Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations
Identifieur interne : 000524 ( PascalFrancis/Corpus ); précédent : 000523; suivant : 000525Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations
Auteurs : Sharon E. Frey ; David I. Bernstein ; Michael A. Gerber ; Harry L. Keyserling ; Flor M. Munoz ; Patricia L. Winokur ; Christine B. Turley ; Richard E. Rupp ; Heather Hill ; Mark Wolff ; Diana L. Noah ; Allison C. Ross ; Gretchen Cress ; Robert B. BelsheSource :
- The Journal of infectious diseases [ 0022-1899 ] ; 2012.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 12-0371849 INIST |
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ET : | Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations |
AU : | FREY (Sharon E.); BERNSTEIN (David I.); GERBER (Michael A.); KEYSERLING (Harry L.); MUNOZ (Flor M.); WINOKUR (Patricia L.); TURLEY (Christine B.); RUPP (Richard E.); HILL (Heather); WOLFF (Mark); NOAH (Diana L.); ROSS (Allison C.); CRESS (Gretchen); BELSHE (Robert B.) |
AF : | Saint Louis University School of Medicine/Missouri/Etats-Unis (1 aut., 14 aut.); Cincinnati Children's Hospital Medical Center/Ohio/Etats-Unis (2 aut., 3 aut.); Emory University School of Medicine and Children's Healthcare of Atlanta/Géorgie (4 aut., 12 aut.); Baylor College of Medicine/Houston, Texas/Etats-Unis (5 aut.); University of Iowa, Carver College of Medicine/Iowa City/Etats-Unis (6 aut., 13 aut.); University of Texas Medical Branch-Galveston/Etats-Unis (7 aut., 8 aut.); The EMMES Corporation/Rockville, Maryland/Etats-Unis (9 aut., 10 aut.); Southern Research Institute/Birmingham, Alabama/Etats-Unis (11 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Royaume-Uni; Da. 2012; Vol. 206; No. 6; Pp. 828-837; Bibl. 24 ref. |
LA : | Anglais |
EA : | Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age. |
CC : | 002A05; 002B05 |
FD : | Réponse immune; Enfant; Vaccination; Infection; Grippe; Virus grippal A(H1N1) |
FG : | Homme; Virose |
ED : | Immune response; Child; Vaccination; Infection; Influenza; Influenzavirus A(H1N1) |
EG : | Human; Viral disease |
SD : | Respuesta inmune; Niño; Vacunación; Infección; Gripe |
LO : | INIST-2052.354000509502200060 |
ID : | 12-0371849 |
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Pascal:12-0371849Le document en format XML
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<series><title level="j" type="main">The Journal of infectious diseases</title>
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<term>Vaccination</term>
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<front><div type="abstract" xml:lang="en">Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.</div>
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<fC01 i1="01" l="ENG"><s0>Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Réponse immune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Immune response</s0>
<s5>05</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Respuesta inmune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Enfant</s0>
<s5>06</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Child</s0>
<s5>06</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Niño</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Vaccination</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Vaccination</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Vacunación</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Infection</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Infection</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Infección</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Grippe</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Influenza</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Gripe</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Virus grippal A(H1N1)</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Influenzavirus A(H1N1)</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fN21><s1>289</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0371849 INIST</NO>
<ET>Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations</ET>
<AU>FREY (Sharon E.); BERNSTEIN (David I.); GERBER (Michael A.); KEYSERLING (Harry L.); MUNOZ (Flor M.); WINOKUR (Patricia L.); TURLEY (Christine B.); RUPP (Richard E.); HILL (Heather); WOLFF (Mark); NOAH (Diana L.); ROSS (Allison C.); CRESS (Gretchen); BELSHE (Robert B.)</AU>
<AF>Saint Louis University School of Medicine/Missouri/Etats-Unis (1 aut., 14 aut.); Cincinnati Children's Hospital Medical Center/Ohio/Etats-Unis (2 aut., 3 aut.); Emory University School of Medicine and Children's Healthcare of Atlanta/Géorgie (4 aut., 12 aut.); Baylor College of Medicine/Houston, Texas/Etats-Unis (5 aut.); University of Iowa, Carver College of Medicine/Iowa City/Etats-Unis (6 aut., 13 aut.); University of Texas Medical Branch-Galveston/Etats-Unis (7 aut., 8 aut.); The EMMES Corporation/Rockville, Maryland/Etats-Unis (9 aut., 10 aut.); Southern Research Institute/Birmingham, Alabama/Etats-Unis (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Royaume-Uni; Da. 2012; Vol. 206; No. 6; Pp. 828-837; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.</EA>
<CC>002A05; 002B05</CC>
<FD>Réponse immune; Enfant; Vaccination; Infection; Grippe; Virus grippal A(H1N1)</FD>
<FG>Homme; Virose</FG>
<ED>Immune response; Child; Vaccination; Infection; Influenza; Influenzavirus A(H1N1)</ED>
<EG>Human; Viral disease</EG>
<SD>Respuesta inmune; Niño; Vacunación; Infección; Gripe</SD>
<LO>INIST-2052.354000509502200060</LO>
<ID>12-0371849</ID>
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