A New Sentinel Surveillance System for Severe Influenza in England Shows a Shift in Age Distribution of Hospitalised Cases in the Post-Pandemic Period
Identifieur interne : 000772 ( Pmc/Checkpoint ); précédent : 000771; suivant : 000773A New Sentinel Surveillance System for Severe Influenza in England Shows a Shift in Age Distribution of Hospitalised Cases in the Post-Pandemic Period
Auteurs : Shelly Bolotin [Royaume-Uni] ; Richard Pebody [Royaume-Uni] ; Peter J. White [Royaume-Uni] ; James Mcmenamin [Royaume-Uni] ; Luke Perera [Royaume-Uni] ; Jonathan S. Nguyen-Van-Tam [Royaume-Uni] ; Thomas Barlow [Royaume-Uni] ; John M. Watson [Royaume-Uni]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
The World Health Organization and European Centre for Disease Prevention and Control have highlighted the importance of establishing systems to monitor severe influenza. Following the H1N1 (2009) influenza pandemic, a sentinel network of 23 Trusts, the UK Severe Influenza Surveillance System (USISS), was established to monitor hospitalisations due to confirmed seasonal influenza in England. This article presents the results of the first season of operation of USISS in 2010/11.
A case was defined as a person hospitalised with confirmed influenza of any type. Weekly aggregate numbers of hospitalised influenza cases, broken down by flu type and level of care, were submitted by participating Trusts. Cases in 2010/11 were compared to cases during the 2009 pandemic in hospitals with available surveillance data for both time periods (n = 19). An unexpected resurgence in seasonal A/H1N1 (2009) influenza activity in England was observed in December 2010 with reports of severe disease. Reported cases over the period of 4 October 2010 to 13 February 2011 were mostly due to influenza A/H1N1 (2009). One thousand and seventy-one cases of influenza A/H1N1 (2009) occurred over this period compared to 409 at the same Trusts over the 2009/10 pandemic period (1 April 2009 to 6 January 2010). Median age of influenza A/H1N1 (2009) cases in 2010/11 was 35 years, compared with 20 years during the pandemic (p = <0.0001).
The Health Protection Agency successfully established a sentinel surveillance system for severe influenza in 2010/11, detecting a rise in influenza cases mirroring other surveillance indicators. The data indicate an upward shift in the age-distribution of influenza A/H1N1 (2009) during the 2010/11 influenza season as compared to the 2009/10 pandemic. Systems to enable the ongoing surveillance of severe influenza will be a key component in understanding and responding to the evolving epidemiology of influenza in the post-pandemic era.
Url:
DOI: 10.1371/journal.pone.0030279
PubMed: 22291929
PubMed Central: 3264602
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>The World Health Organization and European Centre for Disease Prevention and Control have highlighted the importance of establishing systems to monitor severe influenza. Following the H1N1 (2009) influenza pandemic, a sentinel network of 23 Trusts, the UK Severe Influenza Surveillance System (USISS), was established to monitor hospitalisations due to confirmed seasonal influenza in England. This article presents the results of the first season of operation of USISS in 2010/11.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>A case was defined as a person hospitalised with confirmed influenza of any type. Weekly aggregate numbers of hospitalised influenza cases, broken down by flu type and level of care, were submitted by participating Trusts. Cases in 2010/11 were compared to cases during the 2009 pandemic in hospitals with available surveillance data for both time periods (n = 19). An unexpected resurgence in seasonal A/H1N1 (2009) influenza activity in England was observed in December 2010 with reports of severe disease. Reported cases over the period of 4 October 2010 to 13 February 2011 were mostly due to influenza A/H1N1 (2009). One thousand and seventy-one cases of influenza A/H1N1 (2009) occurred over this period compared to 409 at the same Trusts over the 2009/10 pandemic period (1 April 2009 to 6 January 2010). Median age of influenza A/H1N1 (2009) cases in 2010/11 was 35 years, compared with 20 years during the pandemic (p = <0.0001).</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>The Health Protection Agency successfully established a sentinel surveillance system for severe influenza in 2010/11, detecting a rise in influenza cases mirroring other surveillance indicators. The data indicate an upward shift in the age-distribution of influenza A/H1N1 (2009) during the 2010/11 influenza season as compared to the 2009/10 pandemic. Systems to enable the ongoing surveillance of severe influenza will be a key component in understanding and responding to the evolving epidemiology of influenza in the post-pandemic era.</p>
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<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Campbell, Cn" uniqKey="Campbell C">CN Campbell</name>
</author>
<author><name sortKey="Mytton, Ot" uniqKey="Mytton O">OT Mytton</name>
</author>
<author><name sortKey="Mclean, Em" uniqKey="Mclean E">EM McLean</name>
</author>
<author><name sortKey="Rutter, Pd" uniqKey="Rutter P">PD Rutter</name>
</author>
<author><name sortKey="Pebody, Rg" uniqKey="Pebody R">RG Pebody</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Rothman, Kj" uniqKey="Rothman K">KJ Rothman</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hardelid, P" uniqKey="Hardelid P">P Hardelid</name>
</author>
<author><name sortKey="Andrews, Nj" uniqKey="Andrews N">NJ Andrews</name>
</author>
<author><name sortKey="Hoschler, K" uniqKey="Hoschler K">K Hoschler</name>
</author>
<author><name sortKey="Stanford, E" uniqKey="Stanford E">E Stanford</name>
</author>
<author><name sortKey="Baguelin, M" uniqKey="Baguelin M">M Baguelin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ellis, J" uniqKey="Ellis J">J Ellis</name>
</author>
<author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name>
</author>
<author><name sortKey="Pebody, R" uniqKey="Pebody R">R Pebody</name>
</author>
<author><name sortKey="Lackenby, A" uniqKey="Lackenby A">A Lackenby</name>
</author>
<author><name sortKey="Thompson, C" uniqKey="Thompson C">C Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Presanis, Am" uniqKey="Presanis A">AM Presanis</name>
</author>
<author><name sortKey="Pebody, Rg" uniqKey="Pebody R">RG Pebody</name>
</author>
<author><name sortKey="Paterson, Bj" uniqKey="Paterson B">BJ Paterson</name>
</author>
<author><name sortKey="Tom, Bd" uniqKey="Tom B">BD Tom</name>
</author>
<author><name sortKey="Birrell, Pj" uniqKey="Birrell P">PJ Birrell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zakikhany, K" uniqKey="Zakikhany K">K Zakikhany</name>
</author>
<author><name sortKey="Degail, Ma" uniqKey="Degail M">MA Degail</name>
</author>
<author><name sortKey="Lamagni, T" uniqKey="Lamagni T">T Lamagni</name>
</author>
<author><name sortKey="Waight, P" uniqKey="Waight P">P Waight</name>
</author>
<author><name sortKey="Guy, R" uniqKey="Guy R">R Guy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Athanasiou, M" uniqKey="Athanasiou M">M Athanasiou</name>
</author>
<author><name sortKey="Baka, A" uniqKey="Baka A">A Baka</name>
</author>
<author><name sortKey="Andreopoulou, A" uniqKey="Andreopoulou A">A Andreopoulou</name>
</author>
<author><name sortKey="Spala, G" uniqKey="Spala G">G Spala</name>
</author>
<author><name sortKey="Karageorgou, K" uniqKey="Karageorgou K">K Karageorgou</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Bansal, S" uniqKey="Bansal S">S Bansal</name>
</author>
<author><name sortKey="Pourbohloul, B" uniqKey="Pourbohloul B">B Pourbohloul</name>
</author>
<author><name sortKey="Hupert, N" uniqKey="Hupert N">N Hupert</name>
</author>
<author><name sortKey="Grenfell, B" uniqKey="Grenfell B">B Grenfell</name>
</author>
<author><name sortKey="Ancel Meyers, L" uniqKey="Ancel Meyers L">L Ancel Meyers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gilbert, V" uniqKey="Gilbert V">V Gilbert</name>
</author>
<author><name sortKey="Caraway, C" uniqKey="Caraway C">C Caraway</name>
</author>
<author><name sortKey="Bruce, J" uniqKey="Bruce J">J Bruce</name>
</author>
<author><name sortKey="Mogabgab, W" uniqKey="Mogabgab W">W Mogabgab</name>
</author>
</analytic>
</biblStruct>
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</subj-group>
</article-categories>
<title-group><article-title>A New Sentinel Surveillance System for Severe Influenza in England Shows a Shift in Age Distribution of Hospitalised Cases in the Post-Pandemic Period</article-title>
<alt-title alt-title-type="running-head">Severe Influenza Surveillance in England</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bolotin</surname>
<given-names>Shelly</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pebody</surname>
<given-names>Richard</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>White</surname>
<given-names>Peter J.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McMenamin</surname>
<given-names>James</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Perera</surname>
<given-names>Luke</given-names>
</name>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nguyen-Van-Tam</surname>
<given-names>Jonathan S.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Barlow</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Watson</surname>
<given-names>John M.</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><collab>for the UK Severe Influenza Surveillance System (USISS) Steering Group</collab>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
<xref ref-type="aff" rid="aff9"><sup>9</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Health Protection Agency, London, United Kingdom</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>MRC Centre for Outbreak Analysis and Modelling, Imperial College School of Public Health, London, United Kingdom</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Health Protection Scotland, NHS National Services, Glasgow, United Kingdom</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>Department of Health, London, United Kingdom</addr-line>
</aff>
<aff id="aff5"><label>5</label>
<addr-line>University of Nottingham, City Hospital, Nottingham, United Kingdom</addr-line>
</aff>
<aff id="aff6"><label>6</label>
<addr-line>Department of Health, London, United Kingdom</addr-line>
</aff>
<aff id="aff7"><label>7</label>
<addr-line>Public Health Wales, Cardiff, United Kingdom</addr-line>
</aff>
<aff id="aff8"><label>8</label>
<addr-line>Public Health Agency, Belfast, United Kingdom</addr-line>
</aff>
<aff id="aff9"><label>9</label>
<addr-line>Royal College of Physicians, London, United Kingdom</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Cowling</surname>
<given-names>Benjamin J.</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1">University of Hong Kong, Hong Kong</aff>
<author-notes><corresp id="cor1">* E-mail: <email>richard.pebody@hpa.org.uk</email>
</corresp>
<fn fn-type="con"><p>Conceived and designed the experiments: RP JMW SB PJW JM LP JSN-V-T TB. Performed the experiments: SB. Analyzed the data: SB. Contributed reagents/materials/analysis tools: SB RP JSN-V-T PJW. Wrote the paper: SB RP JMW PJW JM LP JSN-V-T TB.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>1</month>
<year>2012</year>
</pub-date>
<volume>7</volume>
<issue>1</issue>
<elocation-id>e30279</elocation-id>
<history><date date-type="received"><day>30</day>
<month>8</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>12</day>
<month>12</month>
<year>2011</year>
</date>
</history>
<permissions><copyright-statement>Bolotin et al.</copyright-statement>
<copyright-year>2012</copyright-year>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>The World Health Organization and European Centre for Disease Prevention and Control have highlighted the importance of establishing systems to monitor severe influenza. Following the H1N1 (2009) influenza pandemic, a sentinel network of 23 Trusts, the UK Severe Influenza Surveillance System (USISS), was established to monitor hospitalisations due to confirmed seasonal influenza in England. This article presents the results of the first season of operation of USISS in 2010/11.</p>
</sec>
<sec><title>Methodology/Principal Findings</title>
<p>A case was defined as a person hospitalised with confirmed influenza of any type. Weekly aggregate numbers of hospitalised influenza cases, broken down by flu type and level of care, were submitted by participating Trusts. Cases in 2010/11 were compared to cases during the 2009 pandemic in hospitals with available surveillance data for both time periods (n = 19). An unexpected resurgence in seasonal A/H1N1 (2009) influenza activity in England was observed in December 2010 with reports of severe disease. Reported cases over the period of 4 October 2010 to 13 February 2011 were mostly due to influenza A/H1N1 (2009). One thousand and seventy-one cases of influenza A/H1N1 (2009) occurred over this period compared to 409 at the same Trusts over the 2009/10 pandemic period (1 April 2009 to 6 January 2010). Median age of influenza A/H1N1 (2009) cases in 2010/11 was 35 years, compared with 20 years during the pandemic (p = <0.0001).</p>
</sec>
<sec><title>Conclusions/Significance</title>
<p>The Health Protection Agency successfully established a sentinel surveillance system for severe influenza in 2010/11, detecting a rise in influenza cases mirroring other surveillance indicators. The data indicate an upward shift in the age-distribution of influenza A/H1N1 (2009) during the 2010/11 influenza season as compared to the 2009/10 pandemic. Systems to enable the ongoing surveillance of severe influenza will be a key component in understanding and responding to the evolving epidemiology of influenza in the post-pandemic era.</p>
</sec>
</abstract>
<counts><page-count count="6"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Grand Londres</li>
<li>Nottinghamshire</li>
</region>
<settlement><li>Londres</li>
<li>Nottingham</li>
</settlement>
<orgName><li>Université de Nottingham</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Bolotin, Shelly" sort="Bolotin, Shelly" uniqKey="Bolotin S" first="Shelly" last="Bolotin">Shelly Bolotin</name>
</region>
<name sortKey="Barlow, Thomas" sort="Barlow, Thomas" uniqKey="Barlow T" first="Thomas" last="Barlow">Thomas Barlow</name>
<name sortKey="Mcmenamin, James" sort="Mcmenamin, James" uniqKey="Mcmenamin J" first="James" last="Mcmenamin">James Mcmenamin</name>
<name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name>
<name sortKey="Nguyen Van Tam, Jonathan S" sort="Nguyen Van Tam, Jonathan S" uniqKey="Nguyen Van Tam J" first="Jonathan S." last="Nguyen-Van-Tam">Jonathan S. Nguyen-Van-Tam</name>
<name sortKey="Pebody, Richard" sort="Pebody, Richard" uniqKey="Pebody R" first="Richard" last="Pebody">Richard Pebody</name>
<name sortKey="Perera, Luke" sort="Perera, Luke" uniqKey="Perera L" first="Luke" last="Perera">Luke Perera</name>
<name sortKey="Watson, John M" sort="Watson, John M" uniqKey="Watson J" first="John M." last="Watson">John M. Watson</name>
<name sortKey="White, Peter J" sort="White, Peter J" uniqKey="White P" first="Peter J." last="White">Peter J. White</name>
<name sortKey="White, Peter J" sort="White, Peter J" uniqKey="White P" first="Peter J." last="White">Peter J. White</name>
</country>
</tree>
</affiliations>
</record>
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