Development of a new disinfectant with very strong anti-influenza viral activity: a preliminary report
Identifieur interne : 000C36 ( Pmc/Checkpoint ); précédent : 000C35; suivant : 000C37Development of a new disinfectant with very strong anti-influenza viral activity: a preliminary report
Auteurs : Hiroki Takakuwa ; Toshiyuki Maruoka ; Tadayo Hata ; Masaaki Miyazawa ; Tomoyo Hata ; Hitoshi Toshimori ; Koichi Otsuki [Japon]Source :
- Environmental Health and Preventive Medicine [ 1342-078X ] ; 2009.
Abstract
We evaluated the effectiveness and safety of a disinfectant newly developed by our laboratories for use against influenza viruses.
The effectiveness of our new disinfectant against avian, swine and human influenza viruses was tested in ovo. The acute toxicity of this disinfectant to two different cultured cell lines was investigated.
This new disinfectant showed very strong anti-influenza viral activity in the in ovo tests. All of the influenza viruses tested were inactivated very quickly. Following exposure to the disinfectant, the infectivity of all viral strains tested had been eliminated within ≤10 min. The infectant showed a weak acute toxicity in vitro.
This new disinfectant is expected to be useful for preventing viral infection during a new influenza pandemic.
Url:
DOI: 10.1007/s12199-009-0112-y
PubMed: 19806430
PubMed Central: 2824105
Affiliations:
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PMC:2824105Le document en format XML
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<author><name sortKey="Takakuwa, Hiroki" sort="Takakuwa, Hiroki" uniqKey="Takakuwa H" first="Hiroki" last="Takakuwa">Hiroki Takakuwa</name>
<affiliation><nlm:aff id="Aff1">Avian Influenza Research Centre, Kyoto Sangyo University, Motoyama Kamigamo, Kita-ku, Kyoto 603-8555 Japan</nlm:aff>
<wicri:noCountry code="subfield">Kyoto 603-8555 Japan</wicri:noCountry>
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<author><name sortKey="Maruoka, Toshiyuki" sort="Maruoka, Toshiyuki" uniqKey="Maruoka T" first="Toshiyuki" last="Maruoka">Toshiyuki Maruoka</name>
<affiliation><nlm:aff id="Aff2">Bacteria Research Center, Shionomiya Hot Spring Hospital–Zaidanhojin Seikenkai, Tondabayashi, Osaka Japan</nlm:aff>
<wicri:noCountry code="subfield">Osaka Japan</wicri:noCountry>
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<series><title level="j">Environmental Health and Preventive Medicine</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>We evaluated the effectiveness and safety of a disinfectant newly developed by our laboratories for use against influenza viruses.</p>
</sec>
<sec><title>Methods</title>
<p>The effectiveness of our new disinfectant against avian, swine and human influenza viruses was tested in ovo. The acute toxicity of this disinfectant to two different cultured cell lines was investigated.</p>
</sec>
<sec><title>Results</title>
<p>This new disinfectant showed very strong anti-influenza viral activity in the in ovo tests. All of the influenza viruses tested were inactivated very quickly. Following exposure to the disinfectant, the infectivity of all viral strains tested had been eliminated within ≤10 min. The infectant showed a weak acute toxicity in vitro.</p>
</sec>
<sec><title>Conclusion</title>
<p>This new disinfectant is expected to be useful for preventing viral infection during a new influenza pandemic.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Environ Health Prev Med</journal-id>
<journal-title-group><journal-title>Environmental Health and Preventive Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1342-078X</issn>
<issn pub-type="epub">1347-4715</issn>
<publisher><publisher-name>Springer Japan</publisher-name>
<publisher-loc>Japan</publisher-loc>
</publisher>
</journal-meta>
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<article-id pub-id-type="pmc">2824105</article-id>
<article-id pub-id-type="publisher-id">112</article-id>
<article-id pub-id-type="doi">10.1007/s12199-009-0112-y</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Short Communication</subject>
</subj-group>
</article-categories>
<title-group><article-title>Development of a new disinfectant with very strong anti-influenza viral activity: a preliminary report</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Takakuwa</surname>
<given-names>Hiroki</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maruoka</surname>
<given-names>Toshiyuki</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hata</surname>
<given-names>Tadayo</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miyazawa</surname>
<given-names>Masaaki</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hata</surname>
<given-names>Tomoyo</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toshimori</surname>
<given-names>Hitoshi</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Otsuki</surname>
<given-names>Koichi</given-names>
</name>
<address><email>k3666@cc.kyoto-su.ac.jp</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<aff id="Aff1"><label>1</label>
Avian Influenza Research Centre, Kyoto Sangyo University, Motoyama Kamigamo, Kita-ku, Kyoto 603-8555 Japan</aff>
<aff id="Aff2"><label>2</label>
Bacteria Research Center, Shionomiya Hot Spring Hospital–Zaidanhojin Seikenkai, Tondabayashi, Osaka Japan</aff>
<aff id="Aff3"><label>3</label>
Department of Immunology, Kinki University School of Medicine, Osakasayama, Osaka Japan</aff>
<aff id="Aff4"><label>4</label>
Avian Zoonoses Research Centre, Faculty of Agriculture, Tottori University, Tottori, Japan</aff>
</contrib-group>
<pub-date pub-type="epub"><day>6</day>
<month>10</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><month>3</month>
<year>2010</year>
</pub-date>
<volume>15</volume>
<issue>2</issue>
<fpage>121</fpage>
<lpage>123</lpage>
<history><date date-type="received"><day>12</day>
<month>11</month>
<year>2008</year>
</date>
<date date-type="accepted"><day>9</day>
<month>9</month>
<year>2009</year>
</date>
</history>
<permissions><copyright-statement>© The Japanese Society for Hygiene 2009</copyright-statement>
</permissions>
<abstract xml:lang="en"><sec><title>Objectives</title>
<p>We evaluated the effectiveness and safety of a disinfectant newly developed by our laboratories for use against influenza viruses.</p>
</sec>
<sec><title>Methods</title>
<p>The effectiveness of our new disinfectant against avian, swine and human influenza viruses was tested in ovo. The acute toxicity of this disinfectant to two different cultured cell lines was investigated.</p>
</sec>
<sec><title>Results</title>
<p>This new disinfectant showed very strong anti-influenza viral activity in the in ovo tests. All of the influenza viruses tested were inactivated very quickly. Following exposure to the disinfectant, the infectivity of all viral strains tested had been eliminated within ≤10 min. The infectant showed a weak acute toxicity in vitro.</p>
</sec>
<sec><title>Conclusion</title>
<p>This new disinfectant is expected to be useful for preventing viral infection during a new influenza pandemic.</p>
</sec>
</abstract>
<kwd-group><title>Keywords</title>
<kwd>Avian influenza virus</kwd>
<kwd>Human influenza virus</kwd>
<kwd>New disinfectant</kwd>
<kwd>Strong activity</kwd>
<kwd>Swine influenza virus</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Japanese Society for Hygiene 2010</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Japon</li>
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<tree><noCountry><name sortKey="Hata, Tadayo" sort="Hata, Tadayo" uniqKey="Hata T" first="Tadayo" last="Hata">Tadayo Hata</name>
<name sortKey="Hata, Tomoyo" sort="Hata, Tomoyo" uniqKey="Hata T" first="Tomoyo" last="Hata">Tomoyo Hata</name>
<name sortKey="Maruoka, Toshiyuki" sort="Maruoka, Toshiyuki" uniqKey="Maruoka T" first="Toshiyuki" last="Maruoka">Toshiyuki Maruoka</name>
<name sortKey="Miyazawa, Masaaki" sort="Miyazawa, Masaaki" uniqKey="Miyazawa M" first="Masaaki" last="Miyazawa">Masaaki Miyazawa</name>
<name sortKey="Takakuwa, Hiroki" sort="Takakuwa, Hiroki" uniqKey="Takakuwa H" first="Hiroki" last="Takakuwa">Hiroki Takakuwa</name>
<name sortKey="Toshimori, Hitoshi" sort="Toshimori, Hitoshi" uniqKey="Toshimori H" first="Hitoshi" last="Toshimori">Hitoshi Toshimori</name>
</noCountry>
<country name="Japon"><noRegion><name sortKey="Otsuki, Koichi" sort="Otsuki, Koichi" uniqKey="Otsuki K" first="Koichi" last="Otsuki">Koichi Otsuki</name>
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