PandemieGrippaleV1, PubMed, Checkpoint, bibRecord, 000A81

Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.

Identifieur interne : 000A81 ( PubMed/Checkpoint ); précédent : 000A80; suivant : 000A82

Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.

Auteurs : Giuseppe Del Giudice [Italie] ; Elena Fragapane ; Giovanni Della Cioppa ; Rino Rappuoli

Source :

Expert opinion on biological therapy [ 1744-7682 ] ; 2013.

RBID : pubmed:23189937

Descripteurs français

KwdFr :
- Adulte, Enfant, Essais cliniques comme sujet, Grippe humaine (), Grippe humaine (immunologie), Humains, Sujet âgé, Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins antigrippaux (usage thérapeutique), Études de faisabilité.
MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Grippe humaine, Vaccins antigrippaux.
- usage thérapeutique : Vaccins antigrippaux.
- Adulte, Enfant, Essais cliniques comme sujet, Grippe humaine, Humains, Sujet âgé, Études de faisabilité.

English descriptors

KwdEn :
- Adult, Aged, Child, Clinical Trials as Topic, Feasibility Studies, Humans, Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza Vaccines (therapeutic use), Influenza, Human (immunology), Influenza, Human (prevention & control).
MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Influenza Vaccines.
- chemical , therapeutic use : Influenza Vaccines.
- immunology : Influenza, Human.
- prevention & control : Influenza, Human.
- Adult, Aged, Child, Clinical Trials as Topic, Feasibility Studies, Humans.

Abstract

Aflunov is an egg-derived, subunit vaccine from Novartis Vaccines and Diagnostics containing 7.5 μg of hemagglutinin (HA) from the avian A/H5N1 virus and the oil-in-water adjuvant MF59.

DOI: 10.1517/14712598.2013.748030
PubMed: 23189937

Affiliations:

Italie

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pubmed:23189937

Le document en format XML

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<author><name sortKey="Del Giudice, Giuseppe" sort="Del Giudice, Giuseppe" uniqKey="Del Giudice G" first="Giuseppe" last="Del Giudice">Giuseppe Del Giudice</name>
<affiliation wicri:level="1"><nlm:affiliation>Novartis Vaccines and Diagnostics, Siena, Italy. giuseppe.del_giudice@novartis.com</nlm:affiliation>
<country xml:lang="fr">Italie</country>
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<front><div type="abstract" xml:lang="en">Aflunov is an egg-derived, subunit vaccine from Novartis Vaccines and Diagnostics containing 7.5 μg of hemagglutinin (HA) from the avian A/H5N1 virus and the oil-in-water adjuvant MF59.</div>
</front>
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<DateCompleted><Year>2013</Year>
<Month>05</Month>
<Day>15</Day>
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<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>06</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-7682</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<Issue>1</Issue>
<PubDate><Year>2013</Year>
<Month>Jan</Month>
</PubDate>
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<Title>Expert opinion on biological therapy</Title>
<ISOAbbreviation>Expert Opin Biol Ther</ISOAbbreviation>
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<ArticleTitle>Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.</ArticleTitle>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Aflunov is an egg-derived, subunit vaccine from Novartis Vaccines and Diagnostics containing 7.5 μg of hemagglutinin (HA) from the avian A/H5N1 virus and the oil-in-water adjuvant MF59.</AbstractText>
<AbstractText Label="AREAS COVERED" NlmCategory="METHODS">Aflunov behaves as a pre-pandemic vaccine. It has a good safety profile at all ages. At all ages, it induces high and persisting antibody titers and activation of HA-specific Th0/Th1 CD4(+) T cells, the levels of which correlate with the neutralizing antibody titers after a booster dose 6 months later. Aflunov triggers strong immunological memory, which persists for at least 6 - 8 years and can be rapidly boosted with a heterovariant vaccine strain, inducing very high neutralizing antibody titers within one week. These antibodies broadly and strongly cross-react with drifted H5N1 virus strains from various clades. Finally, the MF59 changes the pattern of HA recognition by antibodies that react with the HA1 more than with the HA2 region.</AbstractText>
<AbstractText Label="EXPERT OPINION" NlmCategory="CONCLUSIONS">The available data show that Aflunov is a pre-pandemic vaccine suitable not only for stockpiling in case of a pandemic, but also before a pandemic is declared, with the ultimate objective of preventing the onset of an influenza pandemic.</AbstractText>
</Abstract>
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Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.

Aflunov®: a vaccine tailored for pre-pandemic and pandemic approaches against influenza.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki