Differential proteomic analysis of respiratory samples from patients suffering from influenza.
Identifieur interne : 000424 ( PubMed/Corpus ); précédent : 000423; suivant : 000425Differential proteomic analysis of respiratory samples from patients suffering from influenza.
Auteurs : Rahul Chavan ; Sandeepan Mukherjee ; Ritwik Dahake ; Domnic Colvin ; Avinash Kale ; Abhay ChowdharySource :
- Virusdisease [ 2347-3584 ] ; 2016.
Abstract
The exact molecular pathways involved in the pathogenesis of influenza are yet unclear. In the present study we investigated the upper respiratory proteome in influenza patients. 200 nasal and throat swab samples were collected from patients suffering from acute respiratory illness. These samples were confirmed for influenza pandemic A/H1N1/2009 and influenza type B using qRT-PCR. 10 similar swabs were collected from healthy individuals and were used as controls. Proteins were extracted from the cell pellets and were subjected to 2-D gel electrophoresis. The differentially expressed proteins were identified using MALDI-TOF. Identified proteins were classified into different functional groups based on functions reported in the databases. 25 % of these proteins were involved in cytoskeletal formation, whereas 14 % were involved in signal transduction. Proteins involved in anti-viral responses, Ca-signaling, transport, and tumor suppression constituted 10 % each, where as 5 % of proteins each belong to Nicotinic acetylcholine receptor, Protein Synthesis and anti-bacterial proteins. 10 % of the proteins have not been described previously. This is the first report on respiratory proteome profile in Influenza patients. The study emphasizes the role of such profiling studies using multiple platforms for bio-marker discoveries, especially non-invasive diagnostic marker in Influenza and other infectious diseases.
DOI: 10.1007/s13337-016-0332-x
PubMed: 28466033
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential proteomic analysis of respiratory samples from patients suffering from influenza.</title><author><name sortKey="Chavan, Rahul" sort="Chavan, Rahul" uniqKey="Chavan R" first="Rahul" last="Chavan">Rahul Chavan</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author><author><name sortKey="Mukherjee, Sandeepan" sort="Mukherjee, Sandeepan" uniqKey="Mukherjee S" first="Sandeepan" last="Mukherjee">Sandeepan Mukherjee</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author><author><name sortKey="Dahake, Ritwik" sort="Dahake, Ritwik" uniqKey="Dahake R" first="Ritwik" last="Dahake">Ritwik Dahake</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author><author><name sortKey="Colvin, Domnic" sort="Colvin, Domnic" uniqKey="Colvin D" first="Domnic" last="Colvin">Domnic Colvin</name><affiliation><nlm:affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</nlm:affiliation></affiliation></author><author><name sortKey="Kale, Avinash" sort="Kale, Avinash" uniqKey="Kale A" first="Avinash" last="Kale">Avinash Kale</name><affiliation><nlm:affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</nlm:affiliation></affiliation></author><author><name sortKey="Chowdhary, Abhay" sort="Chowdhary, Abhay" uniqKey="Chowdhary A" first="Abhay" last="Chowdhary">Abhay Chowdhary</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:28466033</idno><idno type="pmid">28466033</idno><idno type="doi">10.1007/s13337-016-0332-x</idno><idno type="wicri:Area/PubMed/Corpus">000424</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000424</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Differential proteomic analysis of respiratory samples from patients suffering from influenza.</title><author><name sortKey="Chavan, Rahul" sort="Chavan, Rahul" uniqKey="Chavan R" first="Rahul" last="Chavan">Rahul Chavan</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author><author><name sortKey="Mukherjee, Sandeepan" sort="Mukherjee, Sandeepan" uniqKey="Mukherjee S" first="Sandeepan" last="Mukherjee">Sandeepan Mukherjee</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author><author><name sortKey="Dahake, Ritwik" sort="Dahake, Ritwik" uniqKey="Dahake R" first="Ritwik" last="Dahake">Ritwik Dahake</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author><author><name sortKey="Colvin, Domnic" sort="Colvin, Domnic" uniqKey="Colvin D" first="Domnic" last="Colvin">Domnic Colvin</name><affiliation><nlm:affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</nlm:affiliation></affiliation></author><author><name sortKey="Kale, Avinash" sort="Kale, Avinash" uniqKey="Kale A" first="Avinash" last="Kale">Avinash Kale</name><affiliation><nlm:affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</nlm:affiliation></affiliation></author><author><name sortKey="Chowdhary, Abhay" sort="Chowdhary, Abhay" uniqKey="Chowdhary A" first="Abhay" last="Chowdhary">Abhay Chowdhary</name><affiliation><nlm:affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Virusdisease</title><idno type="ISSN">2347-3584</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The exact molecular pathways involved in the pathogenesis of influenza are yet unclear. In the present study we investigated the upper respiratory proteome in influenza patients. 200 nasal and throat swab samples were collected from patients suffering from acute respiratory illness. These samples were confirmed for influenza pandemic A/H1N1/2009 and influenza type B using qRT-PCR. 10 similar swabs were collected from healthy individuals and were used as controls. Proteins were extracted from the cell pellets and were subjected to 2-D gel electrophoresis. The differentially expressed proteins were identified using MALDI-TOF. Identified proteins were classified into different functional groups based on functions reported in the databases. 25 % of these proteins were involved in cytoskeletal formation, whereas 14 % were involved in signal transduction. Proteins involved in anti-viral responses, Ca-signaling, transport, and tumor suppression constituted 10 % each, where as 5 % of proteins each belong to Nicotinic acetylcholine receptor, Protein Synthesis and anti-bacterial proteins. 10 % of the proteins have not been described previously. This is the first report on respiratory proteome profile in Influenza patients. The study emphasizes the role of such profiling studies using multiple platforms for bio-marker discoveries, especially non-invasive diagnostic marker in Influenza and other infectious diseases.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28466033</PMID><DateRevised><Year>2019</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2347-3584</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Virusdisease</Title><ISOAbbreviation>Virusdisease</ISOAbbreviation></Journal><ArticleTitle>Differential proteomic analysis of respiratory samples from patients suffering from influenza.</ArticleTitle><Pagination><MedlinePgn>226-233</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s13337-016-0332-x</ELocationID><Abstract><AbstractText>The exact molecular pathways involved in the pathogenesis of influenza are yet unclear. In the present study we investigated the upper respiratory proteome in influenza patients. 200 nasal and throat swab samples were collected from patients suffering from acute respiratory illness. These samples were confirmed for influenza pandemic A/H1N1/2009 and influenza type B using qRT-PCR. 10 similar swabs were collected from healthy individuals and were used as controls. Proteins were extracted from the cell pellets and were subjected to 2-D gel electrophoresis. The differentially expressed proteins were identified using MALDI-TOF. Identified proteins were classified into different functional groups based on functions reported in the databases. 25 % of these proteins were involved in cytoskeletal formation, whereas 14 % were involved in signal transduction. Proteins involved in anti-viral responses, Ca-signaling, transport, and tumor suppression constituted 10 % each, where as 5 % of proteins each belong to Nicotinic acetylcholine receptor, Protein Synthesis and anti-bacterial proteins. 10 % of the proteins have not been described previously. This is the first report on respiratory proteome profile in Influenza patients. The study emphasizes the role of such profiling studies using multiple platforms for bio-marker discoveries, especially non-invasive diagnostic marker in Influenza and other infectious diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chavan</LastName><ForeName>Rahul</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mukherjee</LastName><ForeName>Sandeepan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dahake</LastName><ForeName>Ritwik</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colvin</LastName><ForeName>Domnic</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kale</LastName><ForeName>Avinash</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0001-9212-9343</Identifier><AffiliationInfo><Affiliation>Department of Chemistry, UM-DAE Center for Excellence in Basic Sciences, Health Centre, University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East), Mumbai, Maharashtra 400098 India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chowdhary</LastName><ForeName>Abhay</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Virology, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg Parel, Mumbai, Maharashtra 400 012 India.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology, Grant Medical College and Sir J.J. Group of Hospitals, Byculla, Mumbai, Maharashtra 400008 India.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>08</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>India</Country><MedlineTA>Virusdisease</MedlineTA><NlmUniqueID>101624144</NlmUniqueID><ISSNLinking>2347-3584</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2-D gel electrophoresis</Keyword><Keyword MajorTopicYN="N">Differential proteome</Keyword><Keyword MajorTopicYN="N">Influenza type B</Keyword><Keyword MajorTopicYN="N">Mass spectrometry</Keyword><Keyword MajorTopicYN="N">Pandemic influenza A/H1N1/2009</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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