Strategies for mitigating an influenza pandemic with pre-pandemic H5N1 vaccines
Identifieur interne : 000727 ( Pmc/Curation ); précédent : 000726; suivant : 000728Strategies for mitigating an influenza pandemic with pre-pandemic H5N1 vaccines
Auteurs : George Milne [Australie] ; Joel Kelso [Australie] ; Heath Kelly [Australie]Source :
- Journal of the Royal Society Interface [ 1742-5689 ] ; 2009.
Abstract
The recent worldwide spread of the swine-origin H1N1 2009 influenza outbreak has resulted in its designation as a pandemic by the World Health Organization. While it appears to result in mild symptoms, concern still exists that a more severe influenza pandemic with a high case fatality ratio might arise by reassortment or mutation of the currently circulating avian influenza (H5N1) virus. Given that recently developed candidate pre-pandemic H5N1 vaccines have shown potential for cross-strain protection, we investigated alternative vaccination strategies that exploit such vaccines using an agent-based simulation model of an actual community of approximately 30 000 people in a developed country. Assuming that a two-dose vaccination regimen would be required, we examined three vaccination strategies: pre-emptive, with vaccination applied prior to emergence of human-transmissible H5N1 influenza; reactive, where vaccination was initiated immediately after the first cases in the community were diagnosed; and a ‘split’ strategy where the first dose was administered pre-emptively during the pre-pandemic phase, with the second dose administered reactively. We showed that by effectively moving the delay between first and second doses into the pre-pandemic period, the split vaccination strategy achieved a substantially better attack rate reduction than the reactive strategy. Our results for an influenza strain with a reproduction number of 1.5 suggest reactive vaccination strategies that may be applicable to the current H1N1 2009 pandemic.
Url:
DOI: 10.1098/rsif.2009.0312
PubMed: 19755499
PubMed Central: 2842780
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000727
Links to Exploration step
PMC:2842780Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Strategies for mitigating an influenza pandemic with pre-pandemic H5N1 vaccines</title>
<author><name sortKey="Milne, George" sort="Milne, George" uniqKey="Milne G" first="George" last="Milne">George Milne</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kelso, Joel" sort="Kelso, Joel" uniqKey="Kelso J" first="Joel" last="Kelso">Joel Kelso</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kelly, Heath" sort="Kelly, Heath" uniqKey="Kelly H" first="Heath" last="Kelly">Heath Kelly</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Population Health, University of Melbourne</institution>
,<addr-line>Melbourne, Victoria</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Epidemiology Unit, Victorian Infectious Diseases Reference Laboratory, Carlton, Victoria</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">19755499</idno>
<idno type="pmc">2842780</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842780</idno>
<idno type="RBID">PMC:2842780</idno>
<idno type="doi">10.1098/rsif.2009.0312</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000727</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000727</idno>
<idno type="wicri:Area/Pmc/Curation">000727</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000727</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Strategies for mitigating an influenza pandemic with pre-pandemic H5N1 vaccines</title>
<author><name sortKey="Milne, George" sort="Milne, George" uniqKey="Milne G" first="George" last="Milne">George Milne</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kelso, Joel" sort="Kelso, Joel" uniqKey="Kelso J" first="Joel" last="Kelso">Joel Kelso</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kelly, Heath" sort="Kelly, Heath" uniqKey="Kelly H" first="Heath" last="Kelly">Heath Kelly</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>School of Population Health, University of Melbourne</institution>
,<addr-line>Melbourne, Victoria</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Epidemiology Unit, Victorian Infectious Diseases Reference Laboratory, Carlton, Victoria</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of the Royal Society Interface</title>
<idno type="ISSN">1742-5689</idno>
<idno type="eISSN">1742-5662</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The recent worldwide spread of the swine-origin H1N1 2009 influenza outbreak has resulted in its designation as a pandemic by the World Health Organization. While it appears to result in mild symptoms, concern still exists that a more severe influenza pandemic with a high case fatality ratio might arise by reassortment or mutation of the currently circulating avian influenza (H5N1) virus. Given that recently developed candidate pre-pandemic H5N1 vaccines have shown potential for cross-strain protection, we investigated alternative vaccination strategies that exploit such vaccines using an agent-based simulation model of an actual community of approximately 30 000 people in a developed country. Assuming that a two-dose vaccination regimen would be required, we examined three vaccination strategies: pre-emptive, with vaccination applied prior to emergence of human-transmissible H5N1 influenza; reactive, where vaccination was initiated immediately after the first cases in the community were diagnosed; and a ‘split’ strategy where the first dose was administered pre-emptively during the pre-pandemic phase, with the second dose administered reactively. We showed that by effectively moving the delay between first and second doses into the pre-pandemic period, the split vaccination strategy achieved a substantially better attack rate reduction than the reactive strategy. Our results for an influenza strain with a reproduction number of 1.5 suggest reactive vaccination strategies that may be applicable to the current H1N1 2009 pandemic.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J R Soc Interface</journal-id>
<journal-id journal-id-type="iso-abbrev">J R Soc Interface</journal-id>
<journal-id journal-id-type="publisher-id">RSIF</journal-id>
<journal-id journal-id-type="hwp">royinterface</journal-id>
<journal-title-group><journal-title>Journal of the Royal Society Interface</journal-title>
</journal-title-group>
<issn pub-type="ppub">1742-5689</issn>
<issn pub-type="epub">1742-5662</issn>
<publisher><publisher-name>The Royal Society</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">19755499</article-id>
<article-id pub-id-type="pmc">2842780</article-id>
<article-id pub-id-type="doi">10.1098/rsif.2009.0312</article-id>
<article-id pub-id-type="publisher-id">rsif20090312</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Articles</subject>
</subj-group>
<subj-group subj-group-type="hwp-journal-coll"><subject>1004</subject>
<subject>44</subject>
</subj-group>
</article-categories>
<title-group><article-title>Strategies for mitigating an influenza pandemic with pre-pandemic H5N1 vaccines</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Milne</surname>
<given-names>George</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kelso</surname>
<given-names>Joel</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kelly</surname>
<given-names>Heath</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>School of Computer Science and Software Engineering</addr-line>
,<institution>The University of Western Australia</institution>
,<addr-line>Perth, Western Australia</addr-line>
,<country>Australia</country>
</aff>
<aff id="af2"><label>2</label>
<institution>School of Population Health, University of Melbourne</institution>
,<addr-line>Melbourne, Victoria</addr-line>
,<country>Australia</country>
</aff>
<aff id="af3"><label>3</label>
<addr-line>Epidemiology Unit, Victorian Infectious Diseases Reference Laboratory, Carlton, Victoria</addr-line>
,<country>Australia</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Author for correspondence (<email>joel@csse.uwa.edu.au</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>6</day>
<month>4</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>9</month>
<year>2009</year>
</pub-date>
<volume>7</volume>
<issue>45</issue>
<fpage>573</fpage>
<lpage>586</lpage>
<history><date date-type="received"><day>24</day>
<month>7</month>
<year>2009</year>
</date>
<date date-type="accepted"><day>18</day>
<month>8</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© 2009 The Royal Society</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="rsif20090312.pdf"></self-uri>
<abstract><p>The recent worldwide spread of the swine-origin H1N1 2009 influenza outbreak has resulted in its designation as a pandemic by the World Health Organization. While it appears to result in mild symptoms, concern still exists that a more severe influenza pandemic with a high case fatality ratio might arise by reassortment or mutation of the currently circulating avian influenza (H5N1) virus. Given that recently developed candidate pre-pandemic H5N1 vaccines have shown potential for cross-strain protection, we investigated alternative vaccination strategies that exploit such vaccines using an agent-based simulation model of an actual community of approximately 30 000 people in a developed country. Assuming that a two-dose vaccination regimen would be required, we examined three vaccination strategies: pre-emptive, with vaccination applied prior to emergence of human-transmissible H5N1 influenza; reactive, where vaccination was initiated immediately after the first cases in the community were diagnosed; and a ‘split’ strategy where the first dose was administered pre-emptively during the pre-pandemic phase, with the second dose administered reactively. We showed that by effectively moving the delay between first and second doses into the pre-pandemic period, the split vaccination strategy achieved a substantially better attack rate reduction than the reactive strategy. Our results for an influenza strain with a reproduction number of 1.5 suggest reactive vaccination strategies that may be applicable to the current H1N1 2009 pandemic.</p>
</abstract>
<kwd-group><kwd>pandemic influenza</kwd>
<kwd>H5N1 vaccines</kwd>
<kwd>vaccination strategies</kwd>
<kwd>epidemic simulation</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000727 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000727 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:2842780 |texte= Strategies for mitigating an influenza pandemic with pre-pandemic H5N1 vaccines }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:19755499" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a PandemieGrippaleV1
This area was generated with Dilib version V0.6.34. |