Plasma cytokine levels and cytokine gene polymorphisms in Mexican patients during the influenza pandemic A(H1N1)pdm09.
Identifieur interne : 000999 ( PubMed/Corpus ); précédent : 000998; suivant : 000A00Plasma cytokine levels and cytokine gene polymorphisms in Mexican patients during the influenza pandemic A(H1N1)pdm09.
Auteurs : Joel Martinez-Oca A ; Angélica Olivo-Diaz ; Tobías Salazar-Dominguez ; Jesús Reyes-Gordillo ; Cynthia Tapia-Aquino ; Fernando Martínez-Hernández ; María Eugenia Manjarrez ; Marco Antonio-Martinez ; Araceli Contreras-Molina ; Rafael Figueroa-Moreno ; Rafael Valdez-Vazquez ; Sim N Kawa-Karasik ; Patricia Rodríguez-Zulueta ; Ana Flisser ; Pablo Maravilla ; Mirza Romero-ValdovinosSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2013.
English descriptors
- KwdEn :
- Adult, Aged, Case-Control Studies, Cytokines (blood), Cytokines (genetics), Female, Humans, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (immunology), Influenza, Human (virology), Male, Mexico, Middle Aged, Plasma (chemistry), Polymorphism, Single Nucleotide, Young Adult.
- MESH :
- chemical , blood : Cytokines.
- chemical , genetics : Cytokines.
- geographic : Mexico.
- chemistry : Plasma.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza, Human.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adult, Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Young Adult.
Abstract
In Mexico, the initial severe cases of the 2009 influenza pandemic virus A (H1N1) [A(H1N1)pdm09] were detected in early March. The immune mechanisms associated with the severe pneumonia caused by infection with this new virus have not been completely elucidated. Polymorphisms in interleukin genes have previously been associated with susceptibility to infectious diseases due to their influence on cytokine production.
DOI: 10.1016/j.jcv.2013.05.013
PubMed: 23809475
Links to Exploration step
pubmed:23809475Le document en format XML
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<author><name sortKey="Romero Valdovinos, Mirza" sort="Romero Valdovinos, Mirza" uniqKey="Romero Valdovinos M" first="Mirza" last="Romero-Valdovinos">Mirza Romero-Valdovinos</name>
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<author><name sortKey="Martinez Oca A, Joel" sort="Martinez Oca A, Joel" uniqKey="Martinez Oca A J" first="Joel" last="Martinez-Oca A">Joel Martinez-Oca A</name>
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<author><name sortKey="Olivo Diaz, Angelica" sort="Olivo Diaz, Angelica" uniqKey="Olivo Diaz A" first="Angélica" last="Olivo-Diaz">Angélica Olivo-Diaz</name>
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<author><name sortKey="Salazar Dominguez, Tobias" sort="Salazar Dominguez, Tobias" uniqKey="Salazar Dominguez T" first="Tobías" last="Salazar-Dominguez">Tobías Salazar-Dominguez</name>
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<author><name sortKey="Reyes Gordillo, Jesus" sort="Reyes Gordillo, Jesus" uniqKey="Reyes Gordillo J" first="Jesús" last="Reyes-Gordillo">Jesús Reyes-Gordillo</name>
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<author><name sortKey="Tapia Aquino, Cynthia" sort="Tapia Aquino, Cynthia" uniqKey="Tapia Aquino C" first="Cynthia" last="Tapia-Aquino">Cynthia Tapia-Aquino</name>
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<author><name sortKey="Manjarrez, Maria Eugenia" sort="Manjarrez, Maria Eugenia" uniqKey="Manjarrez M" first="María Eugenia" last="Manjarrez">María Eugenia Manjarrez</name>
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<author><name sortKey="Antonio Martinez, Marco" sort="Antonio Martinez, Marco" uniqKey="Antonio Martinez M" first="Marco" last="Antonio-Martinez">Marco Antonio-Martinez</name>
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<author><name sortKey="Valdez Vazquez, Rafael" sort="Valdez Vazquez, Rafael" uniqKey="Valdez Vazquez R" first="Rafael" last="Valdez-Vazquez">Rafael Valdez-Vazquez</name>
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<author><name sortKey="Kawa Karasik, Sim N" sort="Kawa Karasik, Sim N" uniqKey="Kawa Karasik S" first="Sim N" last="Kawa-Karasik">Sim N Kawa-Karasik</name>
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<author><name sortKey="Maravilla, Pablo" sort="Maravilla, Pablo" uniqKey="Maravilla P" first="Pablo" last="Maravilla">Pablo Maravilla</name>
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<author><name sortKey="Romero Valdovinos, Mirza" sort="Romero Valdovinos, Mirza" uniqKey="Romero Valdovinos M" first="Mirza" last="Romero-Valdovinos">Mirza Romero-Valdovinos</name>
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<series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title>
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<term>Cytokines (genetics)</term>
<term>Female</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
<term>Mexico</term>
<term>Middle Aged</term>
<term>Plasma (chemistry)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Young Adult</term>
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<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Plasma</term>
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<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">In Mexico, the initial severe cases of the 2009 influenza pandemic virus A (H1N1) [A(H1N1)pdm09] were detected in early March. The immune mechanisms associated with the severe pneumonia caused by infection with this new virus have not been completely elucidated. Polymorphisms in interleukin genes have previously been associated with susceptibility to infectious diseases due to their influence on cytokine production.</div>
</front>
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<DateCompleted><Year>2014</Year>
<Month>03</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>08</Month>
<Day>12</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5967</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>58</Volume>
<Issue>1</Issue>
<PubDate><Year>2013</Year>
<Month>Sep</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title>
<ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Plasma cytokine levels and cytokine gene polymorphisms in Mexican patients during the influenza pandemic A(H1N1)pdm09.</ArticleTitle>
<Pagination><MedlinePgn>108-13</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jcv.2013.05.013</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1386-6532(13)00193-5</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">In Mexico, the initial severe cases of the 2009 influenza pandemic virus A (H1N1) [A(H1N1)pdm09] were detected in early March. The immune mechanisms associated with the severe pneumonia caused by infection with this new virus have not been completely elucidated. Polymorphisms in interleukin genes have previously been associated with susceptibility to infectious diseases due to their influence on cytokine production.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">The present case-control study was performed to compare several immunologic and genetic parameters of patients and controls during the initial phase of the pandemic.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Sixty-five patients who were hospitalized due to infection with the influenza A(H1N1)pdm09 virus and 46 healthy controls were studied. A hemagglutination inhibition assay (HIA) was performed to measure anti-influenza antibody titers in these subjects. Protein levels of the cytokines interleukin (IL)-4, IL-6, IL-8, IL-10, tumor necrosis factor-α (TNFα), interferon gamma (IFNγ), transforming growth factor beta (TGFβ)1 and TGFβ2 were quantified in plasma. Single nucleotide polymorphisms in IL6, IL10 and TNFα were also assessed.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Influenza patients had lower antibody titers and produced significantly higher levels of IL-6, IL-10 and TNFα than healthy controls. The frequencies of the TNFα -308G, IL-10 -592C and IL-10 -1082A alleles and the IL10 -1082(A/A) genotype were associated with susceptibility to severe disease, while the haplotypes TNFα AG and IL-10 GTA and GCA were associated with protection from severe disease [P=0.016, OR (CI)=0.11 (0.01-0.96); P=0.0187, OR (CI)=0.34 (0.13-0.85); P=0.013, OR (CI)=0.39 (0.18-0.83)].</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study demonstrates that the influenza A(H1N1)pdm09 patients and healthy controls have different profiles of immune parameters and that there is an association between IL-10 and TNFα polymorphisms and the outcome of this disease.</AbstractText>
<CopyrightInformation>Copyright © 2013 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martinez-Ocaña</LastName>
<ForeName>Joel</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Hospital General Dr. Manuel Gea González, México, DF 14080, Mexico.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Olivo-Diaz</LastName>
<ForeName>Angélica</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Salazar-Dominguez</LastName>
<ForeName>Tobías</ForeName>
<Initials>T</Initials>
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<Author ValidYN="Y"><LastName>Reyes-Gordillo</LastName>
<ForeName>Jesús</ForeName>
<Initials>J</Initials>
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<Author ValidYN="Y"><LastName>Tapia-Aquino</LastName>
<ForeName>Cynthia</ForeName>
<Initials>C</Initials>
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<Author ValidYN="Y"><LastName>Martínez-Hernández</LastName>
<ForeName>Fernando</ForeName>
<Initials>F</Initials>
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<Author ValidYN="Y"><LastName>Manjarrez</LastName>
<ForeName>María Eugenia</ForeName>
<Initials>ME</Initials>
</Author>
<Author ValidYN="Y"><LastName>Antonio-Martinez</LastName>
<ForeName>Marco</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Contreras-Molina</LastName>
<ForeName>Araceli</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Figueroa-Moreno</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Valdez-Vazquez</LastName>
<ForeName>Rafael</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kawa-Karasik</LastName>
<ForeName>Simón</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rodríguez-Zulueta</LastName>
<ForeName>Patricia</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Flisser</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Maravilla</LastName>
<ForeName>Pablo</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Romero-Valdovinos</LastName>
<ForeName>Mirza</ForeName>
<Initials>M</Initials>
</Author>
</AuthorList>
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<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>06</Month>
<Day>26</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>J Clin Virol</MedlineTA>
<NlmUniqueID>9815671</NlmUniqueID>
<ISSNLinking>1386-6532</ISSNLinking>
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<MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">A(H1N1)pdm09</Keyword>
<Keyword MajorTopicYN="N">Cytokine plasma levels</Keyword>
<Keyword MajorTopicYN="N">Cytokine polymorphism</Keyword>
<Keyword MajorTopicYN="N">HIA</Keyword>
<Keyword MajorTopicYN="N">Hemagglutination Inhibition assay</Keyword>
<Keyword MajorTopicYN="N">IL-10</Keyword>
<Keyword MajorTopicYN="N">Influenza</Keyword>
<Keyword MajorTopicYN="N">Pandemic A/H1N1</Keyword>
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