Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.
Identifieur interne : 000970 ( PubMed/Corpus ); précédent : 000969; suivant : 000971Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.
Auteurs : Carolyn M. Hendrickson ; Michael A. MatthaySource :
- Seminars in respiratory and critical care medicine [ 1098-9048 ] ; 2013.
English descriptors
- KwdEn :
- Acute Lung Injury (diagnosis), Acute Lung Injury (epidemiology), Acute Lung Injury (virology), Animals, Disease Outbreaks, Fluorescent Antibody Technique, Direct, Humans, Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (epidemiology), Pneumonia, Viral (complications), Polymerase Chain Reaction (methods), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (epidemiology).
- MESH :
- complications : Pneumonia, Viral.
- diagnosis : Acute Lung Injury.
- epidemiology : Acute Lung Injury, Influenza, Human, Severe Acute Respiratory Syndrome.
- isolation & purification : Influenza A Virus, H1N1 Subtype, SARS Virus.
- methods : Polymerase Chain Reaction.
- virology : Acute Lung Injury.
- Animals, Disease Outbreaks, Fluorescent Antibody Technique, Direct, Humans.
Abstract
Acute viral pneumonia is an important cause of acute lung injury (ALI), although not enough is known about the exact incidence of viral infection in ALI. Polymerase chain reaction-based assays, direct fluorescent antigen (DFA) assays, and viral cultures can detect viruses in samples from the human respiratory tract, but the presence of the virus does not prove it to be a pathogen, nor does it give information regarding the interaction of viruses with the host immune response and bacterial flora of the respiratory tract. The severe acute respiratory syndrome (SARS) epidemic and the 2009 H1N1 influenza pandemic provided a better understanding of how viral pathogens mediate lung injury. Although the viruses initially infect the respiratory epithelium, the relative role of epithelial damage and endothelial dysfunction has not been well defined. The inflammatory host immune response to H1N1 infection is a major contributor to lung injury. The SARS coronavirus causes lung injury and inflammation in part through actions on the nonclassical renin angiotensin pathway. The lessons learned from the pandemic outbreaks of SARS coronavirus and H1N1 capture key principles of virally mediated ALI. There are pathogen-specific pathways underlying virally mediated ALI that converge onto a common end pathway resulting in diffuse alveolar damage. In terms of therapy, lung protective ventilation is the cornerstone of supportive care. There is little evidence that corticosteroids are beneficial, and they might be harmful. Future therapeutic strategies may be targeted to specific pathogens, the pathogenetic pathways in the host immune response, or enhancing repair and regeneration of tissue damage.
DOI: 10.1055/s-0033-1351122
PubMed: 23934716
Links to Exploration step
pubmed:23934716Le document en format XML
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Matthay</name></author></analytic><series><title level="j">Seminars in respiratory and critical care medicine</title><idno type="eISSN">1098-9048</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute Lung Injury (diagnosis)</term><term>Acute Lung Injury (epidemiology)</term><term>Acute Lung Injury (virology)</term><term>Animals</term><term>Disease Outbreaks</term><term>Fluorescent Antibody Technique, Direct</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (epidemiology)</term><term>Pneumonia, Viral (complications)</term><term>Polymerase Chain Reaction (methods)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Acute Lung Injury</term><term>Influenza, Human</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Acute Lung Injury</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Outbreaks</term><term>Fluorescent Antibody Technique, Direct</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Acute viral pneumonia is an important cause of acute lung injury (ALI), although not enough is known about the exact incidence of viral infection in ALI. Polymerase chain reaction-based assays, direct fluorescent antigen (DFA) assays, and viral cultures can detect viruses in samples from the human respiratory tract, but the presence of the virus does not prove it to be a pathogen, nor does it give information regarding the interaction of viruses with the host immune response and bacterial flora of the respiratory tract. The severe acute respiratory syndrome (SARS) epidemic and the 2009 H1N1 influenza pandemic provided a better understanding of how viral pathogens mediate lung injury. Although the viruses initially infect the respiratory epithelium, the relative role of epithelial damage and endothelial dysfunction has not been well defined. The inflammatory host immune response to H1N1 infection is a major contributor to lung injury. The SARS coronavirus causes lung injury and inflammation in part through actions on the nonclassical renin angiotensin pathway. The lessons learned from the pandemic outbreaks of SARS coronavirus and H1N1 capture key principles of virally mediated ALI. There are pathogen-specific pathways underlying virally mediated ALI that converge onto a common end pathway resulting in diffuse alveolar damage. In terms of therapy, lung protective ventilation is the cornerstone of supportive care. There is little evidence that corticosteroids are beneficial, and they might be harmful. Future therapeutic strategies may be targeted to specific pathogens, the pathogenetic pathways in the host immune response, or enhancing repair and regeneration of tissue damage. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23934716</PMID><DateCompleted><Year>2014</Year><Month>03</Month><Day>19</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-9048</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>4</Issue><PubDate><Year>2013</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Seminars in respiratory and critical care medicine</Title><ISOAbbreviation>Semin Respir Crit Care Med</ISOAbbreviation></Journal><ArticleTitle>Viral pathogens and acute lung injury: investigations inspired by the SARS epidemic and the 2009 H1N1 influenza pandemic.</ArticleTitle><Pagination><MedlinePgn>475-86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1055/s-0033-1351122</ELocationID><Abstract><AbstractText>Acute viral pneumonia is an important cause of acute lung injury (ALI), although not enough is known about the exact incidence of viral infection in ALI. Polymerase chain reaction-based assays, direct fluorescent antigen (DFA) assays, and viral cultures can detect viruses in samples from the human respiratory tract, but the presence of the virus does not prove it to be a pathogen, nor does it give information regarding the interaction of viruses with the host immune response and bacterial flora of the respiratory tract. The severe acute respiratory syndrome (SARS) epidemic and the 2009 H1N1 influenza pandemic provided a better understanding of how viral pathogens mediate lung injury. Although the viruses initially infect the respiratory epithelium, the relative role of epithelial damage and endothelial dysfunction has not been well defined. The inflammatory host immune response to H1N1 infection is a major contributor to lung injury. The SARS coronavirus causes lung injury and inflammation in part through actions on the nonclassical renin angiotensin pathway. The lessons learned from the pandemic outbreaks of SARS coronavirus and H1N1 capture key principles of virally mediated ALI. There are pathogen-specific pathways underlying virally mediated ALI that converge onto a common end pathway resulting in diffuse alveolar damage. In terms of therapy, lung protective ventilation is the cornerstone of supportive care. There is little evidence that corticosteroids are beneficial, and they might be harmful. Future therapeutic strategies may be targeted to specific pathogens, the pathogenetic pathways in the host immune response, or enhancing repair and regeneration of tissue damage. </AbstractText><CopyrightInformation>Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hendrickson</LastName><ForeName>Carolyn M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, Cardiovascular Research Institute, University of California-San Francisco, CA 94143, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matthay</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 HL051854</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 HL051856</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL51854</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37HL51856</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Semin Respir Crit Care 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MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23934716</ArticleId><ArticleId IdType="doi">10.1055/s-0033-1351122</ArticleId><ArticleId IdType="pmc">PMC4045622</ArticleId><ArticleId IdType="mid">NIHMS579893</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Lancet. 2003 May 24;361(9371):1761-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12781533</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2009 Aug 8;374(9688):451-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19643469</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Res. 2012 Mar;22(3):528-38</Citation><ArticleIdList><ArticleId IdType="pubmed">22025253</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2009 Nov 4;302(17):1888-95</Citation><ArticleIdList><ArticleId IdType="pubmed">19822628</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2010;14(6):R203</Citation><ArticleIdList><ArticleId IdType="pubmed">21062445</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2010 Aug;38(8):1644-50</Citation><ArticleIdList><ArticleId IdType="pubmed">20562704</ArticleId></ArticleIdList></Reference><Reference><Citation>Influenza Other Respir Viruses. 2013 Jan;7(1):18-26</Citation><ArticleIdList><ArticleId IdType="pubmed">22329841</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2012 Jun 28;486(7404):456-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22739293</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2009 Nov;145(2):260-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19635508</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2006 Jun 15;354(24):2564-75</Citation><ArticleIdList><ArticleId IdType="pubmed">16714767</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1935-44</Citation><ArticleIdList><ArticleId IdType="pubmed">19815859</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2005 Oct 20;353(16):1685-93</Citation><ArticleIdList><ArticleId IdType="pubmed">16236739</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Infect Dis. 2011 Apr;24(2):152-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21252660</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 Jul 31;349(5):507-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12890854</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2010 Aug;151(2):192-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20493216</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Jul 24;325(5939):481-3</Citation><ArticleIdList><ArticleId IdType="pubmed">19574348</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Virol. 2004 Dec;31(4):304-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15494274</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2004 Aug 15;39(4):511-6</Citation><ArticleIdList><ArticleId IdType="pubmed">15356814</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2004 Jun;203(2):631-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15141377</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 Jan;86(2):667-78</Citation><ArticleIdList><ArticleId IdType="pubmed">22072765</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Clin. 2011 Jul;27(3):719-33</Citation><ArticleIdList><ArticleId IdType="pubmed">21742225</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2009 May;82(2):A110-22</Citation><ArticleIdList><ArticleId IdType="pubmed">19176218</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2005 Jul 7;436(7047):112-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16001071</ArticleId></ArticleIdList></Reference><Reference><Citation>World J Biol Chem. 2010 May 26;1(5):85-94</Citation><ArticleIdList><ArticleId IdType="pubmed">21540994</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2010 Jan 1;181(1):72-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19875682</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):238-43</Citation><ArticleIdList><ArticleId IdType="pubmed">22300564</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2010 Jan 7;362(1):27-35</Citation><ArticleIdList><ArticleId IdType="pubmed">20032319</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S75-82</Citation><ArticleIdList><ArticleId IdType="pubmed">21342903</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 Oct 2;58(38):1071-4</Citation><ArticleIdList><ArticleId IdType="pubmed">19798021</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2012 May;40(5):1487-98</Citation><ArticleIdList><ArticleId IdType="pubmed">22511131</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2011 May;85(9):4234-45</Citation><ArticleIdList><ArticleId IdType="pubmed">21325418</ArticleId></ArticleIdList></Reference><Reference><Citation>Respir Res. 2008;9:57</Citation><ArticleIdList><ArticleId IdType="pubmed">18671884</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Cell Mol Biol. 2012 Jul;47(1):120-7</Citation><ArticleIdList><ArticleId IdType="pubmed">22427537</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):680-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19564631</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2008;4(8):e1000115</Citation><ArticleIdList><ArticleId IdType="pubmed">18670648</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Jul 24;325(5939):484-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19574347</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2010;5(10):e13757</Citation><ArticleIdList><ArticleId IdType="pubmed">21060798</ArticleId></ArticleIdList></Reference><Reference><Citation>Pulm Pharmacol Ther. 2013 Aug;26(4):427-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22449512</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation><ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Biol Med (Maywood). 2010 Aug;235(8):981-8</Citation><ArticleIdList><ArticleId IdType="pubmed">20660098</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2000 May 4;342(18):1334-49</Citation><ArticleIdList><ArticleId IdType="pubmed">10793167</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2010 Apr;137(4):916-25</Citation><ArticleIdList><ArticleId IdType="pubmed">20022969</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2009 Aug;35(8):1471-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19529910</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Pathol. 2011 Jul;179(1):199-210</Citation><ArticleIdList><ArticleId IdType="pubmed">21703402</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Intern Med. 2004 Nov 2;141(9):662-73</Citation><ArticleIdList><ArticleId IdType="pubmed">15520422</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Med. 2006 Sep;3(9):e343</Citation><ArticleIdList><ArticleId IdType="pubmed">16968120</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Aug;84(15):7569-80</Citation><ArticleIdList><ArticleId IdType="pubmed">20504924</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2011 Sep 16;146(6):980-91</Citation><ArticleIdList><ArticleId IdType="pubmed">21925319</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jun 4;289(21):2801-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12734147</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2009 Nov 4;302(17):1872-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19822627</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2009 Oct 15;183(8):5301-10</Citation><ArticleIdList><ArticleId IdType="pubmed">19783685</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunobiology. 1993 Nov;189(3-4):340-55</Citation><ArticleIdList><ArticleId IdType="pubmed">8125516</ArticleId></ArticleIdList></Reference><Reference><Citation>J Mol Med (Berl). 2012 Jun;90(6):637-47</Citation><ArticleIdList><ArticleId IdType="pubmed">22246130</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(1):e29347</Citation><ArticleIdList><ArticleId IdType="pubmed">22235288</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2006 Nov;210(3):288-97</Citation><ArticleIdList><ArticleId IdType="pubmed">17031779</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2009 Aug 20;460(7258):1021-5</Citation><ArticleIdList><ArticleId IdType="pubmed">19672242</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2010 Sep;138(3):568-77</Citation><ArticleIdList><ArticleId IdType="pubmed">20435656</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1925-34</Citation><ArticleIdList><ArticleId IdType="pubmed">19815860</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Mol Immunol. 2010 May;7(3):164-74</Citation><ArticleIdList><ArticleId IdType="pubmed">20383173</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2003 Nov 27;426(6965):450-4</Citation><ArticleIdList><ArticleId IdType="pubmed">14647384</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Signal. 2011 Jul;23(7):1069-75</Citation><ArticleIdList><ArticleId IdType="pubmed">21130872</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2003 Jul;200(3):282-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12845623</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2010 Jul 1;182(1):41-8</Citation><ArticleIdList><ArticleId IdType="pubmed">20203241</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 Jul 17;58(27):749-52</Citation><ArticleIdList><ArticleId IdType="pubmed">19609249</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2010 Feb;38(2):596-601</Citation><ArticleIdList><ArticleId IdType="pubmed">19851091</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2009;13(6):R201</Citation><ArticleIdList><ArticleId IdType="pubmed">20003352</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2012 Aug;122(8):2731-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22850883</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2009 Jun 18;360(25):2605-15</Citation><ArticleIdList><ArticleId IdType="pubmed">19423869</ArticleId></ArticleIdList></Reference><Reference><Citation>Respir Physiol Neurobiol. 2011 Sep 15;178(2):235-41</Citation><ArticleIdList><ArticleId IdType="pubmed">21726671</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 2011 May 1;183(9):1127-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21531953</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2010 Jan;36(1):33-41</Citation><ArticleIdList><ArticleId IdType="pubmed">19924393</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2010 Apr;16(4):595-603</Citation><ArticleIdList><ArticleId IdType="pubmed">20350372</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharm Sci. 2009 Oct 8;38(3):215-23</Citation><ArticleIdList><ArticleId IdType="pubmed">19616097</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 2005 Aug;17(4):404-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15950449</ArticleId></ArticleIdList></Reference><Reference><Citation>Mod Pathol. 2005 Jan;18(1):1-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15272286</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2011 Dec;225(4):618-27</Citation><ArticleIdList><ArticleId IdType="pubmed">22009550</ArticleId></ArticleIdList></Reference><Reference><Citation>Rev Med Virol. 2010 Nov;20(6):372-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20931610</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2010 Feb;6(2):e1000756</Citation><ArticleIdList><ArticleId IdType="pubmed">20140198</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2009 Dec 1;183(11):7441-50</Citation><ArticleIdList><ArticleId IdType="pubmed">19917678</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2010 May 15;201(10):1517-21</Citation><ArticleIdList><ArticleId IdType="pubmed">20367331</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2009 Nov;59(5):366-70</Citation><ArticleIdList><ArticleId IdType="pubmed">19747506</ArticleId></ArticleIdList></Reference><Reference><Citation>Chest. 2009 Apr;135(4):936-43</Citation><ArticleIdList><ArticleId IdType="pubmed">19188549</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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