Evaluation of Immune Response Against Inactivated Avian Influenza (H9N2) Vaccine, by Using Chitosan Nanoparticles.
Identifieur interne : 000559 ( PubMed/Corpus ); précédent : 000558; suivant : 000560Evaluation of Immune Response Against Inactivated Avian Influenza (H9N2) Vaccine, by Using Chitosan Nanoparticles.
Auteurs : Iraj Khalili ; Rahim Ghadimipour ; Saeed Sadigh Eteghad ; Mohsen Fathi Najafi ; Mohammad Majid Ebrahimi ; Naser Godsian ; Yousef Sefidi Heris ; Mohammad Taghi KhaliliSource :
- Jundishapur journal of microbiology [ 2008-3645 ] ; 2015.
Abstract
Influenza A is a virus that affects a wide range of animals and also human beings. Avian influenza virus (AIV) subtype H9N2 has the potential to create influenza pandemic and vaccination is a common solution for this problem. The vaccine, used for rapid intervention, should be safe to use and highly effective, after a single administration. Chitosan nanoparticles (CNP) have already been recommended as a new adjuvant for inactivated AIV H9N2 vaccine immunization.
DOI: 10.5812/jjm.27035
PubMed: 26865942
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of Immune Response Against Inactivated Avian Influenza (H9N2) Vaccine, by Using Chitosan Nanoparticles.</title><author><name sortKey="Khalili, Iraj" sort="Khalili, Iraj" uniqKey="Khalili I" first="Iraj" last="Khalili">Iraj Khalili</name><affiliation><nlm:affiliation>Laboratory of Virus Biobank, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Ghadimipour, Rahim" sort="Ghadimipour, Rahim" uniqKey="Ghadimipour R" first="Rahim" last="Ghadimipour">Rahim Ghadimipour</name><affiliation><nlm:affiliation>Department of Research and Development, Razi Vaccine and Serum Research Institute, Ahvaz, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Sadigh Eteghad, Saeed" sort="Sadigh Eteghad, Saeed" uniqKey="Sadigh Eteghad S" first="Saeed" last="Sadigh Eteghad">Saeed Sadigh Eteghad</name><affiliation><nlm:affiliation>Neurosciences Research Center, Tabriz University of Medical Science, Tabriz, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Fathi Najafi, Mohsen" sort="Fathi Najafi, Mohsen" uniqKey="Fathi Najafi M" first="Mohsen" last="Fathi Najafi">Mohsen Fathi Najafi</name><affiliation><nlm:affiliation>Department of Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Ebrahimi, Mohammad Majid" sort="Ebrahimi, Mohammad Majid" uniqKey="Ebrahimi M" first="Mohammad Majid" last="Ebrahimi">Mohammad Majid Ebrahimi</name><affiliation><nlm:affiliation>Department of Poultry Research and Vaccine Production, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Godsian, Naser" sort="Godsian, Naser" uniqKey="Godsian N" first="Naser" last="Godsian">Naser Godsian</name><affiliation><nlm:affiliation>Department of Poultry Vaccines Quality Control, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Sefidi Heris, Yousef" sort="Sefidi Heris, Yousef" uniqKey="Sefidi Heris Y" first="Yousef" last="Sefidi Heris">Yousef Sefidi Heris</name><affiliation><nlm:affiliation>Higher Education Institute of Rab-Rashidi, Tabriz, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Khalili, Mohammad Taghi" sort="Khalili, Mohammad Taghi" uniqKey="Khalili M" first="Mohammad Taghi" last="Khalili">Mohammad Taghi Khalili</name><affiliation><nlm:affiliation>Department of Poultry Inactivated Vaccines, Razi Vaccine and Serum Research Institute, Marand, IR Iran.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26865942</idno><idno type="pmid">26865942</idno><idno type="doi">10.5812/jjm.27035</idno><idno type="wicri:Area/PubMed/Corpus">000559</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000559</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of Immune Response Against Inactivated Avian Influenza (H9N2) Vaccine, by Using Chitosan Nanoparticles.</title><author><name sortKey="Khalili, Iraj" sort="Khalili, Iraj" uniqKey="Khalili I" first="Iraj" last="Khalili">Iraj Khalili</name><affiliation><nlm:affiliation>Laboratory of Virus Biobank, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Ghadimipour, Rahim" sort="Ghadimipour, Rahim" uniqKey="Ghadimipour R" first="Rahim" last="Ghadimipour">Rahim Ghadimipour</name><affiliation><nlm:affiliation>Department of Research and Development, Razi Vaccine and Serum Research Institute, Ahvaz, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Sadigh Eteghad, Saeed" sort="Sadigh Eteghad, Saeed" uniqKey="Sadigh Eteghad S" first="Saeed" last="Sadigh Eteghad">Saeed Sadigh Eteghad</name><affiliation><nlm:affiliation>Neurosciences Research Center, Tabriz University of Medical Science, Tabriz, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Fathi Najafi, Mohsen" sort="Fathi Najafi, Mohsen" uniqKey="Fathi Najafi M" first="Mohsen" last="Fathi Najafi">Mohsen Fathi Najafi</name><affiliation><nlm:affiliation>Department of Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Ebrahimi, Mohammad Majid" sort="Ebrahimi, Mohammad Majid" uniqKey="Ebrahimi M" first="Mohammad Majid" last="Ebrahimi">Mohammad Majid Ebrahimi</name><affiliation><nlm:affiliation>Department of Poultry Research and Vaccine Production, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Godsian, Naser" sort="Godsian, Naser" uniqKey="Godsian N" first="Naser" last="Godsian">Naser Godsian</name><affiliation><nlm:affiliation>Department of Poultry Vaccines Quality Control, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Sefidi Heris, Yousef" sort="Sefidi Heris, Yousef" uniqKey="Sefidi Heris Y" first="Yousef" last="Sefidi Heris">Yousef Sefidi Heris</name><affiliation><nlm:affiliation>Higher Education Institute of Rab-Rashidi, Tabriz, IR Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Khalili, Mohammad Taghi" sort="Khalili, Mohammad Taghi" uniqKey="Khalili M" first="Mohammad Taghi" last="Khalili">Mohammad Taghi Khalili</name><affiliation><nlm:affiliation>Department of Poultry Inactivated Vaccines, Razi Vaccine and Serum Research Institute, Marand, IR Iran.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Jundishapur journal of microbiology</title><idno type="ISSN">2008-3645</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza A is a virus that affects a wide range of animals and also human beings. Avian influenza virus (AIV) subtype H9N2 has the potential to create influenza pandemic and vaccination is a common solution for this problem. The vaccine, used for rapid intervention, should be safe to use and highly effective, after a single administration. Chitosan nanoparticles (CNP) have already been recommended as a new adjuvant for inactivated AIV H9N2 vaccine immunization.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">26865942</PMID><DateCompleted><Year>2016</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2008-3645</ISSN><JournalIssue CitedMedium="Print"><Volume>8</Volume><Issue>12</Issue><PubDate><Year>2015</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Jundishapur journal of microbiology</Title><ISOAbbreviation>Jundishapur J Microbiol</ISOAbbreviation></Journal><ArticleTitle>Evaluation of Immune Response Against Inactivated Avian Influenza (H9N2) Vaccine, by Using Chitosan Nanoparticles.</ArticleTitle><Pagination><MedlinePgn>e27035</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.5812/jjm.27035</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Influenza A is a virus that affects a wide range of animals and also human beings. Avian influenza virus (AIV) subtype H9N2 has the potential to create influenza pandemic and vaccination is a common solution for this problem. The vaccine, used for rapid intervention, should be safe to use and highly effective, after a single administration. Chitosan nanoparticles (CNP) have already been recommended as a new adjuvant for inactivated AIV H9N2 vaccine immunization.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This study aimed at the evaluation and better understanding of optimum concentration of CNP preparations and also, assessment of loading capacity of AIV into CNP, as an adjuvant in specific pathogen-free (SPF) chickens.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">For measurement of vaccine-antibody response, different types of CNP were injected intramuscularly, in a single dose, to 21-day-old specific pathogen-free chickens. Chickens were monitored for the efficacy of the nanoparticles and, also, their immune response, during a follow up of 7 weeks, by using hemagglutination-inhibition (HI) test. The CNP were prepared according to modified ionic gelation method and inactivated antigen was loaded in four hemagglutinin units (HAU) concentrations. Loading capacity of nanoparticles was determined by hemagglutination (HA) method. Inactivated A/H9N2 AIV was mixed with chitosan of low molecular weight.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The CNP did not cause any mortality or side effects, when chickens were administered the prepared vaccine. The results strongly showed that this novel vaccine significantly enhances the immunogenicity of inactivated AIV, comparing with ISA70 (SEPPIC, Puteaux, France) adjuvant that is used routinely in the Razi Serum and Vaccine Research and Production Institute, Karaj, Iran, to reduce ISA70's side effects.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The AIV loaded into CNP vaccines induce appropriate antibody titers, after a single immunization, while requiring a low dose of antigen. The CNP also represent an interesting new platform for antigen delivery and a promising adjuvant candidate for H9N2 inactivated influenza vaccine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Khalili</LastName><ForeName>Iraj</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Laboratory of Virus Biobank, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghadimipour</LastName><ForeName>Rahim</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Research and Development, Razi Vaccine and Serum Research Institute, Ahvaz, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sadigh Eteghad</LastName><ForeName>Saeed</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Neurosciences Research Center, Tabriz University of Medical Science, Tabriz, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fathi Najafi</LastName><ForeName>Mohsen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebrahimi</LastName><ForeName>Mohammad Majid</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Poultry Research and Vaccine Production, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godsian</LastName><ForeName>Naser</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Poultry Vaccines Quality Control, Razi Vaccine and Serum Research Institute, Karaj, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sefidi Heris</LastName><ForeName>Yousef</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Higher Education Institute of Rab-Rashidi, Tabriz, IR Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khalili</LastName><ForeName>Mohammad Taghi</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Department of Poultry Inactivated Vaccines, Razi Vaccine and Serum Research Institute, Marand, IR Iran.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>Iran</Country><MedlineTA>Jundishapur J Microbiol</MedlineTA><NlmUniqueID>101515122</NlmUniqueID><ISSNLinking>2008-3645</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chitosan</Keyword><Keyword MajorTopicYN="N">H9N2 Subtype</Keyword><Keyword MajorTopicYN="N">Hemagglutination Inhibition Tests</Keyword><Keyword MajorTopicYN="N">Influenza A Virus</Keyword><Keyword MajorTopicYN="N">Nanoparticles</Keyword><Keyword MajorTopicYN="N">Vaccines</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>02</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26865942</ArticleId><ArticleId 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