Reconstruction of the 1918 influenza virus: unexpected rewards from the past.
Identifieur interne : 000C06 ( PubMed/Corpus ); précédent : 000C05; suivant : 000C07Reconstruction of the 1918 influenza virus: unexpected rewards from the past.
Auteurs : Jeffery K. Taubenberger ; David Baltimore ; Peter C. Doherty ; Howard Markel ; David M. Morens ; Robert G. Webster ; Ian A. WilsonSource :
- mBio [ 2150-7511 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- history : Influenza, Human, Pandemics.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- History, 20th Century, Humans.
Abstract
The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.
DOI: 10.1128/mBio.00201-12
PubMed: 22967978
Links to Exploration step
pubmed:22967978Le document en format XML
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<front><div type="abstract" xml:lang="en">The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.</div>
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<Abstract><AbstractText>The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.</AbstractText>
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