Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong.
Identifieur interne : 001036 ( PubMed/Corpus ); précédent : 001035; suivant : 001037Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong.
Auteurs : Y. Zhou ; D M W. Ng ; W-H Seto ; D K M. Ip ; H K H. Kwok ; E S K. Ma ; S. Ng ; L L H. Lau ; J T Wu ; J S M. Peiris ; B J CowlingSource :
- The Journal of hospital infection [ 1532-2939 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (blood), Cross-Sectional Studies, Female, Health Personnel, Hong Kong (epidemiology), Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (virology), Male, Middle Aged, Occupational Exposure, Risk Factors, Seroepidemiologic Studies.
- MESH :
- chemical , blood : Antibodies, Viral.
- geographic , epidemiology : Hong Kong.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adult, Cross-Sectional Studies, Female, Health Personnel, Humans, Male, Middle Aged, Occupational Exposure, Risk Factors, Seroepidemiologic Studies.
Abstract
During the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave.
DOI: 10.1016/j.jhin.2011.02.017
PubMed: 21501896
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pubmed:21501896Le document en format XML
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Zhou</name><affiliation><nlm:affiliation>Infectious Disease Epidemiology Group, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, D M W" sort="Ng, D M W" uniqKey="Ng D" first="D M W" last="Ng">D M W. Ng</name></author><author><name sortKey="Seto, W H" sort="Seto, W H" uniqKey="Seto W" first="W-H" last="Seto">W-H Seto</name></author><author><name sortKey="Ip, D K M" sort="Ip, D K M" uniqKey="Ip D" first="D K M" last="Ip">D K M. Ip</name></author><author><name sortKey="Kwok, H K H" sort="Kwok, H K H" uniqKey="Kwok H" first="H K H" last="Kwok">H K H. Kwok</name></author><author><name sortKey="Ma, E S K" sort="Ma, E S K" uniqKey="Ma E" first="E S K" last="Ma">E S K. Ma</name></author><author><name sortKey="Ng, S" sort="Ng, S" uniqKey="Ng S" first="S" last="Ng">S. Ng</name></author><author><name sortKey="Lau, L L H" sort="Lau, L L H" uniqKey="Lau L" first="L L H" last="Lau">L L H. Lau</name></author><author><name sortKey="Wu, J T" sort="Wu, J T" uniqKey="Wu J" first="J T" last="Wu">J T Wu</name></author><author><name sortKey="Peiris, J S M" sort="Peiris, J S M" uniqKey="Peiris J" first="J S M" last="Peiris">J S M. Peiris</name></author><author><name sortKey="Cowling, B J" sort="Cowling, B J" uniqKey="Cowling B" first="B J" last="Cowling">B J Cowling</name></author></analytic><series><title level="j">The Journal of hospital infection</title><idno type="eISSN">1532-2939</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Health Personnel</term><term>Hong Kong (epidemiology)</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (immunology)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Middle Aged</term><term>Occupational Exposure</term><term>Risk Factors</term><term>Seroepidemiologic Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cross-Sectional Studies</term><term>Female</term><term>Health Personnel</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Occupational Exposure</term><term>Risk Factors</term><term>Seroepidemiologic Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21501896</PMID><DateCompleted><Year>2011</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1532-2939</ISSN><JournalIssue CitedMedium="Internet"><Volume>78</Volume><Issue>4</Issue><PubDate><Year>2011</Year><Month>Aug</Month></PubDate></JournalIssue><Title>The Journal of hospital infection</Title><ISOAbbreviation>J. Hosp. Infect.</ISOAbbreviation></Journal><ArticleTitle>Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong.</ArticleTitle><Pagination><MedlinePgn>308-11</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jhin.2011.02.017</ELocationID><Abstract><AbstractText>During the first wave of an influenza pandemic prior to the availability of an effective vaccine, healthcare workers (HCWs) may be at particular risk of infection with the novel influenza strain. We conducted a cross-sectional study of the prevalence of antibody to pandemic influenza A (H1N1) 2009 (pH1N1) among HCWs in Hong Kong in February-March 2010 following the first pandemic wave. Sera collected from HCWs were tested for antibody to pH1N1 influenza virus by viral neutralisation (VN). We assessed factors associated with higher antibody titres, and we compared antibody titres in HCWs with those in a separate community study. In total we enrolled 703 HCWs. Among 599 HCWs who did not report receipt of pH1N1 vaccine, 12% had antibody titre ≥1:40 by VN. There were no significant differences in the age-specific proportions of unvaccinated HCWs with antibody titre ≥1:40 compared with the general community following the first wave of pH1N1. Under good adherence to infection control guidelines, potential occupational exposures in the hospital setting did not appear to be associated with any substantial excess risk of pH1N1 infection in HCWs. Most HCWs had low antibody titres following the first pandemic wave.</AbstractText><CopyrightInformation>Copyright © 2011 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Infectious Disease Epidemiology Group, School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>D M W</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Seto</LastName><ForeName>W-H</ForeName><Initials>WH</Initials></Author><Author ValidYN="Y"><LastName>Ip</LastName><ForeName>D K M</ForeName><Initials>DK</Initials></Author><Author ValidYN="Y"><LastName>Kwok</LastName><ForeName>H K H</ForeName><Initials>HK</Initials></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>E S K</ForeName><Initials>ES</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>L L H</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>J T</ForeName><Initials>JT</Initials></Author><Author ValidYN="Y"><LastName>Peiris</LastName><ForeName>J S M</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Cowling</LastName><ForeName>B J</ForeName><Initials>BJ</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>04</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Hosp Infect</MedlineTA><NlmUniqueID>8007166</NlmUniqueID><ISSNLinking>0195-6701</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003430" MajorTopicYN="N">Cross-Sectional Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006282" MajorTopicYN="Y">Health Personnel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006723" MajorTopicYN="N" Type="Geographic">Hong Kong</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" 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Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>09</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21501896</ArticleId><ArticleId IdType="pii">S0195-6701(11)00113-7</ArticleId><ArticleId IdType="doi">10.1016/j.jhin.2011.02.017</ArticleId><ArticleId 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