Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets
Identifieur interne : 000750 ( Pmc/Curation ); précédent : 000749; suivant : 000751Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets
Auteurs : Minhui Guan [États-Unis] ; Jeffrey S. Hall [États-Unis] ; Xiaojian Zhang [États-Unis] ; Robert J. Dusek [États-Unis] ; Alicia K. Olivier [États-Unis] ; Liyuan Liu [États-Unis] ; Lei Li [États-Unis] ; Scott Krauss [États-Unis] ; Angela Danner [États-Unis] ; Tao Li [États-Unis] ; Wiriya Rutvisuttinunt [États-Unis] ; Xiaoxu Lin [États-Unis] ; Gunnar T. Hallgrimsson [Islande] ; Sunna B. Ragnarsdottir [Islande] ; Solvi R. Vignisson [Islande] ; Josh Teslaa [États-Unis] ; Sean W. Nashold [États-Unis] ; Richard Jarman [États-Unis] ; Xiu-Feng Wan [États-Unis]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Abstract
Subtype H10 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among seals. In the fall of 2015, H10N7 viruses were recovered from gulls in Iceland, and genomic analyses showed that the viruses were genetically related with IAVs that caused outbreaks among seals in Europe a year earlier. These gull-origin viruses showed high binding affinity to human-like glycan receptors. Transmission studies in ferrets demonstrated that the gull-origin IAV could infect ferrets, and that the virus could be transmitted between ferrets through direct contact and aerosol droplets. This study demonstrated that avian H10 IAV can infect mammals and be transmitted among them without adaptation. Thus, avian H10 IAV is a candidate for influenza pandemic preparedness and should be monitored in wildlife and at the animal-human interface.
Url:
DOI: 10.1128/JVI.00282-19
PubMed: 30996092
PubMed Central: 6580963
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Hall</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Xiaojian" sort="Zhang, Xiaojian" uniqKey="Zhang X" first="Xiaojian" last="Zhang">Xiaojian Zhang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi</wicri:regionArea></affiliation></author><author><name sortKey="Dusek, Robert J" sort="Dusek, Robert J" uniqKey="Dusek R" first="Robert J." last="Dusek">Robert J. Dusek</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Olivier, Alicia K" sort="Olivier, Alicia K" uniqKey="Olivier A" first="Alicia K." last="Olivier">Alicia K. Olivier</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Liyuan" sort="Liu, Liyuan" uniqKey="Liu L" first="Liyuan" last="Liu">Liyuan Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi</wicri:regionArea></affiliation></author><author><name sortKey="Li, Lei" sort="Li, Lei" uniqKey="Li L" first="Lei" last="Li">Lei Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi</wicri:regionArea></affiliation></author><author><name sortKey="Krauss, Scott" sort="Krauss, Scott" uniqKey="Krauss S" first="Scott" last="Krauss">Scott Krauss</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Danner, Angela" sort="Danner, Angela" uniqKey="Danner A" first="Angela" last="Danner">Angela Danner</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee</wicri:regionArea></affiliation></author><author><name sortKey="Li, Tao" sort="Li, Tao" uniqKey="Li T" first="Tao" last="Li">Tao Li</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Rutvisuttinunt, Wiriya" sort="Rutvisuttinunt, Wiriya" uniqKey="Rutvisuttinunt W" first="Wiriya" last="Rutvisuttinunt">Wiriya Rutvisuttinunt</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Lin, Xiaoxu" sort="Lin, Xiaoxu" uniqKey="Lin X" first="Xiaoxu" last="Lin">Xiaoxu Lin</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Hallgrimsson, Gunnar T" sort="Hallgrimsson, Gunnar T" uniqKey="Hallgrimsson G" first="Gunnar T." last="Hallgrimsson">Gunnar T. Hallgrimsson</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Ragnarsdottir, Sunna B" sort="Ragnarsdottir, Sunna B" uniqKey="Ragnarsdottir S" first="Sunna B." last="Ragnarsdottir">Sunna B. Ragnarsdottir</name><affiliation wicri:level="1"><nlm:aff id="aff7"><addr-line>Southwest Iceland Nature Research Centre, Sandgerdi, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Southwest Iceland Nature Research Centre, Sandgerdi</wicri:regionArea></affiliation></author><author><name sortKey="Vignisson, Solvi R" sort="Vignisson, Solvi R" uniqKey="Vignisson S" first="Solvi R." last="Vignisson">Solvi R. Vignisson</name><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>Sudurnes Science and Learning Center, Sandgerdi, Iceland</addr-line></nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Sudurnes Science and Learning Center, Sandgerdi</wicri:regionArea></affiliation></author><author><name sortKey="Teslaa, Josh" sort="Teslaa, Josh" uniqKey="Teslaa J" first="Josh" last="Teslaa">Josh Teslaa</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Nashold, Sean W" sort="Nashold, Sean W" uniqKey="Nashold S" first="Sean W." last="Nashold">Sean W. Nashold</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin</wicri:regionArea></affiliation></author><author><name sortKey="Jarman, Richard" sort="Jarman, Richard" uniqKey="Jarman R" first="Richard" last="Jarman">Richard Jarman</name><affiliation wicri:level="1"><nlm:aff id="aff5"><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland</wicri:regionArea></affiliation></author><author><name sortKey="Wan, Xiu Feng" sort="Wan, Xiu Feng" uniqKey="Wan X" first="Xiu-Feng" last="Wan">Xiu-Feng Wan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Subtype H10 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among seals. In the fall of 2015, H10N7 viruses were recovered from gulls in Iceland, and genomic analyses showed that the viruses were genetically related with IAVs that caused outbreaks among seals in Europe a year earlier. These gull-origin viruses showed high binding affinity to human-like glycan receptors. Transmission studies in ferrets demonstrated that the gull-origin IAV could infect ferrets, and that the virus could be transmitted between ferrets through direct contact and aerosol droplets. This study demonstrated that avian H10 IAV can infect mammals and be transmitted among them without adaptation. Thus, avian H10 IAV is a candidate for influenza pandemic preparedness and should be monitored in wildlife and at the animal-human interface.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Virol</journal-id><journal-id journal-id-type="iso-abbrev">J. Virol</journal-id><journal-id journal-id-type="hwp">jvi</journal-id><journal-id journal-id-type="pmc">jvi</journal-id><journal-id journal-id-type="publisher-id">JVI</journal-id><journal-title-group><journal-title>Journal of Virology</journal-title></journal-title-group><issn pub-type="ppub">0022-538X</issn><issn pub-type="epub">1098-5514</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">30996092</article-id><article-id pub-id-type="pmc">6580963</article-id><article-id pub-id-type="publisher-id">00282-19</article-id><article-id pub-id-type="doi">10.1128/JVI.00282-19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pathogenesis and Immunity</subject></subj-group></article-categories><title-group><article-title>Aerosol Transmission of Gull-Origin Iceland Subtype H10N7 Influenza A Virus in Ferrets</article-title><alt-title alt-title-type="running-head">Aerosol Transmission of H10N7 IAV in Ferrets</alt-title><alt-title alt-title-type="short-authors">Guan et al.</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Guan</surname><given-names>Minhui</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Hall</surname><given-names>Jeffrey S.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Zhang</surname><given-names>Xiaojian</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Dusek</surname><given-names>Robert J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Olivier</surname><given-names>Alicia K.</given-names></name><xref ref-type="aff" rid="aff3"><sup>c</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Liu</surname><given-names>Liyuan</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Li</surname><given-names>Lei</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Krauss</surname><given-names>Scott</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Danner</surname><given-names>Angela</given-names></name><xref ref-type="aff" rid="aff4"><sup>d</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Li</surname><given-names>Tao</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Rutvisuttinunt</surname><given-names>Wiriya</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Lin</surname><given-names>Xiaoxu</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Hallgrimsson</surname><given-names>Gunnar T.</given-names></name><xref ref-type="aff" rid="aff6"><sup>f</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Ragnarsdottir</surname><given-names>Sunna B.</given-names></name><xref ref-type="aff" rid="aff7"><sup>g</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Vignisson</surname><given-names>Solvi R.</given-names></name><xref ref-type="aff" rid="aff8"><sup>h</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>TeSlaa</surname><given-names>Josh</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Nashold</surname><given-names>Sean W.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" equal-contrib="no"><name><surname>Jarman</surname><given-names>Richard</given-names></name><xref ref-type="aff" rid="aff5"><sup>e</sup></xref></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="no"><name><surname>Wan</surname><given-names>Xiu-Feng</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label><addr-line>Department of Basic Science, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></aff><aff id="aff2"><label>b</label><addr-line>United States Geological Survey National Wildlife Health Center, Madison, Wisconsin, USA</addr-line></aff><aff id="aff3"><label>c</label><addr-line>Department of Population and Pathobiology Medicine, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi, USA</addr-line></aff><aff id="aff4"><label>d</label><addr-line>Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA</addr-line></aff><aff id="aff5"><label>e</label><addr-line>Viral Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA</addr-line></aff><aff id="aff6"><label>f</label><addr-line>University of Iceland, Reykjavik, Iceland</addr-line></aff><aff id="aff7"><label>g</label><addr-line>Southwest Iceland Nature Research Centre, Sandgerdi, Iceland</addr-line></aff><aff id="aff8"><label>h</label><addr-line>Sudurnes Science and Learning Center, Sandgerdi, Iceland</addr-line></aff></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>García-Sastre</surname><given-names>Adolfo</given-names></name><role>Editor</role><aff>Icahn School of Medicine at Mount Sinai</aff></contrib></contrib-group><author-notes><corresp id="cor1">Address correspondence to Xiu-Feng Wan, <email>wan@cvm.msstate.edu</email>.</corresp><fn fn-type="equal"><p>M.G. and J.S.H. contributed equally to this work.</p></fn><fn fn-type="other"><p><bold>Citation</bold> Guan M, Hall JS, Zhang X, Dusek RJ, Olivier AK, Liu L, Li L, Krauss S, Danner A, Li T, Rutvisuttinunt W, Lin X, Hallgrimsson GT, Ragnarsdottir SB, Vignisson SR, TeSlaa J, Nashold SW, Jarman R, Wan X-F. 2019. Aerosol transmission of gull-origin Iceland subtype H10N7 influenza A virus in ferrets. J Virol 93:e00282-19. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/JVI.00282-19">https://doi.org/10.1128/JVI.00282-19</ext-link>.</p></fn></author-notes><pub-date pub-type="epreprint"><day>17</day><month>4</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>14</day><month>6</month><year>2019</year></pub-date><pub-date pub-type="collection"><day>1</day><month>7</month><year>2019</year></pub-date><volume>93</volume><issue>13</issue><elocation-id>e00282-19</elocation-id><history><date date-type="received"><day>19</day><month>2</month><year>2019</year></date><date date-type="accepted"><day>9</day><month>4</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 American Society for Microbiology.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder><license license-type="asm" xlink:href="https://doi.org/10.1128/ASMCopyrightv2"><license-p><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/ASMCopyrightv2">All Rights Reserved</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="JVI.00282-19.pdf"></self-uri><abstract abstract-type="precis"><p>Subtype H10 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among seals. In the fall of 2015, H10N7 viruses were recovered from gulls in Iceland, and genomic analyses showed that the viruses were genetically related with IAVs that caused outbreaks among seals in Europe a year earlier. These gull-origin viruses showed high binding affinity to human-like glycan receptors. Transmission studies in ferrets demonstrated that the gull-origin IAV could infect ferrets, and that the virus could be transmitted between ferrets through direct contact and aerosol droplets. This study demonstrated that avian H10 IAV can infect mammals and be transmitted among them without adaptation. Thus, avian H10 IAV is a candidate for influenza pandemic preparedness and should be monitored in wildlife and at the animal-human interface.</p></abstract><abstract><title>ABSTRACT</title><p>Subtype H10 influenza A viruses (IAVs) have been recovered from domestic poultry and various aquatic bird species, and sporadic transmission of these IAVs from avian species to mammals (i.e., human, seal, and mink) are well documented. In 2015, we isolated four H10N7 viruses from gulls in Iceland. Genomic analyses showed four gene segments in the viruses were genetically associated with H10 IAVs that caused influenza outbreaks and deaths among European seals in 2014. Antigenic characterization suggested minimal antigenic variation among these H10N7 isolates and other archived H10 viruses recovered from human, seal, mink, and various avian species in Asia, Europe, and North America. Glycan binding preference analyses suggested that, similar to other avian-origin H10 IAVs, these gull-origin H10N7 IAVs bound to both avian-like alpha 2,3-linked sialic acids and human-like alpha 2,6-linked sialic acids. However, when the gull-origin viruses were compared with another Eurasian avian-origin H10N8 IAV, which caused human infections, the gull-origin virus showed significantly higher binding affinity to human-like glycan receptors. Results from a ferret experiment demonstrated that a gull-origin H10N7 IAV replicated well in turbinate, trachea, and lung, but replication was most efficient in turbinate and trachea. This gull-origin H10N7 virus can be transmitted between ferrets through the direct contact and aerosol routes, without prior adaptation. Gulls share their habitat with other birds and mammals and have frequent contact with humans; therefore, gull-origin H10N7 IAVs could pose a risk to public health. Surveillance and monitoring of these IAVs at the wild bird-human interface should be continued.</p><p><bold>IMPORTANCE</bold> Subtype H10 avian influenza A viruses (IAVs) have caused sporadic human infections and enzootic outbreaks among seals. In the fall of 2015, H10N7 viruses were recovered from gulls in Iceland, and genomic analyses showed that the viruses were genetically related with IAVs that caused outbreaks among seals in Europe a year earlier. These gull-origin viruses showed high binding affinity to human-like glycan receptors. Transmission studies in ferrets demonstrated that the gull-origin IAV could infect ferrets, and that the virus could be transmitted between ferrets through direct contact and aerosol droplets. This study demonstrated that avian H10 IAV can infect mammals and be transmitted among them without adaptation. Thus, avian H10 IAV is a candidate for influenza pandemic preparedness and should be monitored in wildlife and at the animal-human interface.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>H10N7</kwd><kwd>aerosol droplet</kwd><kwd>alpha 2,3-linked sialic acids</kwd><kwd>alpha 2,6-linked sialic acids</kwd><kwd>avian influenza virus</kwd><kwd>glycan receptor binding</kwd><kwd>gull</kwd><kwd>influenza A virus</kwd><kwd>pathogenesis</kwd><kwd>transmission</kwd></kwd-group><funding-group><award-group id="award1"><funding-source><institution-wrap><institution>HHS | National Institutes of Health (NIH)</institution><institution-id>https://doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id>R21AI135820</award-id><principal-award-recipient><name><surname>Wan</surname><given-names>Xiu-Feng</given-names></name></principal-award-recipient></award-group><award-group id="award2"><funding-source><institution-wrap><institution>HHS | National Institutes of Health (NIH)</institution><institution-id>https://doi.org/10.13039/100000002</institution-id></institution-wrap></funding-source><award-id>HHSN272201400006C</award-id><principal-award-recipient><name><surname>Hall </surname><given-names>Jeffrey S.</given-names></name></principal-award-recipient></award-group></funding-group><counts><count count="1" count-type="supplementary-material"></count><fig-count count="7"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="80"></ref-count><page-count count="16"></page-count><word-count count="11128"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>July 2019</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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