Potential Impact of Influenza A/H1N1 Pandemic and Hand-Gels on Acute Diarrhea Epidemic in France
Identifieur interne : 000D74 ( Pmc/Curation ); précédent : 000D73; suivant : 000D75Potential Impact of Influenza A/H1N1 Pandemic and Hand-Gels on Acute Diarrhea Epidemic in France
Auteurs : Pascal Crépey [France] ; Mathilde Pivette [France] ; Moïse Desvarieux [France, États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
The 2009 A/H1N1 influenza pandemic has received a great deal of attention from public health authorities. Our study examines whether this pandemic and the resulting public health measures could have impacted acute diarrhea, a prevalent, highly transmissible and historically monitored disease.
Using augmentation procedures of national data for the previous five years (2004–2009), we estimated the expected timing and incidence of acute diarrhea in France in 2009–2010 and evaluated differences with the observed. We also reviewed national hand gels for the same period.
Number of episodes of acute diarrhea in France in 2009–2010 was significantly lower than expected until the third week of December (−24%, 95% CI [−36%; −9%]), then significantly higher (+40%, 95% CI [22%; 62%]), leading to a surplus of 574,440 episodes. The epidemic was delayed by 5 weeks with a peak 1.3 times higher than expected. Hand-gels sales inversely correlated with incidence of both influenza-like illness and acute diarrheal disease. Among individuals >65 yo, no excess cases of influenza and no excess rebound in acute diarrhea were observed, despite similar delay in the onset of the seasonal diarrheal epidemic.
Our results suggest that at least one endemic disease had an unexpected behavior in 2009–2010. Acute diarrhea seems to have been controlled during the beginning of the pandemic in all age groups, but later peaked higher than expected in the younger population. The all-age delay in seasonal onset seems partly attributable to hand-gels use, while the differential magnitude of the seasonal epidemic between young and old, concurrent for both influenza and acute diarrhea, is compatible with disease interaction.
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DOI: 10.1371/journal.pone.0075226
PubMed: 24124479
PubMed Central: 3790785
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sortKey="Pivette, Mathilde" sort="Pivette, Mathilde" uniqKey="Pivette M" first="Mathilde" last="Pivette">Mathilde Pivette</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>École des hautes études en santé publique Rennes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>École des hautes études en santé publique Rennes, Sorbonne Paris Cité, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>MAP5, Université René Descartes-Paris5, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>MAP5, Université René Descartes-Paris5, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Desvarieux, Moise" sort="Desvarieux, Moise" uniqKey="Desvarieux M" first="Moïse" last="Desvarieux">Moïse Desvarieux</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>École des hautes études en santé publique Rennes, Sorbonne 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Rennes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>École des hautes études en santé publique Rennes, Sorbonne Paris Cité, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>UMR EPV Emergence des Pathologies Virales –190, Aix-Marseille University, Marseille, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UMR EPV Emergence des Pathologies Virales –190, Aix-Marseille University, Marseille</wicri:regionArea></affiliation></author><author><name sortKey="Pivette, Mathilde" sort="Pivette, Mathilde" uniqKey="Pivette M" first="Mathilde" last="Pivette">Mathilde Pivette</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>École des hautes études en santé publique Rennes, Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>École des hautes études en santé publique Rennes, 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America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>U 738, Institut National de la Santé et de la Recherche Médicale, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>U 738, Institut National de la Santé et de la Recherche Médicale, Paris</wicri:regionArea></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The 2009 A/H1N1 influenza pandemic has received a great deal of attention from public health authorities. Our study examines whether this pandemic and the resulting public health measures could have impacted acute diarrhea, a prevalent, highly transmissible and historically monitored disease.</p></sec><sec><title>Methods</title><p>Using augmentation procedures of national data for the previous five years (2004–2009), we estimated the expected timing and incidence of acute diarrhea in France in 2009–2010 and evaluated differences with the observed. We also reviewed national hand gels for the same period.</p></sec><sec><title>Findings</title><p>Number of episodes of acute diarrhea in France in 2009–2010 was significantly lower than expected until the third week of December (−24%, 95% CI [−36%; −9%]), then significantly higher (+40%, 95% CI [22%; 62%]), leading to a surplus of 574,440 episodes. The epidemic was delayed by 5 weeks with a peak 1.3 times higher than expected. Hand-gels sales inversely correlated with incidence of both influenza-like illness and acute diarrheal disease. Among individuals >65 yo, no excess cases of influenza and no excess rebound in acute diarrhea were observed, despite similar delay in the onset of the seasonal diarrheal epidemic.</p></sec><sec><title>Interpretation</title><p>Our results suggest that at least one endemic disease had an unexpected behavior in 2009–2010. Acute diarrhea seems to have been controlled during the beginning of the pandemic in all age groups, but later peaked higher than expected in the younger population. The all-age delay in seasonal onset seems partly attributable to hand-gels use, while the differential magnitude of the seasonal epidemic between young and old, concurrent for both influenza and acute diarrhea, is compatible with disease interaction.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Jt" uniqKey="Wu J">JT Wu</name></author><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author><author><name sortKey="Lau, Ehy" uniqKey="Lau E">EHY Lau</name></author><author><name sortKey="Ip, Dkm" uniqKey="Ip D">DKM Ip</name></author><author><name sortKey="Ho, L M" uniqKey="Ho L">L-M Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glass, Rj" uniqKey="Glass R">RJ Glass</name></author><author><name sortKey="Glass, Lm" uniqKey="Glass L">LM 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uniqKey="Flahault A">A Flahault</name></author><author><name sortKey="Blanchon, T" uniqKey="Blanchon T">T Blanchon</name></author><author><name sortKey="Dorleans, Y" uniqKey="Dorleans Y">Y Dorléans</name></author><author><name sortKey="Toubiana, L" uniqKey="Toubiana L">L Toubiana</name></author><author><name sortKey="Vibert, Jf" uniqKey="Vibert J">JF Vibert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author><author><name sortKey="Valleron, A J" uniqKey="Valleron A">A-J Valleron</name></author><author><name sortKey="Boelle, P Y" uniqKey="Boelle P">P-Y Boëlle</name></author><author><name sortKey="Flahault, A" uniqKey="Flahault A">A Flahault</name></author><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serfling, Re" uniqKey="Serfling R">RE Serfling</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fox, A" uniqKey="Fox A">A Fox</name></author><author><name sortKey="Hoa, Lnm" uniqKey="Hoa L">LNM Hoa</name></author><author><name sortKey="Horby, P" uniqKey="Horby P">P Horby</name></author><author><name sortKey="Van Doorn, Hr" uniqKey="Van Doorn H">HR Van Doorn</name></author><author><name sortKey="Trung, Nv" uniqKey="Trung N">NV Trung</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lemaitre, M" uniqKey="Lemaitre M">M Lemaitre</name></author><author><name sortKey="Carrat, F" uniqKey="Carrat F">F Carrat</name></author><author><name sortKey="Rey, G" uniqKey="Rey G">G Rey</name></author><author><name sortKey="Miller, M" uniqKey="Miller M">M Miller</name></author><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Singer, M" uniqKey="Singer M">M Singer</name></author><author><name sortKey="Clair, S" uniqKey="Clair S">S Clair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grmek, Md" uniqKey="Grmek M">MD Grmek</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24124479</article-id><article-id pub-id-type="pmc">3790785</article-id><article-id pub-id-type="publisher-id">PONE-D-12-28798</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0075226</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Potential Impact of Influenza A/H1N1 Pandemic and Hand-Gels on Acute Diarrhea Epidemic in France</article-title><alt-title alt-title-type="running-head">Impact of A/H1N1 and Hand-Gels on Acute Diarrhea</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Crépey</surname><given-names>Pascal</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pivette</surname><given-names>Mathilde</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Desvarieux</surname><given-names>Moïse</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>École des hautes études en santé publique Rennes, Sorbonne Paris Cité, Paris, France</addr-line></aff><aff id="aff2"><label>2</label><addr-line>UMR EPV Emergence des Pathologies Virales –190, Aix-Marseille University, Marseille, France</addr-line></aff><aff id="aff3"><label>3</label><addr-line>MAP5, Université René Descartes-Paris5, Paris, France</addr-line></aff><aff id="aff4"><label>4</label><addr-line>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States of America</addr-line></aff><aff id="aff5"><label>5</label><addr-line>U 738, Institut National de la Santé et de la Recherche Médicale, Paris, France</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Cowling</surname><given-names>Benjamin J.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Hong Kong, Hong Kong</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>pascal.crepey@ehesp.fr</email></corresp><fn fn-type="COI-statement"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: PC MD. Performed the experiments: PC MP. Analyzed the data: PC MP MD. Contributed reagents/materials/analysis tools: PC MP. Wrote the paper: PC MP MD.</p></fn></author-notes><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>4</day><month>10</month><year>2013</year></pub-date><volume>8</volume><issue>10</issue><elocation-id>e75226</elocation-id><history><date date-type="received"><day>20</day><month>9</month><year>2012</year></date><date date-type="accepted"><day>13</day><month>8</month><year>2013</year></date></history><permissions><copyright-statement>© 2013 Crépey et al</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Crépey et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>The 2009 A/H1N1 influenza pandemic has received a great deal of attention from public health authorities. Our study examines whether this pandemic and the resulting public health measures could have impacted acute diarrhea, a prevalent, highly transmissible and historically monitored disease.</p></sec><sec><title>Methods</title><p>Using augmentation procedures of national data for the previous five years (2004–2009), we estimated the expected timing and incidence of acute diarrhea in France in 2009–2010 and evaluated differences with the observed. We also reviewed national hand gels for the same period.</p></sec><sec><title>Findings</title><p>Number of episodes of acute diarrhea in France in 2009–2010 was significantly lower than expected until the third week of December (−24%, 95% CI [−36%; −9%]), then significantly higher (+40%, 95% CI [22%; 62%]), leading to a surplus of 574,440 episodes. The epidemic was delayed by 5 weeks with a peak 1.3 times higher than expected. Hand-gels sales inversely correlated with incidence of both influenza-like illness and acute diarrheal disease. Among individuals >65 yo, no excess cases of influenza and no excess rebound in acute diarrhea were observed, despite similar delay in the onset of the seasonal diarrheal epidemic.</p></sec><sec><title>Interpretation</title><p>Our results suggest that at least one endemic disease had an unexpected behavior in 2009–2010. Acute diarrhea seems to have been controlled during the beginning of the pandemic in all age groups, but later peaked higher than expected in the younger population. The all-age delay in seasonal onset seems partly attributable to hand-gels use, while the differential magnitude of the seasonal epidemic between young and old, concurrent for both influenza and acute diarrhea, is compatible with disease interaction.</p></sec></abstract><funding-group><funding-statement>This study was funded by Ecole des Hautes Etudes en Santé Publique. No external funding used for this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="6"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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