Assessing the State of Knowledge Regarding the Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review and Narrative Synthesis
Identifieur interne : 000317 ( Pmc/Checkpoint ); précédent : 000316; suivant : 000318Assessing the State of Knowledge Regarding the Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review and Narrative Synthesis
Auteurs : Patrick Saunders-Hastings ; Jane Reisman ; Daniel KrewskiSource :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Influenza pandemics occur when a novel influenza strain, to which humans are immunologically naïve, emerges to cause infection and illness on a global scale. Differences in the viral properties of pandemic strains, relative to seasonal ones, can alter the effectiveness of interventions typically implemented to control seasonal influenza burden. As a result, annual control activities may not be sufficient to contain an influenza pandemic.
This study seeks to inform pandemic policy and planning initiatives by reviewing the effectiveness of previous interventions to reduce pandemic influenza transmission and infection. Results will inform the planning and design of more focused in-depth systematic reviews for specific types of interventions, thus providing the most comprehensive and current understanding of the potential for alternative interventions to mitigate the burden of pandemic influenza.
A systematic review and narrative synthesis of existing systematic reviews and meta-analyses examining intervention effectiveness in containing pandemic influenza transmission was conducted using information collected from five databases (PubMed, Medline, Cochrane, Embase, and Cinahl/EBSCO). Two independent reviewers conducted study screening and quality assessment, extracting data related to intervention impact and effectiveness.
Most included reviews were of moderate to high quality. Although the degree of statistical heterogeneity precluded meta-analysis, the present systematic review examines the wide variety of interventions that can impact influenza transmission in different ways. While it appears that pandemic influenza vaccination provides significant protection against infection, there was insufficient evidence to conclude that antiviral prophylaxis, seasonal influenza cross-protection, or a range of non-pharmaceutical strategies would provide appreciable protection when implemented in isolation. It is likely that an optimal intervention strategy will employ a combination of interventions in a layered approach, though more research is needed to substantiate this proposition.
PROSPERO 42016039803
Url:
DOI: 10.1371/journal.pone.0168262
PubMed: 27977760
PubMed Central: 5158032
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing the State of Knowledge Regarding the Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review and Narrative Synthesis</title><author><name sortKey="Saunders Hastings, Patrick" sort="Saunders Hastings, Patrick" uniqKey="Saunders Hastings P" first="Patrick" last="Saunders-Hastings">Patrick Saunders-Hastings</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Reisman, Jane" sort="Reisman, Jane" uniqKey="Reisman J" first="Jane" last="Reisman">Jane Reisman</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27977760</idno><idno type="pmc">5158032</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5158032</idno><idno type="RBID">PMC:5158032</idno><idno type="doi">10.1371/journal.pone.0168262</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000C49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C49</idno><idno type="wicri:Area/Pmc/Curation">000C49</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C49</idno><idno type="wicri:Area/Pmc/Checkpoint">000317</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessing the State of Knowledge Regarding the Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review and Narrative Synthesis</title><author><name sortKey="Saunders Hastings, Patrick" sort="Saunders Hastings, Patrick" uniqKey="Saunders Hastings P" first="Patrick" last="Saunders-Hastings">Patrick Saunders-Hastings</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Reisman, Jane" sort="Reisman, Jane" uniqKey="Reisman J" first="Jane" last="Reisman">Jane Reisman</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Influenza pandemics occur when a novel influenza strain, to which humans are immunologically naïve, emerges to cause infection and illness on a global scale. Differences in the viral properties of pandemic strains, relative to seasonal ones, can alter the effectiveness of interventions typically implemented to control seasonal influenza burden. As a result, annual control activities may not be sufficient to contain an influenza pandemic.</p></sec><sec id="sec002"><title>Purpose</title><p>This study seeks to inform pandemic policy and planning initiatives by reviewing the effectiveness of previous interventions to reduce pandemic influenza transmission and infection. Results will inform the planning and design of more focused in-depth systematic reviews for specific types of interventions, thus providing the most comprehensive and current understanding of the potential for alternative interventions to mitigate the burden of pandemic influenza.</p></sec><sec id="sec003"><title>Methods</title><p>A systematic review and narrative synthesis of existing systematic reviews and meta-analyses examining intervention effectiveness in containing pandemic influenza transmission was conducted using information collected from five databases (PubMed, Medline, Cochrane, Embase, and Cinahl/EBSCO). Two independent reviewers conducted study screening and quality assessment, extracting data related to intervention impact and effectiveness.</p></sec><sec id="sec004"><title>Results and Discussion</title><p>Most included reviews were of moderate to high quality. Although the degree of statistical heterogeneity precluded meta-analysis, the present systematic review examines the wide variety of interventions that can impact influenza transmission in different ways. While it appears that pandemic influenza vaccination provides significant protection against infection, there was insufficient evidence to conclude that antiviral prophylaxis, seasonal influenza cross-protection, or a range of non-pharmaceutical strategies would provide appreciable protection when implemented in isolation. It is likely that an optimal intervention strategy will employ a combination of interventions in a layered approach, though more research is needed to substantiate this proposition.</p></sec><sec id="sec005"><title>Trial Registration</title><p>PROSPERO 42016039803</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Longini, Im" uniqKey="Longini I">IM Longini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molinari, Na" uniqKey="Molinari N">NA Molinari</name></author><author><name sortKey="Ortega Sanchez, Ir" uniqKey="Ortega Sanchez I">IR Ortega-Sanchez</name></author><author><name sortKey="Messonnier, Ml" uniqKey="Messonnier M">ML Messonnier</name></author><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Wortley, Pm" uniqKey="Wortley P">PM Wortley</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Waring, J" uniqKey="Waring J">J Waring</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jordan, Eo" uniqKey="Jordan E">EO Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patterson, Kd" uniqKey="Patterson K">KD Patterson</name></author><author><name sortKey="Pyle, Gf" uniqKey="Pyle G">GF Pyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, N" uniqKey="Johnson N">N Johnson</name></author><author><name sortKey="Mueller, J" uniqKey="Mueller J">J Mueller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Humphries, M" uniqKey="Humphries M">M Humphries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cruz, At" uniqKey="Cruz A">AT Cruz</name></author><author><name sortKey="Tittle, Ko" uniqKey="Tittle K">KO Tittle</name></author><author><name sortKey="Smith, Er" uniqKey="Smith E">ER Smith</name></author><author><name sortKey="Sirbaugh, Pe" uniqKey="Sirbaugh P">PE Sirbaugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nap, R" uniqKey="Nap R">R Nap</name></author><author><name sortKey="Andriessen, P" uniqKey="Andriessen P">P Andriessen</name></author><author><name sortKey="Meesen, N" uniqKey="Meesen N">N Meesen</name></author><author><name sortKey="Werf, T" uniqKey="Werf T">T Werf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meltzer, Mi" uniqKey="Meltzer M">MI Meltzer</name></author><author><name sortKey="Patel, A" uniqKey="Patel A">A Patel</name></author><author><name sortKey="Ajao, A" uniqKey="Ajao A">A Ajao</name></author><author><name sortKey="Nystrom, Sv" uniqKey="Nystrom S">SV Nystrom</name></author><author><name sortKey="Koonin, Lm" uniqKey="Koonin L">LM Koonin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barbisch, Df" uniqKey="Barbisch D">DF Barbisch</name></author><author><name sortKey="Koenig, Kl" uniqKey="Koenig K">KL Koenig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schultz, Ch" uniqKey="Schultz C">CH Schultz</name></author><author><name sortKey="Koenig, Kl" uniqKey="Koenig K">KL Koenig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiao, Hu" uniqKey="Jiao H">HU Jiao</name></author><author><name sortKey="X, L" uniqKey="X L">L X</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name></author><author><name sortKey="Yu, A" uniqKey="Yu A">A Yu</name></author><author><name sortKey="Ho, Syw" uniqKey="Ho S">SYW Ho</name></author><author><name sortKey="Carr, Mj" uniqKey="Carr M">MJ Carr</name></author><author><name sortKey="Zheng, W" uniqKey="Zheng W">W Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name></author><author><name sortKey="Langat, P" uniqKey="Langat P">P Langat</name></author><author><name sortKey="Reid, Sm" uniqKey="Reid S">SM Reid</name></author><author><name sortKey="Lam, Tt Y" uniqKey="Lam T">TT-Y Lam</name></author><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name></author><author><name sortKey="Kelly, M" uniqKey="Kelly M">M Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murray, Ka" uniqKey="Murray K">KA Murray</name></author><author><name sortKey="Allen, T" uniqKey="Allen T">T Allen</name></author><author><name sortKey="Loh, E" uniqKey="Loh E">E Loh</name></author><author><name sortKey="Machalaba, C" uniqKey="Machalaba C">C Machalaba</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name></author><author><name sortKey="Jay Russell, M" uniqKey="Jay Russell M">M Jay-Russell</name></author><author><name sortKey="Doyle, Pm" uniqKey="Doyle P">PM Doyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hollenbeck, Je" uniqKey="Hollenbeck J">JE Hollenbeck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moher, D" uniqKey="Moher D">D Moher</name></author><author><name sortKey="Liberati, A" uniqKey="Liberati A">A Liberati</name></author><author><name sortKey="Tetzlaff, J" uniqKey="Tetzlaff J">J Tetzlaff</name></author><author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shea, Bj" uniqKey="Shea B">BJ Shea</name></author><author><name sortKey="Grimshaw, Jm" uniqKey="Grimshaw J">JM Grimshaw</name></author><author><name sortKey="Wells, Ga" uniqKey="Wells G">GA Wells</name></author><author><name sortKey="Boers, M" uniqKey="Boers M">M Boers</name></author><author><name sortKey="Andersson, N" uniqKey="Andersson N">N Andersson</name></author><author><name sortKey="Hamel, C" uniqKey="Hamel C">C Hamel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shea, Bj" uniqKey="Shea B">BJ Shea</name></author><author><name sortKey="Hamel, C" uniqKey="Hamel C">C Hamel</name></author><author><name sortKey="Wells, Ga" uniqKey="Wells G">GA Wells</name></author><author><name sortKey="Bouter, Lm" uniqKey="Bouter L">LM Bouter</name></author><author><name sortKey="Kristjansson, E" uniqKey="Kristjansson E">E Kristjansson</name></author><author><name sortKey="Grimshaw, J" uniqKey="Grimshaw J">J Grimshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malik, Vs" uniqKey="Malik V">VS Malik</name></author><author><name sortKey="Hu, Fb" uniqKey="Hu F">FB Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bahia, L" uniqKey="Bahia L">L Bahia</name></author><author><name sortKey="Coutinho, Esf" uniqKey="Coutinho E">ESF Coutinho</name></author><author><name sortKey="Barufaldi, La" uniqKey="Barufaldi L">LA Barufaldi</name></author><author><name sortKey="De Azevedo Abreu, G" uniqKey="De Azevedo Abreu G">G de Azevedo Abreu</name></author><author><name sortKey="Malhao, Ta" uniqKey="Malhao T">TA Malhão</name></author><author><name sortKey="Ribeiro De Souza, Cp" uniqKey="Ribeiro De Souza C">CP Ribeiro de Souza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Remschmidt, C" uniqKey="Remschmidt C">C Remschmidt</name></author><author><name sortKey="Wichmann, O" uniqKey="Wichmann O">O Wichmann</name></author><author><name sortKey="Harder, T" uniqKey="Harder T">T Harder</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michiels, B" uniqKey="Michiels B">B Michiels</name></author><author><name sortKey="Van Puyenbroeck, K" uniqKey="Van Puyenbroeck K">K Van Puyenbroeck</name></author><author><name sortKey="Verhoeven, V" uniqKey="Verhoeven V">V Verhoeven</name></author><author><name sortKey="Vermeire, E" uniqKey="Vermeire E">E Vermeire</name></author><author><name sortKey="Coenen, S" uniqKey="Coenen S">S Coenen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Michiels, B" uniqKey="Michiels B">B Michiels</name></author><author><name sortKey="Govaerts, F" uniqKey="Govaerts F">F Govaerts</name></author><author><name sortKey="Remmen, R" uniqKey="Remmen R">R Remmen</name></author><author><name sortKey="Vermeire, E" uniqKey="Vermeire E">E Vermeire</name></author><author><name sortKey="Coenen, S" uniqKey="Coenen S">S Coenen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breteler, Jk" uniqKey="Breteler J">JK Breteler</name></author><author><name sortKey="Tam, Js" uniqKey="Tam J">JS Tam</name></author><author><name sortKey="Jit, M" uniqKey="Jit M">M Jit</name></author><author><name sortKey="Ket, Jc" uniqKey="Ket J">JC Ket</name></author><author><name sortKey="De Boer, Mr" uniqKey="De Boer M">MR De Boer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chien, Yw" uniqKey="Chien Y">YW Chien</name></author><author><name sortKey="Klugman, Kp" uniqKey="Klugman K">KP Klugman</name></author><author><name sortKey="Morens, Dm" uniqKey="Morens D">DM Morens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V Demicheli</name></author><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name></author><author><name sortKey="Al Ansary Lubna, A" uniqKey="Al Ansary Lubna A">A Al-Ansary Lubna</name></author><author><name sortKey="Ferroni, E" uniqKey="Ferroni E">E Ferroni</name></author><author><name sortKey="Rivetti, A" uniqKey="Rivetti A">A Rivetti</name></author><author><name sortKey="Di Pietrantonj, C" uniqKey="Di Pietrantonj C">C Di Pietrantonj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name></author><author><name sortKey="Rivetti, A" uniqKey="Rivetti A">A Rivetti</name></author><author><name sortKey="Di Pietrantonj, C" uniqKey="Di Pietrantonj C">C Di Pietrantonj</name></author><author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V Demicheli</name></author><author><name sortKey="Ferroni, E" uniqKey="Ferroni E">E Ferroni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manzoli, L" uniqKey="Manzoli L">L Manzoli</name></author><author><name sortKey="De Vito, C" uniqKey="De Vito C">C De Vito</name></author><author><name sortKey="Salanti, G" uniqKey="Salanti G">G Salanti</name></author><author><name sortKey="D Addario, M" uniqKey="D Addario M">M D'Addario</name></author><author><name sortKey="Villari, P" uniqKey="Villari P">P Villari</name></author><author><name sortKey="Ioannidis, Jp" uniqKey="Ioannidis J">JP Ioannidis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, Mt" uniqKey="Osterholm M">MT Osterholm</name></author><author><name sortKey="Kelley, Ns" uniqKey="Kelley N">NS Kelley</name></author><author><name sortKey="Sommer, A" uniqKey="Sommer A">A Sommer</name></author><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Jk" uniqKey="Yin J">JK Yin</name></author><author><name sortKey="Chow, Myk" uniqKey="Chow M">MYK Chow</name></author><author><name sortKey="Khandaker, G" uniqKey="Khandaker G">G Khandaker</name></author><author><name sortKey="King, C" uniqKey="King C">C King</name></author><author><name sortKey="Richmond, P" uniqKey="Richmond P">P Richmond</name></author><author><name sortKey="Heron, L" uniqKey="Heron L">L Heron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Jk" uniqKey="Yin J">JK Yin</name></author><author><name sortKey="Khandaker, G" uniqKey="Khandaker G">G Khandaker</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H Rashid</name></author><author><name sortKey="Heron, L" uniqKey="Heron L">L Heron</name></author><author><name sortKey="Ridda, I" uniqKey="Ridda I">I Ridda</name></author><author><name sortKey="Booy, R" uniqKey="Booy R">R Booy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fielding, Je" uniqKey="Fielding J">JE Fielding</name></author><author><name sortKey="Kelly, Ha" uniqKey="Kelly H">HA Kelly</name></author><author><name sortKey="Mercer, Gn" uniqKey="Mercer G">GN Mercer</name></author><author><name sortKey="Glass, K" uniqKey="Glass K">K Glass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name></author><author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V Demicheli</name></author><author><name sortKey="Di Pietrantonj, C" uniqKey="Di Pietrantonj C">C Di Pietrantonj</name></author><author><name sortKey="Rivetti, D" uniqKey="Rivetti D">D Rivetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mizumoto, K" uniqKey="Mizumoto K">K Mizumoto</name></author><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Zy" uniqKey="Li Z">ZY Li</name></author><author><name sortKey="Chen, Jy" uniqKey="Chen J">JY Chen</name></author><author><name sortKey="Zhang, Yl" uniqKey="Zhang Y">YL Zhang</name></author><author><name sortKey="Fu, Wm" uniqKey="Fu W">WM Fu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mukerji, S" uniqKey="Mukerji S">S Mukerji</name></author><author><name sortKey="Macintyre, Cr" uniqKey="Macintyre C">CR MacIntyre</name></author><author><name sortKey="Newall, At" uniqKey="Newall A">AT Newall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Vwy" uniqKey="Wong V">VWY Wong</name></author><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author><author><name sortKey="Aiello, Ae" uniqKey="Aiello A">AE Aiello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, C" uniqKey="Jackson C">C Jackson</name></author><author><name sortKey="Vynnycky, E" uniqKey="Vynnycky E">E Vynnycky</name></author><author><name sortKey="Hawker, J" uniqKey="Hawker J">J Hawker</name></author><author><name sortKey="Olowokure, B" uniqKey="Olowokure B">B Olowokure</name></author><author><name sortKey="Mangtani, P" uniqKey="Mangtani P">P Mangtani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Jh" uniqKey="Li J">JH Li</name></author><author><name sortKey="Wang, Rq" uniqKey="Wang R">RQ Wang</name></author><author><name sortKey="Guo, Wj" uniqKey="Guo W">WJ Guo</name></author><author><name sortKey="Li, Js" uniqKey="Li J">JS Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Velasco, R" uniqKey="Perez Velasco R">R Perez Velasco</name></author><author><name sortKey="Praditsitthikorn, N" uniqKey="Praditsitthikorn N">N Praditsitthikorn</name></author><author><name sortKey="Wichmann, K" uniqKey="Wichmann K">K Wichmann</name></author><author><name sortKey="Mohara, A" uniqKey="Mohara A">A Mohara</name></author><author><name sortKey="Kotirum, S" uniqKey="Kotirum S">S Kotirum</name></author><author><name sortKey="Tantivess, S" uniqKey="Tantivess S">S Tantivess</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name></author><author><name sortKey="Xu, F" uniqKey="Xu F">F Xu</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Lu, M" uniqKey="Lu M">M Lu</name></author><author><name sortKey="Miao, L" uniqKey="Miao L">L Miao</name></author><author><name sortKey="Gao, T" uniqKey="Gao T">T Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, T" uniqKey="Yamada T">T Yamada</name></author><author><name sortKey="Yamada, T" uniqKey="Yamada T">T Yamada</name></author><author><name sortKey="Morikawa, M" uniqKey="Morikawa M">M Morikawa</name></author><author><name sortKey="Cho, K" uniqKey="Cho K">K Cho</name></author><author><name sortKey="Endo, T" uniqKey="Endo T">T Endo</name></author><author><name sortKey="Sato, Ss" uniqKey="Sato S">SS Sato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortqvist, A" uniqKey="Ortqvist A">A Ortqvist</name></author><author><name sortKey="Berggren, I" uniqKey="Berggren I">I Berggren</name></author><author><name sortKey="Insulander, M" uniqKey="Insulander M">M Insulander</name></author><author><name sortKey="De Jong, B" uniqKey="De Jong B">B de Jong</name></author><author><name sortKey="Svenungsson, B" uniqKey="Svenungsson B">B Svenungsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gilca, R" uniqKey="Gilca R">R Gilca</name></author><author><name sortKey="Deceuninck, G" uniqKey="Deceuninck G">G Deceuninck</name></author><author><name sortKey="De Serres, G" uniqKey="De Serres G">G De Serres</name></author><author><name sortKey="Boulianne, N" uniqKey="Boulianne N">N Boulianne</name></author><author><name sortKey="Sauvageau, C" uniqKey="Sauvageau C">C Sauvageau</name></author><author><name sortKey="Quach, C" uniqKey="Quach C">C Quach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mahmud, S" uniqKey="Mahmud S">S Mahmud</name></author><author><name sortKey="Hammond, G" uniqKey="Hammond G">G Hammond</name></author><author><name sortKey="Elliott, L" uniqKey="Elliott L">L Elliott</name></author><author><name sortKey="Hilderman, T" uniqKey="Hilderman T">T Hilderman</name></author><author><name sortKey="Kurbis, C" uniqKey="Kurbis C">C Kurbis</name></author><author><name sortKey="Caetano, P" uniqKey="Caetano P">P Caetano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Buynder, Pg" uniqKey="Van Buynder P">PG Van Buynder</name></author><author><name sortKey="Dhaliwal, Jk" uniqKey="Dhaliwal J">JK Dhaliwal</name></author><author><name sortKey="Van Buynder, Jl" uniqKey="Van Buynder J">JL Van Buynder</name></author><author><name sortKey="Couturier, C" uniqKey="Couturier C">C Couturier</name></author><author><name sortKey="Minville Leblanc, M" uniqKey="Minville Leblanc M">M Minville-Leblanc</name></author><author><name sortKey="Garceau, R" uniqKey="Garceau R">R Garceau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valenciano, M" uniqKey="Valenciano M">M Valenciano</name></author><author><name sortKey="Kissling, E" uniqKey="Kissling E">E Kissling</name></author><author><name sortKey="Cohen, J M" uniqKey="Cohen J">J-M Cohen</name></author><author><name sortKey="Oroszi, B" uniqKey="Oroszi B">B Oroszi</name></author><author><name sortKey="Barret, A S" uniqKey="Barret A">A-S Barret</name></author><author><name sortKey="Rizzo, C" uniqKey="Rizzo C">C Rizzo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mogabgab, Wj" uniqKey="Mogabgab W">WJ Mogabgab</name></author><author><name sortKey="Leiderman, E" uniqKey="Leiderman E">E Leiderman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suess, T" uniqKey="Suess T">T Suess</name></author><author><name sortKey="Remschmidt, C" uniqKey="Remschmidt C">C Remschmidt</name></author><author><name sortKey="Schink, S" uniqKey="Schink S">S Schink</name></author><author><name sortKey="Luchtenberg, M" uniqKey="Luchtenberg M">M Luchtenberg</name></author><author><name sortKey="Haas, W" uniqKey="Haas W">W Haas</name></author><author><name sortKey="Krause, G" uniqKey="Krause G">G Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name></author><author><name sortKey="Del Mar, Cb" uniqKey="Del Mar C">CB Del Mar</name></author><author><name sortKey="Dooley, L" uniqKey="Dooley L">L Dooley</name></author><author><name sortKey="Ferroni, E" uniqKey="Ferroni E">E Ferroni</name></author><author><name sortKey="Al Ansary, La" uniqKey="Al Ansary L">LA Al-Ansary</name></author><author><name sortKey="Bawazeer, Ga" uniqKey="Bawazeer G">GA Bawazeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torner, N" uniqKey="Torner N">N Torner</name></author><author><name sortKey="Soldevila, N" uniqKey="Soldevila N">N Soldevila</name></author><author><name sortKey="Garcia, Jj" uniqKey="Garcia J">JJ Garcia</name></author><author><name sortKey="Launes, C" uniqKey="Launes C">C Launes</name></author><author><name sortKey="Godoy, P" uniqKey="Godoy P">P Godoy</name></author><author><name sortKey="Castilla, J" uniqKey="Castilla J">J Castilla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suess, T" uniqKey="Suess T">T Suess</name></author><author><name sortKey="Remschmidt, C" uniqKey="Remschmidt C">C Remschmidt</name></author><author><name sortKey="Schink, S" uniqKey="Schink S">S Schink</name></author><author><name sortKey="Luchtenberg, M" uniqKey="Luchtenberg M">M Luchtenberg</name></author><author><name sortKey="Haas, W" uniqKey="Haas W">W Haas</name></author><author><name sortKey="Krause, G" uniqKey="Krause G">G Krause</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas Roger, E" uniqKey="Thomas Roger E">E Thomas Roger</name></author><author><name sortKey="Lorenzetti Diane, L" uniqKey="Lorenzetti Diane L">L Lorenzetti Diane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Fang, Vj" uniqKey="Fang V">VJ Fang</name></author><author><name sortKey="Cheng, Ck" uniqKey="Cheng C">CK Cheng</name></author><author><name sortKey="Fung, Ro" uniqKey="Fung R">RO Fung</name></author><author><name sortKey="Wai, W" uniqKey="Wai W">W Wai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Jt" uniqKey="Lau J">JT Lau</name></author><author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name></author><author><name sortKey="Tsui, H" uniqKey="Tsui H">H Tsui</name></author><author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lowen, A" uniqKey="Lowen A">A Lowen</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name></author><author><name sortKey="Jones, Ma" uniqKey="Jones M">MA Jones</name></author><author><name sortKey="Doshi, P" uniqKey="Doshi P">P Doshi</name></author><author><name sortKey="Del Mar, Cb" uniqKey="Del Mar C">CB Del Mar</name></author><author><name sortKey="Hama, R" uniqKey="Hama R">R Hama</name></author><author><name sortKey="Thompson, Mj" uniqKey="Thompson M">MJ Thompson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Longini, I" uniqKey="Longini I">I Longini</name></author><author><name sortKey="Halloran, Me" uniqKey="Halloran M">ME Halloran</name></author><author><name sortKey="Nizam, A" uniqKey="Nizam A">A Nizam</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mitchell, Md" uniqKey="Mitchell M">MD Mitchell</name></author><author><name sortKey="Mikkelsen, Me" uniqKey="Mikkelsen M">ME Mikkelsen</name></author><author><name sortKey="Umscheid, Ca" uniqKey="Umscheid C">CA Umscheid</name></author><author><name sortKey="Lee, I" uniqKey="Lee I">I Lee</name></author><author><name sortKey="Fuchs, Bd" uniqKey="Fuchs B">BD Fuchs</name></author><author><name sortKey="Halpern, Sd" uniqKey="Halpern S">SD Halpern</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muthuri, Sg" uniqKey="Muthuri S">SG Muthuri</name></author><author><name sortKey="Myles, Pr" uniqKey="Myles P">PR Myles</name></author><author><name sortKey="Venkatesan, S" uniqKey="Venkatesan S">S Venkatesan</name></author><author><name sortKey="Leonardi Bee, J" uniqKey="Leonardi Bee J">J Leonardi-Bee</name></author><author><name sortKey="Nguyen Van Tam, Js" uniqKey="Nguyen Van Tam J">JS Nguyen-Van-Tam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muthuri, Sg" uniqKey="Muthuri S">SG Muthuri</name></author><author><name sortKey="Venkatesan, S" uniqKey="Venkatesan S">S Venkatesan</name></author><author><name sortKey="Myles, Pr" uniqKey="Myles P">PR Myles</name></author><author><name sortKey="Leonardi Bee, J" uniqKey="Leonardi Bee J">J Leonardi-Bee</name></author><author><name sortKey="Al Khuwaitir, Ts" uniqKey="Al Khuwaitir T">TS Al Khuwaitir</name></author><author><name sortKey="Al Mamun, A" uniqKey="Al Mamun A">A Al Mamun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muthuri, Sg" uniqKey="Muthuri S">SG Muthuri</name></author><author><name sortKey="Venkatesan, S" uniqKey="Venkatesan S">S Venkatesan</name></author><author><name sortKey="Myles, Pr" uniqKey="Myles P">PR Myles</name></author><author><name sortKey="Leonardi Bee, J" uniqKey="Leonardi Bee J">J Leonardi-Bee</name></author><author><name sortKey="Lim, Ws" uniqKey="Lim W">WS Lim</name></author><author><name sortKey="Al Mamun, A" uniqKey="Al Mamun A">A Al Mamun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ortiz, Jr" uniqKey="Ortiz J">JR Ortiz</name></author><author><name sortKey="Rudd, Ke" uniqKey="Rudd K">KE Rudd</name></author><author><name sortKey="Clark, Dv" uniqKey="Clark D">DV Clark</name></author><author><name sortKey="Jacob, St" uniqKey="Jacob S">ST Jacob</name></author><author><name sortKey="West, Te" uniqKey="West T">TE West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodrigo, C" uniqKey="Rodrigo C">C Rodrigo</name></author><author><name sortKey="Leonardi Bee, J" uniqKey="Leonardi Bee J">J Leonardi-Bee</name></author><author><name sortKey="Nguyen Van Tam, Js" uniqKey="Nguyen Van Tam J">JS Nguyen-Van-Tam</name></author><author><name sortKey="Lim, Ws" uniqKey="Lim W">WS Lim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudd, Ke" uniqKey="Rudd K">KE Rudd</name></author><author><name sortKey="Ortiz, Jr" uniqKey="Ortiz J">JR Ortiz</name></author><author><name sortKey="Clark, Dv" uniqKey="Clark D">DV Clark</name></author><author><name sortKey="Jacob, St" uniqKey="Jacob S">ST Jacob</name></author><author><name sortKey="West, Te" uniqKey="West T">TE West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venkatesan, S" uniqKey="Venkatesan S">S Venkatesan</name></author><author><name sortKey="Myles, Pr" uniqKey="Myles P">PR Myles</name></author><author><name sortKey="Leonardi Bee, J" uniqKey="Leonardi Bee J">J Leonardi-Bee</name></author><author><name sortKey="Nguyen Van Tam, Js" uniqKey="Nguyen Van Tam J">JS Nguyen-Van-Tam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Jw" uniqKey="Yang J">JW Yang</name></author><author><name sortKey="Fan, Lc" uniqKey="Fan L">LC Fan</name></author><author><name sortKey="Miao, Xy" uniqKey="Miao X">XY Miao</name></author><author><name sortKey="Mao, B" uniqKey="Mao B">B Mao</name></author><author><name sortKey="Li, Mh" uniqKey="Li M">MH Li</name></author><author><name sortKey="Lu, Hw" uniqKey="Lu H">HW Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muthuri, Sg" uniqKey="Muthuri S">SG Muthuri</name></author><author><name sortKey="Venkatesan, S" uniqKey="Venkatesan S">S Venkatesan</name></author><author><name sortKey="Myles, Pr" uniqKey="Myles P">PR Myles</name></author><author><name sortKey="Leonardi Bee, J" uniqKey="Leonardi Bee J">J Leonardi-Bee</name></author><author><name sortKey="Lim, Ws" uniqKey="Lim W">WS Lim</name></author><author><name sortKey="Al Mamun, A" uniqKey="Al Mamun A">A Al Mamun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bitar, D" uniqKey="Bitar D">D Bitar</name></author><author><name sortKey="Goubar, A" uniqKey="Goubar A">A Goubar</name></author><author><name sortKey="Desenclos, Jc" uniqKey="Desenclos J">JC Desenclos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name></author><author><name sortKey="Kamiya, K" uniqKey="Kamiya K">K Kamiya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hale, Mj" uniqKey="Hale M">MJ Hale</name></author><author><name sortKey="Hoskins, Rs" uniqKey="Hoskins R">RS Hoskins</name></author><author><name sortKey="Baker, Mg" uniqKey="Baker M">MG Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author><author><name sortKey="Donnelly, Ca" uniqKey="Donnelly C">CA Donnelly</name></author><author><name sortKey="Zhou, L" uniqKey="Zhou L">L Zhou</name></author><author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name></author><author><name sortKey="Xiang, N" uniqKey="Xiang N">N Xiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author><author><name sortKey="Lau, Ll" uniqKey="Lau L">LL Lau</name></author><author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name></author><author><name sortKey="Wong, Hw" uniqKey="Wong H">HW Wong</name></author><author><name sortKey="Fang, Vj" uniqKey="Fang V">VJ Fang</name></author><author><name sortKey="Riley, S" uniqKey="Riley S">S Riley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, V" uniqKey="Smith V">V Smith</name></author><author><name sortKey="Devane, D" uniqKey="Devane D">D Devane</name></author><author><name sortKey="Begley, Cm" uniqKey="Begley C">CM Begley</name></author><author><name sortKey="Clarke, M" uniqKey="Clarke M">M Clarke</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id><journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosone</journal-id><journal-title-group><journal-title>PLoS ONE</journal-title></journal-title-group><issn pub-type="epub">1932-6203</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, CA USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27977760</article-id><article-id pub-id-type="pmc">5158032</article-id><article-id pub-id-type="doi">10.1371/journal.pone.0168262</article-id><article-id pub-id-type="publisher-id">PONE-D-16-41053</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Infectious Diseases</subject><subj-group><subject>Viral Diseases</subject><subj-group><subject>Influenza</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject><subj-group><subject>Research Assessment</subject><subj-group><subject>Systematic Reviews</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Research and Analysis Methods</subject><subj-group><subject>Mathematical and Statistical Techniques</subject><subj-group><subject>Statistical Methods</subject><subj-group><subject>Meta-Analysis</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Physical Sciences</subject><subj-group><subject>Mathematics</subject><subj-group><subject>Statistics (Mathematics)</subject><subj-group><subject>Statistical Methods</subject><subj-group><subject>Meta-Analysis</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccines</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Microbiology</subject><subj-group><subject>Virology</subject><subj-group><subject>Viral Vaccines</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Prophylaxis</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Prophylaxis</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Prophylaxis</subject></subj-group></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccine Development</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Immunology</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccine Development</subject></subj-group></subj-group></subj-group></subj-group><subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject><subj-group><subject>Public and Occupational Health</subject><subj-group><subject>Preventive Medicine</subject><subj-group><subject>Vaccination and Immunization</subject><subj-group><subject>Vaccine Development</subject></subj-group></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Assessing the State of Knowledge Regarding the Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review and Narrative Synthesis</article-title><alt-title alt-title-type="running-head">Effectiveness of Interventions to Contain Pandemic Influenza Transmission: A Systematic Review</alt-title></title-group><contrib-group><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0002-3602-0842</contrib-id><name><surname>Saunders-Hastings</surname><given-names>Patrick</given-names></name><xref ref-type="aff" rid="aff001"></xref><xref ref-type="corresp" rid="cor001">*</xref></contrib><contrib contrib-type="author"><name><surname>Reisman</surname><given-names>Jane</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib><contrib contrib-type="author"><name><surname>Krewski</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff001"></xref></contrib></contrib-group><aff id="aff001"><addr-line>University of Ottawa, McLaughlin Centre for Population Health Risk Assessment, Ottawa, Ontario, Canada</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Cowling</surname><given-names>Benjamin J.</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University of Hong Kong, HONG KONG</addr-line></aff><author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>The authors have declared that no competing interests exist.</p></fn><fn fn-type="con"><p><list list-type="simple"><list-item><p><bold>Conceptualization:</bold> PSH.</p></list-item><list-item><p><bold>Data curation:</bold> PSH.</p></list-item><list-item><p><bold>Formal analysis:</bold> PSH JR.</p></list-item><list-item><p><bold>Investigation:</bold> PSH JR.</p></list-item><list-item><p><bold>Methodology:</bold> PSH.</p></list-item><list-item><p><bold>Resources:</bold> PSH.</p></list-item><list-item><p><bold>Supervision:</bold> DK.</p></list-item><list-item><p><bold>Validation:</bold> PSH.</p></list-item><list-item><p><bold>Visualization:</bold> PSH.</p></list-item><list-item><p><bold>Writing – original draft:</bold> PSH.</p></list-item><list-item><p><bold>Writing – review & editing:</bold> PSH JR DK.</p></list-item></list></p></fn><corresp id="cor001">* E-mail: <email>psaun076@uottawa.ca</email></corresp></author-notes><pub-date pub-type="epub"><day>15</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>11</volume><issue>12</issue><elocation-id>e0168262</elocation-id><history><date date-type="received"><day>14</day><month>10</month><year>2016</year></date><date date-type="accepted"><day>28</day><month>11</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Saunders-Hastings et al</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Saunders-Hastings et al</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="pone.0168262.pdf"></self-uri><abstract><sec id="sec001"><title>Background</title><p>Influenza pandemics occur when a novel influenza strain, to which humans are immunologically naïve, emerges to cause infection and illness on a global scale. Differences in the viral properties of pandemic strains, relative to seasonal ones, can alter the effectiveness of interventions typically implemented to control seasonal influenza burden. As a result, annual control activities may not be sufficient to contain an influenza pandemic.</p></sec><sec id="sec002"><title>Purpose</title><p>This study seeks to inform pandemic policy and planning initiatives by reviewing the effectiveness of previous interventions to reduce pandemic influenza transmission and infection. Results will inform the planning and design of more focused in-depth systematic reviews for specific types of interventions, thus providing the most comprehensive and current understanding of the potential for alternative interventions to mitigate the burden of pandemic influenza.</p></sec><sec id="sec003"><title>Methods</title><p>A systematic review and narrative synthesis of existing systematic reviews and meta-analyses examining intervention effectiveness in containing pandemic influenza transmission was conducted using information collected from five databases (PubMed, Medline, Cochrane, Embase, and Cinahl/EBSCO). Two independent reviewers conducted study screening and quality assessment, extracting data related to intervention impact and effectiveness.</p></sec><sec id="sec004"><title>Results and Discussion</title><p>Most included reviews were of moderate to high quality. Although the degree of statistical heterogeneity precluded meta-analysis, the present systematic review examines the wide variety of interventions that can impact influenza transmission in different ways. While it appears that pandemic influenza vaccination provides significant protection against infection, there was insufficient evidence to conclude that antiviral prophylaxis, seasonal influenza cross-protection, or a range of non-pharmaceutical strategies would provide appreciable protection when implemented in isolation. It is likely that an optimal intervention strategy will employ a combination of interventions in a layered approach, though more research is needed to substantiate this proposition.</p></sec><sec id="sec005"><title>Trial Registration</title><p>PROSPERO 42016039803</p></sec></abstract><funding-group><funding-statement>The authors received no specific funding for this work.</funding-statement></funding-group><counts><fig-count count="1"></fig-count><table-count count="3"></table-count><page-count count="17"></page-count></counts><custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name><meta-value>All relevant data are within the paper and its Supporting Information files.</meta-value></custom-meta></custom-meta-group></article-meta><notes><title>Data Availability</title><p>All relevant data are within the paper and its Supporting Information files.</p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Krewski, Daniel" sort="Krewski, Daniel" uniqKey="Krewski D" first="Daniel" last="Krewski">Daniel Krewski</name><name sortKey="Reisman, Jane" sort="Reisman, Jane" uniqKey="Reisman J" first="Jane" last="Reisman">Jane Reisman</name><name sortKey="Saunders Hastings, Patrick" sort="Saunders Hastings, Patrick" uniqKey="Saunders Hastings P" first="Patrick" last="Saunders-Hastings">Patrick Saunders-Hastings</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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