Reconstruction of the 1918 influenza virus: unexpected rewards from the past.
Identifieur interne : 000C06 ( PubMed/Corpus ); précédent : 000C05; suivant : 000C07Reconstruction of the 1918 influenza virus: unexpected rewards from the past.
Auteurs : Jeffery K. Taubenberger ; David Baltimore ; Peter C. Doherty ; Howard Markel ; David M. Morens ; Robert G. Webster ; Ian A. WilsonSource :
- mBio [ 2150-7511 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- history : Influenza, Human, Pandemics.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- History, 20th Century, Humans.
Abstract
The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.
DOI: 10.1128/mBio.00201-12
PubMed: 22967978
Links to Exploration step
pubmed:22967978Le document en format XML
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Doherty</name></author><author><name sortKey="Markel, Howard" sort="Markel, Howard" uniqKey="Markel H" first="Howard" last="Markel">Howard Markel</name></author><author><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M" last="Morens">David M. Morens</name></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G" last="Webster">Robert G. Webster</name></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A" last="Wilson">Ian A. Wilson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22967978</idno><idno type="pmid">22967978</idno><idno type="doi">10.1128/mBio.00201-12</idno><idno type="wicri:Area/PubMed/Corpus">000C06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C06</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reconstruction of the 1918 influenza virus: unexpected rewards from the past.</title><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K" last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. taubenbergerj@niaid.nih.gov</nlm:affiliation></affiliation></author><author><name sortKey="Baltimore, David" sort="Baltimore, David" uniqKey="Baltimore D" first="David" last="Baltimore">David Baltimore</name></author><author><name sortKey="Doherty, Peter C" sort="Doherty, Peter C" uniqKey="Doherty P" first="Peter C" last="Doherty">Peter C. Doherty</name></author><author><name sortKey="Markel, Howard" sort="Markel, Howard" uniqKey="Markel H" first="Howard" last="Markel">Howard Markel</name></author><author><name sortKey="Morens, David M" sort="Morens, David M" uniqKey="Morens D" first="David M" last="Morens">David M. Morens</name></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G" last="Webster">Robert G. Webster</name></author><author><name sortKey="Wilson, Ian A" sort="Wilson, Ian A" uniqKey="Wilson I" first="Ian A" last="Wilson">Ian A. Wilson</name></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>History, 20th Century</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (history)</term><term>Influenza, Human (virology)</term><term>Pandemics (history)</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="history" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>History, 20th Century</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22967978</PMID><DateCompleted><Year>2013</Year><Month>01</Month><Day>16</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>27</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">2150-7511</ISSN><JournalIssue CitedMedium="Internet"><Volume>3</Volume><Issue>5</Issue><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>mBio</Title><ISOAbbreviation>mBio</ISOAbbreviation></Journal><ArticleTitle>Reconstruction of the 1918 influenza virus: unexpected rewards from the past.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1128/mBio.00201-12</ELocationID><ELocationID EIdType="pii" ValidYN="Y">e00201-12</ELocationID><Abstract><AbstractText>The influenza pandemic of 1918-1919 killed approximately 50 million people. The unusually severe morbidity and mortality associated with the pandemic spurred physicians and scientists to isolate the etiologic agent, but the virus was not isolated in 1918. In 1996, it became possible to recover and sequence highly degraded fragments of influenza viral RNA retained in preserved tissues from several 1918 victims. These viral RNA sequences eventually permitted reconstruction of the complete 1918 virus, which has yielded, almost a century after the deaths of its victims, novel insights into influenza virus biology and pathogenesis and has provided important information about how to prevent and control future pandemics.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Taubenberger</LastName><ForeName>Jeffery K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. taubenbergerj@niaid.nih.gov</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baltimore</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Doherty</LastName><ForeName>Peter C</ForeName><Initials>PC</Initials></Author><Author ValidYN="Y"><LastName>Markel</LastName><ForeName>Howard</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Morens</LastName><ForeName>David M</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Webster</LastName><ForeName>Robert G</ForeName><Initials>RG</Initials></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Ian A</ForeName><Initials>IA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016456">Historical Article</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>mBio</MedlineTA><NlmUniqueID>101519231</NlmUniqueID></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D049673" MajorTopicYN="N">History, 20th Century</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" 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