PandemieGrippaleV1, PubMed, Checkpoint, bibRecord, 000684

Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice.

Identifieur interne : 000684 ( PubMed/Checkpoint ); précédent : 000683; suivant : 000685

Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice.

Auteurs : Nobuyuki Nosaka [Japon] ; Masato Yashiro [Japon] ; Mutsuko Yamada [Japon] ; Yosuke Fujii [Japon] ; Hirokazu Tsukahara [Japon] ; Keyue Liu [Japon] ; Masahiro Nishibori [Japon] ; Akihiro Matsukawa [Japon] ; Tsuneo Morishima [Japon]

Source :

Critical care (London, England) [ 1466-609X ] ; 2015.

RBID : pubmed:26067826

Descripteurs français

KwdFr :
- Administration par voie intraveineuse, Animaux, Anticorps monoclonaux (administration et posologie), Cellules rénales canines Madin-Darby, Chiens, Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (traitement médicamenteux), Mâle, Pneumopathie virale (anatomopathologie), Pneumopathie virale (immunologie), Pneumopathie virale (traitement médicamenteux), Protéine HMGB1 (antagonistes et inhibiteurs), Protéine HMGB1 (immunologie), Résultat thérapeutique, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (immunologie).
MESH :
- administration et posologie : Anticorps monoclonaux.
- anatomopathologie : Infections à Orthomyxoviridae, Pneumopathie virale.
- antagonistes et inhibiteurs : Protéine HMGB1.
- immunologie : Infections à Orthomyxoviridae, Pneumopathie virale, Protéine HMGB1, Sous-type H1N1 du virus de la grippe A.
- traitement médicamenteux : Infections à Orthomyxoviridae, Pneumopathie virale.
- Administration par voie intraveineuse, Animaux, Cellules rénales canines Madin-Darby, Chiens, Mâle, Résultat thérapeutique, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A.

English descriptors

KwdEn :
- Administration, Intravenous, Animals, Antibodies, Monoclonal (administration & dosage), Dogs, HMGB1 Protein (antagonists & inhibitors), HMGB1 Protein (immunology), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (immunology), Madin Darby Canine Kidney Cells, Male, Mice, Mice, Inbred C57BL, Orthomyxoviridae Infections (drug therapy), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Pneumonia, Viral (drug therapy), Pneumonia, Viral (immunology), Pneumonia, Viral (pathology), Treatment Outcome.
MESH :
- chemical , administration & dosage : Antibodies, Monoclonal.
- chemical , antagonists & inhibitors : HMGB1 Protein.
- chemical , immunology : HMGB1 Protein.
- drug effects : Influenza A Virus, H1N1 Subtype.
- drug therapy : Orthomyxoviridae Infections, Pneumonia, Viral.
- immunology : Influenza A Virus, H1N1 Subtype, Orthomyxoviridae Infections, Pneumonia, Viral.
- pathology : Orthomyxoviridae Infections, Pneumonia, Viral.
- Administration, Intravenous, Animals, Dogs, Madin Darby Canine Kidney Cells, Male, Mice, Mice, Inbred C57BL, Treatment Outcome.

Abstract

Provision for the emergence of an influenza pandemic is an urgent issue. The discovery of a novel anti-influenza therapeutic approach would increase the effectiveness of traditional virus-based strategies. This study was undertaken to evaluate the therapeutic effects of anti-high mobility group box-1 (HMGB1) monoclonal antibody (mAb) treatment on influenza A virus (H1N1)-induced pneumonia in mice.

DOI: 10.1186/s13054-015-0983-9
PubMed: 26067826

Affiliations:

Japon

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000646
to stream PubMed, to step Curation: 000646

Links to Exploration step

pubmed:26067826

Le document en format XML

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<term>Animals</term>
<term>Antibodies, Monoclonal (administration & dosage)</term>
<term>Dogs</term>
<term>HMGB1 Protein (antagonists & inhibitors)</term>
<term>HMGB1 Protein (immunology)</term>
<term>Influenza A Virus, H1N1 Subtype (drug effects)</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Madin Darby Canine Kidney Cells</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Orthomyxoviridae Infections (drug therapy)</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>Pneumonia, Viral (pathology)</term>
<term>Treatment Outcome</term>
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<term>Animaux</term>
<term>Anticorps monoclonaux (administration et posologie)</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Chiens</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Infections à Orthomyxoviridae (traitement médicamenteux)</term>
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<term>Protéine HMGB1 (immunologie)</term>
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<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
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<term>Pneumopathie virale</term>
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<term>Pneumonia, Viral</term>
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<term>Animals</term>
<term>Dogs</term>
<term>Madin Darby Canine Kidney Cells</term>
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<term>Animaux</term>
<term>Cellules rénales canines Madin-Darby</term>
<term>Chiens</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Provision for the emergence of an influenza pandemic is an urgent issue. The discovery of a novel anti-influenza therapeutic approach would increase the effectiveness of traditional virus-based strategies. This study was undertaken to evaluate the therapeutic effects of anti-high mobility group box-1 (HMGB1) monoclonal antibody (mAb) treatment on influenza A virus (H1N1)-induced pneumonia in mice.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26067826</PMID>
<DateCompleted><Year>2015</Year>
<Month>11</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<PubDate><Year>2015</Year>
<Month>Jun</Month>
<Day>11</Day>
</PubDate>
</JournalIssue>
<Title>Critical care (London, England)</Title>
<ISOAbbreviation>Crit Care</ISOAbbreviation>
</Journal>
<ArticleTitle>Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice.</ArticleTitle>
<Pagination><MedlinePgn>249</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s13054-015-0983-9</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Provision for the emergence of an influenza pandemic is an urgent issue. The discovery of a novel anti-influenza therapeutic approach would increase the effectiveness of traditional virus-based strategies. This study was undertaken to evaluate the therapeutic effects of anti-high mobility group box-1 (HMGB1) monoclonal antibody (mAb) treatment on influenza A virus (H1N1)-induced pneumonia in mice.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Nine-week-old male C57BL/6 mice were inoculated with H1N1, then anti-HMGB1 mAb or control mAb were administered intravenously at 1, 24 and 48 hours after H1N1 inoculation and the survival rate was analyzed. Lung lavage and histopathological analysis were performed on days 3, 5, 7 and 10 after inoculation.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Anti-HMGB1 mAb significantly improved the survival rate of H1N1-inoculated mice (1 out of 15 versus 8 out of 15 deaths in the anti-HMGB1 mAb-treated group versus the control mAb-treated group, p < 0.01), although the treatment did not affect virus propagation in the lungs. The treatment also significantly attenuated histological changes and neutrophil infiltration in the lungs of H1N1-inoculated mice. This was associated with inhibition of HMGB1 and suppression of inflammatory cytokine/chemokine expression and oxidative stress enhancement, which were observed in H1N1-inoculated mice. The expression of receptor for advanced glycation end products and nuclear factor κB was attenuated by the treatment.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Anti-HMGB1 mAb may provide a novel and effective pharmacological strategy for severe influenza virus infection in humans by reducing the inflammatory responses induced by HMGB1.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nosaka</LastName>
<ForeName>Nobuyuki</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. pv702xz5@s.okayama-u.ac.jp.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yashiro</LastName>
<ForeName>Masato</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. yashiro@md.okayama-u.ac.jp.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yamada</LastName>
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Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice.

Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice.

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