PandemieGrippaleV1, PascalFrancis, Corpus, bibRecord, 001B24

Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus

Identifieur interne : 001B24 ( PascalFrancis/Corpus ); précédent : 001B23; suivant : 001B25

Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus

Auteurs : Takeshi Ichinohe ; Noriyo Nagata ; Peter Strong ; Shin-Ichi Tamura ; Hidehiro Takahashi ; Ai Ninomiya ; Masaki Imai ; Takato Odagiri ; Masato Tashiro ; Hirofumi Sawa ; Joe Chiba ; Takeshi Kurata ; Tetsutaro Sata ; Hideki Hasegawa

Source :

Journal of medical virology [ 0146-6615 ] ; 2007.

RBID : Pascal:07-0263587

Descripteurs français

Pascal (Inist)
- Influenzavirus, Prévention, Pouvoir pathogène, Immunité naturelle, Grippe aviaire.

English descriptors

KwdEn :
- Avian influenza, Influenzavirus, Natural immunity, Pathogenicity, Prevention.

Abstract

Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-α. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactictreatmentwith chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A05				`@2 79`
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A08	`01`	`1`	`ENG`	`@1 Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus`
A11	`01`	`1`		`@1 ICHINOHE (Takeshi)`
A11	`02`	`1`		`@1 NAGATA (Noriyo)`
A11	`03`	`1`		`@1 STRONG (Peter)`
A11	`04`	`1`		`@1 TAMURA (Shin-Ichi)`
A11	`05`	`1`		`@1 TAKAHASHI (Hidehiro)`
A11	`06`	`1`		`@1 NINOMIYA (Ai)`
A11	`07`	`1`		`@1 IMAI (Masaki)`
A11	`08`	`1`		`@1 ODAGIRI (Takato)`
A11	`09`	`1`		`@1 TASHIRO (Masato)`
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A11	`11`	`1`		`@1 CHIBA (Joe)`
A11	`12`	`1`		`@1 KURATA (Takeshi)`
A11	`13`	`1`		`@1 SATA (Tetsutaro)`
A11	`14`	`1`		`@1 HASEGAWA (Hideki)`
A14	`01`			`@1 Department of Pathology, National Institute of Infectious Diseases, Gakuen @2 Musashimurayama-shi, Tokyo @3 JPN @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 5 aut. @Z 12 aut. @Z 13 aut. @Z 14 aut.`
A14	`02`			`@1 Department of Biological Science and Technology, Tokyo University of Science, Yamazaki @2 Noda, Chiba @3 JPN @Z 1 aut. @Z 11 aut.`
A14	`03`			`@1 CMP Therapeutics Ltd @2 Oxford @3 GBR @Z 3 aut.`
A14	`04`			`@1 Department of Virology III, National Institute of Infectious Diseases, Gakuen @2 Musashimurayama-shi, Tokyo @3 JPN @Z 6 aut. @Z 7 aut. @Z 8 aut. @Z 9 aut.`
A14	`05`			`@1 Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control @2 Kita-ku, Sapporo @3 JPN @Z 10 aut.`
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C01	`01`		`ENG`	@0 Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-α. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactictreatmentwith chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.
C02	`01`	`X`		`@0 002A05C10`
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C03	`04`	`X`	`FRE`	`@0 Immunité naturelle @5 07`
C03	`04`	`X`	`ENG`	`@0 Natural immunity @5 07`
C03	`04`	`X`	`SPA`	`@0 Inmunidad natural @5 07`
C03	`05`	`X`	`FRE`	`@0 Grippe aviaire @4 CD @5 96`
C03	`05`	`X`	`ENG`	`@0 Avian influenza @4 CD @5 96`
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C07	`01`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
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C07	`02`	`X`	`FRE`	`@0 Virus @2 NW`
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C07	`04`	`X`	`FRE`	`@0 Virose @5 16`
C07	`04`	`X`	`ENG`	`@0 Viral disease @5 16`
C07	`04`	`X`	`SPA`	`@0 Virosis @5 16`
N21				`@1 176`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0263587 INIST
ET :	Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus
AU :	ICHINOHE (Takeshi); NAGATA (Noriyo); STRONG (Peter); TAMURA (Shin-Ichi); TAKAHASHI (Hidehiro); NINOMIYA (Ai); IMAI (Masaki); ODAGIRI (Takato); TASHIRO (Masato); SAWA (Hirofumi); CHIBA (Joe); KURATA (Takeshi); SATA (Tetsutaro); HASEGAWA (Hideki)
AF :	Department of Pathology, National Institute of Infectious Diseases, Gakuen/Musashimurayama-shi, Tokyo/Japon (1 aut., 2 aut., 4 aut., 5 aut., 12 aut., 13 aut., 14 aut.); Department of Biological Science and Technology, Tokyo University of Science, Yamazaki/Noda, Chiba/Japon (1 aut., 11 aut.); CMP Therapeutics Ltd/Oxford/Royaume-Uni (3 aut.); Department of Virology III, National Institute of Infectious Diseases, Gakuen/Musashimurayama-shi, Tokyo/Japon (6 aut., 7 aut., 8 aut., 9 aut.); Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control/Kita-ku, Sapporo/Japon (10 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of medical virology; ISSN 0146-6615; Coden JMVIDB; Etats-Unis; Da. 2007; Vol. 79; No. 6; Pp. 811-819; Bibl. 3/4 p.
LA :	Anglais
EA :	Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-α. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactictreatmentwith chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.
CC :	002A05C10; 002B05C02J; 002A05C04
FD :	Influenzavirus; Prévention; Pouvoir pathogène; Immunité naturelle; Grippe aviaire
FG :	Orthomyxoviridae; Virus; Infection; Virose
ED :	Influenzavirus; Prevention; Pathogenicity; Natural immunity; Avian influenza
EG :	Orthomyxoviridae; Virus; Infection; Viral disease
SD :	Influenzavirus; Prevención; Poder patógeno; Inmunidad natural; Gripe aviar
LO :	INIST-17422.354000149577660210
ID :	07-0263587

Links to Exploration step

Pascal:07-0263587

Le document en format XML

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<author><name sortKey="Odagiri, Takato" sort="Odagiri, Takato" uniqKey="Odagiri T" first="Takato" last="Odagiri">Takato Odagiri</name>
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<author><name sortKey="Tashiro, Masato" sort="Tashiro, Masato" uniqKey="Tashiro M" first="Masato" last="Tashiro">Masato Tashiro</name>
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<author><name sortKey="Chiba, Joe" sort="Chiba, Joe" uniqKey="Chiba J" first="Joe" last="Chiba">Joe Chiba</name>
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<author><name sortKey="Hasegawa, Hideki" sort="Hasegawa, Hideki" uniqKey="Hasegawa H" first="Hideki" last="Hasegawa">Hideki Hasegawa</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, National Institute of Infectious Diseases, Gakuen</s1>
<s2>Musashimurayama-shi, Tokyo</s2>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus</title>
<author><name sortKey="Ichinohe, Takeshi" sort="Ichinohe, Takeshi" uniqKey="Ichinohe T" first="Takeshi" last="Ichinohe">Takeshi Ichinohe</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, National Institute of Infectious Diseases, Gakuen</s1>
<s2>Musashimurayama-shi, Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<affiliation><inist:fA14 i1="02"><s1>Department of Biological Science and Technology, Tokyo University of Science, Yamazaki</s1>
<s2>Noda, Chiba</s2>
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<sZ>1 aut.</sZ>
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<author><name sortKey="Nagata, Noriyo" sort="Nagata, Noriyo" uniqKey="Nagata N" first="Noriyo" last="Nagata">Noriyo Nagata</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, National Institute of Infectious Diseases, Gakuen</s1>
<s2>Musashimurayama-shi, Tokyo</s2>
<s3>JPN</s3>
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<author><name sortKey="Strong, Peter" sort="Strong, Peter" uniqKey="Strong P" first="Peter" last="Strong">Peter Strong</name>
<affiliation><inist:fA14 i1="03"><s1>CMP Therapeutics Ltd</s1>
<s2>Oxford</s2>
<s3>GBR</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tamura, Shin Ichi" sort="Tamura, Shin Ichi" uniqKey="Tamura S" first="Shin-Ichi" last="Tamura">Shin-Ichi Tamura</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, National Institute of Infectious Diseases, Gakuen</s1>
<s2>Musashimurayama-shi, Tokyo</s2>
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<author><name sortKey="Takahashi, Hidehiro" sort="Takahashi, Hidehiro" uniqKey="Takahashi H" first="Hidehiro" last="Takahashi">Hidehiro Takahashi</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Pathology, National Institute of Infectious Diseases, Gakuen</s1>
<s2>Musashimurayama-shi, Tokyo</s2>
<s3>JPN</s3>
<sZ>1 aut.</sZ>
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<author><name sortKey="Ninomiya, Ai" sort="Ninomiya, Ai" uniqKey="Ninomiya A" first="Ai" last="Ninomiya">Ai Ninomiya</name>
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<front><div type="abstract" xml:lang="en">Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-α. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactictreatmentwith chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.</div>
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<ET>Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus</ET>
<AU>ICHINOHE (Takeshi); NAGATA (Noriyo); STRONG (Peter); TAMURA (Shin-Ichi); TAKAHASHI (Hidehiro); NINOMIYA (Ai); IMAI (Masaki); ODAGIRI (Takato); TASHIRO (Masato); SAWA (Hirofumi); CHIBA (Joe); KURATA (Takeshi); SATA (Tetsutaro); HASEGAWA (Hideki)</AU>
<AF>Department of Pathology, National Institute of Infectious Diseases, Gakuen/Musashimurayama-shi, Tokyo/Japon (1 aut., 2 aut., 4 aut., 5 aut., 12 aut., 13 aut., 14 aut.); Department of Biological Science and Technology, Tokyo University of Science, Yamazaki/Noda, Chiba/Japon (1 aut., 11 aut.); CMP Therapeutics Ltd/Oxford/Royaume-Uni (3 aut.); Department of Virology III, National Institute of Infectious Diseases, Gakuen/Musashimurayama-shi, Tokyo/Japon (6 aut., 7 aut., 8 aut., 9 aut.); Department of Molecular Pathobiology, 21st Century COE Program for Zoonosis Control, Hokkaido University Research Center for Zoonosis Control/Kita-ku, Sapporo/Japon (10 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
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<EA>Highly pathogenic avian influenza virus (H5N1) is an emerging pathogen with the potential to cause great harm to humans, and there is concern about the potential for a new influenza pandemic. This virus is resistant to the antiviral effects of interferons and tumor necrosis factor-α. However, the mechanism of interferon-independent protective innate immunity is not well understood. The prophylactic effects of chitin microparticles as a stimulator of innate mucosal immunity against a recently obtained strain of H5N1 influenza virus infection were examined in mice. Clinical parameters and the survival rate of mice treated by intranasal application of chitin microparticles were significantly improved compared to non-treated mice after a lethal influenza virus challenge. Flow cytometric analysis revealed that the number of natural killer cells that expressed tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and that had migrated into the cervical lymph node was markedly increased (26-fold) after intranasal treatment with chitin microparticles. In addition, the level of IL-6 and interferon-gamma-inducible protein-10 (IP-10) in the nasal mucosa after H5N1 influenza virus challenge was decreased by prophylactictreatmentwith chitin microparticles. These results suggest that prophylactic intranasal administration of chitin microparticles enhanced the local accumulation of natural killer cells and suppressed hyper-induction of cytokines, resulting in an innate immune response to prevent pathogenesis of H5N1 influenza virus.</EA>
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Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus

Prophylactic effects of chitin microparticles on highly pathogenic H5N1 influenza virus

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