Influenza, evolution, and the next pandemic
Identifieur interne : 000F20 ( Pmc/Curation ); précédent : 000F19; suivant : 000F21Influenza, evolution, and the next pandemic
Auteurs : David S. Fedson [France]Source :
- Evolution, Medicine, and Public Health [ 2050-6201 ] ; 2018.
Abstract
Mortality rates in influenza appear to have been shaped by evolution. During the 1918 pandemic, mortality rates were lower in children compared with adults. This mortality difference occurs in a wide variety of infectious diseases. It has been replicated in mice and might be due to greater tolerance of infection, not greater resistance. Importantly, combination treatment with inexpensive and widely available generic drugs (e.g. statins and angiotensin receptor blockers) might change the damaging host response in adults to a more tolerant response in children. These drugs might work by modifying endothelial dysfunction, mitochondrial biogenesis and immunometabolism. Treating the host response might be the only practical way to reduce global mortality during the next influenza pandemic. It might also help reduce mortality due to seasonal influenza and other forms of acute critical illness. To realize these benefits, we need laboratory and clinical studies of host response treatment before and after puberty.
Url:
DOI: 10.1093/emph/eoy027
PubMed: 30455951
PubMed Central: 6234328
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influenza, evolution, and the next pandemic</title><author><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S" last="Fedson">David S. Fedson</name><affiliation wicri:level="1"><nlm:aff id="eoy027-aff1">57, chemin du Lavoir, Sergy Haut, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>57, chemin du Lavoir, Sergy Haut</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">30455951</idno><idno type="pmc">6234328</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234328</idno><idno type="RBID">PMC:6234328</idno><idno type="doi">10.1093/emph/eoy027</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000F20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F20</idno><idno type="wicri:Area/Pmc/Curation">000F20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F20</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Influenza, evolution, and the next pandemic</title><author><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S" last="Fedson">David S. Fedson</name><affiliation wicri:level="1"><nlm:aff id="eoy027-aff1">57, chemin du Lavoir, Sergy Haut, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>57, chemin du Lavoir, Sergy Haut</wicri:regionArea></affiliation></author></analytic><series><title level="j">Evolution, Medicine, and Public Health</title><idno type="eISSN">2050-6201</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Mortality rates in influenza appear to have been shaped by evolution. During the 1918 pandemic, mortality rates were lower in children compared with adults. This mortality difference occurs in a wide variety of infectious diseases. It has been replicated in mice and might be due to greater tolerance of infection, not greater resistance. Importantly, combination treatment with inexpensive and widely available generic drugs (e.g. statins and angiotensin receptor blockers) might change the damaging host response in adults to a more tolerant response in children. These drugs might work by modifying endothelial dysfunction, mitochondrial biogenesis and immunometabolism. Treating the host response might be the only practical way to reduce global mortality during the next influenza pandemic. It might also help reduce mortality due to seasonal influenza and other forms of acute critical illness. To realize these benefits, we need laboratory and clinical studies of host response treatment before and after puberty.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wells, Jck" uniqKey="Wells J">JCK Wells</name></author><author><name sortKey="Nesse, Rm" uniqKey="Nesse R">RM Nesse</name></author><author><name sortKey="Sear, R" uniqKey="Sear R">R Sear</name></author><author><name sortKey="Johnstone, Ra" uniqKey="Johnstone R">RA Johnstone</name></author><author><name sortKey="Stearns, Sc" uniqKey="Stearns S">SC. Stearns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS Fedson</name></author><author><name sortKey="Dunnill, P" uniqKey="Dunnill P">P. Dunnill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, R" uniqKey="Ahmed R">R Ahmed</name></author><author><name sortKey="Oldstone, Mba" uniqKey="Oldstone M">MBA Oldstone</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS. Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nelson, Mi" uniqKey="Nelson M">MI Nelson</name></author><author><name sortKey="Edelman, L" uniqKey="Edelman L">L Edelman</name></author><author><name sortKey="Spiro, Dj" uniqKey="Spiro D">DJ Spiro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mamelund, Se" uniqKey="Mamelund S">SE. Mamelund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name></author><author><name sortKey="Malosh, Re" uniqKey="Malosh R">RE Malosh</name></author><author><name sortKey="Petrie, Jg" uniqKey="Petrie J">JG Petrie</name></author><author><name sortKey="Martin, Et" uniqKey="Martin E">ET. Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joyce, Mg" uniqKey="Joyce M">MG Joyce</name></author><author><name sortKey="Wheatley, Ak" uniqKey="Wheatley A">AK Wheatley</name></author><author><name sortKey="Thomas, Pv" uniqKey="Thomas P">PV Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Eisenstein, J" uniqKey="Eisenstein J">J Eisenstein</name></author><author><name sortKey="Reid, Ah" uniqKey="Reid A">AH Reid</name></author><author><name sortKey="Janczewski, Ta" uniqKey="Janczewski T">TA Janczewski</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagnon, A" uniqKey="Gagnon A">A Gagnon</name></author><author><name sortKey="Miller, Ms" uniqKey="Miller M">MS Miller</name></author><author><name sortKey="Hallman, Sa" uniqKey="Hallman S">SA Hallman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author><author><name sortKey="Han, Gz" uniqKey="Han G">GZ Han</name></author><author><name sortKey="Rambaut, A" uniqKey="Rambaut A">A. Rambaut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagnon, A" uniqKey="Gagnon A">A Gagnon</name></author><author><name sortKey="Madrenas, J" uniqKey="Madrenas J">J Madrenas</name></author><author><name sortKey="Miller, Ms" uniqKey="Miller M">MS. Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gostic, Km" uniqKey="Gostic K">KM Gostic</name></author><author><name sortKey="Ambrose, M" uniqKey="Ambrose M">M Ambrose</name></author><author><name sortKey="Worobey, M" uniqKey="Worobey M">M Worobey</name></author><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO. Lloyd-Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jacobs, Jh" uniqKey="Jacobs J">JH Jacobs</name></author><author><name sortKey="Archer, Bn" uniqKey="Archer B">BN Archer</name></author><author><name sortKey="Baker, Mg" uniqKey="Baker M">MG Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagnon, A" uniqKey="Gagnon A">A Gagnon</name></author><author><name sortKey="Acosta" uniqKey="Acosta">Acosta</name></author><author><name sortKey="Hallman, E" uniqKey="Hallman E">E Hallman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author><author><name sortKey="Epstein, Sl" uniqKey="Epstein S">SL. Epstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kosikova, M" uniqKey="Kosikova M">M Kosikova</name></author><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Radvak" uniqKey="Radvak">Radvak</name></author><author><name sortKey="Ye, P" uniqKey="Ye P">P Ye</name></author><author><name sortKey="Wan, Z" uniqKey="Wan Z">Z Wan</name></author><author><name sortKey="Xie, Xf" uniqKey="Xie X">XF Xie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suber, F" uniqKey="Suber F">F Suber</name></author><author><name sortKey="Kobzik, L" uniqKey="Kobzik L">L. Kobzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Robinson, Dp" uniqKey="Robinson D">DP Robinson</name></author><author><name sortKey="Lorenzo, Me" uniqKey="Lorenzo M">ME Lorenzo</name></author><author><name sortKey="Jian, W" uniqKey="Jian W">W Jian</name></author><author><name sortKey="Klein, Sl" uniqKey="Klein S">SL. Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joachim, R" uniqKey="Joachim R">R Joachim</name></author><author><name sortKey="Suber, F" uniqKey="Suber F">F Suber</name></author><author><name sortKey="Kobzik, L" uniqKey="Kobzik L">L. Kobzik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takao, K" uniqKey="Takao K">K Takao</name></author><author><name sortKey="Miyakawa, T" uniqKey="Miyakawa T">T. Miyakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Efron, Pa" uniqKey="Efron P">PA Efron</name></author><author><name sortKey="Mohr, Am" uniqKey="Mohr A">AM Mohr</name></author><author><name sortKey="Moore, Fa" uniqKey="Moore F">FA Moore</name></author><author><name sortKey="Moldawer, Ll" uniqKey="Moldawer L">LL. Moldawer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ks" uniqKey="Kim K">KS Kim</name></author><author><name sortKey="Jung, H" uniqKey="Jung H">H Jung</name></author><author><name sortKey="Shin, Ik" uniqKey="Shin I">IK Shin</name></author><author><name sortKey="Choi, Br" uniqKey="Choi B">BR Choi</name></author><author><name sortKey="Kim, Dh" uniqKey="Kim D">DH. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peteranderl, C" uniqKey="Peteranderl C">C Peteranderl</name></author><author><name sortKey="Herold, S" uniqKey="Herold S">S Herold</name></author><author><name sortKey="Schmoldt, C" uniqKey="Schmoldt C">C. Schmoldt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piantadosi, Ca" uniqKey="Piantadosi C">CA Piantadosi</name></author><author><name sortKey="Suliman, Hb" uniqKey="Suliman H">HB. Suliman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imai, Y1" uniqKey="Imai Y">Y1 Imai</name></author><author><name sortKey="Kuba, K" uniqKey="Kuba K">K Kuba</name></author><author><name sortKey="Neely, Gg" uniqKey="Neely G">GG Neely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, M" uniqKey="Liu M">M Liu</name></author><author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name></author><author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name></author><author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name></author><author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name></author><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teijaro, Jr" uniqKey="Teijaro J">JR Teijaro</name></author><author><name sortKey="Walsh, Kb" uniqKey="Walsh K">KB Walsh</name></author><author><name sortKey="Cahalan, S" uniqKey="Cahalan S">S Cahalan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armstrong, Sm" uniqKey="Armstrong S">SM Armstrong</name></author><author><name sortKey="Mubareka, S" uniqKey="Mubareka S">S Mubareka</name></author><author><name sortKey="Lee, Wl" uniqKey="Lee W">WL. Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tam, Vc" uniqKey="Tam V">VC Tam</name></author><author><name sortKey="Quehenberger, O" uniqKey="Quehenberger O">O Quehenberger</name></author><author><name sortKey="Oshansky, Cm" uniqKey="Oshansky C">CM Oshansky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serhan, Cn" uniqKey="Serhan C">CN. Serhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sachdev, U" uniqKey="Sachdev U">U Sachdev</name></author><author><name sortKey="Lotze, Mt" uniqKey="Lotze M">MT. Lotze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feizi, N" uniqKey="Feizi N">N Feizi</name></author><author><name sortKey="Mehrbod, P" uniqKey="Mehrbod P">P Mehrbod</name></author><author><name sortKey="Romani, B" uniqKey="Romani B">B Romani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Shu, Y" uniqKey="Shu Y">Y Shu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, Mt" uniqKey="Chung M">MT Chung</name></author><author><name sortKey="Lee, Ym" uniqKey="Lee Y">YM Lee</name></author><author><name sortKey="Shen, Hh" uniqKey="Shen H">HH Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Medzhitov, R" uniqKey="Medzhitov R">R Medzhitov</name></author><author><name sortKey="Schneider, Ds" uniqKey="Schneider D">DS Schneider</name></author><author><name sortKey="Soares, Mp" uniqKey="Soares M">MP. Soares</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soares, Mp" uniqKey="Soares M">MP Soares</name></author><author><name sortKey="Teixeira, L" uniqKey="Teixeira L">L Teixeira</name></author><author><name sortKey="Moita, Lf" uniqKey="Moita L">LF. Moita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meunier, I" uniqKey="Meunier I">I Meunier</name></author><author><name sortKey="Kaufmann, E" uniqKey="Kaufmann E">E Kaufmann</name></author><author><name sortKey="Downey, J" uniqKey="Downey J">J Downey</name></author><author><name sortKey="Divangahi, M" uniqKey="Divangahi M">M. Divangahi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Crane, Mj" uniqKey="Crane M">MJ Crane</name></author><author><name sortKey="Lee" uniqKey="Lee">Lee</name></author><author><name sortKey="Fitzgerald, Km" uniqKey="Fitzgerald K">KM FitzGerald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Neill, La" uniqKey="O Neill L">LA O'Neill</name></author><author><name sortKey="Kishton, Rj" uniqKey="Kishton R">RJ Kishton</name></author><author><name sortKey="Rathmell, J" uniqKey="Rathmell J">J. Rathmell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rambold, As" uniqKey="Rambold A">AS Rambold</name></author><author><name sortKey="Pearce, El" uniqKey="Pearce E">EL. Pearce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kovats, S" uniqKey="Kovats S">S. Kovats</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chandler, Jd" uniqKey="Chandler J">JD Chandler</name></author><author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name></author><author><name sortKey="Ko, Ej" uniqKey="Ko E">EJ Ko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ellison, Pt" uniqKey="Ellison P">PT. Ellison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayward, Ac" uniqKey="Hayward A">AC Hayward</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Goonetilleke, N" uniqKey="Goonetilleke N">N Goonetilleke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casanova, Jl" uniqKey="Casanova J">JL. Casanova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piasecka, B" uniqKey="Piasecka B">B Piasecka</name></author><author><name sortKey="Duffy, D" uniqKey="Duffy D">D Duffy</name></author><author><name sortKey="Urrutia, A" uniqKey="Urrutia A">A Urrutia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcclain, Mt" uniqKey="Mcclain M">MT McClain</name></author><author><name sortKey="Henao, R" uniqKey="Henao R">R Henao</name></author><author><name sortKey="Williams, J" uniqKey="Williams J">J Williams</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author><author><name sortKey="Zaas, Ak" uniqKey="Zaas A">AK Zaas</name></author><author><name sortKey="Rao, A" uniqKey="Rao A">A Rao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matilainen, O" uniqKey="Matilainen O">O Matilainen</name></author><author><name sortKey="Quir S, Pm" uniqKey="Quir S P">PM Quirós</name></author><author><name sortKey="Auwerx, J" uniqKey="Auwerx J">J. Auwerx</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pociask, Da" uniqKey="Pociask D">DA Pociask</name></author><author><name sortKey="Robinson, Km" uniqKey="Robinson K">KM Robinson</name></author><author><name sortKey="Chen, K" uniqKey="Chen K">K Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feinberg, Ap" uniqKey="Feinberg A">AP. Feinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burger, O" uniqKey="Burger O">O Burger</name></author><author><name sortKey="Baudisch, A" uniqKey="Baudisch A">A Baudisch</name></author><author><name sortKey="Vaupel, Jw" uniqKey="Vaupel J">JW. Vaupel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carlton, Ed" uniqKey="Carlton E">ED Carlton</name></author><author><name sortKey="Cooper, Cl" uniqKey="Cooper C">CL Cooper</name></author><author><name sortKey="Demas, Ge" uniqKey="Demas G">GE. Demas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="L Pez, M" uniqKey="L Pez M">M López</name></author><author><name sortKey="Tena Sempere, M" uniqKey="Tena Sempere M">M. Tena-Sempere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lomniczi, A" uniqKey="Lomniczi A">A Lomniczi</name></author><author><name sortKey="Ojeda, Sr" uniqKey="Ojeda S">SR. Ojeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, Ssh" uniqKey="Huang S">SSH Huang</name></author><author><name sortKey="Banner, D" uniqKey="Banner D">D Banner</name></author><author><name sortKey="Degousee, N" uniqKey="Degousee N">N Degousee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yi, X" uniqKey="Yi X">X Yi</name></author><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Li, N" uniqKey="Li N">N Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barsness, Ka" uniqKey="Barsness K">KA Barsness</name></author><author><name sortKey="Bensard, Dd" uniqKey="Bensard D">DD Bensard</name></author><author><name sortKey="Partrick, Da" uniqKey="Partrick D">DA Partrick</name></author><author><name sortKey="Calkins, Cm" uniqKey="Calkins C">CM Calkins</name></author><author><name sortKey="Hendrickson, Rj" uniqKey="Hendrickson R">RJ Hendrickson</name></author><author><name sortKey="Mcintyre, Rc" uniqKey="Mcintyre R">RC McIntyre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barsness, Ka" uniqKey="Barsness K">KA Barsness</name></author><author><name sortKey="Bensard, Dd" uniqKey="Bensard D">DD Bensard</name></author><author><name sortKey="Partrick, Da" uniqKey="Partrick D">DA Partrick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwang, W" uniqKey="Hwang W">W Hwang</name></author><author><name sortKey="Lee, Cg" uniqKey="Lee C">CG Lee</name></author><author><name sortKey="Lee, C" uniqKey="Lee C">C Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, T" uniqKey="Shin T">T Shin</name></author><author><name sortKey="Kuboki, S" uniqKey="Kuboki S">S Kuboki</name></author><author><name sortKey="Huber, N" uniqKey="Huber N">N Huber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oesterle, 68" uniqKey="Oesterle 6">68. Oesterle</name></author><author><name sortKey="Laufs, A" uniqKey="Laufs A">A Laufs</name></author><author><name sortKey="Liao, Ujk" uniqKey="Liao U">UJK Liao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Di Raimondo, D" uniqKey="Di Raimondo D">D Di Raimondo</name></author><author><name sortKey="Tuttolomondo, A" uniqKey="Tuttolomondo A">A Tuttolomondo</name></author><author><name sortKey="Butta, C" uniqKey="Butta C">C Butta</name></author><author><name sortKey="Miceli, S" uniqKey="Miceli S">S Miceli</name></author><author><name sortKey="Licata, G" uniqKey="Licata G">G Licata</name></author><author><name sortKey="Pinto, A" uniqKey="Pinto A">A. Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saisho, Y" uniqKey="Saisho Y">Y. Saisho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Cj" uniqKey="Murray C">CJ Murray</name></author><author><name sortKey="Lopez, Ad" uniqKey="Lopez A">AD Lopez</name></author><author><name sortKey="Chin, B" uniqKey="Chin B">B Chin</name></author><author><name sortKey="Feehan, D" uniqKey="Feehan D">D Feehan</name></author><author><name sortKey="Hill, Kh" uniqKey="Hill K">KH. Hill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gates, B" uniqKey="Gates B">B. Gates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shi, J" uniqKey="Shi J">J Shi</name></author><author><name sortKey="Deng, G" uniqKey="Deng G">G Deng</name></author><author><name sortKey="Kong, H" uniqKey="Kong H">H Kong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iuliano, Ad" uniqKey="Iuliano A">AD Iuliano</name></author><author><name sortKey="Roguski, Km" uniqKey="Roguski K">KM Roguski</name></author><author><name sortKey="Chang, Hm" uniqKey="Chang H">HM Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paules, Ci" uniqKey="Paules C">CI Paules</name></author><author><name sortKey="Marston, Hd" uniqKey="Marston H">HD Marston</name></author><author><name sortKey="Eisinger, Rw" uniqKey="Eisinger R">RW Eisinger</name></author><author><name sortKey="Baltimore, D" uniqKey="Baltimore D">D Baltimore</name></author><author><name sortKey="Fauci, As" uniqKey="Fauci A">AS. Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Cs" uniqKey="Anderson C">CS Anderson</name></author><author><name sortKey="Ortega, S" uniqKey="Ortega S">S Ortega</name></author><author><name sortKey="Chaves, Fa" uniqKey="Chaves F">FA Chaves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jk" uniqKey="Park J">JK Park</name></author><author><name sortKey="Han, A" uniqKey="Han A">A Han</name></author><author><name sortKey="Czajkowski, L" uniqKey="Czajkowski L">L Czajkowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eccleston Turner, M" uniqKey="Eccleston Turner M">M Eccleston-Turner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedson, Ds" uniqKey="Fedson D">DS. Fedson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name></author><author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name></author><author><name sortKey="Beigel, Jh" uniqKey="Beigel J">JH. Beigel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ayala, Fj" uniqKey="Ayala F">FJ. Ayala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Starr, I" uniqKey="Starr I">I. Starr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baddeley, M" uniqKey="Baddeley M">M. Baddeley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Casadevall, A" uniqKey="Casadevall A">A Casadevall</name></author><author><name sortKey="Fang, Fc" uniqKey="Fang F">FC. Fang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Evol Med Public Health</journal-id><journal-id journal-id-type="iso-abbrev">Evol Med Public Health</journal-id><journal-id journal-id-type="publisher-id">emph</journal-id><journal-title-group><journal-title>Evolution, Medicine, and Public Health</journal-title></journal-title-group><issn pub-type="epub">2050-6201</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30455951</article-id><article-id pub-id-type="pmc">6234328</article-id><article-id pub-id-type="doi">10.1093/emph/eoy027</article-id><article-id pub-id-type="publisher-id">eoy027</article-id><article-categories><subj-group subj-group-type="heading"><subject>Commentary</subject></subj-group></article-categories><title-group><article-title>Influenza, evolution, and the next pandemic</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Fedson</surname><given-names>David S</given-names></name><xref ref-type="corresp" rid="eoy027-cor1"></xref><pmc-comment>davidsfedson@gmail.com </pmc-comment>
<xref ref-type="aff" rid="eoy027-aff1"></xref></contrib></contrib-group><aff id="eoy027-aff1">57, chemin du Lavoir, Sergy Haut, France</aff><author-notes><corresp id="eoy027-cor1">Corresponding author. Tel: +33-4-50-99-13-06; E-mail: <email>davidsfedson@gmail.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub" iso-8601-date="2018-10-03"><day>03</day><month>10</month><year>2018</year></pub-date><volume>2018</volume><issue>1</issue><fpage>260</fpage><lpage>269</lpage><history><date date-type="received"><day>3</day><month>2</month><year>2018</year></date><date date-type="accepted"><day>29</day><month>8</month><year>2018</year></date></history><permissions><copyright-statement>© The Author(s) 2018. Published by Oxford University Press on behalf of the <italic>Foundation for Evolution, Medicine, and Public Health</italic>.</copyright-statement><copyright-year>2018</copyright-year><license license-type="oup-standard" xlink:href="https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model"><license-p>This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (<ext-link ext-link-type="uri" xlink:href="https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model">https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model</ext-link>)</license-p></license></permissions><self-uri xlink:href="eoy027.pdf"></self-uri><abstract><title>Abstract</title><p>Mortality rates in influenza appear to have been shaped by evolution. During the 1918 pandemic, mortality rates were lower in children compared with adults. This mortality difference occurs in a wide variety of infectious diseases. It has been replicated in mice and might be due to greater tolerance of infection, not greater resistance. Importantly, combination treatment with inexpensive and widely available generic drugs (e.g. statins and angiotensin receptor blockers) might change the damaging host response in adults to a more tolerant response in children. These drugs might work by modifying endothelial dysfunction, mitochondrial biogenesis and immunometabolism. Treating the host response might be the only practical way to reduce global mortality during the next influenza pandemic. It might also help reduce mortality due to seasonal influenza and other forms of acute critical illness. To realize these benefits, we need laboratory and clinical studies of host response treatment before and after puberty.</p></abstract><kwd-group><kwd>pandemic influenza</kwd><kwd>immunomodulatory treatment</kwd><kwd>mortality in children and adults</kwd><kwd>global public health</kwd><kwd>generic drugs </kwd></kwd-group><counts><page-count count="10"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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