2009 H1N1 Influenza: A Twenty-First Century Pandemic With Roots in the Early Twentieth Century
Identifieur interne : 000B11 ( Pmc/Checkpoint ); précédent : 000B10; suivant : 000B122009 H1N1 Influenza: A Twenty-First Century Pandemic With Roots in the Early Twentieth Century
Auteurs : Monica M. FarleySource :
- The American Journal of the Medical Sciences [ 0002-9629 ] ; 2010.
Abstract
A swine-origin H1N1 triple-reassortant influenza A virus found to be a distant relative of the 1918 “Spanish flu” virus emerged in April 2009 to give rise to the first influenza pandemic of the 21st century. Although disease was generally mild and similar to seasonal influenza, severe manifestations including respiratory failure were noted in some, particularly those with underlying conditions such as asthma, pregnancy and immunosuppression. Children and younger adults accounted for most cases, hospitalizations and deaths. A reverse transcriptase-polymerase chain reaction assay was superior to antigen-based rapid tests for diagnosis. All 2009 H1N1 pandemic influenza strains were susceptible to 1 or more neuraminidase inhibitors. Monovalent, unadjuvanted 2009 H1N1 vaccines were licensed in the United States in September 2009 and initially targeted to younger individuals, pregnant women, caretakers of infants and healthcare providers. The 2009 H1N1 pandemic highlights the need for modernization of influenza vaccines, improved diagnostics and more rigorous evaluation of mitigation strategies.
Url:
DOI: 10.1097/MAJ.0b013e3181e937b0
PubMed: 20697263
PubMed Central: 7119454
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">2009 H1N1 Influenza: A Twenty-First Century Pandemic With Roots in the Early Twentieth Century</title><author><name sortKey="Farley, Monica M" sort="Farley, Monica M" uniqKey="Farley M" first="Monica M." last="Farley">Monica M. Farley</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20697263</idno><idno type="pmc">7119454</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119454</idno><idno type="RBID">PMC:7119454</idno><idno type="doi">10.1097/MAJ.0b013e3181e937b0</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000912</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000912</idno><idno type="wicri:Area/Pmc/Curation">000912</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000912</idno><idno type="wicri:Area/Pmc/Checkpoint">000B11</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000B11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">2009 H1N1 Influenza: A Twenty-First Century Pandemic With Roots in the Early Twentieth Century</title><author><name sortKey="Farley, Monica M" sort="Farley, Monica M" uniqKey="Farley M" first="Monica M." last="Farley">Monica M. Farley</name></author></analytic><series><title level="j">The American Journal of the Medical Sciences</title><idno type="ISSN">0002-9629</idno><idno type="eISSN">1538-2990</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A swine-origin H1N1 triple-reassortant influenza A virus found to be a distant relative of the 1918 “Spanish flu” virus emerged in April 2009 to give rise to the first influenza pandemic of the 21st century. Although disease was generally mild and similar to seasonal influenza, severe manifestations including respiratory failure were noted in some, particularly those with underlying conditions such as asthma, pregnancy and immunosuppression. Children and younger adults accounted for most cases, hospitalizations and deaths. A reverse transcriptase-polymerase chain reaction assay was superior to antigen-based rapid tests for diagnosis. All 2009 H1N1 pandemic influenza strains were susceptible to 1 or more neuraminidase inhibitors. Monovalent, unadjuvanted 2009 H1N1 vaccines were licensed in the United States in September 2009 and initially targeted to younger individuals, pregnant women, caretakers of infants and healthcare providers. The 2009 H1N1 pandemic highlights the need for modernization of influenza vaccines, improved diagnostics and more rigorous evaluation of mitigation strategies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fauci, A S" uniqKey="Fauci A">A.S. Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Novel Swine Origin Influenza A H1n1 Virus Investigation Team" uniqKey="Novel Swine Origin Influenza A H1n1 Virus Investigation Team">Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, D M" uniqKey="Morens D">D.M. Morens</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J.K. Taubenberger</name></author><author><name sortKey="Fauci, A S" uniqKey="Fauci A">A.S. Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zimmer, S M" uniqKey="Zimmer S">S.M. Zimmer</name></author><author><name sortKey="Burke, D S" uniqKey="Burke D">D.S. Burke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gatherer, D" uniqKey="Gatherer D">D. Gatherer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kilbourne, E D" uniqKey="Kilbourne E">E.D. Kilbourne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J.K. Taubenberger</name></author><author><name sortKey="Morens, D M" uniqKey="Morens D">D.M. Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koen, J S" uniqKey="Koen J">J.S. Koen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kolata, G" uniqKey="Kolata G">G. Kolata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shope, R E" uniqKey="Shope R">R.E. Shope</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shope, R E" uniqKey="Shope R">R.E. Shope</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, G J" uniqKey="Smith G">G.J. Smith</name></author><author><name sortKey="Vijaykrishna, D" uniqKey="Vijaykrishna D">D. Vijaykrishna</name></author><author><name sortKey="Bahl, J" uniqKey="Bahl J">J. Bahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowdle, W R" uniqKey="Dowdle W">W.R. Dowdle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gaydos, J C" uniqKey="Gaydos J">J.C. Gaydos</name></author><author><name sortKey="Top, F H" uniqKey="Top F">F.H. Top</name></author><author><name sortKey="Hodder, R A" uniqKey="Hodder R">R.A. Hodder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kendal, A P" uniqKey="Kendal A">A.P. Kendal</name></author><author><name sortKey="Noble, G R" uniqKey="Noble G">G.R. Noble</name></author><author><name sortKey="Skehel, J J" uniqKey="Skehel J">J.J. Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J.K. Taubenberger</name></author><author><name sortKey="Reid, A H" uniqKey="Reid A">A.H. Reid</name></author><author><name sortKey="Krafft, A E" uniqKey="Krafft A">A.E. Krafft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olsen, C W" uniqKey="Olsen C">C.W. Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Newman, A P" uniqKey="Newman A">A.P. Newman</name></author><author><name sortKey="Reisdorf, E" uniqKey="Reisdorf E">E. Reisdorf</name></author><author><name sortKey="Beinemann, J" uniqKey="Beinemann J">J. Beinemann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shinde, V" uniqKey="Shinde V">V. Shinde</name></author><author><name sortKey="Bridges, C B" uniqKey="Bridges C">C.B. Bridges</name></author><author><name sortKey="Uyeki, T M" uniqKey="Uyeki T">T.M. Uyeki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J.K. Taubenberger</name></author><author><name sortKey="Reid, A H" uniqKey="Reid A">A.H. Reid</name></author><author><name sortKey="Lourens, R M" uniqKey="Lourens R">R.M. Lourens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tumpey, T M" uniqKey="Tumpey T">T.M. Tumpey</name></author><author><name sortKey="Basler, C F" uniqKey="Basler C">C.F. Basler</name></author><author><name sortKey="Aguilar, P V" uniqKey="Aguilar P">P.V. Aguilar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Homeland Security Council" uniqKey="Homeland Security Council">Homeland Security Council</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J.K. Taubenberger</name></author><author><name sortKey="Morens, D M" uniqKey="Morens D">D.M. Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garten, R J" uniqKey="Garten R">R.J. Garten</name></author><author><name sortKey="Davis, C T" uniqKey="Davis C">C.T. Davis</name></author><author><name sortKey="Russell, C A" uniqKey="Russell C">C.A. Russell</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cao, B" uniqKey="Cao B">B. Cao</name></author><author><name sortKey="Xing Wang, L" uniqKey="Xing Wang L">L. Xing-Wang</name></author><author><name sortKey="Mao, Y" uniqKey="Mao Y">Y. Mao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, S" uniqKey="Jain S">S. Jain</name></author><author><name sortKey="Kamimoto, L" uniqKey="Kamimoto L">L. Kamimoto</name></author><author><name sortKey="Bramley, A M" uniqKey="Bramley A">A.M. Bramley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K. Hancock</name></author><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V. Veguilla</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, E" uniqKey="Miller E">E. Miller</name></author><author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K. Hoschler</name></author><author><name sortKey="Hardedid, P" uniqKey="Hardedid P">P. Hardedid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Libster, R" uniqKey="Libster R">R. Libster</name></author><author><name sortKey="Bugna, J" uniqKey="Bugna J">J. Bugna</name></author><author><name sortKey="Coviello, S" uniqKey="Coviello S">S. Coviello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Louie, J K" uniqKey="Louie J">J.K. Louie</name></author><author><name sortKey="Acosta, M" uniqKey="Acosta M">M. Acosta</name></author><author><name sortKey="Winter, K" uniqKey="Winter K">K. Winter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name></author><author><name sortKey="Zarychanski, R" uniqKey="Zarychanski R">R. Zarychanski</name></author><author><name sortKey="Pinto, R" uniqKey="Pinto R">R. Pinto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morens, D M" uniqKey="Morens D">D.M. Morens</name></author><author><name sortKey="Taubenberger, J K" uniqKey="Taubenberger J">J.K. Taubenberger</name></author><author><name sortKey="Fauci, A S" uniqKey="Fauci A">A.S. Fauci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccullers, J A" uniqKey="Mccullers J">J.A. McCullers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brundage, J F" uniqKey="Brundage J">J.F. Brundage</name></author><author><name sortKey="Shanks, G D" uniqKey="Shanks G">G.D. Shanks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brundage, J F" uniqKey="Brundage J">J.F. Brundage</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfeiffer, R" uniqKey="Pfeiffer R">R. Pfeiffer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faix, D J" uniqKey="Faix D">D.J. Faix</name></author><author><name sortKey="Sherman, S S" uniqKey="Sherman S">S.S. Sherman</name></author><author><name sortKey="Waterman, S H" uniqKey="Waterman S">S.H. Waterman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blyth, C C" uniqKey="Blyth C">C.C. Blyth</name></author><author><name sortKey="Iredell, J R" uniqKey="Iredell J">J.R. Iredell</name></author><author><name sortKey="Dwyer, D E" uniqKey="Dwyer D">D.E. Dwyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, K H" uniqKey="Chan K">K.H. Chan</name></author><author><name sortKey="Lai, S T" uniqKey="Lai S">S.T. Lai</name></author><author><name sortKey="Poon, L L M" uniqKey="Poon L">L.L.M. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Palese, P" uniqKey="Palese P">P. Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halloran, M E" uniqKey="Halloran M">M.E. Halloran</name></author><author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name></author><author><name sortKey="Eubank, S" uniqKey="Eubank S">S. Eubank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davey, V J" uniqKey="Davey V">V.J. Davey</name></author><author><name sortKey="Glass, R J" uniqKey="Glass R">R.J. Glass</name></author><author><name sortKey="Min, J H" uniqKey="Min J">J.H. Min</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandemic Influenza Outbreak Research Modelling Team Pan Inform" uniqKey="Pandemic Influenza Outbreak Research Modelling Team Pan Inform">Pandemic Influenza Outbreak Research Modelling Team (Pan-InfORM)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barry, J M" uniqKey="Barry J">J.M. Barry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stein, R A" uniqKey="Stein R">R.A. Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hatchett, R J" uniqKey="Hatchett R">R.J. Hatchett</name></author><author><name sortKey="Mecher, C E" uniqKey="Mecher C">C.E. Mecher</name></author><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M. Lipsitch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bootsma, M C J" uniqKey="Bootsma M">M.C.J. Bootsma</name></author><author><name sortKey="Ferguson, N M" uniqKey="Ferguson N">N.M. Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, D M" uniqKey="Bell D">D.M. Bell</name></author><author><name sortKey="World Health Organization Writing Group" uniqKey="World Health Organization Writing Group">World Health Organization Writing Group</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, D M" uniqKey="Bell D">D.M. Bell</name></author><author><name sortKey="World Health Organization Writing Group" uniqKey="World Health Organization Writing Group">World Health Organization Writing Group</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lurie, N" uniqKey="Lurie N">N. Lurie</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T. Jefferson</name></author><author><name sortKey="Del Mar, C" uniqKey="Del Mar C">C. Del Mar</name></author><author><name sortKey="Dooley, L" uniqKey="Dooley L">L. Dooley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gralton, J" uniqKey="Gralton J">J. Gralton</name></author><author><name sortKey="Mclaws, M L" uniqKey="Mclaws M">M.-L. McLaws</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loeb, M" uniqKey="Loeb M">M. Loeb</name></author><author><name sortKey="Dafoe, N" uniqKey="Dafoe N">N. Dafoe</name></author><author><name sortKey="Mahony, J" uniqKey="Mahony J">J. Mahony</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Doshi, P" uniqKey="Doshi P">P. Doshi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reed, C" uniqKey="Reed C">C. Reed</name></author><author><name sortKey="Angulo, F J" uniqKey="Angulo F">F.J. Angulo</name></author><author><name sortKey="Swerdlow, D L" uniqKey="Swerdlow D">D.L. Swerdlow</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Med Sci</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Med. Sci</journal-id><journal-title-group><journal-title>The American Journal of the Medical Sciences</journal-title></journal-title-group><issn pub-type="ppub">0002-9629</issn><issn pub-type="epub">1538-2990</issn><publisher><publisher-name>Southern Society for Clinical Investigation. Published by Elsevier Inc.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20697263</article-id><article-id pub-id-type="pmc">7119454</article-id><article-id pub-id-type="publisher-id">S0002-9629(15)31499-3</article-id><article-id pub-id-type="doi">10.1097/MAJ.0b013e3181e937b0</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>2009 H1N1 Influenza: A Twenty-First Century Pandemic With Roots in the Early Twentieth Century</article-title></title-group><contrib-group><contrib contrib-type="author" id="au0010"><name><surname>Farley</surname><given-names>Monica M.</given-names></name><degrees>MD</degrees><email>mfarley@emory.edu</email><xref rid="cor0010" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af0010">Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine and the Atlanta VA Medical Center, Atlanta, Georgia.</aff><author-notes><corresp id="cor0010"><label>*</label>Emory University School of Medicine, 1670 Clairmont Road, Decatur, GA 30033 <email>mfarley@emory.edu</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>16</day><month>12</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>9</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>16</day><month>12</month><year>2015</year></pub-date><volume>340</volume><issue>3</issue><fpage>202</fpage><lpage>208</lpage><permissions><copyright-statement>Copyright © 2010 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2010</copyright-year><copyright-holder>Southern Society for Clinical Investigation</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="ab0010"><p>A swine-origin H1N1 triple-reassortant influenza A virus found to be a distant relative of the 1918 “Spanish flu” virus emerged in April 2009 to give rise to the first influenza pandemic of the 21st century. Although disease was generally mild and similar to seasonal influenza, severe manifestations including respiratory failure were noted in some, particularly those with underlying conditions such as asthma, pregnancy and immunosuppression. Children and younger adults accounted for most cases, hospitalizations and deaths. A reverse transcriptase-polymerase chain reaction assay was superior to antigen-based rapid tests for diagnosis. All 2009 H1N1 pandemic influenza strains were susceptible to 1 or more neuraminidase inhibitors. Monovalent, unadjuvanted 2009 H1N1 vaccines were licensed in the United States in September 2009 and initially targeted to younger individuals, pregnant women, caretakers of infants and healthcare providers. The 2009 H1N1 pandemic highlights the need for modernization of influenza vaccines, improved diagnostics and more rigorous evaluation of mitigation strategies.</p></abstract><kwd-group id="kws0010"><title>Key Indexing Terms</title><kwd>Pandemic</kwd><kwd>Influenza</kwd><kwd>Swine-origin</kwd><kwd>H1N1</kwd><kwd>Hemagglutinin</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Farley, Monica M" sort="Farley, Monica M" uniqKey="Farley M" first="Monica M." last="Farley">Monica M. Farley</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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