Virulence determinants of pandemic A(H1N1)2009 influenza virus in a mouse model.
Identifieur interne : 000878 ( PubMed/Checkpoint ); précédent : 000877; suivant : 000879Virulence determinants of pandemic A(H1N1)2009 influenza virus in a mouse model.
Auteurs : Ryuta Uraki [Japon] ; Maki Kiso ; Kyoko Shinya ; Hideo Goto ; Ryo Takano ; Kiyoko Iwatsuki-Horimoto ; Kazuo Takahashi ; Rod S. Daniels ; Olav Hungnes ; Tokiko Watanabe ; Yoshihiro Kawaoka [États-Unis]Source :
- Journal of virology [ 1098-5514 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Facteurs de virulence (génétique), Facteurs de virulence (métabolisme), Femelle, Humains, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (virologie), Modèles animaux de maladie humaine, Protéines virales (génétique), Protéines virales (métabolisme), Souris, Souris de lignée BALB C, Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Sous-type H1N1 du virus de la grippe A (pathogénicité), Virulence, Virus recombinants (génétique), Virus recombinants (isolement et purification), Virus recombinants (pathogénicité).
- MESH :
- anatomopathologie : Infections à Orthomyxoviridae.
- génétique : Facteurs de virulence, Protéines virales, Sous-type H1N1 du virus de la grippe A, Virus recombinants.
- isolement et purification : Sous-type H1N1 du virus de la grippe A, Virus recombinants.
- métabolisme : Facteurs de virulence, Protéines virales.
- pathogénicité : Sous-type H1N1 du virus de la grippe A, Virus recombinants.
- virologie : Infections à Orthomyxoviridae.
- Animaux, Femelle, Humains, Modèles animaux de maladie humaine, Souris, Souris de lignée BALB C, Virulence.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Female, Humans, Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza A Virus, H1N1 Subtype (pathogenicity), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (virology), Reassortant Viruses (genetics), Reassortant Viruses (isolation & purification), Reassortant Viruses (pathogenicity), Viral Proteins (genetics), Viral Proteins (metabolism), Virulence, Virulence Factors (genetics), Virulence Factors (metabolism).
- MESH :
- chemical , genetics : Viral Proteins, Virulence Factors.
- genetics : Influenza A Virus, H1N1 Subtype, Reassortant Viruses.
- isolation & purification : Influenza A Virus, H1N1 Subtype, Reassortant Viruses.
- chemical , metabolism : Viral Proteins, Virulence Factors.
- pathogenicity : Influenza A Virus, H1N1 Subtype, Reassortant Viruses.
- pathology : Orthomyxoviridae Infections.
- virology : Orthomyxoviridae Infections.
- Animals, Disease Models, Animal, Female, Humans, Mice, Mice, Inbred BALB C, Virulence.
Abstract
A novel swine-origin H1N1 influenza virus [A(H1N1)pdm09 virus] caused the 2009 influenza pandemic. Most patients exhibited mild symptoms similar to seasonal influenza, but some experienced severe clinical signs and, in the worst cases, died. Such differences in symptoms are generally associated with preexisting medical conditions, but recent reports indicate the possible involvement of viral factors in clinical severity. To better understand the mechanism of pathogenicity of the A(H1N1)pdm09 virus, here, we compared five viruses that are genetically similar but were isolated from patients with either severe or mild symptoms. In a mouse model, A/Norway/3487/2009 (Norway3487) virus exhibited greater pathogenicity than did A/Osaka/164/2009 (Osaka164) virus. By exploiting reassortant viruses between these two viruses, we found that viruses possessing the hemagglutinin (HA) gene of Norway3487 in the genetic background of Osaka164 were more pathogenic in mice than other reassortant viruses, indicating a role for HA in the high virulence of Norway3487 virus. Intriguingly, a virus possessing HA, NA, and NS derived from Norway3487 exhibited greater pathogenicity in mice in concert with PB2 and PB1 derived from Osaka164 than did the parental Norway3487 virus. These findings demonstrate that reassortment between A(H1N1)pdm09 viruses can lead to increased pathogenicity and highlight the need for continued surveillance of A(H1N1)pdm09 viruses.
DOI: 10.1128/JVI.01565-12
PubMed: 23221570
Affiliations:
- Japon, États-Unis
- Région de Kantō, Wisconsin
- Madison (Wisconsin), Tokyo
- Université de Tokyo, Université du Wisconsin à Madison
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:23221570Le document en format XML
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<front><div type="abstract" xml:lang="en">A novel swine-origin H1N1 influenza virus [A(H1N1)pdm09 virus] caused the 2009 influenza pandemic. Most patients exhibited mild symptoms similar to seasonal influenza, but some experienced severe clinical signs and, in the worst cases, died. Such differences in symptoms are generally associated with preexisting medical conditions, but recent reports indicate the possible involvement of viral factors in clinical severity. To better understand the mechanism of pathogenicity of the A(H1N1)pdm09 virus, here, we compared five viruses that are genetically similar but were isolated from patients with either severe or mild symptoms. In a mouse model, A/Norway/3487/2009 (Norway3487) virus exhibited greater pathogenicity than did A/Osaka/164/2009 (Osaka164) virus. By exploiting reassortant viruses between these two viruses, we found that viruses possessing the hemagglutinin (HA) gene of Norway3487 in the genetic background of Osaka164 were more pathogenic in mice than other reassortant viruses, indicating a role for HA in the high virulence of Norway3487 virus. Intriguingly, a virus possessing HA, NA, and NS derived from Norway3487 exhibited greater pathogenicity in mice in concert with PB2 and PB1 derived from Osaka164 than did the parental Norway3487 virus. These findings demonstrate that reassortment between A(H1N1)pdm09 viruses can lead to increased pathogenicity and highlight the need for continued surveillance of A(H1N1)pdm09 viruses.</div>
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<Abstract><AbstractText>A novel swine-origin H1N1 influenza virus [A(H1N1)pdm09 virus] caused the 2009 influenza pandemic. Most patients exhibited mild symptoms similar to seasonal influenza, but some experienced severe clinical signs and, in the worst cases, died. Such differences in symptoms are generally associated with preexisting medical conditions, but recent reports indicate the possible involvement of viral factors in clinical severity. To better understand the mechanism of pathogenicity of the A(H1N1)pdm09 virus, here, we compared five viruses that are genetically similar but were isolated from patients with either severe or mild symptoms. In a mouse model, A/Norway/3487/2009 (Norway3487) virus exhibited greater pathogenicity than did A/Osaka/164/2009 (Osaka164) virus. By exploiting reassortant viruses between these two viruses, we found that viruses possessing the hemagglutinin (HA) gene of Norway3487 in the genetic background of Osaka164 were more pathogenic in mice than other reassortant viruses, indicating a role for HA in the high virulence of Norway3487 virus. Intriguingly, a virus possessing HA, NA, and NS derived from Norway3487 exhibited greater pathogenicity in mice in concert with PB2 and PB1 derived from Osaka164 than did the parental Norway3487 virus. These findings demonstrate that reassortment between A(H1N1)pdm09 viruses can lead to increased pathogenicity and highlight the need for continued surveillance of A(H1N1)pdm09 viruses.</AbstractText>
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<ReferenceList><Reference><Citation>Nature. 1983 Jul 7-13;304(5921):76-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6191220</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Curr. 2009 Nov 03;1:RRN1126</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20029664</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Virol. 2009 Jul;45(3):169-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19540800</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1935-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19815859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>EMBO J. 2009 Jun 17;28(12):1803-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19461581</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2011 Oct 1;204(7):1008-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21881115</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Biol. 2006 Feb 3;355(5):1143-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16343533</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Jun 19;324(5934):1557-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19433588</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Sep;74(18):8502-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10954551</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Dec;85(24):13195-203</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21937653</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Nov;84(22):12069-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20826688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):308-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14691253</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Struct Mol Biol. 2008 May;15(5):500-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18454157</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1983 Jun;127(2):361-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6868370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2010;6(8):e1001034</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20700447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Jul 10;325(5937):197-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19465683</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Sep;81(17):9601-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17567688</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2009 Nov 4;302(17):1872-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19822627</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2009;14(33). pii: 19309</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19712643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2004 Mar 30;321(1):120-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15033571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2011;6(9):e25091</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21966421</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virol J. 2010;7:325</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21083933</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2011 Jun;158(1-2):124-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21458512</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2006 Jun;12(6):881-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16707041</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9345-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10430945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Sep 7;293(5536):1840-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11546875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Euro Surveill. 2009 Jun 11;14(23):19237</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19531339</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2005 Sep;79(18):12058-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16140781</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 Nov;84(22):11802-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20844044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 1993 Aug;29(2):155-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8212857</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2010 May 6;362(18):1708-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20445182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2009 Nov 4;302(17):1896-902</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19887665</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21312-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19995968</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1983 Dec;131(2):394-408</Citation>
<ArticleIdList><ArticleId IdType="pubmed">6197808</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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