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The post-2009 influenza pandemic era: time to revisit antibody immunodominance.

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The post-2009 influenza pandemic era: time to revisit antibody immunodominance.

Auteurs : Kristien Van Reeth

Source :

The Journal of clinical investigation [ 1558-8238 ] ; 2018.

RBID : pubmed:30295644

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux, Cochons d'Inde, Grippe humaine, Humains, Hémagglutinines, Infections à Orthomyxoviridae, Souris, Sous-type H1N1 du virus de la grippe A (immunologie), Vaccins antigrippaux.
MESH :
- immunologie : Sous-type H1N1 du virus de la grippe A.
- Animaux, Anticorps antiviraux, Cochons d'Inde, Grippe humaine, Humains, Hémagglutinines, Infections à Orthomyxoviridae, Souris, Vaccins antigrippaux.

English descriptors

KwdEn :
- Animals, Antibodies, Viral, Guinea Pigs, Hemagglutinins, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza Vaccines, Influenza, Human, Mice, Orthomyxoviridae Infections.
MESH :
- chemical : Antibodies, Viral, Hemagglutinins, Influenza Vaccines.
- immunology : Influenza A Virus, H1N1 Subtype.
- Animals, Guinea Pigs, Humans, Influenza, Human, Mice, Orthomyxoviridae Infections.

Abstract

The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift, thereby limiting vaccine efficacy. Bypassing the immune system's tendency to focus on the most variable regions of the HA may be a step toward more broadly protective influenza vaccines. However, this requires a better understanding of the biological meaning of immunodominance, and of the hierarchy between different antigenic sites. In this issue of the JCI, Liu et al. determined the immunodominance of the five antigenic sites of the HA head in experimentally infected mice, guinea pigs, and ferrets. All three species exhibited different preferences for the five sites of the 2009 pandemic H1N1 strain. Moreover, human subjects exhibited yet a different pattern of immunodominance following immunization with the standard inactivated influenza vaccine. Together, these results have important implications for influenza vaccine design and interpretation of animal models.

DOI: 10.1172/JCI124151
PubMed: 30295644

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The current inactivated influenza vaccines rely on the induction of neutralizing antibodies against the head domain of the viral hemagglutinin (HA). The HA head contains five immunodominant antigenic sites, all of which are subject to antigenic drift, thereby limiting vaccine efficacy. Bypassing the immune system's tendency to focus on the most variable regions of the HA may be a step toward more broadly protective influenza vaccines. However, this requires a better understanding of the biological meaning of immunodominance, and of the hierarchy between different antigenic sites. In this issue of the JCI, Liu et al. determined the immunodominance of the five antigenic sites of the HA head in experimentally infected mice, guinea pigs, and ferrets. All three species exhibited different preferences for the five sites of the 2009 pandemic H1N1 strain. Moreover, human subjects exhibited yet a different pattern of immunodominance following immunization with the standard inactivated influenza vaccine. Together, these results have important implications for influenza vaccine design and interpretation of animal models.</div>
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<ReferenceList><Reference><Citation>Microbiol Spectr. 2014 Oct;2(5):null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26104373</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9047-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22615367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2014 Nov 21;346(6212):996-1000</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25414313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2018 Nov 1;128(11):4992-4996</Citation>
<ArticleIdList><ArticleId IdType="pubmed">30188868</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pathogens. 2014 Oct 21;3(4):845-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25436508</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 1982 Dec;31(2 Pt 1):417-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6186384</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2017 Apr;18(4):464-473</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28192418</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Immunol. 2018 Jul;39(7):549-561</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29789196</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2013 Jul 29;210(8):1493-500</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23857983</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2011 Jun 1;3(85):85ra48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21632986</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Trends Microbiol. 2015 Mar;23(3):142-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25564096</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>ILAR J. 2015;56(1):44-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25991697</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunol Rev. 2011 Jan;239(1):167-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21198671</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Top Microbiol Immunol. 2015;386:301-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25007847</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2573-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22308500</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Transl Med. 2015 Dec 2;7(316):316ra192</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26631631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>NPJ Vaccines. 2017;2:null</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29250437</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2011 Jan 17;208(1):181-93</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21220454</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7):</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28663208</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Immunol. 2017 Apr;18(4):456-463</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28192417</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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The post-2009 influenza pandemic era: time to revisit antibody immunodominance.

The post-2009 influenza pandemic era: time to revisit antibody immunodominance.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki