Progress in structure-based drug design against influenza A virus.
Identifieur interne : 000C85 ( PubMed/Corpus ); précédent : 000C84; suivant : 000C86Progress in structure-based drug design against influenza A virus.
Auteurs : Qi-Shi Du ; Hang Wei ; Ri-Bo Huang ; Kuo-Chen ChouSource :
- Expert opinion on drug discovery [ 1746-045X ] ; 2011.
Abstract
The 2009-H1N1 influenza pandemic has prompted new global efforts to develop new drugs and drug design techniques to combat influenza viruses. While there have been a number of attempts to provide drugs to treat influenza, drug resistance has been a major problem with only four drugs currently approved by the FDA for its treatment.
DOI: 10.1517/17460441.2011.571671
PubMed: 22646152
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Progress in structure-based drug design against influenza A virus.</title><author><name sortKey="Du, Qi Shi" sort="Du, Qi Shi" uniqKey="Du Q" first="Qi-Shi" last="Du">Qi-Shi Du</name><affiliation><nlm:affiliation>Guangxi University, Life Science and Biotechnology College, Nanning, Guangxi, 530004 , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Hang" sort="Wei, Hang" uniqKey="Wei H" first="Hang" last="Wei">Hang Wei</name></author><author><name sortKey="Huang, Ri Bo" sort="Huang, Ri Bo" uniqKey="Huang R" first="Ri-Bo" last="Huang">Ri-Bo Huang</name></author><author><name sortKey="Chou, Kuo Chen" sort="Chou, Kuo Chen" uniqKey="Chou K" first="Kuo-Chen" last="Chou">Kuo-Chen Chou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:22646152</idno><idno type="pmid">22646152</idno><idno type="doi">10.1517/17460441.2011.571671</idno><idno type="wicri:Area/PubMed/Corpus">000C85</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C85</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Progress in structure-based drug design against influenza A virus.</title><author><name sortKey="Du, Qi Shi" sort="Du, Qi Shi" uniqKey="Du Q" first="Qi-Shi" last="Du">Qi-Shi Du</name><affiliation><nlm:affiliation>Guangxi University, Life Science and Biotechnology College, Nanning, Guangxi, 530004 , China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Hang" sort="Wei, Hang" uniqKey="Wei H" first="Hang" last="Wei">Hang Wei</name></author><author><name sortKey="Huang, Ri Bo" sort="Huang, Ri Bo" uniqKey="Huang R" first="Ri-Bo" last="Huang">Ri-Bo Huang</name></author><author><name sortKey="Chou, Kuo Chen" sort="Chou, Kuo Chen" uniqKey="Chou K" first="Kuo-Chen" last="Chou">Kuo-Chen Chou</name></author></analytic><series><title level="j">Expert opinion on drug discovery</title><idno type="eISSN">1746-045X</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The 2009-H1N1 influenza pandemic has prompted new global efforts to develop new drugs and drug design techniques to combat influenza viruses. While there have been a number of attempts to provide drugs to treat influenza, drug resistance has been a major problem with only four drugs currently approved by the FDA for its treatment.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">22646152</PMID><DateCompleted><Year>2012</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2014</Year><Month>07</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1746-045X</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>6</Issue><PubDate><Year>2011</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Expert opinion on drug discovery</Title><ISOAbbreviation>Expert Opin Drug Discov</ISOAbbreviation></Journal><ArticleTitle>Progress in structure-based drug design against influenza A virus.</ArticleTitle><Pagination><MedlinePgn>619-31</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1517/17460441.2011.571671</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The 2009-H1N1 influenza pandemic has prompted new global efforts to develop new drugs and drug design techniques to combat influenza viruses. While there have been a number of attempts to provide drugs to treat influenza, drug resistance has been a major problem with only four drugs currently approved by the FDA for its treatment.</AbstractText><AbstractText Label="AREAS COVERED" NlmCategory="METHODS">In this review, the drug-resistant problem of influenza A viruses is discussed and summarized. The article also introduces the experimental and computational structures of drug targeting proteins, neuraminidases, and of the M2 proton channel. Furthermore, the article illustrates the latest drug candidates and techniques of computer-aided drug design with examples of their application, including virtual in silico screening and scoring, AutoDock and evolutionary technique AutoGrow.</AbstractText><AbstractText Label="EXPERT OPINION" NlmCategory="CONCLUSIONS">Structure-based drug design is the inventive process for finding new drugs based on the structural knowledge of the biological target. Computer-aided drug design strategies and techniques will make drug discovery more effective and economical. It is anticipated that the recent advances in structure-based drug design techniques will greatly help scientists to develop more powerful and specific drugs to fight the next generation of influenza viruses.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Qi-Shi</ForeName><Initials>QS</Initials><AffiliationInfo><Affiliation>Guangxi University, Life Science and Biotechnology College, Nanning, Guangxi, 530004 , China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Hang</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Ri-Bo</ForeName><Initials>RB</Initials></Author><Author ValidYN="Y"><LastName>Chou</LastName><ForeName>Kuo-Chen</ForeName><Initials>KC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>03</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Opin Drug Discov</MedlineTA><NlmUniqueID>101295755</NlmUniqueID><ISSNLinking>1746-0441</ISSNLinking></MedlineJournalInfo></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22646152</ArticleId><ArticleId IdType="doi">10.1517/17460441.2011.571671</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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