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Pandemic (H1N1) 2009 influenza virus induces weaker host immune responses in vitro: a possible mechanism of high transmissibility.

Identifieur interne : 000E98 ( PubMed/Checkpoint ); précédent : 000E97; suivant : 000E99

Pandemic (H1N1) 2009 influenza virus induces weaker host immune responses in vitro: a possible mechanism of high transmissibility.

Auteurs : Sanjay Mukherjee [Inde] ; Veena C. Vipat ; Akhilesh C. Mishra ; Shailesh D. Pawar ; Alok K. Chakrabarti

Source :

RBID : pubmed:21439068

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English descriptors

Abstract

The world has recently overcome the first influenza pandemic of the 21st century caused by a novel H1N1 virus (pH1N1) which is a triple reassortant comprising genes derived from avian, human, and swine influenza viruses and antigenically quite different from seasonal H1N1 strains. Although the case fatality rates have decreased in many developed countries, the situation is still alarming in many developing countries including India where considerable numbers of new cases are appearing everyday. There is still a high morbidity and mortality of susceptible adult as well as young population without having underlying health issues due to the influenza infection.

DOI: 10.1186/1743-422X-8-140
PubMed: 21439068


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<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
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<term>Influenza, Human (genetics)</term>
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<term>Grippe humaine (génétique)</term>
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<term>Sous-type H1N1 du virus de la grippe A</term>
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<term>Influenza A Virus, H1N1 Subtype</term>
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<div type="abstract" xml:lang="en">The world has recently overcome the first influenza pandemic of the 21st century caused by a novel H1N1 virus (pH1N1) which is a triple reassortant comprising genes derived from avian, human, and swine influenza viruses and antigenically quite different from seasonal H1N1 strains. Although the case fatality rates have decreased in many developed countries, the situation is still alarming in many developing countries including India where considerable numbers of new cases are appearing everyday. There is still a high morbidity and mortality of susceptible adult as well as young population without having underlying health issues due to the influenza infection.</div>
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<ArticleTitle>Pandemic (H1N1) 2009 influenza virus induces weaker host immune responses in vitro: a possible mechanism of high transmissibility.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The world has recently overcome the first influenza pandemic of the 21st century caused by a novel H1N1 virus (pH1N1) which is a triple reassortant comprising genes derived from avian, human, and swine influenza viruses and antigenically quite different from seasonal H1N1 strains. Although the case fatality rates have decreased in many developed countries, the situation is still alarming in many developing countries including India where considerable numbers of new cases are appearing everyday. There is still a high morbidity and mortality of susceptible adult as well as young population without having underlying health issues due to the influenza infection.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">To achieve a better understanding of the risk posed by the pH1N1 and to understand its pathogenicity, we studied the host gene expression response to Indian isolate of pH1N1 infection and compared it with seasonal H1N1 infection. The response was studied at four different time points (4, 8, 16 and 24 h) post infection (hpi) in A549 cells using microarray platform. We found that pH1N1 induces immune response earlier than seasonal H1N1 viruses, but at the later stages of infection there is a suppression of host immune responses. The infection with pH1N1 resulted in considerable decrease in the expression of cytokine and other immune genes namely IL8, STAT1, B2 M and IL4 compared to seasonal H1N1.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We propose that the inability to induce strong innate immune response could be a reason for the high transmissibility, pathogenicity and mortality caused by pH1N1 virus.</AbstractText>
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<Citation>PLoS One. 2009;4(12):e8072</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20011590</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS Pathog. 2009 Oct;5(10):e1000604</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19798428</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2010 Feb;84(3):1414-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19939920</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2010;5(3):e9693</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20300625</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virology. 2010 Jun 5;401(2):257-65</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20334888</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2010;5(5):e10540</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20479875</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Vaccine. 2010 Jul 12;28(31):4895-902</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20553769</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virol J. 2010;7:219</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20828378</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Immunol. 2010 Oct 15;185(8):4812-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20844191</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Clin Virol. 2010 Nov;49(3):186-91</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20732830</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2010;5(10). pii: e13099. doi: 10.1371/journal.pone.0013099</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20957032</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Virology. 2010 Dec 20;408(2):146-58</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20934196</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Crit Care. 2010;14(5):R167</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20840779</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Am J Pathol. 2007 Oct;171(4):1089-92</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17717138</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cytokine. 2008 Sep;43(3):336-41</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18694646</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3455-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19218453</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2009 Aug 20;460(7258):1021-5</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19672242</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>PLoS One. 2009;4(12):e8393</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20037642</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
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