Serveur d'exploration sur les pandémies grippales

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Comparison between virus shedding and fever duration after treating children with pandemic A H1N1/09 and children with A H3N2 with a neuraminidase inhibitor.

Identifieur interne : 000830 ( PubMed/Corpus ); précédent : 000829; suivant : 000831

Comparison between virus shedding and fever duration after treating children with pandemic A H1N1/09 and children with A H3N2 with a neuraminidase inhibitor.

Auteurs : Norio Sugaya ; Yuko Sakai-Tagawa ; Masahiro Bamba ; Rieko Yasuhara ; Masahiko Yamazaki ; Chiharu Kawakami ; Yoshio Yamaguchi ; Yoshiaki Ide ; Masataka Ichikawa ; Keiko Mitamura ; Yoshihiro Kawaoka

Source :

RBID : pubmed:24832015

English descriptors

Abstract

Shedding of the pandemic virus during an influenza pandemic is thought to persist longer than shedding of influenza viruses during annual influenza seasons, because people have much less immunity against a pandemic influenza. A correlation is thought to exist between the length of virus shedding and the clinical severity of influenza illness.

DOI: 10.3851/IMP2798
PubMed: 24832015

Links to Exploration step

pubmed:24832015

Le document en format XML

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<term>Enzyme Inhibitors (therapeutic use)</term>
<term>Female</term>
<term>Fever (drug therapy)</term>
<term>Fever (physiopathology)</term>
<term>Fever (virology)</term>
<term>Guanidines (therapeutic use)</term>
<term>Humans</term>
<term>Infant</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (enzymology)</term>
<term>Influenza A Virus, H1N1 Subtype (growth & development)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H3N2 Subtype (drug effects)</term>
<term>Influenza A Virus, H3N2 Subtype (enzymology)</term>
<term>Influenza A Virus, H3N2 Subtype (growth & development)</term>
<term>Influenza A Virus, H3N2 Subtype (pathogenicity)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (physiopathology)</term>
<term>Influenza, Human (virology)</term>
<term>Male</term>
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<term>Neuraminidase (metabolism)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Severity of Illness Index</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
<term>Viral Proteins (metabolism)</term>
<term>Virus Shedding (drug effects)</term>
<term>Zanamivir (analogs & derivatives)</term>
<term>Zanamivir (therapeutic use)</term>
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<term>Zanamivir</term>
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<term>Neuraminidase</term>
<term>Viral Proteins</term>
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<term>Neuraminidase</term>
<term>Viral Proteins</term>
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<term>Antiviral Agents</term>
<term>Cyclopentanes</term>
<term>Enzyme Inhibitors</term>
<term>Guanidines</term>
<term>Oseltamivir</term>
<term>Zanamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Virus Shedding</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Fever</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en">
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
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<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
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<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
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<div type="abstract" xml:lang="en">Shedding of the pandemic virus during an influenza pandemic is thought to persist longer than shedding of influenza viruses during annual influenza seasons, because people have much less immunity against a pandemic influenza. A correlation is thought to exist between the length of virus shedding and the clinical severity of influenza illness.</div>
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<Month>11</Month>
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<Year>2015</Year>
<Month>03</Month>
<Day>06</Day>
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<Title>Antiviral therapy</Title>
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<ArticleTitle>Comparison between virus shedding and fever duration after treating children with pandemic A H1N1/09 and children with A H3N2 with a neuraminidase inhibitor.</ArticleTitle>
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<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Shedding of the pandemic virus during an influenza pandemic is thought to persist longer than shedding of influenza viruses during annual influenza seasons, because people have much less immunity against a pandemic influenza. A correlation is thought to exist between the length of virus shedding and the clinical severity of influenza illness.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We compared the virus isolation rates of children with pandemic A H1N1/09 influenza infection and children with A H3N2 influenza infection after the patients had been treated with one of three neuraminidase inhibitors (NAI) such as peramivir, laninamivir and oseltamivir. The clinical effectiveness of each NAI was assessed on the basis of the duration of the febrile period after the start of treatment.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Influenza viruses were isolated from 15 of the 34 patients in the A H3N2 group (mean age 6.2 years) and from 4 of the 25 patients in the A H1N1/09 (mean age 5.6 years) virus group (44.1% versus 16.0%; P<0.05). However, the differences between the duration of fever in the patients in the A H3N2 group and A H1N1/09 group after treatment with the NAIs were not significant.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The virus isolation rates after treatment with each of the NAIs were significantly lower in the A H1N1/09 group, suggesting that the pandemic A H1N1/09 virus was more sensitive to the NAIs than the seasonal A H3N2 virus was. Clinically, there were no significant differences in the effectiveness of the NAIs between the H1N1/09 infected group and H3N2 infected group.</AbstractText>
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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:24832015" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a PandemieGrippaleV1 

Wicri

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