PandemieGrippaleV1, PascalFrancis, Curation, bibRecord, 001923

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

Identifieur interne : 001923 ( PascalFrancis/Curation ); précédent : 001922; suivant : 001924

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

Auteurs : Linda L. Theisen [Luxembourg (pays)] ; Claude P. Muller [Luxembourg (pays)]

Source :

Antiviral research [ 0166-3542 ] ; 2012.

RBID : Pascal:12-0378938

Descripteurs français

Pascal (Inist)
- Extrait, Pelargonium, Racine, Influenzavirus, In vitro, Activité biologique, In vivo, Virus grippal A, Polyphénol, Flavonoïde, Antiviral.

English descriptors

KwdEn :
- Antiviral, Biological activity, Extract, Flavonoid, In vitro, In vivo, Influenza A virus, Influenzavirus, Pelargonium, Polyphenol, Root.

Abstract

A prodelphinidin-rich extract from Pelargonium sidoides DC, EPs® 7630 (Umckaloabo®), which is licensed to treat respiratory tract infections such as acute bronchitis, was investigated for its antiviral effects. EPs® 7630 showed dose-dependent anti-influenza activity at non-toxic concentrations against pandemic H1N1, oseltamivir-sensitive and -resistant seasonal H1N1, seasonal H3N2 and the laboratory H1N1 strain A/Puerto Rico/8/34, while it had no antiviral activity against adenovirus or measles virus. The extract inhibited an early step of influenza infection and impaired viral hemagglutination as well as neuraminidase activity. However, EPs® 7630 did not exhibit a direct virucidal effect, as virus preincubation (unlike cell preincubation) with the extract did not influence infectivity. Importantly, EPs® 7630 showed no propensity to resistance development in vitro. Analysis of EPs® 7630 constituents revealed that prodelphinidins represent the active principle. Chain length influenced antiviral activity, as monomers and dimers were less effective than oligo- and polymers. Importantly, gallocatechin and its stereoisomer epigallocatechin exert antiviral activity also in their monomeric form. In addition, EPs® 7630 administered by inhalation significantly improved survival, body weight and body temperature of influenza-infected mice, without obvious toxicity, demonstrating the benefit of EPs® 7630 in treatment of influenza.

A01	`01`	`1`		`@0 0166-3542`
A02	`01`			`@0 ARSRDR`
A03		`1`		`@0 Antivir. res.`
A05				`@2 94`
A06				`@2 2`
A08	`01`	`1`	`ENG`	`@1 EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo`
A11	`01`	`1`		`@1 THEISEN (Linda L.)`
A11	`02`	`1`		`@1 MULLER (Claude P.)`
A14	`01`			`@1 Institute of Immunology, Centre de Recherche Public de la SantélLaboratoire National de Santé, 20A rue Auguste Lumière @2 1950 Luxembourg @3 LUX @Z 1 aut. @Z 2 aut.`
A20				`@1 147-156`
A21				`@1 2012`
A23	`01`			`@0 ENG`
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A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 1 p.`
A47	`01`	`1`		`@0 12-0378938`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Antiviral research`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 A prodelphinidin-rich extract from Pelargonium sidoides DC, EPs® 7630 (Umckaloabo®), which is licensed to treat respiratory tract infections such as acute bronchitis, was investigated for its antiviral effects. EPs® 7630 showed dose-dependent anti-influenza activity at non-toxic concentrations against pandemic H1N1, oseltamivir-sensitive and -resistant seasonal H1N1, seasonal H3N2 and the laboratory H1N1 strain A/Puerto Rico/8/34, while it had no antiviral activity against adenovirus or measles virus. The extract inhibited an early step of influenza infection and impaired viral hemagglutination as well as neuraminidase activity. However, EPs® 7630 did not exhibit a direct virucidal effect, as virus preincubation (unlike cell preincubation) with the extract did not influence infectivity. Importantly, EPs® 7630 showed no propensity to resistance development in vitro. Analysis of EPs® 7630 constituents revealed that prodelphinidins represent the active principle. Chain length influenced antiviral activity, as monomers and dimers were less effective than oligo- and polymers. Importantly, gallocatechin and its stereoisomer epigallocatechin exert antiviral activity also in their monomeric form. In addition, EPs® 7630 administered by inhalation significantly improved survival, body weight and body temperature of influenza-infected mice, without obvious toxicity, demonstrating the benefit of EPs® 7630 in treatment of influenza.
C02	`01`	`X`		`@0 002B02S05`
C03	`01`	`X`	`FRE`	`@0 Extrait @5 01`
C03	`01`	`X`	`ENG`	`@0 Extract @5 01`
C03	`01`	`X`	`SPA`	`@0 Extracto @5 01`
C03	`02`	`X`	`FRE`	`@0 Pelargonium @2 NS @5 02`
C03	`02`	`X`	`ENG`	`@0 Pelargonium @2 NS @5 02`
C03	`02`	`X`	`SPA`	`@0 Pelargonium @2 NS @5 02`
C03	`03`	`X`	`FRE`	`@0 Racine @5 03`
C03	`03`	`X`	`ENG`	`@0 Root @5 03`
C03	`03`	`X`	`SPA`	`@0 Raíz @5 03`
C03	`04`	`X`	`FRE`	`@0 Influenzavirus @2 NW @5 04`
C03	`04`	`X`	`ENG`	`@0 Influenzavirus @2 NW @5 04`
C03	`04`	`X`	`SPA`	`@0 Influenzavirus @2 NW @5 04`
C03	`05`	`X`	`FRE`	`@0 In vitro @5 05`
C03	`05`	`X`	`ENG`	`@0 In vitro @5 05`
C03	`05`	`X`	`SPA`	`@0 In vitro @5 05`
C03	`06`	`X`	`FRE`	`@0 Activité biologique @5 06`
C03	`06`	`X`	`ENG`	`@0 Biological activity @5 06`
C03	`06`	`X`	`SPA`	`@0 Actividad biológica @5 06`
C03	`07`	`X`	`FRE`	`@0 In vivo @5 07`
C03	`07`	`X`	`ENG`	`@0 In vivo @5 07`
C03	`07`	`X`	`SPA`	`@0 In vivo @5 07`
C03	`08`	`X`	`FRE`	`@0 Virus grippal A @2 NW @5 08`
C03	`08`	`X`	`ENG`	`@0 Influenza A virus @2 NW @5 08`
C03	`08`	`X`	`SPA`	`@0 Influenza A virus @2 NW @5 08`
C03	`09`	`X`	`FRE`	`@0 Polyphénol @5 09`
C03	`09`	`X`	`ENG`	`@0 Polyphenol @5 09`
C03	`09`	`X`	`SPA`	`@0 Polifenol @5 09`
C03	`10`	`X`	`FRE`	`@0 Flavonoïde @5 10`
C03	`10`	`X`	`ENG`	`@0 Flavonoid @5 10`
C03	`10`	`X`	`SPA`	`@0 Flavonoide @5 10`
C03	`11`	`X`	`FRE`	`@0 Antiviral @5 11`
C03	`11`	`X`	`ENG`	`@0 Antiviral @5 11`
C03	`11`	`X`	`SPA`	`@0 Antiviral @5 11`
C07	`01`	`X`	`FRE`	`@0 Geraniaceae @2 NS`
C07	`01`	`X`	`ENG`	`@0 Geraniaceae @2 NS`
C07	`01`	`X`	`SPA`	`@0 Geraniaceae @2 NS`
C07	`02`	`X`	`FRE`	`@0 Dicotyledones @2 NS`
C07	`02`	`X`	`ENG`	`@0 Dicotyledones @2 NS`
C07	`02`	`X`	`SPA`	`@0 Dicotyledones @2 NS`
C07	`03`	`X`	`FRE`	`@0 Angiospermae @2 NS`
C07	`03`	`X`	`ENG`	`@0 Angiospermae @2 NS`
C07	`03`	`X`	`SPA`	`@0 Angiospermae @2 NS`
C07	`04`	`X`	`FRE`	`@0 Spermatophyta @2 NS`
C07	`04`	`X`	`ENG`	`@0 Spermatophyta @2 NS`
C07	`04`	`X`	`SPA`	`@0 Spermatophyta @2 NS`
C07	`05`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`05`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`05`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
C07	`06`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`06`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`06`	`X`	`SPA`	`@0 Virus @2 NW`
C07	`07`	`X`	`FRE`	`@0 Influenzavirus A @2 NW`
C07	`07`	`X`	`ENG`	`@0 Influenzavirus A @2 NW`
C07	`07`	`X`	`SPA`	`@0 Influenzavirus A @2 NW`
C07	`08`	`X`	`FRE`	`@0 Phénols @2 FX @5 37`
C07	`08`	`X`	`ENG`	`@0 Phenols @2 FX @5 37`
C07	`08`	`X`	`SPA`	`@0 Fenoles @2 FX @5 37`
N21				`@1 296`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Pascal:12-0378938

Le document en format XML

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<front><div type="abstract" xml:lang="en">A prodelphinidin-rich extract from Pelargonium sidoides DC, EPs® 7630 (Umckaloabo®), which is licensed to treat respiratory tract infections such as acute bronchitis, was investigated for its antiviral effects. EPs® 7630 showed dose-dependent anti-influenza activity at non-toxic concentrations against pandemic H1N1, oseltamivir-sensitive and -resistant seasonal H1N1, seasonal H3N2 and the laboratory H1N1 strain A/Puerto Rico/8/34, while it had no antiviral activity against adenovirus or measles virus. The extract inhibited an early step of influenza infection and impaired viral hemagglutination as well as neuraminidase activity. However, EPs® 7630 did not exhibit a direct virucidal effect, as virus preincubation (unlike cell preincubation) with the extract did not influence infectivity. Importantly, EPs® 7630 showed no propensity to resistance development in vitro. Analysis of EPs® 7630 constituents revealed that prodelphinidins represent the active principle. Chain length influenced antiviral activity, as monomers and dimers were less effective than oligo- and polymers. Importantly, gallocatechin and its stereoisomer epigallocatechin exert antiviral activity also in their monomeric form. In addition, EPs® 7630 administered by inhalation significantly improved survival, body weight and body temperature of influenza-infected mice, without obvious toxicity, demonstrating the benefit of EPs® 7630 in treatment of influenza.</div>
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<fC01 i1="01" l="ENG"><s0>A prodelphinidin-rich extract from Pelargonium sidoides DC, EPs® 7630 (Umckaloabo®), which is licensed to treat respiratory tract infections such as acute bronchitis, was investigated for its antiviral effects. EPs® 7630 showed dose-dependent anti-influenza activity at non-toxic concentrations against pandemic H1N1, oseltamivir-sensitive and -resistant seasonal H1N1, seasonal H3N2 and the laboratory H1N1 strain A/Puerto Rico/8/34, while it had no antiviral activity against adenovirus or measles virus. The extract inhibited an early step of influenza infection and impaired viral hemagglutination as well as neuraminidase activity. However, EPs® 7630 did not exhibit a direct virucidal effect, as virus preincubation (unlike cell preincubation) with the extract did not influence infectivity. Importantly, EPs® 7630 showed no propensity to resistance development in vitro. Analysis of EPs® 7630 constituents revealed that prodelphinidins represent the active principle. Chain length influenced antiviral activity, as monomers and dimers were less effective than oligo- and polymers. Importantly, gallocatechin and its stereoisomer epigallocatechin exert antiviral activity also in their monomeric form. In addition, EPs® 7630 administered by inhalation significantly improved survival, body weight and body temperature of influenza-infected mice, without obvious toxicity, demonstrating the benefit of EPs® 7630 in treatment of influenza.</s0>
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<s5>07</s5>
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<s5>07</s5>
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<s5>09</s5>
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<s5>10</s5>
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<s5>10</s5>
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<s5>11</s5>
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<s5>11</s5>
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<fC03 i1="11" i2="X" l="SPA"><s0>Antiviral</s0>
<s5>11</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Geraniaceae</s0>
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<s2>NS</s2>
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<fC07 i1="02" i2="X" l="FRE"><s0>Dicotyledones</s0>
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<s2>NS</s2>
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<fC07 i1="02" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Phénols</s0>
<s2>FX</s2>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Phenols</s0>
<s2>FX</s2>
<s5>37</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Fenoles</s0>
<s2>FX</s2>
<s5>37</s5>
</fC07>
<fN21><s1>296</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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   |texte=   EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo
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EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo

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