Investigation of an outbreak of acute respiratory disease in an indigenous village in Brazil: Contribution of Influenza A(H1N1)pdm09 and human respiratory syncytial viruses.
Identifieur interne : 000119 ( PubMed/Curation ); précédent : 000118; suivant : 000120Investigation of an outbreak of acute respiratory disease in an indigenous village in Brazil: Contribution of Influenza A(H1N1)pdm09 and human respiratory syncytial viruses.
Auteurs : Andrey Moreira Cardoso [Brésil] ; Paola Cristina Resende [Brésil] ; Enny S. Paixao [Royaume-Uni] ; Felipe G. Tavares [Brésil] ; Yasmin N. Farias [Brésil] ; Carla Tatiana G. Barreto [Brésil] ; Lídia N. Pantoja [Brésil] ; Fernanda L. Ferreira [Brésil] ; André Luiz Martins [Brésil] ; Ângela Barbosa Lima [Brésil] ; Daniella A. Fernandes [Brésil] ; Patrícia Machado Sanches [Brésil] ; Walquiria A F. Almeida [Brésil] ; Laura C. Rodrigues [Royaume-Uni] ; Marilda M. Siqueira [Brésil]Source :
- PloS one [ 1932-6203 ] ; 2019.
Descripteurs français
- KwdFr :
- Adolescent, Brésil (épidémiologie), Enfant, Enfant d'âge préscolaire, Femelle, Flambées de maladies, Grippe humaine (), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Infections de l'appareil respiratoire (), Infections de l'appareil respiratoire (virologie), Infections de l'appareil respiratoire (épidémiologie), Mâle, Nourrisson, Saisons, Sous-type H1N1 du virus de la grippe A (pathogénicité), Troubles respiratoires (), Troubles respiratoires (virologie), Troubles respiratoires (épidémiologie), Vaccination, Vaccins antigrippaux (usage thérapeutique).
- MESH :
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- usage thérapeutique : Vaccins antigrippaux.
- virologie : Grippe humaine, Infections de l'appareil respiratoire, Troubles respiratoires.
- épidémiologie : Brésil, Grippe humaine, Infections de l'appareil respiratoire, Troubles respiratoires.
- Adolescent, Enfant, Enfant d'âge préscolaire, Femelle, Flambées de maladies, Grippe humaine, Humains, Infections de l'appareil respiratoire, Mâle, Nourrisson, Saisons, Troubles respiratoires, Vaccination.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Adolescent, Brazil (epidemiology), Child, Child, Preschool, Disease Outbreaks, Female, Humans, Infant, Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza Vaccines (therapeutic use), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Influenza, Human (virology), Male, Respiration Disorders (epidemiology), Respiration Disorders (prevention & control), Respiration Disorders (virology), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (prevention & control), Respiratory Tract Infections (virology), Seasons, Vaccination.
- MESH :
- chemical , therapeutic use : Influenza Vaccines.
- geographic , epidemiology : Brazil.
- epidemiology : Influenza, Human, Respiration Disorders, Respiratory Tract Infections.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- prevention & control : Influenza, Human, Respiration Disorders, Respiratory Tract Infections.
- virology : Influenza, Human, Respiration Disorders, Respiratory Tract Infections.
- Adolescent, Child, Child, Preschool, Disease Outbreaks, Female, Humans, Infant, Male, Seasons, Vaccination.
Abstract
Analyses of the 2009 H1N1 influenza pandemic and post-pandemic years showed high attack rates and severity among indigenous populations. This study presents the characteristics of the first documented influenza outbreak in indigenous peoples in Brazil, that occurred from 30th March to 14th April 2016 in a Guarani village in Southeast Region. Acute respiratory infections were prospectively investigated. The majority of the 73 cases were influenza-like illness (ILI) (63.0%) or severe acute respiratory infection (SARI) (20.5%). The ILI+SARI attack rate (35.9%) decreased with increasing age. There was a high influenza vaccination rate (86.3%), but no statistically significant difference in vaccination rates between severe and non-severe cases was seen (p = 0.334). Molecular analyses of 19.2% of the cases showed 100% positivity for influenza A(H1N1)pdm09 and/or hRSV. Influenza A(H1N1)pdm09 was included in the 6B.1 genetic group, a distinct cluster with 13 amino acid substitutions of A/California/07/2009-like. The hRSV were clustered in the BA-like genetic group. The early arrival of the influenza season overlapping usual hRSV season, the circulation of a drifted influenza virus not covered by vaccine and the high prevalence of risk factors for infection and severity in the village jointly can explain the high attack rate of ARI, even with a high rate of influenza vaccination. The results reinforce the importance of surveillance of respiratory viruses, timely vaccination and controlling risk factors for infection and severity of in the indigenous populations in order to preventing disease and related deaths, particularly in children.
DOI: 10.1371/journal.pone.0218925
PubMed: 31283762
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<author><name sortKey="Fernandes, Daniella A" sort="Fernandes, Daniella A" uniqKey="Fernandes D" first="Daniella A" last="Fernandes">Daniella A. Fernandes</name>
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<author><name sortKey="Sanches, Patricia Machado" sort="Sanches, Patricia Machado" uniqKey="Sanches P" first="Patrícia Machado" last="Sanches">Patrícia Machado Sanches</name>
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<author><name sortKey="Almeida, Walquiria A F" sort="Almeida, Walquiria A F" uniqKey="Almeida W" first="Walquiria A F" last="Almeida">Walquiria A F. Almeida</name>
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<author><name sortKey="Rodrigues, Laura C" sort="Rodrigues, Laura C" uniqKey="Rodrigues L" first="Laura C" last="Rodrigues">Laura C. Rodrigues</name>
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<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Femelle</term>
<term>Flambées de maladies</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Infections de l'appareil respiratoire</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Saisons</term>
<term>Troubles respiratoires</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term>
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<front><div type="abstract" xml:lang="en">Analyses of the 2009 H1N1 influenza pandemic and post-pandemic years showed high attack rates and severity among indigenous populations. This study presents the characteristics of the first documented influenza outbreak in indigenous peoples in Brazil, that occurred from 30th March to 14th April 2016 in a Guarani village in Southeast Region. Acute respiratory infections were prospectively investigated. The majority of the 73 cases were influenza-like illness (ILI) (63.0%) or severe acute respiratory infection (SARI) (20.5%). The ILI+SARI attack rate (35.9%) decreased with increasing age. There was a high influenza vaccination rate (86.3%), but no statistically significant difference in vaccination rates between severe and non-severe cases was seen (p = 0.334). Molecular analyses of 19.2% of the cases showed 100% positivity for influenza A(H1N1)pdm09 and/or hRSV. Influenza A(H1N1)pdm09 was included in the 6B.1 genetic group, a distinct cluster with 13 amino acid substitutions of A/California/07/2009-like. The hRSV were clustered in the BA-like genetic group. The early arrival of the influenza season overlapping usual hRSV season, the circulation of a drifted influenza virus not covered by vaccine and the high prevalence of risk factors for infection and severity in the village jointly can explain the high attack rate of ARI, even with a high rate of influenza vaccination. The results reinforce the importance of surveillance of respiratory viruses, timely vaccination and controlling risk factors for infection and severity of in the indigenous populations in order to preventing disease and related deaths, particularly in children.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31283762</PMID>
<DateCompleted><Year>2020</Year>
<Month>02</Month>
<Day>18</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<Issue>7</Issue>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Investigation of an outbreak of acute respiratory disease in an indigenous village in Brazil: Contribution of Influenza A(H1N1)pdm09 and human respiratory syncytial viruses.</ArticleTitle>
<Pagination><MedlinePgn>e0218925</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0218925</ELocationID>
<Abstract><AbstractText>Analyses of the 2009 H1N1 influenza pandemic and post-pandemic years showed high attack rates and severity among indigenous populations. This study presents the characteristics of the first documented influenza outbreak in indigenous peoples in Brazil, that occurred from 30th March to 14th April 2016 in a Guarani village in Southeast Region. Acute respiratory infections were prospectively investigated. The majority of the 73 cases were influenza-like illness (ILI) (63.0%) or severe acute respiratory infection (SARI) (20.5%). The ILI+SARI attack rate (35.9%) decreased with increasing age. There was a high influenza vaccination rate (86.3%), but no statistically significant difference in vaccination rates between severe and non-severe cases was seen (p = 0.334). Molecular analyses of 19.2% of the cases showed 100% positivity for influenza A(H1N1)pdm09 and/or hRSV. Influenza A(H1N1)pdm09 was included in the 6B.1 genetic group, a distinct cluster with 13 amino acid substitutions of A/California/07/2009-like. The hRSV were clustered in the BA-like genetic group. The early arrival of the influenza season overlapping usual hRSV season, the circulation of a drifted influenza virus not covered by vaccine and the high prevalence of risk factors for infection and severity in the village jointly can explain the high attack rate of ARI, even with a high rate of influenza vaccination. The results reinforce the importance of surveillance of respiratory viruses, timely vaccination and controlling risk factors for infection and severity of in the indigenous populations in order to preventing disease and related deaths, particularly in children.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cardoso</LastName>
<ForeName>Andrey Moreira</ForeName>
<Initials>AM</Initials>
<Identifier Source="ORCID">0000-0002-7591-7791</Identifier>
<AffiliationInfo><Affiliation>Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Resende</LastName>
<ForeName>Paola Cristina</ForeName>
<Initials>PC</Initials>
<AffiliationInfo><Affiliation>Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Paixao</LastName>
<ForeName>Enny S</ForeName>
<Initials>ES</Initials>
<AffiliationInfo><Affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tavares</LastName>
<ForeName>Felipe G</ForeName>
<Initials>FG</Initials>
<AffiliationInfo><Affiliation>Universidade Federal Fluminense, Niterói, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Farias</LastName>
<ForeName>Yasmin N</ForeName>
<Initials>YN</Initials>
<AffiliationInfo><Affiliation>Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Barreto</LastName>
<ForeName>Carla Tatiana G</ForeName>
<Initials>CTG</Initials>
<AffiliationInfo><Affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pantoja</LastName>
<ForeName>Lídia N</ForeName>
<Initials>LN</Initials>
<AffiliationInfo><Affiliation>Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferreira</LastName>
<ForeName>Fernanda L</ForeName>
<Initials>FL</Initials>
<AffiliationInfo><Affiliation>Secretaria Especial de Saúde Indígena, Curitiba, PR, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martins</LastName>
<ForeName>André Luiz</ForeName>
<Initials>AL</Initials>
<AffiliationInfo><Affiliation>Secretaria Especial de Saúde Indígena, Curitiba, PR, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lima</LastName>
<ForeName>Ângela Barbosa</ForeName>
<Initials>ÂB</Initials>
<AffiliationInfo><Affiliation>Secretaria Especial de Saúde Indígena, Curitiba, PR, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fernandes</LastName>
<ForeName>Daniella A</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>Secretaria Especial de Saúde Indígena, Curitiba, PR, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sanches</LastName>
<ForeName>Patrícia Machado</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Secretaria Municipal de Saúde de Paraty, Paraty, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Almeida</LastName>
<ForeName>Walquiria A F</ForeName>
<Initials>WAF</Initials>
<AffiliationInfo><Affiliation>Secretaria de Vigilância em Saúde, Brasília, DF, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rodrigues</LastName>
<ForeName>Laura C</ForeName>
<Initials>LC</Initials>
<AffiliationInfo><Affiliation>London School of Hygiene and Tropical Medicine, London, United Kingdom.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Siqueira</LastName>
<ForeName>Marilda M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brazil.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>07</Month>
<Day>08</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS One</MedlineTA>
<NlmUniqueID>101285081</NlmUniqueID>
<ISSNLinking>1932-6203</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Nature. 2020 Apr;580(7802):185</RefSource>
<PMID Version="1">32265568</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001938" MajorTopicYN="N" Type="Geographic">Brazil</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004196" MajorTopicYN="N">Disease Outbreaks</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012120" MajorTopicYN="N">Respiration Disorders</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012141" MajorTopicYN="N">Respiratory Tract Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="N">prevention & control</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012621" MajorTopicYN="N">Seasons</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014611" MajorTopicYN="N">Vaccination</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<CoiStatement>The authors have declared that no competing interests exist.</CoiStatement>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>09</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>06</Month>
<Day>13</Day>
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<Day>9</Day>
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