A novel method to produce Influenza A virus matrix protein M1 Capsid Like Particles (CLPs).
Identifieur interne : 000837 ( PubMed/Corpus ); précédent : 000836; suivant : 000838A novel method to produce Influenza A virus matrix protein M1 Capsid Like Particles (CLPs).
Auteurs : Vahid Baniasadi ; Sunil K. LalSource :
- Journal of virological methods [ 1879-0984 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Birds, Capsid (immunology), Capsid (metabolism), Capsid (ultrastructure), Humans, Influenza A virus (immunology), Influenza A virus (physiology), Influenza Vaccines (immunology), Influenza in Birds (prevention & control), Influenza in Birds (virology), Influenza, Human (prevention & control), Influenza, Human (virology), Vaccines, Virus-Like Particle (immunology), Viral Matrix Proteins (immunology), Viral Matrix Proteins (metabolism).
- MESH :
- chemical , blood : Antibodies, Viral.
- immunology : Capsid, Influenza A virus, Influenza Vaccines, Vaccines, Virus-Like Particle, Viral Matrix Proteins.
- metabolism : Capsid, Viral Matrix Proteins.
- physiology : Influenza A virus.
- prevention & control : Influenza in Birds, Influenza, Human.
- ultrastructure : Capsid.
- virology : Influenza in Birds, Influenza, Human.
- Animals, Birds, Humans.
Abstract
Avian influenza viruses represent a growing threat for an influenza pandemic. The currently licensed influenza vaccines have inherent drawbacks which has led many research groups to explore different approaches of vaccine development among which Virus Like particles (VLPs) seem like a promising alternative in the near future. Although it is known that the Matrix 1 protein (M1) of influenza plays an essential role in VLP formation and it is documented that M1 is able to form dimers, it is not clear if M1 is capable of forming higher order structures without the interference of other influenza proteins or cell derived envelope. Here, for the first time we have demonstrated that expression of M1 alone is enough to form a Capsid Like Particle (CLP) without the requirement of any other external factor.
DOI: 10.1016/j.jviromet.2014.03.027
PubMed: 24797458
Links to Exploration step
pubmed:24797458Le document en format XML
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<author><name sortKey="Baniasadi, Vahid" sort="Baniasadi, Vahid" uniqKey="Baniasadi V" first="Vahid" last="Baniasadi">Vahid Baniasadi</name>
<affiliation><nlm:affiliation>Virology Group, International Centre for Genetic Engineering & Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</nlm:affiliation>
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<author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name>
<affiliation><nlm:affiliation>Virology Group, International Centre for Genetic Engineering & Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India. Electronic address: sunilklal@icgeb.res.in.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A novel method to produce Influenza A virus matrix protein M1 Capsid Like Particles (CLPs).</title>
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<author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name>
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<front><div type="abstract" xml:lang="en">Avian influenza viruses represent a growing threat for an influenza pandemic. The currently licensed influenza vaccines have inherent drawbacks which has led many research groups to explore different approaches of vaccine development among which Virus Like particles (VLPs) seem like a promising alternative in the near future. Although it is known that the Matrix 1 protein (M1) of influenza plays an essential role in VLP formation and it is documented that M1 is able to form dimers, it is not clear if M1 is capable of forming higher order structures without the interference of other influenza proteins or cell derived envelope. Here, for the first time we have demonstrated that expression of M1 alone is enough to form a Capsid Like Particle (CLP) without the requirement of any other external factor.</div>
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<Abstract><AbstractText>Avian influenza viruses represent a growing threat for an influenza pandemic. The currently licensed influenza vaccines have inherent drawbacks which has led many research groups to explore different approaches of vaccine development among which Virus Like particles (VLPs) seem like a promising alternative in the near future. Although it is known that the Matrix 1 protein (M1) of influenza plays an essential role in VLP formation and it is documented that M1 is able to form dimers, it is not clear if M1 is capable of forming higher order structures without the interference of other influenza proteins or cell derived envelope. Here, for the first time we have demonstrated that expression of M1 alone is enough to form a Capsid Like Particle (CLP) without the requirement of any other external factor.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation>
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