PandemieGrippaleV1, PascalFrancis, Corpus, bibRecord, 000524

Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations

Identifieur interne : 000524 ( PascalFrancis/Corpus ); précédent : 000523; suivant : 000525

Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations

Auteurs : Sharon E. Frey ; David I. Bernstein ; Michael A. Gerber ; Harry L. Keyserling ; Flor M. Munoz ; Patricia L. Winokur ; Christine B. Turley ; Richard E. Rupp ; Heather Hill ; Mark Wolff ; Diana L. Noah ; Allison C. Ross ; Gretchen Cress ; Robert B. Belshe

Source :

The Journal of infectious diseases [ 0022-1899 ] ; 2012.

RBID : Pascal:12-0371849

Descripteurs français

Pascal (Inist)
- Réponse immune, Enfant, Vaccination, Infection, Grippe, Virus grippal A(H1N1).

English descriptors

KwdEn :
- Child, Immune response, Infection, Influenza, Influenzavirus A(H1N1), Vaccination.

Abstract

Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0022-1899`
A02	`01`			`@0 JIDIAQ`
A03		`1`		`@0 J. infect. dis.`
A05				`@2 206`
A06				`@2 6`
A08	`01`	`1`	`ENG`	`@1 Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations`
A11	`01`	`1`		`@1 FREY (Sharon E.)`
A11	`02`	`1`		`@1 BERNSTEIN (David I.)`
A11	`03`	`1`		`@1 GERBER (Michael A.)`
A11	`04`	`1`		`@1 KEYSERLING (Harry L.)`
A11	`05`	`1`		`@1 MUNOZ (Flor M.)`
A11	`06`	`1`		`@1 WINOKUR (Patricia L.)`
A11	`07`	`1`		`@1 TURLEY (Christine B.)`
A11	`08`	`1`		`@1 RUPP (Richard E.)`
A11	`09`	`1`		`@1 HILL (Heather)`
A11	`10`	`1`		`@1 WOLFF (Mark)`
A11	`11`	`1`		`@1 NOAH (Diana L.)`
A11	`12`	`1`		`@1 ROSS (Allison C.)`
A11	`13`	`1`		`@1 CRESS (Gretchen)`
A11	`14`	`1`		`@1 BELSHE (Robert B.)`
A14	`01`			`@1 Saint Louis University School of Medicine @2 Missouri @3 USA @Z 1 aut. @Z 14 aut.`
A14	`02`			`@1 Cincinnati Children's Hospital Medical Center @2 Ohio @3 USA @Z 2 aut. @Z 3 aut.`
A14	`03`			`@1 Emory University School of Medicine and Children's Healthcare of Atlanta @3 GEO @Z 4 aut. @Z 12 aut.`
A14	`04`			`@1 Baylor College of Medicine @2 Houston, Texas @3 USA @Z 5 aut.`
A14	`05`			`@1 University of Iowa, Carver College of Medicine @2 Iowa City @3 USA @Z 6 aut. @Z 13 aut.`
A14	`06`			`@1 University of Texas Medical Branch-Galveston @3 USA @Z 7 aut. @Z 8 aut.`
A14	`07`			`@1 The EMMES Corporation @2 Rockville, Maryland @3 USA @Z 9 aut. @Z 10 aut.`
A14	`08`			`@1 Southern Research Institute @2 Birmingham, Alabama @3 USA @Z 11 aut.`
A20				`@1 828-837`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 2052 @5 354000509502200060`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 24 ref.`
A47	`01`	`1`		`@0 12-0371849`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 The Journal of infectious diseases`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.
C02	`01`	`X`		`@0 002A05`
C02	`02`	`X`		`@0 002B05`
C03	`01`	`X`	`FRE`	`@0 Réponse immune @5 05`
C03	`01`	`X`	`ENG`	`@0 Immune response @5 05`
C03	`01`	`X`	`SPA`	`@0 Respuesta inmune @5 05`
C03	`02`	`X`	`FRE`	`@0 Enfant @5 06`
C03	`02`	`X`	`ENG`	`@0 Child @5 06`
C03	`02`	`X`	`SPA`	`@0 Niño @5 06`
C03	`03`	`X`	`FRE`	`@0 Vaccination @5 07`
C03	`03`	`X`	`ENG`	`@0 Vaccination @5 07`
C03	`03`	`X`	`SPA`	`@0 Vacunación @5 07`
C03	`04`	`X`	`FRE`	`@0 Infection @5 08`
C03	`04`	`X`	`ENG`	`@0 Infection @5 08`
C03	`04`	`X`	`SPA`	`@0 Infección @5 08`
C03	`05`	`X`	`FRE`	`@0 Grippe @5 14`
C03	`05`	`X`	`ENG`	`@0 Influenza @5 14`
C03	`05`	`X`	`SPA`	`@0 Gripe @5 14`
C03	`06`	`X`	`FRE`	`@0 Virus grippal A(H1N1) @4 CD @5 96`
C03	`06`	`X`	`ENG`	`@0 Influenzavirus A(H1N1) @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Homme`
C07	`01`	`X`	`ENG`	`@0 Human`
C07	`01`	`X`	`SPA`	`@0 Hombre`
C07	`02`	`X`	`FRE`	`@0 Virose`
C07	`02`	`X`	`ENG`	`@0 Viral disease`
C07	`02`	`X`	`SPA`	`@0 Virosis`
N21				`@1 289`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 12-0371849 INIST
ET :	Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations
AU :	FREY (Sharon E.); BERNSTEIN (David I.); GERBER (Michael A.); KEYSERLING (Harry L.); MUNOZ (Flor M.); WINOKUR (Patricia L.); TURLEY (Christine B.); RUPP (Richard E.); HILL (Heather); WOLFF (Mark); NOAH (Diana L.); ROSS (Allison C.); CRESS (Gretchen); BELSHE (Robert B.)
AF :	Saint Louis University School of Medicine/Missouri/Etats-Unis (1 aut., 14 aut.); Cincinnati Children's Hospital Medical Center/Ohio/Etats-Unis (2 aut., 3 aut.); Emory University School of Medicine and Children's Healthcare of Atlanta/Géorgie (4 aut., 12 aut.); Baylor College of Medicine/Houston, Texas/Etats-Unis (5 aut.); University of Iowa, Carver College of Medicine/Iowa City/Etats-Unis (6 aut., 13 aut.); University of Texas Medical Branch-Galveston/Etats-Unis (7 aut., 8 aut.); The EMMES Corporation/Rockville, Maryland/Etats-Unis (9 aut., 10 aut.); Southern Research Institute/Birmingham, Alabama/Etats-Unis (11 aut.)
DT :	Publication en série; Niveau analytique
SO :	The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Royaume-Uni; Da. 2012; Vol. 206; No. 6; Pp. 828-837; Bibl. 24 ref.
LA :	Anglais
EA :	Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.
CC :	002A05; 002B05
FD :	Réponse immune; Enfant; Vaccination; Infection; Grippe; Virus grippal A(H1N1)
FG :	Homme; Virose
ED :	Immune response; Child; Vaccination; Infection; Influenza; Influenzavirus A(H1N1)
EG :	Human; Viral disease
SD :	Respuesta inmune; Niño; Vacunación; Infección; Gripe
LO :	INIST-2052.354000509502200060
ID :	12-0371849

Links to Exploration step

Pascal:12-0371849

Le document en format XML

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<author><name sortKey="Noah, Diana L" sort="Noah, Diana L" uniqKey="Noah D" first="Diana L." last="Noah">Diana L. Noah</name>
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<author><name sortKey="Ross, Allison C" sort="Ross, Allison C" uniqKey="Ross A" first="Allison C." last="Ross">Allison C. Ross</name>
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<author><name sortKey="Cress, Gretchen" sort="Cress, Gretchen" uniqKey="Cress G" first="Gretchen" last="Cress">Gretchen Cress</name>
<affiliation><inist:fA14 i1="05"><s1>University of Iowa, Carver College of Medicine</s1>
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<author><name sortKey="Belshe, Robert B" sort="Belshe, Robert B" uniqKey="Belshe R" first="Robert B." last="Belshe">Robert B. Belshe</name>
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<s3>USA</s3>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations</title>
<author><name sortKey="Frey, Sharon E" sort="Frey, Sharon E" uniqKey="Frey S" first="Sharon E." last="Frey">Sharon E. Frey</name>
<affiliation><inist:fA14 i1="01"><s1>Saint Louis University School of Medicine</s1>
<s2>Missouri</s2>
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<author><name sortKey="Gerber, Michael A" sort="Gerber, Michael A" uniqKey="Gerber M" first="Michael A." last="Gerber">Michael A. Gerber</name>
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<author><name sortKey="Keyserling, Harry L" sort="Keyserling, Harry L" uniqKey="Keyserling H" first="Harry L." last="Keyserling">Harry L. Keyserling</name>
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<author><name sortKey="Munoz, Flor M" sort="Munoz, Flor M" uniqKey="Munoz F" first="Flor M." last="Munoz">Flor M. Munoz</name>
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<author><name sortKey="Winokur, Patricia L" sort="Winokur, Patricia L" uniqKey="Winokur P" first="Patricia L." last="Winokur">Patricia L. Winokur</name>
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<s2>Iowa City</s2>
<s3>USA</s3>
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</inist:fA14>
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<author><name sortKey="Turley, Christine B" sort="Turley, Christine B" uniqKey="Turley C" first="Christine B." last="Turley">Christine B. Turley</name>
<affiliation><inist:fA14 i1="06"><s1>University of Texas Medical Branch-Galveston</s1>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Rupp, Richard E" sort="Rupp, Richard E" uniqKey="Rupp R" first="Richard E." last="Rupp">Richard E. Rupp</name>
<affiliation><inist:fA14 i1="06"><s1>University of Texas Medical Branch-Galveston</s1>
<s3>USA</s3>
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<author><name sortKey="Wolff, Mark" sort="Wolff, Mark" uniqKey="Wolff M" first="Mark" last="Wolff">Mark Wolff</name>
<affiliation><inist:fA14 i1="07"><s1>The EMMES Corporation</s1>
<s2>Rockville, Maryland</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
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<author><name sortKey="Noah, Diana L" sort="Noah, Diana L" uniqKey="Noah D" first="Diana L." last="Noah">Diana L. Noah</name>
<affiliation><inist:fA14 i1="08"><s1>Southern Research Institute</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
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</inist:fA14>
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</author>
<author><name sortKey="Ross, Allison C" sort="Ross, Allison C" uniqKey="Ross A" first="Allison C." last="Ross">Allison C. Ross</name>
<affiliation><inist:fA14 i1="03"><s1>Emory University School of Medicine and Children's Healthcare of Atlanta</s1>
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<sZ>12 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cress, Gretchen" sort="Cress, Gretchen" uniqKey="Cress G" first="Gretchen" last="Cress">Gretchen Cress</name>
<affiliation><inist:fA14 i1="05"><s1>University of Iowa, Carver College of Medicine</s1>
<s2>Iowa City</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Belshe, Robert B" sort="Belshe, Robert B" uniqKey="Belshe R" first="Robert B." last="Belshe">Robert B. Belshe</name>
<affiliation><inist:fA14 i1="01"><s1>Saint Louis University School of Medicine</s1>
<s2>Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2012">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term>
<term>Immune response</term>
<term>Infection</term>
<term>Influenza</term>
<term>Influenzavirus A(H1N1)</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Réponse immune</term>
<term>Enfant</term>
<term>Vaccination</term>
<term>Infection</term>
<term>Grippe</term>
<term>Virus grippal A(H1N1)</term>
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<front><div type="abstract" xml:lang="en">Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.</div>
</front>
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<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0>
</fA01>
<fA02 i1="01"><s0>JIDIAQ</s0>
</fA02>
<fA03 i2="1"><s0>J. infect. dis.</s0>
</fA03>
<fA05><s2>206</s2>
</fA05>
<fA06><s2>6</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>FREY (Sharon E.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>BERNSTEIN (David I.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>GERBER (Michael A.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>KEYSERLING (Harry L.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>MUNOZ (Flor M.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>WINOKUR (Patricia L.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>TURLEY (Christine B.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>RUPP (Richard E.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>HILL (Heather)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>WOLFF (Mark)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>NOAH (Diana L.)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>ROSS (Allison C.)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>CRESS (Gretchen)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>BELSHE (Robert B.)</s1>
</fA11>
<fA14 i1="01"><s1>Saint Louis University School of Medicine</s1>
<s2>Missouri</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>14 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Cincinnati Children's Hospital Medical Center</s1>
<s2>Ohio</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Emory University School of Medicine and Children's Healthcare of Atlanta</s1>
<s3>GEO</s3>
<sZ>4 aut.</sZ>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>University of Iowa, Carver College of Medicine</s1>
<s2>Iowa City</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>University of Texas Medical Branch-Galveston</s1>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>The EMMES Corporation</s1>
<s2>Rockville, Maryland</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Southern Research Institute</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA20><s1>828-837</s1>
</fA20>
<fA21><s1>2012</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>2052</s2>
<s5>354000509502200060</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2012 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>12-0371849</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Réponse immune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Immune response</s0>
<s5>05</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Respuesta inmune</s0>
<s5>05</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Enfant</s0>
<s5>06</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Child</s0>
<s5>06</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Niño</s0>
<s5>06</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Vaccination</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Vaccination</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Vacunación</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Infection</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Infection</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Infección</s0>
<s5>08</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Grippe</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Influenza</s0>
<s5>14</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Gripe</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Virus grippal A(H1N1)</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Influenzavirus A(H1N1)</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Homme</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Human</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hombre</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fN21><s1>289</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
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<server><NO>PASCAL 12-0371849 INIST</NO>
<ET>Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations</ET>
<AU>FREY (Sharon E.); BERNSTEIN (David I.); GERBER (Michael A.); KEYSERLING (Harry L.); MUNOZ (Flor M.); WINOKUR (Patricia L.); TURLEY (Christine B.); RUPP (Richard E.); HILL (Heather); WOLFF (Mark); NOAH (Diana L.); ROSS (Allison C.); CRESS (Gretchen); BELSHE (Robert B.)</AU>
<AF>Saint Louis University School of Medicine/Missouri/Etats-Unis (1 aut., 14 aut.); Cincinnati Children's Hospital Medical Center/Ohio/Etats-Unis (2 aut., 3 aut.); Emory University School of Medicine and Children's Healthcare of Atlanta/Géorgie (4 aut., 12 aut.); Baylor College of Medicine/Houston, Texas/Etats-Unis (5 aut.); University of Iowa, Carver College of Medicine/Iowa City/Etats-Unis (6 aut., 13 aut.); University of Texas Medical Branch-Galveston/Etats-Unis (7 aut., 8 aut.); The EMMES Corporation/Rockville, Maryland/Etats-Unis (9 aut., 10 aut.); Southern Research Institute/Birmingham, Alabama/Etats-Unis (11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>The Journal of infectious diseases; ISSN 0022-1899; Coden JIDIAQ; Royaume-Uni; Da. 2012; Vol. 206; No. 6; Pp. 828-837; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Background. Administering 2 separate vaccines for seasonal and pandemic influenza was necessary in 2009. Therefore, we conducted a randomized trial of monovalent 2009 H1N1 influenza vaccine (2009 H1N1 vaccine) and seasonal trivalent inactivated influenza vaccine (TIV; split virion) given sequentially or concurrently in previously vaccinated children. Methods. Children randomized to 4 study groups and stratified by age received 1 dose of seasonal TIV and 2 doses of 2009 H1N1 vaccine in 1 of 4 combinations. Injections were given at 21-day intervals and serum samples for hemagglutination inhibition antibody responses were obtained prior to and 21 days after each vaccination. Reactogenicity and adverse events were monitored. Results. All combinations of vaccines were safe in the 531 children enrolled. Generally, 1 dose of 2009 H1N1 vaccine and 1 dose of TIV, regardless of sequence or concurrency of administration, was immunogenic in children ≥10 years of age; children <10 years of age required 2 doses of 2009 H1N1 vaccine. Conclusions. Vaccines were generally well tolerated. The immune responses to 2009 H1N1 vaccine were adequate regardless of the sequence of vaccination in all age groups but the sequence affected titers to TIV antigens. Two doses of 2009 H1N1 vaccine were required to achieve a protective immune response in children <10 years of age.</EA>
<CC>002A05; 002B05</CC>
<FD>Réponse immune; Enfant; Vaccination; Infection; Grippe; Virus grippal A(H1N1)</FD>
<FG>Homme; Virose</FG>
<ED>Immune response; Child; Vaccination; Infection; Influenza; Influenzavirus A(H1N1)</ED>
<EG>Human; Viral disease</EG>
<SD>Respuesta inmune; Niño; Vacunación; Infección; Gripe</SD>
<LO>INIST-2052.354000509502200060</LO>
<ID>12-0371849</ID>
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Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations

Safety and Immune Responses in Children After Concurrent or Sequential 2009 H1N1 and 2009-2010 Seasonal Trivalent Influenza Vaccinations

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