Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study
Identifieur interne : 001C66 ( PascalFrancis/Curation ); précédent : 001C65; suivant : 001C67Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study
Auteurs : HAIYING CHEN [République populaire de Chine] ; HUI YUAN [République populaire de Chine] ; RONGBAO GAO [République populaire de Chine] ; JINXIANG ZHANG [République populaire de Chine] ; DAYAN WANG [République populaire de Chine] ; YING XIONG [République populaire de Chine] ; GUOYIN FAN [République populaire de Chine] ; FAN YANG [République populaire de Chine] ; XIAODAN LI [République populaire de Chine] ; JIANFANG ZHOU [République populaire de Chine] ; SHUMEI ZOU [République populaire de Chine] ; LEI YANG [République populaire de Chine] ; TAO CHEN [République populaire de Chine] ; LIBO DONG [République populaire de Chine] ; HONG BO [République populaire de Chine] ; XIANG ZHAO [République populaire de Chine] ; YE ZHANG [République populaire de Chine] ; YU LAN [République populaire de Chine] ; TIAN BAI [République populaire de Chine] ; JIE DONG [République populaire de Chine] ; QUN LI [République populaire de Chine] ; SHIWEN WANG [République populaire de Chine] ; YANPING ZHANG [République populaire de Chine] ; HUI LI [République populaire de Chine] ; TIAN GONG [République populaire de Chine] ; YONG SHI [République populaire de Chine] ; XIANSHENG NI [République populaire de Chine] ; JIANXIONG LI [République populaire de Chine] ; JUN ZHOU [République populaire de Chine] ; JIYI FAN [République populaire de Chine] ; JINGWEN WU [République populaire de Chine] ; XIANFENG ZHOU [République populaire de Chine] ; MAOHONG HU [République populaire de Chine] ; JIANGUO WAN [République populaire de Chine] ; WEIZHONG YANG [République populaire de Chine] ; DEXIN LI [République populaire de Chine] ; GUIZHEN WU [République populaire de Chine] ; ZIJIAN FENG [République populaire de Chine] ; George F. Gao [République populaire de Chine] ; YU WANG [République populaire de Chine] ; QI JIN [République populaire de Chine] ; MINGBIN LIU [République populaire de Chine] ; YUELONG SHU [République populaire de Chine]Source :
- Lancet : (British edition) [ 0140-6736 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Santé publique, Médecine.
English descriptors
- KwdEn :
Abstract
Background Human infections with different avian influenza viruses-eg, H5N1, H9N2, and H7N9-have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. Methods We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. Findings A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GInSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein-which is associated with mammalian adaptation-was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. Interpretation The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Funding Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.
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<author><name sortKey="Hui Yuan" sort="Hui Yuan" uniqKey="Hui Yuan" last="Hui Yuan">HUI YUAN</name>
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<author><name sortKey="Jianfang Zhou" sort="Jianfang Zhou" uniqKey="Jianfang Zhou" last="Jianfang Zhou">JIANFANG ZHOU</name>
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<author><name sortKey="Shumei Zou" sort="Shumei Zou" uniqKey="Shumei Zou" last="Shumei Zou">SHUMEI ZOU</name>
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<author><name sortKey="Lei Yang" sort="Lei Yang" uniqKey="Lei Yang" last="Lei Yang">LEI YANG</name>
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<author><name sortKey="Tao Chen" sort="Tao Chen" uniqKey="Tao Chen" last="Tao Chen">TAO CHEN</name>
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<author><name sortKey="Libo Dong" sort="Libo Dong" uniqKey="Libo Dong" last="Libo Dong">LIBO DONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<author><name sortKey="Hong Bo" sort="Hong Bo" uniqKey="Hong Bo" last="Hong Bo">HONG BO</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<author><name sortKey="Xiang Zhao" sort="Xiang Zhao" uniqKey="Xiang Zhao" last="Xiang Zhao">XIANG ZHAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<author><name sortKey="Ye Zhang" sort="Ye Zhang" uniqKey="Ye Zhang" last="Ye Zhang">YE ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<author><name sortKey="Yu Lan" sort="Yu Lan" uniqKey="Yu Lan" last="Yu Lan">YU LAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<author><name sortKey="Tian Bai" sort="Tian Bai" uniqKey="Tian Bai" last="Tian Bai">TIAN BAI</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<author><name sortKey="Jie Dong" sort="Jie Dong" uniqKey="Jie Dong" last="Jie Dong">JIE DONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
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<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Qun Li" sort="Qun Li" uniqKey="Qun Li" last="Qun Li">QUN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Shiwen Wang" sort="Shiwen Wang" uniqKey="Shiwen Wang" last="Shiwen Wang">SHIWEN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yanping Zhang" sort="Yanping Zhang" uniqKey="Yanping Zhang" last="Yanping Zhang">YANPING ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Hui Li" sort="Hui Li" uniqKey="Hui Li" last="Hui Li">HUI LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Tian Gong" sort="Tian Gong" uniqKey="Tian Gong" last="Tian Gong">TIAN GONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yong Shi" sort="Yong Shi" uniqKey="Yong Shi" last="Yong Shi">YONG SHI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xiansheng Ni" sort="Xiansheng Ni" uniqKey="Xiansheng Ni" last="Xiansheng Ni">XIANSHENG NI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jianxiong Li" sort="Jianxiong Li" uniqKey="Jianxiong Li" last="Jianxiong Li">JIANXIONG LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jun Zhou" sort="Jun Zhou" uniqKey="Jun Zhou" last="Jun Zhou">JUN ZHOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jiyi Fan" sort="Jiyi Fan" uniqKey="Jiyi Fan" last="Jiyi Fan">JIYI FAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Donghu District Center for Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jingwen Wu" sort="Jingwen Wu" uniqKey="Jingwen Wu" last="Jingwen Wu">JINGWEN WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xianfeng Zhou" sort="Xianfeng Zhou" uniqKey="Xianfeng Zhou" last="Xianfeng Zhou">XIANFENG ZHOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Maohong Hu" sort="Maohong Hu" uniqKey="Maohong Hu" last="Maohong Hu">MAOHONG HU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jianguo Wan" sort="Jianguo Wan" uniqKey="Jianguo Wan" last="Jianguo Wan">JIANGUO WAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>First Hospital of Nanchang</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Weizhong Yang" sort="Weizhong Yang" uniqKey="Weizhong Yang" last="Weizhong Yang">WEIZHONG YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Dexin Li" sort="Dexin Li" uniqKey="Dexin Li" last="Dexin Li">DEXIN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Guizhen Wu" sort="Guizhen Wu" uniqKey="Guizhen Wu" last="Guizhen Wu">GUIZHEN WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Zijian Feng" sort="Zijian Feng" uniqKey="Zijian Feng" last="Zijian Feng">ZIJIAN FENG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yu Wang" sort="Yu Wang" uniqKey="Yu Wang" last="Yu Wang">YU WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Qi Jin" sort="Qi Jin" uniqKey="Qi Jin" last="Qi Jin">QI JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>8 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Mingbin Liu" sort="Mingbin Liu" uniqKey="Mingbin Liu" last="Mingbin Liu">MINGBIN LIU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yuelong Shu" sort="Yuelong Shu" uniqKey="Yuelong Shu" last="Yuelong Shu">YUELONG SHU</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</s1>
<s2>Hangzhou</s2>
<s3>CHN</s3>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">14-0055760</idno>
<date when="2014">2014</date>
<idno type="stanalyst">PASCAL 14-0055760 INIST</idno>
<idno type="RBID">Pascal:14-0055760</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000152</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001C66</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study</title>
<author><name sortKey="Haiying Chen" sort="Haiying Chen" uniqKey="Haiying Chen" last="Haiying Chen">HAIYING CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Hui Yuan" sort="Hui Yuan" uniqKey="Hui Yuan" last="Hui Yuan">HUI YUAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Rongbao Gao" sort="Rongbao Gao" uniqKey="Rongbao Gao" last="Rongbao Gao">RONGBAO GAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jinxiang Zhang" sort="Jinxiang Zhang" uniqKey="Jinxiang Zhang" last="Jinxiang Zhang">JINXIANG ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>First Hospital of Nanchang</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Dayan Wang" sort="Dayan Wang" uniqKey="Dayan Wang" last="Dayan Wang">DAYAN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Ying Xiong" sort="Ying Xiong" uniqKey="Ying Xiong" last="Ying Xiong">YING XIONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Guoyin Fan" sort="Guoyin Fan" uniqKey="Guoyin Fan" last="Guoyin Fan">GUOYIN FAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Fan Yang" sort="Fan Yang" uniqKey="Fan Yang" last="Fan Yang">FAN YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>8 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xiaodan Li" sort="Xiaodan Li" uniqKey="Xiaodan Li" last="Xiaodan Li">XIAODAN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jianfang Zhou" sort="Jianfang Zhou" uniqKey="Jianfang Zhou" last="Jianfang Zhou">JIANFANG ZHOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
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<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Shumei Zou" sort="Shumei Zou" uniqKey="Shumei Zou" last="Shumei Zou">SHUMEI ZOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Lei Yang" sort="Lei Yang" uniqKey="Lei Yang" last="Lei Yang">LEI YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Tao Chen" sort="Tao Chen" uniqKey="Tao Chen" last="Tao Chen">TAO CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Libo Dong" sort="Libo Dong" uniqKey="Libo Dong" last="Libo Dong">LIBO DONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Hong Bo" sort="Hong Bo" uniqKey="Hong Bo" last="Hong Bo">HONG BO</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
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<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xiang Zhao" sort="Xiang Zhao" uniqKey="Xiang Zhao" last="Xiang Zhao">XIANG ZHAO</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Ye Zhang" sort="Ye Zhang" uniqKey="Ye Zhang" last="Ye Zhang">YE ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
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<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yu Lan" sort="Yu Lan" uniqKey="Yu Lan" last="Yu Lan">YU LAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Tian Bai" sort="Tian Bai" uniqKey="Tian Bai" last="Tian Bai">TIAN BAI</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jie Dong" sort="Jie Dong" uniqKey="Jie Dong" last="Jie Dong">JIE DONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Qun Li" sort="Qun Li" uniqKey="Qun Li" last="Qun Li">QUN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Shiwen Wang" sort="Shiwen Wang" uniqKey="Shiwen Wang" last="Shiwen Wang">SHIWEN WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yanping Zhang" sort="Yanping Zhang" uniqKey="Yanping Zhang" last="Yanping Zhang">YANPING ZHANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
<sZ>38 aut.</sZ>
<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Hui Li" sort="Hui Li" uniqKey="Hui Li" last="Hui Li">HUI LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Tian Gong" sort="Tian Gong" uniqKey="Tian Gong" last="Tian Gong">TIAN GONG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yong Shi" sort="Yong Shi" uniqKey="Yong Shi" last="Yong Shi">YONG SHI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Xiansheng Ni" sort="Xiansheng Ni" uniqKey="Xiansheng Ni" last="Xiansheng Ni">XIANSHENG NI</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jianxiong Li" sort="Jianxiong Li" uniqKey="Jianxiong Li" last="Jianxiong Li">JIANXIONG LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jun Zhou" sort="Jun Zhou" uniqKey="Jun Zhou" last="Jun Zhou">JUN ZHOU</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Jiangxi Provincial Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jiyi Fan" sort="Jiyi Fan" uniqKey="Jiyi Fan" last="Jiyi Fan">JIYI FAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Donghu District Center for Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Jingwen Wu" sort="Jingwen Wu" uniqKey="Jingwen Wu" last="Jingwen Wu">JINGWEN WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
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<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
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<author><name sortKey="Jianguo Wan" sort="Jianguo Wan" uniqKey="Jianguo Wan" last="Jianguo Wan">JIANGUO WAN</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>First Hospital of Nanchang</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>34 aut.</sZ>
</inist:fA14>
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</affiliation>
</author>
<author><name sortKey="Weizhong Yang" sort="Weizhong Yang" uniqKey="Weizhong Yang" last="Weizhong Yang">WEIZHONG YANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
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<country>République populaire de Chine</country>
</affiliation>
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<author><name sortKey="Dexin Li" sort="Dexin Li" uniqKey="Dexin Li" last="Dexin Li">DEXIN LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
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</affiliation>
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<author><name sortKey="Guizhen Wu" sort="Guizhen Wu" uniqKey="Guizhen Wu" last="Guizhen Wu">GUIZHEN WU</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
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<author><name sortKey="Zijian Feng" sort="Zijian Feng" uniqKey="Zijian Feng" last="Zijian Feng">ZIJIAN FENG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
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<author><name sortKey="Gao, George F" sort="Gao, George F" uniqKey="Gao G" first="George F." last="Gao">George F. Gao</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
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</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yu Wang" sort="Yu Wang" uniqKey="Yu Wang" last="Yu Wang">YU WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
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<author><name sortKey="Qi Jin" sort="Qi Jin" uniqKey="Qi Jin" last="Qi Jin">QI JIN</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>8 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Mingbin Liu" sort="Mingbin Liu" uniqKey="Mingbin Liu" last="Mingbin Liu">MINGBIN LIU</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
</author>
<author><name sortKey="Yuelong Shu" sort="Yuelong Shu" uniqKey="Yuelong Shu" last="Yuelong Shu">YUELONG SHU</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
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<country>République populaire de Chine</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</s1>
<s2>Hangzhou</s2>
<s3>CHN</s3>
<sZ>43 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
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</analytic>
<series><title level="j" type="main">Lancet : (British edition)</title>
<title level="j" type="abbreviated">Lancet : (Br. ed.)</title>
<idno type="ISSN">0140-6736</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Lancet : (British edition)</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Avian influenza</term>
<term>Epidemiology</term>
<term>Fatal course</term>
<term>Influenza A</term>
<term>Influenza A virus</term>
<term>Influenzavirus A</term>
<term>Medicine</term>
<term>Public health</term>
<term>Symptomatology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Grippe aviaire</term>
<term>Symptomatologie</term>
<term>Epidémiologie</term>
<term>Santé publique</term>
<term>Forme létale</term>
<term>Influenzavirus A</term>
<term>Virus grippal A</term>
<term>Grippe A</term>
<term>Médecine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Santé publique</term>
<term>Médecine</term>
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<front><div type="abstract" xml:lang="en">Background Human infections with different avian influenza viruses-eg, H5N1, H9N2, and H7N9-have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. Methods We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. Findings A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GInSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein-which is associated with mammalian adaptation-was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. Interpretation The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Funding Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study</s1>
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</fA11>
<fA14 i1="01"><s1>Nanchang City Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>1 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>24 aut.</sZ>
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<s2>Nanchang</s2>
<s3>CHN</s3>
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<fA14 i1="03"><s1>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>3 aut.</sZ>
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<sZ>36 aut.</sZ>
<sZ>37 aut.</sZ>
<sZ>43 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>First Hospital of Nanchang</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>4 aut.</sZ>
<sZ>34 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>8 aut.</sZ>
<sZ>41 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Chinese Center for Disease Control and Prevention</s1>
<s2>Beijing</s2>
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<sZ>21 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>35 aut.</sZ>
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<sZ>39 aut.</sZ>
<sZ>40 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Donghu District Center for Disease Control and Prevention</s1>
<s2>Nanchang</s2>
<s3>CHN</s3>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</s1>
<s2>Hangzhou</s2>
<s3>CHN</s3>
<sZ>43 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Background Human infections with different avian influenza viruses-eg, H5N1, H9N2, and H7N9-have raised concerns about pandemic potential worldwide. We report the first human infection with a novel reassortant avian influenza A H10N8 virus. Methods We obtained and analysed clinical, epidemiological, and virological data from a patient from Nanchang City, China. Tracheal aspirate specimens were tested for influenza virus and other possible pathogens by RT-PCR, viral culture, and sequence analyses. A maximum likelihood phylogenetic tree was constructed. Findings A woman aged 73 years presented with fever and was admitted to hospital on Nov 30, 2013. She developed multiple organ failure and died 9 days after illness onset. A novel reassortant avian influenza A H10N8 virus was isolated from the tracheal aspirate specimen obtained from the patient 7 days after onset of illness. Sequence analyses revealed that all the genes of the virus were of avian origin, with six internal genes from avian influenza A H9N2 viruses. The aminoacid motif GInSerGly at residues 226-228 of the haemagglutinin protein indicated avian-like receptor binding preference. A mixture of glutamic acid and lysine at residue 627 in PB2 protein-which is associated with mammalian adaptation-was detected in the original tracheal aspirate samples. The virus was sensitive to neuraminidase inhibitors. Sputum and blood cultures and deep sequencing analysis indicated no co-infection with bacteria or fungi. Epidemiological investigation established that the patient had visited a live poultry market 4 days before illness onset. Interpretation The novel reassortant H10N8 virus obtained is distinct from previously reported H10N8 viruses. The virus caused human infection and could have been associated with the death of a patient. Funding Emergency Research Project on human infection with avian influenza H7N9 virus, the National Basic Research Program of China, and the National Mega-projects for Infectious Diseases.</s0>
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<fC03 i1="02" i2="X" l="SPA"><s0>Sintomatología</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Epidémiologie</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Epidemiology</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Epidemiología</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Santé publique</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Public health</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Salud pública</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Forme létale</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Fatal course</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Curso fatal</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Influenzavirus A</s0>
<s2>NW</s2>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Influenzavirus A</s0>
<s2>NW</s2>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Influenzavirus A</s0>
<s2>NW</s2>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Virus grippal A</s0>
<s2>NW</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Grippe A</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Influenza A</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Gripe A</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Médecine</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Medicine</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Medicina</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fN21><s1>069</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>
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