PandemieGrippaleV1, PascalFrancis, Corpus, bibRecord, 001228

Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy

Identifieur interne : 001228 ( PascalFrancis/Corpus ); précédent : 001227; suivant : 001229

Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy

Auteurs : Alberto Cagigi ; Anna Nilsson ; Simone Pensieroso ; Francesca Chiodi

Source :

Lancet. Infectious diseases : (print) [ 1473-3099 ] ; 2010.

RBID : Pascal:10-0325970

Descripteurs français

Pascal (Inist)
- SIDA, Grippe, Immunoprophylaxie, Chimiothérapie, Cellule β, Vaccination, Virus HIV1, Antiviral, Protocole HAART.

English descriptors

KwdEn :
- AIDS, Antiviral, Chemotherapy, HIV-1 virus, Immunoprophylaxis, Influenza, Vaccination, β Cell.

Abstract

Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`01`			`@1 Department of Laboratory Medicine, Karolinska Institutet @2 Stockholm @3 SWE @Z 1 aut.`
A14	`02`			`@1 Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet @2 Stockholm @3 SWE @Z 2 aut. @Z 3 aut. @Z 4 aut.`
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C07	`01`	`X`	`FRE`	`@0 Virose`
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C07	`03`	`X`	`ENG`	`@0 Treatment`
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C07	`10`	`X`	`FRE`	`@0 Prévention @5 40`
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C07	`10`	`X`	`SPA`	`@0 Prevención @5 40`
N21				`@1 207`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 10-0325970 INIST
ET :	Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy
AU :	CAGIGI (Alberto); NILSSON (Anna); PENSIEROSO (Simone); CHIODI (Francesca)
AF :	Department of Laboratory Medicine, Karolinska Institutet/Stockholm/Suède (1 aut.); Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet/Stockholm/Suède (2 aut., 3 aut., 4 aut.); Paediatric Infectious Diseases Unit, Department of Women and Child Health, Karolinska Institutet/Stockholm/Suède (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Lancet. Infectious diseases : (print); ISSN 1473-3099; Royaume-Uni; Da. 2010; Vol. 10; No. 7; Pp. 499-503; Bibl. 66 ref.
LA :	Anglais
EA :	Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV.
CC :	002B05C02D; 002B05C02C; 002B06D01
FD :	SIDA; Grippe; Immunoprophylaxie; Chimiothérapie; Cellule β; Vaccination; Virus HIV1; Antiviral; Protocole HAART
FG :	Virose; Infection; Traitement; Virus immunodéficience humaine; Lentivirus; Retroviridae; Virus; Immunodéficit; Immunopathologie; Prévention
ED :	AIDS; Influenza; Immunoprophylaxis; Chemotherapy; β Cell; Vaccination; HIV-1 virus; Antiviral
EG :	Viral disease; Infection; Treatment; Human immunodeficiency virus; Lentivirus; Retroviridae; Virus; Immune deficiency; Immunopathology; Prevention
SD :	SIDA; Gripe; Inmunoprofilaxia; Quimioterapia; Célula β; Vacunación; HIV-1 virus; Antiviral
LO :	INIST-27478.354000180746180060
ID :	10-0325970

Links to Exploration step

Pascal:10-0325970

Le document en format XML

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<front><div type="abstract" xml:lang="en">Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV.</div>
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<fC01 i1="01" l="ENG"><s0>Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV.</s0>
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<server><NO>PASCAL 10-0325970 INIST</NO>
<ET>Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy</ET>
<AU>CAGIGI (Alberto); NILSSON (Anna); PENSIEROSO (Simone); CHIODI (Francesca)</AU>
<AF>Department of Laboratory Medicine, Karolinska Institutet/Stockholm/Suède (1 aut.); Department of Microbiology, Tumour and Cell Biology, Karolinska Institutet/Stockholm/Suède (2 aut., 3 aut., 4 aut.); Paediatric Infectious Diseases Unit, Department of Women and Child Health, Karolinska Institutet/Stockholm/Suède (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Lancet. Infectious diseases : (print); ISSN 1473-3099; Royaume-Uni; Da. 2010; Vol. 10; No. 7; Pp. 499-503; Bibl. 66 ref.</SO>
<LA>Anglais</LA>
<EA>Although HIV-1 infection does not directly target B cells, B-cell numbers are reduced and their function is impaired during HIV infection. Antibody titres against antigens previously encountered through vaccination or natural infection are low in patients with HIV Intrinsic B-cell defects might be involved in the impairment of humoral immunity during early HIV infection. Abnormal T-cell activation and the altered expression of molecules involved in the B-cell homing process cause dysfunctional interaction between T and B cells in the germinal centres of lymphoid tissues, which might impair B-cell responses during HIV infection. Class-switch recombination is also impaired in individuals with HIV. Protective immune responses against T-cell-dependent antigens, including influenza antigens, rely on the production of neutralising antibodies. Impaired B-cell responses during HIV infection could therefore hamper the effectiveness of vaccinations against seasonal influenza or the new pandemic influenza A H1N1 vaccines in individuals with HIV. By maintaining B-cell responses, highly active antiretroviral therapy might improve the efficacy of influenza vaccines in individuals with HIV.</EA>
<CC>002B05C02D; 002B05C02C; 002B06D01</CC>
<FD>SIDA; Grippe; Immunoprophylaxie; Chimiothérapie; Cellule β; Vaccination; Virus HIV1; Antiviral; Protocole HAART</FD>
<FG>Virose; Infection; Traitement; Virus immunodéficience humaine; Lentivirus; Retroviridae; Virus; Immunodéficit; Immunopathologie; Prévention</FG>
<ED>AIDS; Influenza; Immunoprophylaxis; Chemotherapy; β Cell; Vaccination; HIV-1 virus; Antiviral</ED>
<EG>Viral disease; Infection; Treatment; Human immunodeficiency virus; Lentivirus; Retroviridae; Virus; Immune deficiency; Immunopathology; Prevention</EG>
<SD>SIDA; Gripe; Inmunoprofilaxia; Quimioterapia; Célula β; Vacunación; HIV-1 virus; Antiviral</SD>
<LO>INIST-27478.354000180746180060</LO>
<ID>10-0325970</ID>
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Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy

Dysfunctional B-cell responses during HIV-1 infection: implication for influenza vaccination and highly active antiretroviral therapy

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