Universal influenza vaccines, a dream to be realized soon.
Identifieur interne : 000840 ( PubMed/Corpus ); précédent : 000839; suivant : 000841Universal influenza vaccines, a dream to be realized soon.
Auteurs : Han Zhang ; Li Wang ; Richard W. Compans ; Bao-Zhong WangSource :
- Viruses [ 1999-4915 ] ; 2014.
English descriptors
- KwdEn :
- Antigens, Viral (genetics), Antigens, Viral (immunology), Conserved Sequence, Cross Protection, Epitopes (genetics), Epitopes (immunology), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Orthomyxoviridae (immunology), Viral Matrix Proteins (genetics), Viral Matrix Proteins (immunology).
- MESH :
- chemical , genetics : Antigens, Viral, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Viral Matrix Proteins.
- chemical , immunology : Antigens, Viral, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Viral Matrix Proteins.
- immunology : Influenza, Human, Orthomyxoviridae.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Conserved Sequence, Cross Protection, Humans.
Abstract
Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine.
DOI: 10.3390/v6051974
PubMed: 24784572
Links to Exploration step
pubmed:24784572Le document en format XML
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Compans</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. rcompan@emory.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Bao Zhong" sort="Wang, Bao Zhong" uniqKey="Wang B" first="Bao-Zhong" last="Wang">Bao-Zhong Wang</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. bwang3@emory.edu.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24784572</idno><idno type="pmid">24784572</idno><idno type="doi">10.3390/v6051974</idno><idno type="wicri:Area/PubMed/Corpus">000840</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000840</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Universal influenza vaccines, a dream to be realized soon.</title><author><name sortKey="Zhang, Han" sort="Zhang, Han" uniqKey="Zhang H" first="Han" last="Zhang">Han Zhang</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. han.zhang@emory.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. lwang40@emory.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W" last="Compans">Richard W. Compans</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. rcompan@emory.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Bao Zhong" sort="Wang, Bao Zhong" uniqKey="Wang B" first="Bao-Zhong" last="Wang">Bao-Zhong Wang</name><affiliation><nlm:affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. bwang3@emory.edu.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigens, Viral (genetics)</term><term>Antigens, Viral (immunology)</term><term>Conserved Sequence</term><term>Cross Protection</term><term>Epitopes (genetics)</term><term>Epitopes (immunology)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Orthomyxoviridae (immunology)</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Matrix Proteins (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term><term>Epitopes</term><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza Vaccines</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Conserved Sequence</term><term>Cross Protection</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24784572</PMID><DateCompleted><Year>2014</Year><Month>12</Month><Day>12</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1999-4915</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>Apr</Month><Day>29</Day></PubDate></JournalIssue><Title>Viruses</Title><ISOAbbreviation>Viruses</ISOAbbreviation></Journal><ArticleTitle>Universal influenza vaccines, a dream to be realized soon.</ArticleTitle><Pagination><MedlinePgn>1974-91</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3390/v6051974</ELocationID><Abstract><AbstractText>Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Han</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. han.zhang@emory.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA. lwang40@emory.edu.</Affiliation></AffiliationInfo></Author><Author 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IdType="pubmed">11870626</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S44-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21342899</ArticleId></ArticleIdList></Reference><Reference><Citation>Nanomedicine. 2013 May;9(4):523-31</Citation><ArticleIdList><ArticleId IdType="pubmed">23178283</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2010 Sep 24;28(41):6704-13</Citation><ArticleIdList><ArticleId IdType="pubmed">20691653</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Pharm Des. 2013;19(31):5587-600</Citation><ArticleIdList><ArticleId IdType="pubmed">23394564</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Clin Pharmacol. 2013 Aug;76(2):210-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23617282</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Infect Dis. 2010 Oct;10(10):712-22</Citation><ArticleIdList><ArticleId IdType="pubmed">20883967</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2004 Aug 13;22(23-24):2993-3003</Citation><ArticleIdList><ArticleId IdType="pubmed">15297047</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Microbiol. 2011 Aug;9(8):590-603</Citation><ArticleIdList><ArticleId IdType="pubmed">21747392</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2013 Aug 28;5(200):200ra114</Citation><ArticleIdList><ArticleId IdType="pubmed">23986398</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Diagn Ther. 2011 Apr 1;15(2):63-81</Citation><ArticleIdList><ArticleId IdType="pubmed">21623644</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2011 Oct 20;365(16):1541-2</Citation><ArticleIdList><ArticleId IdType="pubmed">22010922</ArticleId></ArticleIdList></Reference><Reference><Citation>Nanomedicine. 2014 Feb;10(2):473-82</Citation><ArticleIdList><ArticleId IdType="pubmed">23988715</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2012;3(2):e00012-12</Citation><ArticleIdList><ArticleId IdType="pubmed">22396479</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Vaccine Immunol. 2012 Jul;19(7):1012-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22573737</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2011 Aug 12;333(6044):850-6</Citation><ArticleIdList><ArticleId IdType="pubmed">21798894</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Immunol. 2012 Jun;32(3):595-603</Citation><ArticleIdList><ArticleId IdType="pubmed">22318394</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2010 May;120(5):1663-73</Citation><ArticleIdList><ArticleId IdType="pubmed">20389023</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 1988 Aug;6(4):304-6</Citation><ArticleIdList><ArticleId IdType="pubmed">2847436</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Med. 2013;64:189-202</Citation><ArticleIdList><ArticleId IdType="pubmed">23327522</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013;8(11):e78947</Citation><ArticleIdList><ArticleId IdType="pubmed">24260136</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2013 Dec 10;172(2):579-88</Citation><ArticleIdList><ArticleId IdType="pubmed">23643528</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 Nov;86(21):11686-97</Citation><ArticleIdList><ArticleId IdType="pubmed">22896619</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2011 Aug 11;29(35):5911-8</Citation><ArticleIdList><ArticleId IdType="pubmed">21723354</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2013;9(10):e1003657</Citation><ArticleIdList><ArticleId IdType="pubmed">24130481</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2010 Mar 3;142(2):187-95</Citation><ArticleIdList><ArticleId IdType="pubmed">19840825</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2010 Oct;9(10):1149-76</Citation><ArticleIdList><ArticleId IdType="pubmed">20923267</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Vaccine Immunol. 2011 Apr;18(4):647-54</Citation><ArticleIdList><ArticleId IdType="pubmed">21288996</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2013 May 16;368(20):1888-97</Citation><ArticleIdList><ArticleId IdType="pubmed">23577628</ArticleId></ArticleIdList></Reference><Reference><Citation>Influenza Res Treat. 2011;2011:126794</Citation><ArticleIdList><ArticleId IdType="pubmed">23074652</ArticleId></ArticleIdList></Reference><Reference><Citation>Biosci Trends. 2013 Apr;7(2):64-76</Citation><ArticleIdList><ArticleId IdType="pubmed">23612075</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Immunol. 2012 Apr;42(4):863-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22531913</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1994 Mar;68(3):1551-63</Citation><ArticleIdList><ArticleId IdType="pubmed">7508997</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomed Res Int. 2013;2013:686549</Citation><ArticleIdList><ArticleId IdType="pubmed">23984396</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2012 Aug 15;4(147):147ra114</Citation><ArticleIdList><ArticleId IdType="pubmed">22896678</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2012 Aug 15;430(1):63-72</Citation><ArticleIdList><ArticleId IdType="pubmed">22595444</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 1991 Jul;183(1):32-43</Citation><ArticleIdList><ArticleId IdType="pubmed">2053285</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2014 Jan;13(1):31-42</Citation><ArticleIdList><ArticleId IdType="pubmed">24192014</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013;8(10):e77084</Citation><ArticleIdList><ArticleId IdType="pubmed">24098576</ArticleId></ArticleIdList></Reference><Reference><Citation>FEMS Immunol Med Microbiol. 2003 Mar 20;35(2):141-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12628550</ArticleId></ArticleIdList></Reference><Reference><Citation>Poult Sci. 2009 Nov;88(11):2244-52</Citation><ArticleIdList><ArticleId IdType="pubmed">19834072</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Immunol. 2008 Jan;38(1):114-26</Citation><ArticleIdList><ArticleId IdType="pubmed">18081037</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Oct;81(20):10869-78</Citation><ArticleIdList><ArticleId IdType="pubmed">17670815</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2004 Dec 2;23(3):366-71</Citation><ArticleIdList><ArticleId IdType="pubmed">15530682</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2009 Jan 22;27(4):530-41</Citation><ArticleIdList><ArticleId IdType="pubmed">19026705</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2476-81</Citation><ArticleIdList><ArticleId IdType="pubmed">24469815</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2012 Apr 16;30(18):2908-13</Citation><ArticleIdList><ArticleId IdType="pubmed">22342501</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Vaccines. 2009 Apr;8(4):499-508</Citation><ArticleIdList><ArticleId IdType="pubmed">19348565</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Immunol. 1996 Nov;26(11):2595-600</Citation><ArticleIdList><ArticleId IdType="pubmed">8921944</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2010;5(12):e14442</Citation><ArticleIdList><ArticleId IdType="pubmed">21203437</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2002 Aug;83(Pt 8):1851-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12124449</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2013;8(10):e76571</Citation><ArticleIdList><ArticleId IdType="pubmed">24204639</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Nov 10;24(44-46):6597-601</Citation><ArticleIdList><ArticleId IdType="pubmed">16814430</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Vaccine Immunol. 2012 Aug;19(8):1119-25</Citation><ArticleIdList><ArticleId IdType="pubmed">22647270</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Jun;87(12):6542-50</Citation><ArticleIdList><ArticleId IdType="pubmed">23576508</ArticleId></ArticleIdList></Reference><Reference><Citation>MBio. 2010 May 18;1(1):null</Citation><ArticleIdList><ArticleId IdType="pubmed">20689752</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Apr 10;324(5924):246-51</Citation><ArticleIdList><ArticleId IdType="pubmed">19251591</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2013 Oct;87(19):10435-46</Citation><ArticleIdList><ArticleId IdType="pubmed">23903831</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Drug Deliv Rev. 2012 Nov;64(14):1547-68</Citation><ArticleIdList><ArticleId IdType="pubmed">22575858</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Pharm Biopharm. 2010 Nov;76(3):336-41</Citation><ArticleIdList><ArticleId IdType="pubmed">20691263</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2013 Sep;99(3):328-35</Citation><ArticleIdList><ArticleId IdType="pubmed">23811283</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods. 2006 Sep;40(1):98-117</Citation><ArticleIdList><ArticleId IdType="pubmed">16997718</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2012 May;86(10):5774-81</Citation><ArticleIdList><ArticleId IdType="pubmed">22398287</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2006 Jun 12;24(24):5158-68</Citation><ArticleIdList><ArticleId IdType="pubmed">16713037</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2003 Jun 2;21(19-20):2616-26</Citation><ArticleIdList><ArticleId IdType="pubmed">12744898</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 1989 Aug;70 ( Pt 8):2221-6</Citation><ArticleIdList><ArticleId IdType="pubmed">2549189</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2010 Aug;84(15):7760-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20484519</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2010 Aug 27;329(5995):1060-4</Citation><ArticleIdList><ArticleId IdType="pubmed">20647428</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2013 Mar;172(1-2):15-23</Citation><ArticleIdList><ArticleId IdType="pubmed">23266401</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1994 Feb;68(2):911-9</Citation><ArticleIdList><ArticleId IdType="pubmed">7507186</ArticleId></ArticleIdList></Reference><Reference><Citation>Vet Immunol Immunopathol. 2012 Mar 15;146(1):92-6</Citation><ArticleIdList><ArticleId IdType="pubmed">22336036</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods. 2006 Sep;40(1):60-5</Citation><ArticleIdList><ArticleId IdType="pubmed">16997714</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Pharm. 2008 Jan 22;347(1-2):109-17</Citation><ArticleIdList><ArticleId IdType="pubmed">17681686</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Feb;88(4):2340-3</Citation><ArticleIdList><ArticleId IdType="pubmed">24307585</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15;305(2):L108-17</Citation><ArticleIdList><ArticleId IdType="pubmed">23709619</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochim Biophys Acta. 2010 Aug;1800(8):846-57</Citation><ArticleIdList><ArticleId IdType="pubmed">20227466</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunotherapy. 2014;6(1):51-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24341884</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2014 Jan;88(1):699-704</Citation><ArticleIdList><ArticleId IdType="pubmed">24155380</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Struct Mol Biol. 2009 Mar;16(3):265-73</Citation><ArticleIdList><ArticleId IdType="pubmed">19234466</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1991 Oct;65(10):5491-8</Citation><ArticleIdList><ArticleId IdType="pubmed">1895397</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2573-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22308500</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2014 Mar 28;178:1-7</Citation><ArticleIdList><ArticleId IdType="pubmed">24417966</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2008 Jun 25;26(27-28):3395-403</Citation><ArticleIdList><ArticleId IdType="pubmed">18511159</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13701-6</Citation><ArticleIdList><ArticleId IdType="pubmed">20615991</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2006 Nov 1;194 Suppl 2:S147-54</Citation><ArticleIdList><ArticleId IdType="pubmed">17163388</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr HIV Res. 2010 Jun;8(4):299-309</Citation><ArticleIdList><ArticleId IdType="pubmed">20353398</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Rev. 2013 Jul;26(3):476-92</Citation><ArticleIdList><ArticleId IdType="pubmed">23824369</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunol Cell Biol. 2010 Jul;88(5):605-11</Citation><ArticleIdList><ArticleId IdType="pubmed">20177411</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2003 Sep;2(9):727-35</Citation><ArticleIdList><ArticleId IdType="pubmed">12951579</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Ther. 2013 Feb;21(2):485-92</Citation><ArticleIdList><ArticleId IdType="pubmed">23247101</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Vaccine Immunol. 2007 Apr;14(4):375-81</Citation><ArticleIdList><ArticleId IdType="pubmed">17329444</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2008 May 22;128(1):50-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18417240</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol J. 2013;10:227</Citation><ArticleIdList><ArticleId IdType="pubmed">23834899</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 1999 Oct;5(10):1157-63</Citation><ArticleIdList><ArticleId IdType="pubmed">10502819</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2013 Oct;19(10):1305-12</Citation><ArticleIdList><ArticleId IdType="pubmed">24056771</ArticleId></ArticleIdList></Reference><Reference><Citation>Nanomedicine (Lond). 2012 Jun;7(6):889-97</Citation><ArticleIdList><ArticleId IdType="pubmed">22734641</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2013 Jul 4;499(7456):102-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23698367</ArticleId></ArticleIdList></Reference><Reference><Citation>Nanomedicine (Lond). 2014 Feb;9(2):237-51</Citation><ArticleIdList><ArticleId IdType="pubmed">23829488</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jan 8;289(2):179-86</Citation><ArticleIdList><ArticleId IdType="pubmed">12517228</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2010 May 7;328(5979):745-8</Citation><ArticleIdList><ArticleId IdType="pubmed">20448183</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2009 Oct 23;27(45):6280-3</Citation><ArticleIdList><ArticleId IdType="pubmed">19840661</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2007 Sep 28;25(39-40):6852-62</Citation><ArticleIdList><ArticleId IdType="pubmed">17719149</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1985 Nov;56(2):502-11</Citation><ArticleIdList><ArticleId IdType="pubmed">3840537</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1982 Aug;79(15):4800-4</Citation><ArticleIdList><ArticleId IdType="pubmed">6956892</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2008 Dec;82(23):11813-23</Citation><ArticleIdList><ArticleId IdType="pubmed">18786995</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18979-84</Citation><ArticleIdList><ArticleId IdType="pubmed">20956293</ArticleId></ArticleIdList></Reference><Reference><Citation>Vaccine. 2008 Jan 10;26(2):201-14</Citation><ArticleIdList><ArticleId IdType="pubmed">18063235</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2011 Aug 12;333(6044):843-50</Citation><ArticleIdList><ArticleId IdType="pubmed">21737702</ArticleId></ArticleIdList></Reference><Reference><Citation>Emerg Infect Dis. 2006 Apr;12(4):569-74</Citation><ArticleIdList><ArticleId IdType="pubmed">16704803</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Transl Med. 2013 May 29;5(187):187ra72</Citation><ArticleIdList><ArticleId IdType="pubmed">23720583</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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