Preventing and treating secondary bacterial infections with antiviral agents.
Identifieur interne : 001053 ( PubMed/Corpus ); précédent : 001052; suivant : 001054Preventing and treating secondary bacterial infections with antiviral agents.
Auteurs : Jonathan A. MccullersSource :
- Antiviral therapy [ 2040-2058 ] ; 2011.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (therapeutic use), Bacterial Infections (complications), Bacterial Infections (drug therapy), Bacterial Infections (prevention & control), Child, Preschool, Disease Models, Animal, Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human (complications), Influenza, Human (drug therapy), Influenza, Human (virology), Mice, Oseltamivir (therapeutic use), Pneumonia, Bacterial (complications), Pneumonia, Bacterial (drug therapy), Pneumonia, Bacterial (prevention & control), Randomized Controlled Trials as Topic, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- complications : Bacterial Infections, Influenza, Human, Pneumonia, Bacterial.
- drug therapy : Bacterial Infections, Influenza, Human, Pneumonia, Bacterial.
- prevention & control : Bacterial Infections, Pneumonia, Bacterial.
- virology : Influenza, Human.
- Animals, Child, Preschool, Disease Models, Animal, Humans, Influenza A Virus, H1N1 Subtype, Mice, Randomized Controlled Trials as Topic, Treatment Outcome.
Abstract
Bacterial super-infections contribute to the significant morbidity and mortality associated with influenza and other respiratory virus infections. There are robust animal model data, but only limited clinical information on the effectiveness of licensed antiviral agents for the treatment of bacterial complications of influenza. The association of secondary bacterial pathogens with fatal pneumonia during the recent H1N1 influenza pandemic highlights the need for new development in this area. Basic and clinical research into viral-bacterial interactions over the past decade has revealed several mechanisms that underlie this synergism. By applying these insights to antiviral drug development, the potential exists to improve outcomes by means other than direct inhibition of the virus.
DOI: 10.3851/IMP1730
PubMed: 21447860
Links to Exploration step
pubmed:21447860Le document en format XML
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There are robust animal model data, but only limited clinical information on the effectiveness of licensed antiviral agents for the treatment of bacterial complications of influenza. The association of secondary bacterial pathogens with fatal pneumonia during the recent H1N1 influenza pandemic highlights the need for new development in this area. Basic and clinical research into viral-bacterial interactions over the past decade has revealed several mechanisms that underlie this synergism. By applying these insights to antiviral drug development, the potential exists to improve outcomes by means other than direct inhibition of the virus.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21447860</PMID><DateCompleted><Year>2011</Year><Month>07</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>2</Issue><PubDate><Year>2011</Year></PubDate></JournalIssue><Title>Antiviral therapy</Title><ISOAbbreviation>Antivir. Ther. 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By applying these insights to antiviral drug development, the potential exists to improve outcomes by means other than direct inhibition of the virus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McCullers</LastName><ForeName>Jonathan A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA. jon.mccullers@stjude.org</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI066349</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AI076816</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI-66349</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United 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