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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">1918 Influenza Receptor Binding Domain Variants Bind and Replicate in Primary Human Airway Cells Regardless of Receptor Specificity</title><author><name sortKey="Davis, A Sally" sort="Davis, A Sally" uniqKey="Davis A" first="A. Sally" last="Davis">A. Sally Davis</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Diagnostic Medicine and Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS</nlm:aff></affiliation></author><author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S." last="Chertow">Daniel S. Chertow</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Qi, Li" sort="Qi, Li" uniqKey="Qi L" first="Li" last="Qi">Li Qi</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Schwartzman, Louis M" sort="Schwartzman, Louis M" uniqKey="Schwartzman L" first="Louis M." last="Schwartzman">Louis M. Schwartzman</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Suzich, Jon" sort="Suzich, Jon" uniqKey="Suzich J" first="Jon" last="Suzich">Jon Suzich</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Alsaaty, Sara" sort="Alsaaty, Sara" uniqKey="Alsaaty S" first="Sara" last="Alsaaty">Sara Alsaaty</name><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Logun, Carolea" sort="Logun, Carolea" uniqKey="Logun C" first="Carolea" last="Logun">Carolea Logun</name><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Shelhamer, James H" sort="Shelhamer, James H" uniqKey="Shelhamer J" first="James H." last="Shelhamer">James H. Shelhamer</name><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27062579</idno><idno type="pmc">4949484</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949484</idno><idno type="RBID">PMC:4949484</idno><idno type="doi">10.1016/j.virol.2016.03.025</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000806</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000806</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">1918 Influenza Receptor Binding Domain Variants Bind and Replicate in Primary Human Airway Cells Regardless of Receptor Specificity</title><author><name sortKey="Davis, A Sally" sort="Davis, A Sally" uniqKey="Davis A" first="A. Sally" last="Davis">A. Sally Davis</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Diagnostic Medicine and Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS</nlm:aff></affiliation></author><author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S." last="Chertow">Daniel S. Chertow</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Qi, Li" sort="Qi, Li" uniqKey="Qi L" first="Li" last="Qi">Li Qi</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Schwartzman, Louis M" sort="Schwartzman, Louis M" uniqKey="Schwartzman L" first="Louis M." last="Schwartzman">Louis M. Schwartzman</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Suzich, Jon" sort="Suzich, Jon" uniqKey="Suzich J" first="Jon" last="Suzich">Jon Suzich</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Alsaaty, Sara" sort="Alsaaty, Sara" uniqKey="Alsaaty S" first="Sara" last="Alsaaty">Sara Alsaaty</name><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Logun, Carolea" sort="Logun, Carolea" uniqKey="Logun C" first="Carolea" last="Logun">Carolea Logun</name><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Shelhamer, James H" sort="Shelhamer, James H" uniqKey="Shelhamer J" first="James H." last="Shelhamer">James H. Shelhamer</name><affiliation><nlm:aff id="A3">Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</nlm:aff></affiliation></author><author><name sortKey="Taubenberger, Jeffery K" sort="Taubenberger, Jeffery K" uniqKey="Taubenberger J" first="Jeffery K." last="Taubenberger">Jeffery K. Taubenberger</name><affiliation><nlm:aff id="A1">Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</nlm:aff></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">The 1918 influenza pandemic caused ~50 million deaths. Many questions remain regarding the origin, pathogenicity, and mechanisms of human adaptation of this virus. Avian-adapted influenza A viruses preferentially bind α2,3-linked sialic acids (Sia) while human-adapted viruses preferentially bind α2,6-linked Sia. A change in Sia preference from α2,3 to α2,6 is thought to be a requirement for human adaptation of avian influenza viruses. Autopsy data from 1918 cases, however, suggest that factors other than Sia preference played a role in viral binding and entry to human airway cells. Here, we evaluated binding and entry of five 1918 influenza receptor binding domain variants in a primary human airway cell model along with control avian and human influenza viruses. We observed that all five variants bound and entered cells efficiently and that Sia preference did not predict entry of influenza A virus to primary human airway cells evaluated in this model.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id><journal-id journal-id-type="pubmed-jr-id">8015</journal-id><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-id journal-id-type="iso-abbrev">Virology</journal-id><journal-title-group><journal-title>Virology</journal-title></journal-title-group><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn></journal-meta><article-meta><article-id pub-id-type="pmid">27062579</article-id><article-id pub-id-type="pmc">4949484</article-id><article-id pub-id-type="doi">10.1016/j.virol.2016.03.025</article-id><article-id pub-id-type="manuscript">NIHMS776373</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>1918 Influenza Receptor Binding Domain Variants Bind and Replicate in Primary Human Airway Cells Regardless of Receptor Specificity</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Davis</surname><given-names>A. Sally</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref rid="FN2" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Chertow</surname><given-names>Daniel S.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref><xref rid="FN2" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Kindrachuk</surname><given-names>Jason</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Qi</surname><given-names>Li</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Schwartzman</surname><given-names>Louis M.</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Suzich</surname><given-names>Jon</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Alsaaty</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Logun</surname><given-names>Carolea</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Shelhamer</surname><given-names>James H.</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Taubenberger</surname><given-names>Jeffery K.</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib></contrib-group><aff id="A1"><label>a</label>Viral Pathogenesis and Evolution Section, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD</aff><aff id="A2"><label>b</label>Diagnostic Medicine and Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS</aff><aff id="A3"><label>c</label>Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. Jeffery K. Taubenberger, M.D., Ph.D., NIAID, 33 North Dr., MSC 3203, Bethesda, MD 20892; Phone: (301) 443-5960; Fax: (301) 480-1696; <email>taubenbergerj@niaid.nih.gov</email></corresp><fn id="FN2" fn-type="equal"><label>1</label><p>These authors contributed equally to this manuscript.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>12</day><month>7</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>11</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2017</year></pub-date><volume>493</volume><fpage>238</fpage><lpage>246</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.virol.2016.03.025</pmc-comment>
<abstract><p id="P2">The 1918 influenza pandemic caused ~50 million deaths. Many questions remain regarding the origin, pathogenicity, and mechanisms of human adaptation of this virus. Avian-adapted influenza A viruses preferentially bind α2,3-linked sialic acids (Sia) while human-adapted viruses preferentially bind α2,6-linked Sia. A change in Sia preference from α2,3 to α2,6 is thought to be a requirement for human adaptation of avian influenza viruses. Autopsy data from 1918 cases, however, suggest that factors other than Sia preference played a role in viral binding and entry to human airway cells. Here, we evaluated binding and entry of five 1918 influenza receptor binding domain variants in a primary human airway cell model along with control avian and human influenza viruses. We observed that all five variants bound and entered cells efficiently and that Sia preference did not predict entry of influenza A virus to primary human airway cells evaluated in this model.</p></abstract><kwd-group><kwd>Influenza A virus</kwd><kwd>Pandemic</kwd><kwd>Receptor binding</kwd><kwd>hemagglutinin</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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