The first influenza pandemic of the new millennium
Identifieur interne : 000094 ( Pmc/Curation ); précédent : 000093; suivant : 000095The first influenza pandemic of the new millennium
Auteurs : Gabriele Neumann ; Yoshihiro KawaokaSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2011.
Abstract
In the spring of 2009, a novel influenza A virus of the H1N1 subtype emerged that transmitted efficiently among humans; by June of 2009, the outbreak reached pandemic status. The pandemic virus possesses six viral RNA segments from so‐called triple reassortant swine viruses that emerged in North American pig populations in the late 1990s and two viral RNA segments from Eurasian avian‐like swine influenza viruses. Most human infections with the virus have been mild; however, severe and fatal infections occurred among certain risk groups, but also among those without any known risk factors. Here, we summarize the evolutionary, epidemiological, clinical, and molecular findings on the pandemic virus. We also discuss the arsenal of antiviral compounds and vaccines available to prevent and treat infections with the virus.
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DOI: 10.1111/j.1750-2659.2011.00231.x
PubMed: 21477134
PubMed Central: 3073629
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(2011) The first influenza pandemic of the new millennium. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750‐2659.2011.00202.x.</p><p>In the spring of 2009, a novel influenza A virus of the H1N1 subtype emerged that transmitted efficiently among humans; by June of 2009, the outbreak reached pandemic status. The pandemic virus possesses six viral RNA segments from so‐called triple reassortant swine viruses that emerged in North American pig populations in the late 1990s and two viral RNA segments from Eurasian avian‐like swine influenza viruses. Most human infections with the virus have been mild; however, severe and fatal infections occurred among certain risk groups, but also among those without any known risk factors. Here, we summarize the evolutionary, epidemiological, clinical, and molecular findings on the pandemic virus. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="iso-abbrev">Influenza Other Respir Viruses</journal-id><journal-id journal-id-type="doi">10.1111/(ISSN)1750-2659</journal-id><journal-id journal-id-type="publisher-id">IRV</journal-id><journal-title-group><journal-title>Influenza and Other Respiratory Viruses</journal-title></journal-title-group><issn pub-type="ppub">1750-2640</issn><issn pub-type="epub">1750-2659</issn><publisher><publisher-name>Blackwell Publishing Ltd</publisher-name><publisher-loc>Oxford, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21477134</article-id><article-id pub-id-type="pmc">3073629</article-id><article-id pub-id-type="doi">10.1111/j.1750-2659.2011.00231.x</article-id><article-id pub-id-type="publisher-id">IRV231</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group><subj-group subj-group-type="overline"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>The first influenza pandemic of the new millennium</article-title><alt-title alt-title-type="left-running-head">Neumann and Kawaoka</alt-title><alt-title alt-title-type="right-running-head">2009 H1N1 Influenza Pandemic</alt-title></title-group><contrib-group><contrib id="cr1" contrib-type="author"><name><surname>Neumann</surname><given-names>Gabriele</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref></contrib><contrib id="cr2" contrib-type="author"><name><surname>Kawaoka</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="a1"><sup>1</sup></xref><xref ref-type="aff" rid="a2"><sup>2</sup></xref><xref ref-type="aff" rid="a3"><sup>3</sup></xref><xref ref-type="aff" rid="a4"><sup>4</sup></xref></contrib></contrib-group><aff id="a1"><label><sup>1</sup></label>Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin‐Madison, Madison, WI, USA.</aff><aff id="a2"><label><sup>2</sup></label>Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.</aff><aff id="a3"><label><sup>3</sup></label>Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.</aff><aff id="a4"><label><sup>4</sup></label>ERATO Infection‐Induced Host Responses Project, Saitama, Japan.</aff><author-notes><corresp id="correspondenceTo">Yoshihiro Kawaoka, Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin‐Madison, 575 Science Drive, Madison, WI 53711, USA. E‐mail: <email>kawaokay@svm.vetmed.wisc.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>28</day><month>2</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2011</year></pub-date><volume>5</volume><issue>3</issue><issue-id pub-id-type="doi">10.1111/irv.2011.5.issue-3</issue-id><fpage>157</fpage><lpage>166</lpage><history>Accepted 14 January 2011. Published Online 28 February 2011.</history><permissions><copyright-statement content-type="article-copyright">© 2011 Blackwell Publishing Ltd</copyright-statement></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="file:IRV-5-157.pdf"></self-uri><abstract><p><italic>Please cite this paper as:</italic> Neumann G, Kawaoka Y. (2011) The first influenza pandemic of the new millennium. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750‐2659.2011.00202.x.</p><p>In the spring of 2009, a novel influenza A virus of the H1N1 subtype emerged that transmitted efficiently among humans; by June of 2009, the outbreak reached pandemic status. The pandemic virus possesses six viral RNA segments from so‐called triple reassortant swine viruses that emerged in North American pig populations in the late 1990s and two viral RNA segments from Eurasian avian‐like swine influenza viruses. Most human infections with the virus have been mild; however, severe and fatal infections occurred among certain risk groups, but also among those without any known risk factors. Here, we summarize the evolutionary, epidemiological, clinical, and molecular findings on the pandemic virus. 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