Pathology and virology findings in cases of fatal influenza A H1 N1 virus infection in 2009-2010
Identifieur interne : 000811 ( PascalFrancis/Corpus ); précédent : 000810; suivant : 000812Pathology and virology findings in cases of fatal influenza A H1 N1 virus infection in 2009-2010
Auteurs : Amanjit Bal ; Vikas Suri ; Baijayantimala Mishra ; Ashish Bhalla ; Ritesh Agarwal ; Anil Abrol ; RADHA KANTA RATHO ; Kusum JoshiSource :
- Histopathology [ 0309-0167 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Aims: To describe the pathological findings, immunohistochemical localization of viral antigen and tissue reverse transcriptase polymerase chain reaction (RT-PCR) findings of different organs in cases of fatal H1N1 influenza virus infection from North India. Methods and results: Nine patients positive for H1N1 virus by a throat swab real-time RT-PCR (rRT-PCR) were included. Underlying risk factors included pregnancy, respiratory diseases, rheumatic heart disease, and chronic kidney disease. Pathological evidence of tracheitis, necrotizing bronchiolitis and diffuse alveolar damage was noted in all of the cases. Influenza viral antigen was observed by immunohistochemistry in the epithelium of the tracheobronchial tree, bronchial glands, gland ducts, and, less frequently, the alveolar epithelial cells. Viral particles were confirmed by electron microscopy in three autopsy cases. Tissue rRT-PCR for H1N1 viral RNA was positive in lung samples, but negative in other organs. Secondary bacterial pneumonia, cytomegalovirus infection and angio-invasive zygomycosis were detected. Conclusions: The pulmonary findings are similar to those described in past pandemics. Secondary fungal and viral infections, which have not been reported previously, were noted. Although the number of cases in this study is small, the findings reinforce the notion that changes in extrapulmonary organs are attributable to multiorgan dysfunction syndrome rather than a viral cytopathic effect, and that there is no transplacental transmission of virus.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 12-0062322 INIST |
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ET : | Pathology and virology findings in cases of fatal influenza A H1 N1 virus infection in 2009-2010 |
AU : | BAL (Amanjit); SURI (Vikas); MISHRA (Baijayantimala); BHALLA (Ashish); AGARWAL (Ritesh); ABROL (Anil); RADHA KANTA RATHO; JOSHI (Kusum) |
AF : | Department of Histopathology, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (1 aut., 8 aut.); Department of Internal Medicine, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (2 aut., 4 aut., 6 aut.); Department of Virology, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (3 aut., 7 aut.); Department of Pulmonary Medicine, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Histopathology; ISSN 0309-0167; Royaume-Uni; Da. 2012; Vol. 60; No. 2; Pp. 326-335; Bibl. 27 ref. |
LA : | Anglais |
EA : | Aims: To describe the pathological findings, immunohistochemical localization of viral antigen and tissue reverse transcriptase polymerase chain reaction (RT-PCR) findings of different organs in cases of fatal H1N1 influenza virus infection from North India. Methods and results: Nine patients positive for H1N1 virus by a throat swab real-time RT-PCR (rRT-PCR) were included. Underlying risk factors included pregnancy, respiratory diseases, rheumatic heart disease, and chronic kidney disease. Pathological evidence of tracheitis, necrotizing bronchiolitis and diffuse alveolar damage was noted in all of the cases. Influenza viral antigen was observed by immunohistochemistry in the epithelium of the tracheobronchial tree, bronchial glands, gland ducts, and, less frequently, the alveolar epithelial cells. Viral particles were confirmed by electron microscopy in three autopsy cases. Tissue rRT-PCR for H1N1 viral RNA was positive in lung samples, but negative in other organs. Secondary bacterial pneumonia, cytomegalovirus infection and angio-invasive zygomycosis were detected. Conclusions: The pulmonary findings are similar to those described in past pandemics. Secondary fungal and viral infections, which have not been reported previously, were noted. Although the number of cases in this study is small, the findings reinforce the notion that changes in extrapulmonary organs are attributable to multiorgan dysfunction syndrome rather than a viral cytopathic effect, and that there is no transplacental transmission of virus. |
CC : | 002B24O; 002B05C02C; 002B11B |
FD : | Anatomopathologie; Virologie; Virus grippal A; Virose; Grippe A; Diffus; Bronchiolite; Lésion; Multiple; Trouble fonctionnel |
FG : | Influenzavirus A; Orthomyxoviridae; Virus; Infection; Pathologie de l'appareil respiratoire; Pathologie des bronches |
ED : | Anatomic pathology; Virology; Influenza A virus; Viral disease; Influenza A; Diffuse; Bronchiolitis; Lesion; Multiple; Dysfunction |
EG : | Influenzavirus A; Orthomyxoviridae; Virus; Infection; Respiratory disease; Bronchus disease |
SD : | Anatomía patológica; Virología; Influenza A virus; Virosis; Gripe A; Difuso; Bronquiolitis; Lesión; Múltiple; Trastorno funcional |
LO : | INIST-17811.354000508629950100 |
ID : | 12-0062322 |
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Pascal:12-0062322Le document en format XML
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<front><div type="abstract" xml:lang="en">Aims: To describe the pathological findings, immunohistochemical localization of viral antigen and tissue reverse transcriptase polymerase chain reaction (RT-PCR) findings of different organs in cases of fatal H1N1 influenza virus infection from North India. Methods and results: Nine patients positive for H1N1 virus by a throat swab real-time RT-PCR (rRT-PCR) were included. Underlying risk factors included pregnancy, respiratory diseases, rheumatic heart disease, and chronic kidney disease. Pathological evidence of tracheitis, necrotizing bronchiolitis and diffuse alveolar damage was noted in all of the cases. Influenza viral antigen was observed by immunohistochemistry in the epithelium of the tracheobronchial tree, bronchial glands, gland ducts, and, less frequently, the alveolar epithelial cells. Viral particles were confirmed by electron microscopy in three autopsy cases. Tissue rRT-PCR for H1N1 viral RNA was positive in lung samples, but negative in other organs. Secondary bacterial pneumonia, cytomegalovirus infection and angio-invasive zygomycosis were detected. Conclusions: The pulmonary findings are similar to those described in past pandemics. Secondary fungal and viral infections, which have not been reported previously, were noted. Although the number of cases in this study is small, the findings reinforce the notion that changes in extrapulmonary organs are attributable to multiorgan dysfunction syndrome rather than a viral cytopathic effect, and that there is no transplacental transmission of virus.</div>
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<fC03 i1="09" i2="X" l="ENG"><s0>Multiple</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Múltiple</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Trouble fonctionnel</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Dysfunction</s0>
<s5>11</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Trastorno funcional</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Respiratory disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie des bronches</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Bronchus disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Bronquio patología</s0>
<s5>38</s5>
</fC07>
<fN21><s1>044</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0062322 INIST</NO>
<ET>Pathology and virology findings in cases of fatal influenza A H1 N1 virus infection in 2009-2010</ET>
<AU>BAL (Amanjit); SURI (Vikas); MISHRA (Baijayantimala); BHALLA (Ashish); AGARWAL (Ritesh); ABROL (Anil); RADHA KANTA RATHO; JOSHI (Kusum)</AU>
<AF>Department of Histopathology, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (1 aut., 8 aut.); Department of Internal Medicine, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (2 aut., 4 aut., 6 aut.); Department of Virology, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (3 aut., 7 aut.); Department of Pulmonary Medicine, Post Graduate Institute of Medical Science & Research (PGIMER), Sector 12/Chandigarh/Inde (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Histopathology; ISSN 0309-0167; Royaume-Uni; Da. 2012; Vol. 60; No. 2; Pp. 326-335; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>Aims: To describe the pathological findings, immunohistochemical localization of viral antigen and tissue reverse transcriptase polymerase chain reaction (RT-PCR) findings of different organs in cases of fatal H1N1 influenza virus infection from North India. Methods and results: Nine patients positive for H1N1 virus by a throat swab real-time RT-PCR (rRT-PCR) were included. Underlying risk factors included pregnancy, respiratory diseases, rheumatic heart disease, and chronic kidney disease. Pathological evidence of tracheitis, necrotizing bronchiolitis and diffuse alveolar damage was noted in all of the cases. Influenza viral antigen was observed by immunohistochemistry in the epithelium of the tracheobronchial tree, bronchial glands, gland ducts, and, less frequently, the alveolar epithelial cells. Viral particles were confirmed by electron microscopy in three autopsy cases. Tissue rRT-PCR for H1N1 viral RNA was positive in lung samples, but negative in other organs. Secondary bacterial pneumonia, cytomegalovirus infection and angio-invasive zygomycosis were detected. Conclusions: The pulmonary findings are similar to those described in past pandemics. Secondary fungal and viral infections, which have not been reported previously, were noted. Although the number of cases in this study is small, the findings reinforce the notion that changes in extrapulmonary organs are attributable to multiorgan dysfunction syndrome rather than a viral cytopathic effect, and that there is no transplacental transmission of virus.</EA>
<CC>002B24O; 002B05C02C; 002B11B</CC>
<FD>Anatomopathologie; Virologie; Virus grippal A; Virose; Grippe A; Diffus; Bronchiolite; Lésion; Multiple; Trouble fonctionnel</FD>
<FG>Influenzavirus A; Orthomyxoviridae; Virus; Infection; Pathologie de l'appareil respiratoire; Pathologie des bronches</FG>
<ED>Anatomic pathology; Virology; Influenza A virus; Viral disease; Influenza A; Diffuse; Bronchiolitis; Lesion; Multiple; Dysfunction</ED>
<EG>Influenzavirus A; Orthomyxoviridae; Virus; Infection; Respiratory disease; Bronchus disease</EG>
<SD>Anatomía patológica; Virología; Influenza A virus; Virosis; Gripe A; Difuso; Bronquiolitis; Lesión; Múltiple; Trastorno funcional</SD>
<LO>INIST-17811.354000508629950100</LO>
<ID>12-0062322</ID>
</server>
</inist>
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