Serveur d'exploration sur les pandémies grippales

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Clinical and Radiological Characteristics of 2009 H1N1 Influenza Associated Pneumonia in Young Male Adults

Identifieur interne : 000625 ( Pmc/Checkpoint ); précédent : 000624; suivant : 000626

Clinical and Radiological Characteristics of 2009 H1N1 Influenza Associated Pneumonia in Young Male Adults

Auteurs : Ji Eun Lee [Corée du Sud] ; Kang-Won Choe [Corée du Sud] ; Sei Won Lee [Corée du Sud]

Source :

RBID : PMC:3663245

Abstract

Purpose

Pneumonia was an important cause of death in 2009 H1N1 influenza pandemic (pH1N1). Clinical characteristics of pH1N1 have been described well, but discriminative characteristics suggesting pH1N1 infection in pneumonia patients are not evident today. We evaluated differences between clinical and radiologic characteristics for those associated and not associated with pH1N1 influenza during the pandemic period.

Materials and Methods

We reviewed all patients with pneumonia who visited the Armed Forces Capital Hospital between July 2009 and February 2010. During this period, all pneumonia patients were tested for pH1N1 by reverse transcription-polymerase chain reaction (RT-PCR) using nasopharyngeal specimens.

Results

In total, 98 patients with pneumonia were enrolled. Their median age was 20 years and all patients were males. Forty-nine (50%) of patients had pH1N1 infection and the others (50%) had negative results in pH1N1 RT-PCR. Patients with pH1N1 infection complained of dyspnea more commonly (83.3% vs. 29.0%; p<0.001), had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores [5 (range, 0-12) vs. 3 (range, 0-11); p<0.01], fewer days of prehospital illness [2 (range, 0-10) vs. 4 (range, 0-14); p=0.001], and a higher chance of bilateral infiltrates on chest X-ray (CXR) (67.3% vs. 14.3%; p<0.001) and ground-glass opacity (GGO) lesions on computed tomography (CT; 48.9% vs. 22.0%; p<0.001) than patients without pH1N1 infection.

Conclusion

Dyspnea, bilateral infiltrates on CXR, and GGO on CT were dominant features in pH1N1-associated pneumonia. Understanding these characteristics can help selection of patients who require prompt antiviral therapy.


Url:
DOI: 10.3349/ymj.2013.54.4.927
PubMed: 23709428
PubMed Central: 3663245


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

PMC:3663245

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Clinical and Radiological Characteristics of 2009 H1N1 Influenza Associated Pneumonia in Young Male Adults</title>
<author>
<name sortKey="Lee, Ji Eun" sort="Lee, Ji Eun" uniqKey="Lee J" first="Ji Eun" last="Lee">Ji Eun Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam</wicri:regionArea>
<wicri:noRegion>Seongnam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang-Won" last="Choe">Kang-Won Choe</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam</wicri:regionArea>
<wicri:noRegion>Seongnam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Sei Won" sort="Lee, Sei Won" uniqKey="Lee S" first="Sei Won" last="Lee">Sei Won Lee</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PMC</idno>
<idno type="pmid">23709428</idno>
<idno type="pmc">3663245</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663245</idno>
<idno type="RBID">PMC:3663245</idno>
<idno type="doi">10.3349/ymj.2013.54.4.927</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000E49</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E49</idno>
<idno type="wicri:Area/Pmc/Curation">000E49</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E49</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000625</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000625</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a" type="main">Clinical and Radiological Characteristics of 2009 H1N1 Influenza Associated Pneumonia in Young Male Adults</title>
<author>
<name sortKey="Lee, Ji Eun" sort="Lee, Ji Eun" uniqKey="Lee J" first="Ji Eun" last="Lee">Ji Eun Lee</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam</wicri:regionArea>
<wicri:noRegion>Seongnam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang-Won" last="Choe">Kang-Won Choe</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam</wicri:regionArea>
<wicri:noRegion>Seongnam</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lee, Sei Won" sort="Lee, Sei Won" uniqKey="Lee S" first="Sei Won" last="Lee">Sei Won Lee</name>
<affiliation wicri:level="3">
<nlm:aff id="A2">Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Corée du Sud</country>
<wicri:regionArea>Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul</wicri:regionArea>
<placeName>
<settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Yonsei Medical Journal</title>
<idno type="ISSN">0513-5796</idno>
<idno type="eISSN">1976-2437</idno>
<imprint>
<date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Purpose</title>
<p>Pneumonia was an important cause of death in 2009 H1N1 influenza pandemic (pH1N1). Clinical characteristics of pH1N1 have been described well, but discriminative characteristics suggesting pH1N1 infection in pneumonia patients are not evident today. We evaluated differences between clinical and radiologic characteristics for those associated and not associated with pH1N1 influenza during the pandemic period.</p>
</sec>
<sec>
<title>Materials and Methods</title>
<p>We reviewed all patients with pneumonia who visited the Armed Forces Capital Hospital between July 2009 and February 2010. During this period, all pneumonia patients were tested for pH1N1 by reverse transcription-polymerase chain reaction (RT-PCR) using nasopharyngeal specimens.</p>
</sec>
<sec>
<title>Results</title>
<p>In total, 98 patients with pneumonia were enrolled. Their median age was 20 years and all patients were males. Forty-nine (50%) of patients had pH1N1 infection and the others (50%) had negative results in pH1N1 RT-PCR. Patients with pH1N1 infection complained of dyspnea more commonly (83.3% vs. 29.0%;
<italic>p</italic>
<0.001), had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores [5 (range, 0-12) vs. 3 (range, 0-11);
<italic>p</italic>
<0.01], fewer days of prehospital illness [2 (range, 0-10) vs. 4 (range, 0-14);
<italic>p</italic>
=0.001], and a higher chance of bilateral infiltrates on chest X-ray (CXR) (67.3% vs. 14.3%;
<italic>p</italic>
<0.001) and ground-glass opacity (GGO) lesions on computed tomography (CT; 48.9% vs. 22.0%;
<italic>p</italic>
<0.001) than patients without pH1N1 infection.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Dyspnea, bilateral infiltrates on CXR, and GGO on CT were dominant features in pH1N1-associated pneumonia. Understanding these characteristics can help selection of patients who require prompt antiviral therapy.</p>
</sec>
</div>
</front>
<back>
<div1 type="bibliography">
<listBibl>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kim, Wj" uniqKey="Kim W">WJ Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author>
<name sortKey="Kamimoto, L" uniqKey="Kamimoto L">L Kamimoto</name>
</author>
<author>
<name sortKey="Bramley, Am" uniqKey="Bramley A">AM Bramley</name>
</author>
<author>
<name sortKey="Schmitz, Am" uniqKey="Schmitz A">AM Schmitz</name>
</author>
<author>
<name sortKey="Benoit, Sr" uniqKey="Benoit S">SR Benoit</name>
</author>
<author>
<name sortKey="Louie, J" uniqKey="Louie J">J Louie</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Viasus, D" uniqKey="Viasus D">D Viasus</name>
</author>
<author>
<name sortKey="Pa O Pardo, Jr" uniqKey="Pa O Pardo J">JR Paño-Pardo</name>
</author>
<author>
<name sortKey="Pach N, J" uniqKey="Pach N J">J Pachón</name>
</author>
<author>
<name sortKey="Riera, M" uniqKey="Riera M">M Riera</name>
</author>
<author>
<name sortKey="L Pez Medrano, F" uniqKey="L Pez Medrano F">F López-Medrano</name>
</author>
<author>
<name sortKey="Payeras, A" uniqKey="Payeras A">A Payeras</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cunha, Ba" uniqKey="Cunha B">BA Cunha</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Riquelme, R" uniqKey="Riquelme R">R Riquelme</name>
</author>
<author>
<name sortKey="Riquelme, M" uniqKey="Riquelme M">M Riquelme</name>
</author>
<author>
<name sortKey="Rioseco, Ml" uniqKey="Rioseco M">ML Rioseco</name>
</author>
<author>
<name sortKey="Inzunza, C" uniqKey="Inzunza C">C Inzunza</name>
</author>
<author>
<name sortKey="Gomez, Y" uniqKey="Gomez Y">Y Gomez</name>
</author>
<author>
<name sortKey="Contreras, C" uniqKey="Contreras C">C Contreras</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Agarwal, Pp" uniqKey="Agarwal P">PP Agarwal</name>
</author>
<author>
<name sortKey="Cinti, S" uniqKey="Cinti S">S Cinti</name>
</author>
<author>
<name sortKey="Kazerooni, Ea" uniqKey="Kazerooni E">EA Kazerooni</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Cunha, Ba" uniqKey="Cunha B">BA Cunha</name>
</author>
<author>
<name sortKey="Pherez, Fm" uniqKey="Pherez F">FM Pherez</name>
</author>
<author>
<name sortKey="Strollo, S" uniqKey="Strollo S">S Strollo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Rello, J" uniqKey="Rello J">J Rello</name>
</author>
<author>
<name sortKey="Rodriguez, A" uniqKey="Rodriguez A">A Rodríguez</name>
</author>
<author>
<name sortKey="Iba Ez, P" uniqKey="Iba Ez P">P Ibañez</name>
</author>
<author>
<name sortKey="Socias, L" uniqKey="Socias L">L Socias</name>
</author>
<author>
<name sortKey="Cebrian, J" uniqKey="Cebrian J">J Cebrian</name>
</author>
<author>
<name sortKey="Marques, A" uniqKey="Marques A">A Marques</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Denholm, Jt" uniqKey="Denholm J">JT Denholm</name>
</author>
<author>
<name sortKey="Gordon, Cl" uniqKey="Gordon C">CL Gordon</name>
</author>
<author>
<name sortKey="Johnson, Pd" uniqKey="Johnson P">PD Johnson</name>
</author>
<author>
<name sortKey="Hewagama, Ss" uniqKey="Hewagama S">SS Hewagama</name>
</author>
<author>
<name sortKey="Stuart, Rl" uniqKey="Stuart R">RL Stuart</name>
</author>
<author>
<name sortKey="Aboltins, C" uniqKey="Aboltins C">C Aboltins</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name>
</author>
<author>
<name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name>
</author>
<author>
<name sortKey="Winter, K" uniqKey="Winter K">K Winter</name>
</author>
<author>
<name sortKey="Jean, C" uniqKey="Jean C">C Jean</name>
</author>
<author>
<name sortKey="Gavali, S" uniqKey="Gavali S">S Gavali</name>
</author>
<author>
<name sortKey="Schechter, R" uniqKey="Schechter R">R Schechter</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Kumar, A" uniqKey="Kumar A">A Kumar</name>
</author>
<author>
<name sortKey="Zarychanski, R" uniqKey="Zarychanski R">R Zarychanski</name>
</author>
<author>
<name sortKey="Pinto, R" uniqKey="Pinto R">R Pinto</name>
</author>
<author>
<name sortKey="Cook, Dj" uniqKey="Cook D">DJ Cook</name>
</author>
<author>
<name sortKey="Marshall, J" uniqKey="Marshall J">J Marshall</name>
</author>
<author>
<name sortKey="Lacroix, J" uniqKey="Lacroix J">J Lacroix</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Soto Abraham, Mv" uniqKey="Soto Abraham M">MV Soto-Abraham</name>
</author>
<author>
<name sortKey="Soriano Rosas, J" uniqKey="Soriano Rosas J">J Soriano-Rosas</name>
</author>
<author>
<name sortKey="Diaz Qui Nez, A" uniqKey="Diaz Qui Nez A">A Díaz-Quiñónez</name>
</author>
<author>
<name sortKey="Silva Pereyra, J" uniqKey="Silva Pereyra J">J Silva-Pereyra</name>
</author>
<author>
<name sortKey="Vazquez Hernandez, P" uniqKey="Vazquez Hernandez P">P Vazquez-Hernandez</name>
</author>
<author>
<name sortKey="Torres L Pez, O" uniqKey="Torres L Pez O">O Torres-López</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name>
</author>
<author>
<name sortKey="Jain, S" uniqKey="Jain S">S Jain</name>
</author>
<author>
<name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name>
</author>
<author>
<name sortKey="Shaw, Mw" uniqKey="Shaw M">MW Shaw</name>
</author>
<author>
<name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author>
<name sortKey="Bertozzi, Sm" uniqKey="Bertozzi S">SM Bertozzi</name>
</author>
<author>
<name sortKey="Colchero, Ma" uniqKey="Colchero M">MA Colchero</name>
</author>
<author>
<name sortKey="Lopez Gatell, H" uniqKey="Lopez Gatell H">H Lopez-Gatell</name>
</author>
<author>
<name sortKey="Alpuche Aranda, C" uniqKey="Alpuche Aranda C">C Alpuche-Aranda</name>
</author>
<author>
<name sortKey="Hernandez, M" uniqKey="Hernandez M">M Hernandez</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Riquelme, R" uniqKey="Riquelme R">R Riquelme</name>
</author>
<author>
<name sortKey="Torres, A" uniqKey="Torres A">A Torres</name>
</author>
<author>
<name sortKey="Rioseco, Ml" uniqKey="Rioseco M">ML Rioseco</name>
</author>
<author>
<name sortKey="Ewig, S" uniqKey="Ewig S">S Ewig</name>
</author>
<author>
<name sortKey="Cill Niz, C" uniqKey="Cill Niz C">C Cillóniz</name>
</author>
<author>
<name sortKey="Riquelme, M" uniqKey="Riquelme M">M Riquelme</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mori, T" uniqKey="Mori T">T Mori</name>
</author>
<author>
<name sortKey="Morii, M" uniqKey="Morii M">M Morii</name>
</author>
<author>
<name sortKey="Terada, K" uniqKey="Terada K">K Terada</name>
</author>
<author>
<name sortKey="Wada, Y" uniqKey="Wada Y">Y Wada</name>
</author>
<author>
<name sortKey="Kuroiwa, Y" uniqKey="Kuroiwa Y">Y Kuroiwa</name>
</author>
<author>
<name sortKey="Hotsubo, T" uniqKey="Hotsubo T">T Hotsubo</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ajlan, Am" uniqKey="Ajlan A">AM Ajlan</name>
</author>
<author>
<name sortKey="Quiney, B" uniqKey="Quiney B">B Quiney</name>
</author>
<author>
<name sortKey="Nicolaou, S" uniqKey="Nicolaou S">S Nicolaou</name>
</author>
<author>
<name sortKey="Muller, Nl" uniqKey="Muller N">NL Müller</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Mollura, Dj" uniqKey="Mollura D">DJ Mollura</name>
</author>
<author>
<name sortKey="Asnis, Ds" uniqKey="Asnis D">DS Asnis</name>
</author>
<author>
<name sortKey="Crupi, Rs" uniqKey="Crupi R">RS Crupi</name>
</author>
<author>
<name sortKey="Conetta, R" uniqKey="Conetta R">R Conetta</name>
</author>
<author>
<name sortKey="Feigin, Ds" uniqKey="Feigin D">DS Feigin</name>
</author>
<author>
<name sortKey="Bray, M" uniqKey="Bray M">M Bray</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Remy Jardin, M" uniqKey="Remy Jardin M">M Remy-Jardin</name>
</author>
<author>
<name sortKey="Remy, J" uniqKey="Remy J">J Remy</name>
</author>
<author>
<name sortKey="Giraud, F" uniqKey="Giraud F">F Giraud</name>
</author>
<author>
<name sortKey="Wattinne, L" uniqKey="Wattinne L">L Wattinne</name>
</author>
<author>
<name sortKey="Gosselin, B" uniqKey="Gosselin B">B Gosselin</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Remy Jardin, M" uniqKey="Remy Jardin M">M Remy-Jardin</name>
</author>
<author>
<name sortKey="Giraud, F" uniqKey="Giraud F">F Giraud</name>
</author>
<author>
<name sortKey="Remy, J" uniqKey="Remy J">J Remy</name>
</author>
<author>
<name sortKey="Copin, Mc" uniqKey="Copin M">MC Copin</name>
</author>
<author>
<name sortKey="Gosselin, B" uniqKey="Gosselin B">B Gosselin</name>
</author>
<author>
<name sortKey="Duhamel, A" uniqKey="Duhamel A">A Duhamel</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="John, Sd" uniqKey="John S">SD John</name>
</author>
<author>
<name sortKey="Ramanathan, J" uniqKey="Ramanathan J">J Ramanathan</name>
</author>
<author>
<name sortKey="Swischuk, Le" uniqKey="Swischuk L">LE Swischuk</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="King, Ma" uniqKey="King M">MA King</name>
</author>
<author>
<name sortKey="Pope Harman, Al" uniqKey="Pope Harman A">AL Pope-Harman</name>
</author>
<author>
<name sortKey="Allen, Jn" uniqKey="Allen J">JN Allen</name>
</author>
<author>
<name sortKey="Christoforidis, Ga" uniqKey="Christoforidis G">GA Christoforidis</name>
</author>
<author>
<name sortKey="Christoforidis, Aj" uniqKey="Christoforidis A">AJ Christoforidis</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Perez Padilla, R" uniqKey="Perez Padilla R">R Perez-Padilla</name>
</author>
<author>
<name sortKey="De La Rosa Zamboni, D" uniqKey="De La Rosa Zamboni D">D de la Rosa-Zamboni</name>
</author>
<author>
<name sortKey="Ponce De Leon, S" uniqKey="Ponce De Leon S">S Ponce de Leon</name>
</author>
<author>
<name sortKey="Hernandez, M" uniqKey="Hernandez M">M Hernandez</name>
</author>
<author>
<name sortKey="Qui Ones Falconi, F" uniqKey="Qui Ones Falconi F">F Quiñones-Falconi</name>
</author>
<author>
<name sortKey="Bautista, E" uniqKey="Bautista E">E Bautista</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Ohrui, T" uniqKey="Ohrui T">T Ohrui</name>
</author>
<author>
<name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name>
</author>
<author>
<name sortKey="Ebihara, S" uniqKey="Ebihara S">S Ebihara</name>
</author>
<author>
<name sortKey="Matsui, T" uniqKey="Matsui T">T Matsui</name>
</author>
<author>
<name sortKey="Nakayama, K" uniqKey="Nakayama K">K Nakayama</name>
</author>
<author>
<name sortKey="Sasaki, H" uniqKey="Sasaki H">H Sasaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Choi, Wi" uniqKey="Choi W">WI Choi</name>
</author>
<author>
<name sortKey="Yim, Jj" uniqKey="Yim J">JJ Yim</name>
</author>
<author>
<name sortKey="Park, J" uniqKey="Park J">J Park</name>
</author>
<author>
<name sortKey="Kim, Sc" uniqKey="Kim S">SC Kim</name>
</author>
<author>
<name sortKey="Na, Mj" uniqKey="Na M">MJ Na</name>
</author>
<author>
<name sortKey="Lee, Wy" uniqKey="Lee W">WY Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Louie, Jk" uniqKey="Louie J">JK Louie</name>
</author>
<author>
<name sortKey="Acosta, M" uniqKey="Acosta M">M Acosta</name>
</author>
<author>
<name sortKey="Jamieson, Dj" uniqKey="Jamieson D">DJ Jamieson</name>
</author>
<author>
<name sortKey="Honein, Ma" uniqKey="Honein M">MA Honein</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jamieson, Dj" uniqKey="Jamieson D">DJ Jamieson</name>
</author>
<author>
<name sortKey="Honein, Ma" uniqKey="Honein M">MA Honein</name>
</author>
<author>
<name sortKey="Rasmussen, Sa" uniqKey="Rasmussen S">SA Rasmussen</name>
</author>
<author>
<name sortKey="Williams, Jl" uniqKey="Williams J">JL Williams</name>
</author>
<author>
<name sortKey="Swerdlow, Dl" uniqKey="Swerdlow D">DL Swerdlow</name>
</author>
<author>
<name sortKey="Biggerstaff, Ms" uniqKey="Biggerstaff M">MS Biggerstaff</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Jung, Jy" uniqKey="Jung J">JY Jung</name>
</author>
<author>
<name sortKey="Park, Ms" uniqKey="Park M">MS Park</name>
</author>
<author>
<name sortKey="Kim, Ys" uniqKey="Kim Y">YS Kim</name>
</author>
<author>
<name sortKey="Park, Bh" uniqKey="Park B">BH Park</name>
</author>
<author>
<name sortKey="Kim, Sk" uniqKey="Kim S">SK Kim</name>
</author>
<author>
<name sortKey="Chang, J" uniqKey="Chang J">J Chang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article">
<pmc-dir>properties open_access</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">Yonsei Med J</journal-id>
<journal-id journal-id-type="iso-abbrev">Yonsei Med. J</journal-id>
<journal-id journal-id-type="publisher-id">YMJ</journal-id>
<journal-title-group>
<journal-title>Yonsei Medical Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">0513-5796</issn>
<issn pub-type="epub">1976-2437</issn>
<publisher>
<publisher-name>Yonsei University College of Medicine</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">23709428</article-id>
<article-id pub-id-type="pmc">3663245</article-id>
<article-id pub-id-type="doi">10.3349/ymj.2013.54.4.927</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Article</subject>
<subj-group>
<subject>Pulmonology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Clinical and Radiological Characteristics of 2009 H1N1 Influenza Associated Pneumonia in Young Male Adults</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Lee</surname>
<given-names>Ji Eun</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Choe</surname>
<given-names>Kang-Won</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Lee</surname>
<given-names>Sei Won</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.</aff>
<aff id="A2">
<label>2</label>
Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.</aff>
<author-notes>
<corresp>Corresponding author: Dr. Sei Won Lee, Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Tel: 82-2-3010-3990, Fax: 82-2-3010-6968,
<email>seiwon@amc.seoul.kr</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<day>01</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub">
<day>14</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>54</volume>
<issue>4</issue>
<fpage>927</fpage>
<lpage>934</lpage>
<history>
<date date-type="received">
<day>09</day>
<month>2</month>
<year>2012</year>
</date>
<date date-type="rev-recd">
<day>26</day>
<month>6</month>
<year>2012</year>
</date>
<date date-type="accepted">
<day>02</day>
<month>7</month>
<year>2012</year>
</date>
</history>
<permissions>
<copyright-statement>© Copyright: Yonsei University College of Medicine 2013</copyright-statement>
<copyright-year>2013</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Purpose</title>
<p>Pneumonia was an important cause of death in 2009 H1N1 influenza pandemic (pH1N1). Clinical characteristics of pH1N1 have been described well, but discriminative characteristics suggesting pH1N1 infection in pneumonia patients are not evident today. We evaluated differences between clinical and radiologic characteristics for those associated and not associated with pH1N1 influenza during the pandemic period.</p>
</sec>
<sec>
<title>Materials and Methods</title>
<p>We reviewed all patients with pneumonia who visited the Armed Forces Capital Hospital between July 2009 and February 2010. During this period, all pneumonia patients were tested for pH1N1 by reverse transcription-polymerase chain reaction (RT-PCR) using nasopharyngeal specimens.</p>
</sec>
<sec>
<title>Results</title>
<p>In total, 98 patients with pneumonia were enrolled. Their median age was 20 years and all patients were males. Forty-nine (50%) of patients had pH1N1 infection and the others (50%) had negative results in pH1N1 RT-PCR. Patients with pH1N1 infection complained of dyspnea more commonly (83.3% vs. 29.0%;
<italic>p</italic>
<0.001), had higher Acute Physiology and Chronic Health Evaluation (APACHE) II scores [5 (range, 0-12) vs. 3 (range, 0-11);
<italic>p</italic>
<0.01], fewer days of prehospital illness [2 (range, 0-10) vs. 4 (range, 0-14);
<italic>p</italic>
=0.001], and a higher chance of bilateral infiltrates on chest X-ray (CXR) (67.3% vs. 14.3%;
<italic>p</italic>
<0.001) and ground-glass opacity (GGO) lesions on computed tomography (CT; 48.9% vs. 22.0%;
<italic>p</italic>
<0.001) than patients without pH1N1 infection.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Dyspnea, bilateral infiltrates on CXR, and GGO on CT were dominant features in pH1N1-associated pneumonia. Understanding these characteristics can help selection of patients who require prompt antiviral therapy.</p>
</sec>
</abstract>
<kwd-group>
<kwd>Pneumonia</kwd>
<kwd>influenza A virus H1N1 subtypes</kwd>
<kwd>viral pneumonia</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group>
<fig id="F1" orientation="portrait" position="float">
<label>Fig. 1</label>
<caption>
<p>Number of total and pH1N1-associated pneumonia cases between July 2009 and February 2010.</p>
</caption>
<graphic xlink:href="ymj-54-927-g001"></graphic>
</fig>
<fig id="F2" orientation="portrait" position="float">
<label>Fig. 2</label>
<caption>
<p>Typical radiographic findings of pneumonia with and without pH1N1 influenza infection. (A) CXR (a) and CT (b) findings of 21-year-old (A-1) and 23-year-old man (A-2) with pH1N1 influenza infection. CXR and CT showed bilateral infiltrates and GGO-dominant infiltrations in multiple lobes. (B) CXR (a) and CT (b) findings of the 21-year-old (B-1) and 20-years-old man (B-2) without pH1N1 influenza infection. CXR and CT showed unilateral consolidation and unilobar consolidation. CXR, chest X-ray; CT, computed tomography; GGO, ground-glass opacity.</p>
</caption>
<graphic xlink:href="ymj-54-927-g002"></graphic>
</fig>
<table-wrap id="T1" orientation="portrait" position="float">
<label>Table 1</label>
<caption>
<p>Baseline Characteristics of the Study Population</p>
</caption>
<graphic xlink:href="ymj-54-927-i001"></graphic>
<table-wrap-foot>
<fn>
<p>BMI, body mass index; BA, bronchial asthma; BT, body temperature; BP, blood pressure.</p>
<p>Data are presented as number (%) of patients, unless otherwise indicated.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T2" orientation="portrait" position="float">
<label>Table 2</label>
<caption>
<p>Comparison of Laboratory Findings between Two Groups</p>
</caption>
<graphic xlink:href="ymj-54-927-i002"></graphic>
<table-wrap-foot>
<fn>
<p>WBC, white blood cell; CRP, C-reactive protein.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T3" orientation="portrait" position="float">
<label>Table 3</label>
<caption>
<p>Comparison of Radiographic Findings between the Groups</p>
</caption>
<graphic xlink:href="ymj-54-927-i003"></graphic>
<table-wrap-foot>
<fn>
<p>CXR, chest X-ray; CT, computed tomography; GGO, grand-ground opacity.</p>
<p>
<sup>*</sup>
Number of patients in whom CT was taken.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T4" orientation="portrait" position="float">
<label>Table 4</label>
<caption>
<p>Comparison with Pneumonia during the Same Season of the Previous Year</p>
</caption>
<graphic xlink:href="ymj-54-927-i004"></graphic>
<table-wrap-foot>
<fn>
<p>CXR, chest X-ray; CT, computed tomography; GGO, grand-ground opacity.</p>
<p>
<sup>*</sup>
Number of patients in whom CT was taken.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="T5" orientation="portrait" position="float">
<label>Table 5</label>
<caption>
<p>Accuracy of H1N1 Influenza Diagnosis by Clinical and Radiographic Characteristics among Patients with Pneumonia</p>
</caption>
<graphic xlink:href="ymj-54-927-i005"></graphic>
<table-wrap-foot>
<fn>
<p>CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; LR+, positive likelihood ratio; LR-, negative likelihood ratio; CXR, chest X-ray; CT, computed tomography; GGO, ground-glass opacity.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
<affiliations>
<list>
<country>
<li>Corée du Sud</li>
</country>
<region>
<li>Région capitale de Séoul</li>
</region>
<settlement>
<li>Séoul</li>
</settlement>
</list>
<tree>
<country name="Corée du Sud">
<noRegion>
<name sortKey="Lee, Ji Eun" sort="Lee, Ji Eun" uniqKey="Lee J" first="Ji Eun" last="Lee">Ji Eun Lee</name>
</noRegion>
<name sortKey="Choe, Kang Won" sort="Choe, Kang Won" uniqKey="Choe K" first="Kang-Won" last="Choe">Kang-Won Choe</name>
<name sortKey="Lee, Sei Won" sort="Lee, Sei Won" uniqKey="Lee S" first="Sei Won" last="Lee">Sei Won Lee</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000625 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000625 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    Pmc
   |étape=   Checkpoint
   |type=    RBID
   |clé=     PMC:3663245
   |texte=   Clinical and Radiological Characteristics of 2009 H1N1 Influenza Associated Pneumonia in Young Male Adults
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i   -Sk "pubmed:23709428" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a PandemieGrippaleV1 

Wicri

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021