Performance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virus
Identifieur interne : 000C33 ( PascalFrancis/Corpus ); précédent : 000C32; suivant : 000C34Performance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virus
Auteurs : Kuo-Chien Tsao ; Yung-Bin Kuo ; Chung-Guei Huang ; Shao-Wen Chau ; Err-Cheng ChanSource :
- Journal of virological methods [ 0166-0934 ] ; 2011.
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English descriptors
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Abstract
The early detection of pandemic influenza strains is a key factor for clinicians in treatment decisions and infection control practices. The aims of this study were to determine the analytical sensitivity and clinical performance of the commercially available influenza rapid tests in Taiwan. Four rapid tests for influenza virus (BinaxNow test, QuickVue test, TRU test, and Formosa Rapid test) were evaluated for their detection limit against four influenza viruses (the 2009 pandemic influenza A virus H1N1, seasonal influenza virus Hl1N1, H3N2, and influenza B virus) circulating in Taiwan. The viral load of these isolates were quantified by rtRT-PCR and then diluted 2-fold serially for the comparison. The lowest detectable viral load of the pandemic influenza A virus H1N1 by the Formosa Rapid test, QuickVue test, TRU test, and Binax Now test was 5.3 × 104, 1.0 × 105, 1.0 × 105, and 4.2 × 105 Copies/μL, respectively. Of these four tests, the two most sensitive tests (the QuickVue test and the Formosa Rapid test) were chosen to evaluate 62 nasopharyngeal specimens from patients who were suspected of infection with pandemic influenza A virus H1N1. The positive rate for the Formosa Rapid test and the QuickVue test were 53.2% (33/62) and 45.2% (28/62) (McNemar's test, P= 0.125), respectively. In conclusion, the Formosa Rapid test was the most sensitive test in the present study for the detection of influenza antigens and its clinical performance was similar to that of the QuickVue test (Kappa=0.776). This suggests that the Formosa Rapid test could be used to aid clinical decision making in primary health care settings during outbreaks of influenza.
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Format Inist (serveur)
| NO : | PASCAL 11-0261367 INIST |
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| ET : | Performance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virus |
| AU : | TSAO (Kuo-Chien); KUO (Yung-Bin); HUANG (Chung-Guei); CHAU (Shao-Wen); CHAN (Err-Cheng) |
| AF : | Department of Laboratory Medicine, Chang Gung Memorial Hospital/Taoyuan/Taïwan (1 aut., 3 aut.); Department of Medical Biotechnology and Laboratory Science, Chang Gung University/Taoyuan/Taïwan (1 aut., 2 aut., 3 aut., 5 aut.); Research Center for Emerging Viral Infections, Chang Gung University/Taoyuan/Taïwan (1 aut., 3 aut.); Department of Biological Science and Technology, National Chiao Tung University/Hsinchu/Taïwan (2 aut.); Department of Laboratory Medicine, Chang Gung Memorial Hospital/Keelung/Taïwan (4 aut.) |
| DT : | Publication en série; Courte communication, note brève; Niveau analytique |
| SO : | Journal of virological methods; ISSN 0166-0934; Coden JVMEDH; Royaume-Uni; Da. 2011; Vol. 173; No. 2; Pp. 387-389; Bibl. 1/4 p. |
| LA : | Anglais |
| EA : | The early detection of pandemic influenza strains is a key factor for clinicians in treatment decisions and infection control practices. The aims of this study were to determine the analytical sensitivity and clinical performance of the commercially available influenza rapid tests in Taiwan. Four rapid tests for influenza virus (BinaxNow test, QuickVue test, TRU test, and Formosa Rapid test) were evaluated for their detection limit against four influenza viruses (the 2009 pandemic influenza A virus H1N1, seasonal influenza virus Hl1N1, H3N2, and influenza B virus) circulating in Taiwan. The viral load of these isolates were quantified by rtRT-PCR and then diluted 2-fold serially for the comparison. The lowest detectable viral load of the pandemic influenza A virus H1N1 by the Formosa Rapid test, QuickVue test, TRU test, and Binax Now test was 5.3 × 104, 1.0 × 105, 1.0 × 105, and 4.2 × 105 Copies/μL, respectively. Of these four tests, the two most sensitive tests (the QuickVue test and the Formosa Rapid test) were chosen to evaluate 62 nasopharyngeal specimens from patients who were suspected of infection with pandemic influenza A virus H1N1. The positive rate for the Formosa Rapid test and the QuickVue test were 53.2% (33/62) and 45.2% (28/62) (McNemar's test, P= 0.125), respectively. In conclusion, the Formosa Rapid test was the most sensitive test in the present study for the detection of influenza antigens and its clinical performance was similar to that of the QuickVue test (Kappa=0.776). This suggests that the Formosa Rapid test could be used to aid clinical decision making in primary health care settings during outbreaks of influenza. |
| CC : | 002A05C09 |
| FD : | Technique rapide; Méthode; Grippe; Virus grippal A(H1N1) |
| FG : | Virose; Infection |
| ED : | Rapid technique; Method; Influenza; Influenzavirus A(H1N1) |
| EG : | Viral disease; Infection |
| SD : | Técnica rápida; Método; Gripe |
| LO : | INIST-18295.354000191579900340 |
| ID : | 11-0261367 |
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aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Research Center for Emerging Viral Infections, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kuo, Yung Bin" sort="Kuo, Yung Bin" uniqKey="Kuo Y" first="Yung-Bin" last="Kuo">Yung-Bin Kuo</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Biotechnology and Laboratory Science, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="04"><s1>Department of Biological Science and Technology, National Chiao Tung University</s1><s2>Hsinchu</s2><s3>TWN</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Huang, Chung Guei" sort="Huang, Chung Guei" uniqKey="Huang C" first="Chung-Guei" last="Huang">Chung-Guei Huang</name><affiliation><inist:fA14 i1="01"><s1>Department of Laboratory Medicine, Chang Gung Memorial Hospital</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Department of Medical Biotechnology and Laboratory Science, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Research Center for Emerging Viral Infections, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chau, Shao Wen" sort="Chau, Shao Wen" uniqKey="Chau S" first="Shao-Wen" last="Chau">Shao-Wen Chau</name><affiliation><inist:fA14 i1="05"><s1>Department of Laboratory Medicine, Chang Gung Memorial Hospital</s1><s2>Keelung</s2><s3>TWN</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chan, Err Cheng" sort="Chan, Err Cheng" uniqKey="Chan E" first="Err-Cheng" last="Chan">Err-Cheng Chan</name><affiliation><inist:fA14 i1="02"><s1>Department of Medical Biotechnology and Laboratory Science, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Journal of virological methods</title><title level="j" type="abbreviated">J. virol. methods</title><idno type="ISSN">0166-0934</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virological methods</title><title level="j" type="abbreviated">J. virol. methods</title><idno type="ISSN">0166-0934</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Influenza</term><term>Influenzavirus A(H1N1)</term><term>Method</term><term>Rapid technique</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Technique rapide</term><term>Méthode</term><term>Grippe</term><term>Virus grippal A(H1N1)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The early detection of pandemic influenza strains is a key factor for clinicians in treatment decisions and infection control practices. The aims of this study were to determine the analytical sensitivity and clinical performance of the commercially available influenza rapid tests in Taiwan. Four rapid tests for influenza virus (BinaxNow test, QuickVue test, TRU test, and Formosa Rapid test) were evaluated for their detection limit against four influenza viruses (the 2009 pandemic influenza A virus H1N1, seasonal influenza virus Hl1N1, H3N2, and influenza B virus) circulating in Taiwan. The viral load of these isolates were quantified by rtRT-PCR and then diluted 2-fold serially for the comparison. The lowest detectable viral load of the pandemic influenza A virus H1N1 by the Formosa Rapid test, QuickVue test, TRU test, and Binax Now test was 5.3 × 10<sup>4</sup>, 1.0 × 10<sup>5</sup>, 1.0 × 10<sup>5</sup>, and 4.2 × 10<sup>5</sup> Copies/μL, respectively. Of these four tests, the two most sensitive tests (the QuickVue test and the Formosa Rapid test) were chosen to evaluate 62 nasopharyngeal specimens from patients who were suspected of infection with pandemic influenza A virus H1N1. The positive rate for the Formosa Rapid test and the QuickVue test were 53.2% (33/62) and 45.2% (28/62) (McNemar's test, P<sub>=</sub> 0.125), respectively. In conclusion, the Formosa Rapid test was the most sensitive test in the present study for the detection of influenza antigens and its clinical performance was similar to that of the QuickVue test (Kappa=0.776). This suggests that the Formosa Rapid test could be used to aid clinical decision making in primary health care settings during outbreaks of influenza.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0166-0934</s0></fA01><fA02 i1="01"><s0>JVMEDH</s0></fA02><fA03 i2="1"><s0>J. virol. methods</s0></fA03><fA05><s2>173</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Performance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virus</s1></fA08><fA11 i1="01" i2="1"><s1>TSAO (Kuo-Chien)</s1></fA11><fA11 i1="02" i2="1"><s1>KUO (Yung-Bin)</s1></fA11><fA11 i1="03" i2="1"><s1>HUANG (Chung-Guei)</s1></fA11><fA11 i1="04" i2="1"><s1>CHAU (Shao-Wen)</s1></fA11><fA11 i1="05" i2="1"><s1>CHAN (Err-Cheng)</s1></fA11><fA14 i1="01"><s1>Department of Laboratory Medicine, Chang Gung Memorial Hospital</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Medical Biotechnology and Laboratory Science, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></fA14><fA14 i1="03"><s1>Research Center for Emerging Viral Infections, Chang Gung University</s1><s2>Taoyuan</s2><s3>TWN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Biological Science and Technology, National Chiao Tung University</s1><s2>Hsinchu</s2><s3>TWN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Laboratory Medicine, Chang Gung Memorial Hospital</s1><s2>Keelung</s2><s3>TWN</s3><sZ>4 aut.</sZ></fA14><fA20><s1>387-389</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18295</s2><s5>354000191579900340</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1/4 p.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0261367</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of virological methods</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>The early detection of pandemic influenza strains is a key factor for clinicians in treatment decisions and infection control practices. The aims of this study were to determine the analytical sensitivity and clinical performance of the commercially available influenza rapid tests in Taiwan. Four rapid tests for influenza virus (BinaxNow test, QuickVue test, TRU test, and Formosa Rapid test) were evaluated for their detection limit against four influenza viruses (the 2009 pandemic influenza A virus H1N1, seasonal influenza virus Hl1N1, H3N2, and influenza B virus) circulating in Taiwan. The viral load of these isolates were quantified by rtRT-PCR and then diluted 2-fold serially for the comparison. The lowest detectable viral load of the pandemic influenza A virus H1N1 by the Formosa Rapid test, QuickVue test, TRU test, and Binax Now test was 5.3 × 10<sup>4</sup>, 1.0 × 10<sup>5</sup>, 1.0 × 10<sup>5</sup>, and 4.2 × 10<sup>5</sup> Copies/μL, respectively. Of these four tests, the two most sensitive tests (the QuickVue test and the Formosa Rapid test) were chosen to evaluate 62 nasopharyngeal specimens from patients who were suspected of infection with pandemic influenza A virus H1N1. The positive rate for the Formosa Rapid test and the QuickVue test were 53.2% (33/62) and 45.2% (28/62) (McNemar's test, P<sub>=</sub> 0.125), respectively. In conclusion, the Formosa Rapid test was the most sensitive test in the present study for the detection of influenza antigens and its clinical performance was similar to that of the QuickVue test (Kappa=0.776). This suggests that the Formosa Rapid test could be used to aid clinical decision making in primary health care settings during outbreaks of influenza.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05C09</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Technique rapide</s0><s5>05</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Rapid technique</s0><s5>05</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Técnica rápida</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Méthode</s0><s5>06</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Method</s0><s5>06</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Método</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Grippe</s0><s5>14</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Influenza</s0><s5>14</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Gripe</s0><s5>14</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Virus grippal A(H1N1)</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Influenzavirus A(H1N1)</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fN21><s1>178</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 11-0261367 INIST</NO><ET>Performance of rapid-test kits for the detection of the pandemic influenza A/H1N1 virus</ET><AU>TSAO (Kuo-Chien); KUO (Yung-Bin); HUANG (Chung-Guei); CHAU (Shao-Wen); CHAN (Err-Cheng)</AU><AF>Department of Laboratory Medicine, Chang Gung Memorial Hospital/Taoyuan/Taïwan (1 aut., 3 aut.); Department of Medical Biotechnology and Laboratory Science, Chang Gung University/Taoyuan/Taïwan (1 aut., 2 aut., 3 aut., 5 aut.); Research Center for Emerging Viral Infections, Chang Gung University/Taoyuan/Taïwan (1 aut., 3 aut.); Department of Biological Science and Technology, National Chiao Tung University/Hsinchu/Taïwan (2 aut.); Department of Laboratory Medicine, Chang Gung Memorial Hospital/Keelung/Taïwan (4 aut.)</AF><DT>Publication en série; Courte communication, note brève; Niveau analytique</DT><SO>Journal of virological methods; ISSN 0166-0934; Coden JVMEDH; Royaume-Uni; Da. 2011; Vol. 173; No. 2; Pp. 387-389; Bibl. 1/4 p.</SO><LA>Anglais</LA><EA>The early detection of pandemic influenza strains is a key factor for clinicians in treatment decisions and infection control practices. The aims of this study were to determine the analytical sensitivity and clinical performance of the commercially available influenza rapid tests in Taiwan. Four rapid tests for influenza virus (BinaxNow test, QuickVue test, TRU test, and Formosa Rapid test) were evaluated for their detection limit against four influenza viruses (the 2009 pandemic influenza A virus H1N1, seasonal influenza virus Hl1N1, H3N2, and influenza B virus) circulating in Taiwan. The viral load of these isolates were quantified by rtRT-PCR and then diluted 2-fold serially for the comparison. The lowest detectable viral load of the pandemic influenza A virus H1N1 by the Formosa Rapid test, QuickVue test, TRU test, and Binax Now test was 5.3 × 10<sup>4</sup>, 1.0 × 10<sup>5</sup>, 1.0 × 10<sup>5</sup>, and 4.2 × 10<sup>5</sup> Copies/μL, respectively. Of these four tests, the two most sensitive tests (the QuickVue test and the Formosa Rapid test) were chosen to evaluate 62 nasopharyngeal specimens from patients who were suspected of infection with pandemic influenza A virus H1N1. The positive rate for the Formosa Rapid test and the QuickVue test were 53.2% (33/62) and 45.2% (28/62) (McNemar's test, P<sub>=</sub> 0.125), respectively. In conclusion, the Formosa Rapid test was the most sensitive test in the present study for the detection of influenza antigens and its clinical performance was similar to that of the QuickVue test (Kappa=0.776). This suggests that the Formosa Rapid test could be used to aid clinical decision making in primary health care settings during outbreaks of influenza.</EA><CC>002A05C09</CC><FD>Technique rapide; Méthode; Grippe; Virus grippal A(H1N1)</FD><FG>Virose; Infection</FG><ED>Rapid technique; Method; Influenza; Influenzavirus A(H1N1)</ED><EG>Viral disease; Infection</EG><SD>Técnica rápida; Método; Gripe</SD><LO>INIST-18295.354000191579900340</LO><ID>11-0261367</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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