosage), Female, Humans, Influenza A Virus, H1N1 Subtype (enzymology), Influenza A Virus, H1N1 Subtype (genetics), Influenza, Human (enzymology), Influenza, Human (epidemiology), Influenza, Human (genetics), Male, Neuraminidase (antagonists & inhibitors), Neuraminidase (genetics), Oseltamivir (administration & dosage), Pandemics, Retrospective Studies, Russia.
- MESH :
- chemical , administration & dosage : Enzyme Inhibitors, Oseltamivir.
- chemical , antagonists & inhibitors : Neuraminidase.
- geographic : Russia.
- drug effects : Drug Resistance, Viral.
- enzymology : Influenza A Virus, H1N1 Subtype, Influenza, Human.
- epidemiology : Influenza, Human.
- genetics : Drug Resistance, Viral, Influenza A Virus, H1N1 Subtype, Influenza, Human, Neuraminidase.
- Animals, Cell Line, Dogs, Female, Humans, Male, Pandemics, Retrospective Studies.
Abstract
The emergent 2009 A(H1N1) pandemic brought into acute focus the problem of choosing the most effective anti-influenza drugs for successive influenza infection spreading control. Oseltamivir and zanamivir, influenza virus neuraminidase inhibitors (NAIs), were recommended by the WHO experts for the treatment and prevention of influenza, including that caused by pandemic strains. A major concern regarding the use of specific antiviral compounds is the emergence of the drug-resistant strains. Oseltamivir carboxylate and zanamivir IC50 values were equal to 0.3-5.2 microM for the most of A(H1N1)pdm09 pandemic strains and 1.6-8.6 microM for the strains of influenza B virus in cell-based ELISA assay (2009-2010 season). All the studied strains of influenza A(H1N1 ) pdm09 (151) and B (22) viruses were sensitive to NAIs (2009-2011 seasons). For the first time in Russia oseltamivir-resistant A(H1N1) pdm09 influenza virus was isolated from the patient on the 5th day of a treatment course of this drug.
PubMed: 23785758
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pubmed:23785758Le document en format XML
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<term>Drug Resistance, Viral (genetics)</term>
<term>Enzyme Inhibitors (administration & dosage)</term>
<term>Female</term>
<term>Humans</term>
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<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (genetics)</term>
<term>Male</term>
<term>Neuraminidase (antagonists & inhibitors)</term>
<term>Neuraminidase (genetics)</term>
<term>Oseltamivir (administration & dosage)</term>
<term>Pandemics</term>
<term>Retrospective Studies</term>
<term>Russia</term>
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<term>Femelle</term>
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<term>Grippe humaine (génétique)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Mâle</term>
<term>Oséltamivir (administration et posologie)</term>
<term>Pandémies</term>
<term>Russie</term>
<term>Résistance virale aux médicaments ()</term>
<term>Résistance virale aux médicaments (génétique)</term>
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<term>Sialidase (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (enzymologie)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Études rétrospectives</term>
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<term>Oseltamivir</term>
</keywords>
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<term>Oséltamivir</term>
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<term>Sous-type H1N1 du virus de la grippe A</term>
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<term>Influenza, Human</term>
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<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human</term>
<term>Neuraminidase</term>
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<term>Résistance virale aux médicaments</term>
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<term>Retrospective Studies</term>
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<term>Femelle</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Russie</term>
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<front><div type="abstract" xml:lang="en">The emergent 2009 A(H1N1) pandemic brought into acute focus the problem of choosing the most effective anti-influenza drugs for successive influenza infection spreading control. Oseltamivir and zanamivir, influenza virus neuraminidase inhibitors (NAIs), were recommended by the WHO experts for the treatment and prevention of influenza, including that caused by pandemic strains. A major concern regarding the use of specific antiviral compounds is the emergence of the drug-resistant strains. Oseltamivir carboxylate and zanamivir IC50 values were equal to 0.3-5.2 microM for the most of A(H1N1)pdm09 pandemic strains and 1.6-8.6 microM for the strains of influenza B virus in cell-based ELISA assay (2009-2010 season). All the studied strains of influenza A(H1N1 ) pdm09 (151) and B (22) viruses were sensitive to NAIs (2009-2011 seasons). For the first time in Russia oseltamivir-resistant A(H1N1) pdm09 influenza virus was isolated from the patient on the 5th day of a treatment course of this drug.</div>
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<DateRevised><Year>2016</Year>
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<Title>Voprosy virusologii</Title>
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<ArticleTitle>[Efficacy of anti-neuraminidase drugs application during and after an influenza pandemic].</ArticleTitle>
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<Abstract><AbstractText>The emergent 2009 A(H1N1) pandemic brought into acute focus the problem of choosing the most effective anti-influenza drugs for successive influenza infection spreading control. Oseltamivir and zanamivir, influenza virus neuraminidase inhibitors (NAIs), were recommended by the WHO experts for the treatment and prevention of influenza, including that caused by pandemic strains. A major concern regarding the use of specific antiviral compounds is the emergence of the drug-resistant strains. Oseltamivir carboxylate and zanamivir IC50 values were equal to 0.3-5.2 microM for the most of A(H1N1)pdm09 pandemic strains and 1.6-8.6 microM for the strains of influenza B virus in cell-based ELISA assay (2009-2010 season). All the studied strains of influenza A(H1N1 ) pdm09 (151) and B (22) viruses were sensitive to NAIs (2009-2011 seasons). For the first time in Russia oseltamivir-resistant A(H1N1) pdm09 influenza virus was isolated from the patient on the 5th day of a treatment course of this drug.</AbstractText>
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