PandemieGrippaleV1, PascalFrancis, Curation, bibRecord, 001945

Recent progress in structure-based anti-influenza drug design

Identifieur interne : 001945 ( PascalFrancis/Curation ); précédent : 001944; suivant : 001946

Recent progress in structure-based anti-influenza drug design

Auteurs : JUAN DU [États-Unis] ; Timothy A. Cross [États-Unis] ; Huan-Xiang Zhou [États-Unis]

Source :

Drug discovery today [ 1359-6446 ] ; 2012.

RBID : Pascal:12-0402293

Descripteurs français

Pascal (Inist)
- Grippe, Médicament, Conception, Technologie pharmaceutique.
Wicri :
- topic : Médicament.

English descriptors

KwdEn :
- Design, Drug, Influenza, Pharmaceutical technology.

Abstract

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.

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A11	`01`	`1`		`@1 JUAN DU`
A11	`02`	`1`		`@1 CROSS (Timothy A.)`
A11	`03`	`1`		`@1 ZHOU (Huan-Xiang)`
A14	`01`			`@1 Department of Physics, Florida State University @2 Tallahassee, FL 32306 @3 USA @Z 1 aut. @Z 3 aut.`
A14	`02`			`@1 Department of Chemistry and Biochemistry, Florida State University @2 Tallahassee, FL 32306 @3 USA @Z 2 aut.`
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A14	`04`			`@1 National High Magnetic Field Laboratory, 1800 E. Paul Dirac Dr. @2 Tallahassee, FL 32310 @3 USA @Z 2 aut.`
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A64	`01`	`1`		`@0 Drug discovery today`
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C01	`01`		`ENG`	@0 Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.
C02	`01`	`X`		`@0 002B02A03`
C03	`01`	`X`	`FRE`	`@0 Grippe @5 01`
C03	`01`	`X`	`ENG`	`@0 Influenza @5 01`
C03	`01`	`X`	`SPA`	`@0 Gripe @5 01`
C03	`02`	`X`	`FRE`	`@0 Médicament @5 02`
C03	`02`	`X`	`ENG`	`@0 Drug @5 02`
C03	`02`	`X`	`SPA`	`@0 Medicamento @5 02`
C03	`03`	`X`	`FRE`	`@0 Conception @5 03`
C03	`03`	`X`	`ENG`	`@0 Design @5 03`
C03	`03`	`X`	`SPA`	`@0 Diseño @5 03`
C03	`04`	`X`	`FRE`	`@0 Technologie pharmaceutique @5 04`
C03	`04`	`X`	`ENG`	`@0 Pharmaceutical technology @5 04`
C03	`04`	`X`	`SPA`	`@0 Tecnología farmacéutica @5 04`
C07	`01`	`X`	`FRE`	`@0 Virose`
C07	`01`	`X`	`ENG`	`@0 Viral disease`
C07	`01`	`X`	`SPA`	`@0 Virosis`
C07	`02`	`X`	`FRE`	`@0 Infection`
C07	`02`	`X`	`ENG`	`@0 Infection`
C07	`02`	`X`	`SPA`	`@0 Infección`
N21				`@1 317`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:12-0402293

Le document en format XML

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<front><div type="abstract" xml:lang="en">Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.</div>
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<fC01 i1="01" l="ENG"><s0>Seasonal and pandemic influenza have caused high morbidity and mortality worldwide. Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern, especially as a result of their drug resistance. The life cycle of influenza viruses has been well studied and nearly all the viral proteins are becoming potential therapeutic targets. In this review, we present an overview of recent progress in structure-based anti-influenza drug design, paying close attention to the increasing role of computation and strategies for overcoming drug resistance.</s0>
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Recent progress in structure-based anti-influenza drug design

Recent progress in structure-based anti-influenza drug design

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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