PandemieGrippaleV1, PubMed, Curation, bibRecord, 000432

Progress of small molecular inhibitors in the development of anti-influenza virus agents.

Identifieur interne : 000432 ( PubMed/Curation ); précédent : 000431; suivant : 000433

Progress of small molecular inhibitors in the development of anti-influenza virus agents.

Auteurs : Xiaoai Wu [République populaire de Chine] ; Xiuli Wu ; Qizheng Sun [République populaire de Chine] ; Chunhui Zhang [République populaire de Chine] ; Shengyong Yang [République populaire de Chine] ; Lin Li [République populaire de Chine] ; Zhiyun Jia [République populaire de Chine]

Source :

Theranostics [ 1838-7640 ] ; 2017.

RBID : pubmed:28382157

Descripteurs français

KwdFr :
- Animaux, Antiviraux (isolement et purification), Antiviraux (pharmacologie), Découverte de médicament (tendances), Humains, Orthomyxoviridae ().
MESH :
- isolement et purification : Antiviraux.
- pharmacologie : Antiviraux.
- tendances : Découverte de médicament.
- Animaux, Humains, Orthomyxoviridae.

English descriptors

KwdEn :
- Animals, Antiviral Agents (isolation & purification), Antiviral Agents (pharmacology), Drug Discovery (trends), Humans, Orthomyxoviridae (drug effects).
MESH :
- chemical , isolation & purification : Antiviral Agents.
- chemical , pharmacology : Antiviral Agents.
- drug effects : Orthomyxoviridae.
- trends : Drug Discovery.
- Animals, Humans.

Abstract

The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small molecular inhibitors play important roles in controlling pandemics while vaccines are developed. Currently, only a few drugs, which function as influenza neuraminidase (NA) inhibitors and M2 ion channel protein inhibitors, are approved in clinical. However, the acquired resistance against current anti-influenza drugs and the emerging mutations of influenza virus itself remain the major challenging unmet medical needs for influenza treatment. It is highly desirable to identify novel anti-influenza agents. This paper reviews the progress of small molecular inhibitors act as antiviral agents, which include hemagglutinin (HA) inhibitors, RNA-dependent RNA polymerase (RdRp) inhibitors, NA inhibitors and M2 ion channel protein inhibitors etc. Moreover, we also summarize new, recently reported potential targets and discuss strategies for the development of new anti-influenza virus drugs.

DOI: 10.7150/thno.17071
PubMed: 28382157

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Xiuli Wu

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<wicri:noCountry code="subField">Ministry of Education</wicri:noCountry>
</affiliation>

Le document en format XML

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<front><div type="abstract" xml:lang="en">The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small molecular inhibitors play important roles in controlling pandemics while vaccines are developed. Currently, only a few drugs, which function as influenza neuraminidase (NA) inhibitors and M2 ion channel protein inhibitors, are approved in clinical. However, the acquired resistance against current anti-influenza drugs and the emerging mutations of influenza virus itself remain the major challenging unmet medical needs for influenza treatment. It is highly desirable to identify novel anti-influenza agents. This paper reviews the progress of small molecular inhibitors act as antiviral agents, which include hemagglutinin (HA) inhibitors, RNA-dependent RNA polymerase (RdRp) inhibitors, NA inhibitors and M2 ion channel protein inhibitors etc. Moreover, we also summarize new, recently reported potential targets and discuss strategies for the development of new anti-influenza virus drugs.</div>
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Progress of small molecular inhibitors in the development of anti-influenza virus agents.

Progress of small molecular inhibitors in the development of anti-influenza virus agents.

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