Universal Influenza Vaccines, a Dream to Be Realized Soon
Identifieur interne : 000417 ( Pmc/Checkpoint ); précédent : 000416; suivant : 000418Universal Influenza Vaccines, a Dream to Be Realized Soon
Auteurs : Han Zhang ; Li Wang ; Richard W. Compans ; Bao-Zhong WangSource :
- Viruses [ 1999-4915 ] ; 2014.
Abstract
Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine.
Url:
DOI: 10.3390/v6051974
PubMed: 24784572
PubMed Central: 4036552
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Universal Influenza Vaccines, a Dream to Be Realized Soon</title><author><name sortKey="Zhang, Han" sort="Zhang, Han" uniqKey="Zhang H" first="Han" last="Zhang">Han Zhang</name></author><author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name></author><author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name></author><author><name sortKey="Wang, Bao Zhong" sort="Wang, Bao Zhong" uniqKey="Wang B" first="Bao-Zhong" last="Wang">Bao-Zhong Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24784572</idno><idno type="pmc">4036552</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036552</idno><idno type="RBID">PMC:4036552</idno><idno type="doi">10.3390/v6051974</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000F69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F69</idno><idno type="wicri:Area/Pmc/Curation">000F69</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F69</idno><idno type="wicri:Area/Pmc/Checkpoint">000417</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000417</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Universal Influenza Vaccines, a Dream to Be Realized Soon</title><author><name sortKey="Zhang, Han" sort="Zhang, Han" uniqKey="Zhang H" first="Han" last="Zhang">Han Zhang</name></author><author><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name></author><author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name></author><author><name sortKey="Wang, Bao Zhong" sort="Wang, Bao Zhong" uniqKey="Wang B" first="Bao-Zhong" last="Wang">Bao-Zhong Wang</name></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Poland, G A" uniqKey="Poland G">G.A. Poland</name></author><author><name sortKey="Jacobson, R M" uniqKey="Jacobson R">R.M. Jacobson</name></author><author><name sortKey="Targonski, P V" uniqKey="Targonski P">P.V. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Viruses</journal-id><journal-id journal-id-type="iso-abbrev">Viruses</journal-id><journal-id journal-id-type="publisher-id">viruses</journal-id><journal-title-group><journal-title>Viruses</journal-title></journal-title-group><issn pub-type="epub">1999-4915</issn><publisher><publisher-name>MDPI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24784572</article-id><article-id pub-id-type="pmc">4036552</article-id><article-id pub-id-type="doi">10.3390/v6051974</article-id><article-id pub-id-type="publisher-id">viruses-06-01974</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Universal Influenza Vaccines, a Dream to Be Realized Soon</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Han</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Li</given-names></name></contrib><contrib contrib-type="author"><name><surname>Compans</surname><given-names>Richard W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Bao-Zhong</given-names></name><xref rid="c1-viruses-06-01974" ref-type="corresp">*</xref></contrib></contrib-group><aff id="af1-viruses-06-01974">Department of Microbiology and Immunology, and Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA 30322, USA; E-Mails:<email>han.zhang@emory.edu</email> (H.Z.);<email>lwang40@emory.edu</email> (L.W.);<email>rcompan@emory.edu</email> (R.W.C.)</aff><author-notes><corresp id="c1-viruses-06-01974"><label>*</label> Author to whom correspondence should be addressed; E-Mail: <email>bwang3@emory.edu</email>; Tel.: +1-404-712-1735; Fax: +1-404-727-3295.</corresp></author-notes><pub-date pub-type="epub"><day>29</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="collection"><month>5</month><year>2014</year></pub-date><volume>6</volume><issue>5</issue><fpage>1974</fpage><lpage>1991</lpage><history><date date-type="received"><day>24</day><month>2</month><year>2014</year></date><date date-type="rev-recd"><day>05</day><month>4</month><year>2014</year></date><date date-type="accepted"><day>22</day><month>4</month><year>2014</year></date></history><permissions><copyright-statement>© 2014 by the authors; licensee MDPI, Basel, Switzerland.</copyright-statement><copyright-year>2014</copyright-year><license><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link>).</license-p></license></permissions><abstract><p>Due to frequent viral antigenic change, current influenza vaccines need to be re-formulated annually to match the circulating strains for battling seasonal influenza epidemics. These vaccines are also ineffective in preventing occasional outbreaks of new influenza pandemic viruses. All these challenges call for the development of universal influenza vaccines capable of conferring broad cross-protection against multiple subtypes of influenza A viruses. Facilitated by the advancement in modern molecular biology, delicate antigen design becomes one of the most effective factors for fulfilling such goals. Conserved epitopes residing in virus surface proteins including influenza matrix protein 2 and the stalk domain of the hemagglutinin draw general interest for improved antigen design. The present review summarizes the recent progress in such endeavors and also covers the encouraging progress in integrated antigen/adjuvant delivery and controlled release technology that facilitate the development of an affordable universal influenza vaccine.</p></abstract><kwd-group><kwd>influenza</kwd><kwd>cross protection</kwd><kwd>universal influenza vaccine</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name><name sortKey="Wang, Bao Zhong" sort="Wang, Bao Zhong" uniqKey="Wang B" first="Bao-Zhong" last="Wang">Bao-Zhong Wang</name><name sortKey="Wang, Li" sort="Wang, Li" uniqKey="Wang L" first="Li" last="Wang">Li Wang</name><name sortKey="Zhang, Han" sort="Zhang, Han" uniqKey="Zhang H" first="Han" last="Zhang">Han Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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