PandemieGrippaleV1, PascalFrancis, Corpus, bibRecord, 000670

Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses

Identifieur interne : 000670 ( PascalFrancis/Corpus ); précédent : 000669; suivant : 000671

Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses

Auteurs : YO HAN JANG ; YOUNG HO BYUN ; YOON JAE LEE ; YUN HA LEE ; Kwang-Hee Lee ; BAIK LIN SEONG

Source :

Journal of virology [ 0022-538X ] ; 2012.

RBID : Pascal:12-0207200

Descripteurs français

Pascal (Inist)
- Virus grippal A, Vaccin, Protection croisée.

English descriptors

KwdEn :
- Cross protection, Influenza A virus, Vaccine.

Abstract

The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 J. virol.`
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A06				`@2 10`
A08	`01`	`1`	`ENG`	`@1 Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses`
A11	`01`	`1`		`@1 YO HAN JANG`
A11	`02`	`1`		`@1 YOUNG HO BYUN`
A11	`03`	`1`		`@1 YOON JAE LEE`
A11	`04`	`1`		`@1 YUN HA LEE`
A11	`05`	`1`		`@1 LEE (Kwang-Hee)`
A11	`06`	`1`		`@1 BAIK LIN SEONG`
A14	`01`			`@1 Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University @2 Seoul @3 KOR @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A20				`@1 5953-5958`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13592 @5 354000509296790540`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 44 ref.`
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A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Journal of virology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.
C02	`01`	`X`		`@0 002A05C10`
C02	`02`	`X`		`@0 002A05C07`
C03	`01`	`X`	`FRE`	`@0 Virus grippal A @2 NW @5 01`
C03	`01`	`X`	`ENG`	`@0 Influenza A virus @2 NW @5 01`
C03	`01`	`X`	`SPA`	`@0 Influenza A virus @2 NW @5 01`
C03	`02`	`X`	`FRE`	`@0 Vaccin @5 05`
C03	`02`	`X`	`ENG`	`@0 Vaccine @5 05`
C03	`02`	`X`	`SPA`	`@0 Vacuna @5 05`
C03	`03`	`X`	`FRE`	`@0 Protection croisée @5 06`
C03	`03`	`X`	`ENG`	`@0 Cross protection @5 06`
C03	`03`	`X`	`SPA`	`@0 Protección cruzada @5 06`
C07	`01`	`X`	`FRE`	`@0 Influenzavirus A @2 NW`
C07	`01`	`X`	`ENG`	`@0 Influenzavirus A @2 NW`
C07	`01`	`X`	`SPA`	`@0 Influenzavirus A @2 NW`
C07	`02`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
N21				`@1 163`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0207200 INIST
ET :	Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses
AU :	YO HAN JANG; YOUNG HO BYUN; YOON JAE LEE; YUN HA LEE; LEE (Kwang-Hee); BAIK LIN SEONG
AF :	Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University/Seoul/Corée, République de (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2012; Vol. 86; No. 10; Pp. 5953-5958; Bibl. 44 ref.
LA :	Anglais
EA :	The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.
CC :	002A05C10; 002A05C07
FD :	Virus grippal A; Vaccin; Protection croisée
FG :	Influenzavirus A; Orthomyxoviridae; Virus
ED :	Influenza A virus; Vaccine; Cross protection
EG :	Influenzavirus A; Orthomyxoviridae; Virus
SD :	Influenza A virus; Vacuna; Protección cruzada
LO :	INIST-13592.354000509296790540
ID :	12-0207200

Links to Exploration step

Pascal:12-0207200

Le document en format XML

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<front><div type="abstract" xml:lang="en">The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.</div>
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<fC01 i1="01" l="ENG"><s0>The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.</s0>
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<server><NO>PASCAL 12-0207200 INIST</NO>
<ET>Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses</ET>
<AU>YO HAN JANG; YOUNG HO BYUN; YOON JAE LEE; YUN HA LEE; LEE (Kwang-Hee); BAIK LIN SEONG</AU>
<AF>Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University/Seoul/Corée, République de (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Journal of virology; ISSN 0022-538X; Etats-Unis; Da. 2012; Vol. 86; No. 10; Pp. 5953-5958; Bibl. 44 ref.</SO>
<LA>Anglais</LA>
<EA>The rapid transmission of the pandemic 2009 H1N1 influenza virus (pH1N1) among humans has raised the concern of a potential emergence of reassortment between pH1N1 and highly pathogenic influenza strains, especially the avian H5N1 influenza virus. Here, we report that the cold-adapted pH1N1 live attenuated vaccine (CApH1N1) elicits cross-reactive immunity to seasonal and H5 influenza A viruses in the mouse model. Immunization with CApH1N1 induced both systemic and mucosal antibodies with broad reactivity to seasonal and H5 strains, including HAPI H5N1 and the avian H5N2 virus, providing complete protection against heterologous and heterosubtypic lethal challenges. Our results not only accentuate the merit of using live attenuated influenza virus vaccines in view of cross-reactivity but also represent the potential of CApH1N1 live vaccine for mitigating the clinical severity of infections that arise from reassortments between pH1N1 and highly pathogenic H5 subtype viruses.</EA>
<CC>002A05C10; 002A05C07</CC>
<FD>Virus grippal A; Vaccin; Protection croisée</FD>
<FG>Influenzavirus A; Orthomyxoviridae; Virus</FG>
<ED>Influenza A virus; Vaccine; Cross protection</ED>
<EG>Influenzavirus A; Orthomyxoviridae; Virus</EG>
<SD>Influenza A virus; Vacuna; Protección cruzada</SD>
<LO>INIST-13592.354000509296790540</LO>
<ID>12-0207200</ID>
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</inist>
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Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses

Cold-Adapted Pandemic 2009 H1N1 Influenza Virus Live Vaccine Elicits Cross-Reactive Immune Responses against Seasonal and H5 Influenza A Viruses

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