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Neonatal Outcomes After Antenatal Influenza Immunization During the 2009 H1N1 Influenza Pandemic: Impact on Preterm Birth, Birth Weight, and Small for Gestational Age Birth

Identifieur interne : 000308 ( PascalFrancis/Corpus ); précédent : 000307; suivant : 000309

Neonatal Outcomes After Antenatal Influenza Immunization During the 2009 H1N1 Influenza Pandemic: Impact on Preterm Birth, Birth Weight, and Small for Gestational Age Birth

Auteurs : Jennifer L. Richards ; Craig Hansen ; Christine Bredfeldt ; Robert A. Bednarczyk ; Mark C. Steinhoff ; Dzifa Adjaye-Gbewonyo ; Kevin Ault ; Mia Gallagher ; Walter Orenstein ; Robert L. Davis ; Saad B. Omer

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RBID : Pascal:13-0157683

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English descriptors

Abstract

Background. Influenza infection during pregnancy is associated with adverse fetal outcomes such as preterm birth and small for gestational age (SGA). Maternal influenza immunization may prevent these adverse infant outcomes during periods of influenza circulation. Methods. We conducted a retrospective cohort study of live births within Kaiser Permanente (KP) Georgia and Mid-Atlantic States (n = 3327) during the period of 2009 influenza A (H1N1) virus circulation. Primary outcomes were third-trimester preterm birth (27-36 weeks), birth weight, low birth weight (LBW, <2500 g), and SGA. Results. There were 327 (9.8%) preterm, 236 (7.4%) LBW, and 267 (8.4%) SGA births. Among H1N1-vaccinated mothers (n = 1125), there were 86 (7.6%) preterm, 68 (6.4%) LBW, and 99 (9.3%) SGA births, and the mean birth weight was 3308.5 g (95% confidence interval [CI], 3276.6-3340.4). Among unvaccinated mothers (n = 1581), there were 191 (12.1%) preterm, 132 (8.8%) LBW, and 123 (8.2%) SGA births, and the mean birth weight was 3245.3 g (95% CI, 3216.5-3274.2). Infants of H1N1-vaccinated mothers had 37% lower odds of being born preterm than infants of unvaccinated mothers (adjusted odds ratio, 0.63 [95% CI, .47-.84]). The mean birth weight difference between infants of H1N1-vaccinated mothers and infants of unvaccinated mothers was 45.1 g (95% CI, 1.8-88.3). There was no significant association between maternal H1N1 influenza immunization and LBW or SGA. Conclusions. Pregnant women who received H1N1 influenza vaccine were less likely to give birth preterm, and gave birth to heavier infants. The findings support US vaccine policy choices to prioritize pregnant women during the 2009 influenza A (H1N1) pandemic.

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A08 01  1  ENG  @1 Neonatal Outcomes After Antenatal Influenza Immunization During the 2009 H1N1 Influenza Pandemic: Impact on Preterm Birth, Birth Weight, and Small for Gestational Age Birth
A11 01  1    @1 RICHARDS (Jennifer L.)
A11 02  1    @1 HANSEN (Craig)
A11 03  1    @1 BREDFELDT (Christine)
A11 04  1    @1 BEDNARCZYK (Robert A.)
A11 05  1    @1 STEINHOFF (Mark C.)
A11 06  1    @1 ADJAYE-GBEWONYO (Dzifa)
A11 07  1    @1 AULT (Kevin)
A11 08  1    @1 GALLAGHER (Mia)
A11 09  1    @1 ORENSTEIN (Walter)
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A11 11  1    @1 OMER (Saad B.)
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C01 01    ENG  @0 Background. Influenza infection during pregnancy is associated with adverse fetal outcomes such as preterm birth and small for gestational age (SGA). Maternal influenza immunization may prevent these adverse infant outcomes during periods of influenza circulation. Methods. We conducted a retrospective cohort study of live births within Kaiser Permanente (KP) Georgia and Mid-Atlantic States (n = 3327) during the period of 2009 influenza A (H1N1) virus circulation. Primary outcomes were third-trimester preterm birth (27-36 weeks), birth weight, low birth weight (LBW, <2500 g), and SGA. Results. There were 327 (9.8%) preterm, 236 (7.4%) LBW, and 267 (8.4%) SGA births. Among H1N1-vaccinated mothers (n = 1125), there were 86 (7.6%) preterm, 68 (6.4%) LBW, and 99 (9.3%) SGA births, and the mean birth weight was 3308.5 g (95% confidence interval [CI], 3276.6-3340.4). Among unvaccinated mothers (n = 1581), there were 191 (12.1%) preterm, 132 (8.8%) LBW, and 123 (8.2%) SGA births, and the mean birth weight was 3245.3 g (95% CI, 3216.5-3274.2). Infants of H1N1-vaccinated mothers had 37% lower odds of being born preterm than infants of unvaccinated mothers (adjusted odds ratio, 0.63 [95% CI, .47-.84]). The mean birth weight difference between infants of H1N1-vaccinated mothers and infants of unvaccinated mothers was 45.1 g (95% CI, 1.8-88.3). There was no significant association between maternal H1N1 influenza immunization and LBW or SGA. Conclusions. Pregnant women who received H1N1 influenza vaccine were less likely to give birth preterm, and gave birth to heavier infants. The findings support US vaccine policy choices to prioritize pregnant women during the 2009 influenza A (H1N1) pandemic.
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Format Inist (serveur)

NO : PASCAL 13-0157683 INIST
ET : Neonatal Outcomes After Antenatal Influenza Immunization During the 2009 H1N1 Influenza Pandemic: Impact on Preterm Birth, Birth Weight, and Small for Gestational Age Birth
AU : RICHARDS (Jennifer L.); HANSEN (Craig); BREDFELDT (Christine); BEDNARCZYK (Robert A.); STEINHOFF (Mark C.); ADJAYE-GBEWONYO (Dzifa); AULT (Kevin); GALLAGHER (Mia); ORENSTEIN (Walter); DAVIS (Robert L.); OMER (Saad B.)
AF : Center for Health Research-Southeast, Kaiser Permanente/Etats-Unis (1 aut., 2 aut., 4 aut., 6 aut., 8 aut., 9 aut., 10 aut., 11 aut.); Rollins School of Public Health, Emory University/Atlanta, Georgia/Etats-Unis (1 aut., 4 aut., 7 aut., 11 aut.); Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States/Rockville, Maryland/Etats-Unis (3 aut.); Cincinnati Children's Hospital Medical Center/Cincinnati, Ohio/Etats-Unis (5 aut.); Bloomberg School of Public Health, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); School of Medicine, Emory University/Atlanta, Georgia/Etats-Unis (7 aut., 11 aut.); Emory Vaccine Center, Emory University/Atlanta, Georgia/Etats-Unis (7 aut., 9 aut., 11 aut.)
DT : Publication en série; Niveau analytique
SO : Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2013; Vol. 56; No. 9; Pp. 1216-1222; Bibl. 35 ref.
LA : Anglais
EA : Background. Influenza infection during pregnancy is associated with adverse fetal outcomes such as preterm birth and small for gestational age (SGA). Maternal influenza immunization may prevent these adverse infant outcomes during periods of influenza circulation. Methods. We conducted a retrospective cohort study of live births within Kaiser Permanente (KP) Georgia and Mid-Atlantic States (n = 3327) during the period of 2009 influenza A (H1N1) virus circulation. Primary outcomes were third-trimester preterm birth (27-36 weeks), birth weight, low birth weight (LBW, <2500 g), and SGA. Results. There were 327 (9.8%) preterm, 236 (7.4%) LBW, and 267 (8.4%) SGA births. Among H1N1-vaccinated mothers (n = 1125), there were 86 (7.6%) preterm, 68 (6.4%) LBW, and 99 (9.3%) SGA births, and the mean birth weight was 3308.5 g (95% confidence interval [CI], 3276.6-3340.4). Among unvaccinated mothers (n = 1581), there were 191 (12.1%) preterm, 132 (8.8%) LBW, and 123 (8.2%) SGA births, and the mean birth weight was 3245.3 g (95% CI, 3216.5-3274.2). Infants of H1N1-vaccinated mothers had 37% lower odds of being born preterm than infants of unvaccinated mothers (adjusted odds ratio, 0.63 [95% CI, .47-.84]). The mean birth weight difference between infants of H1N1-vaccinated mothers and infants of unvaccinated mothers was 45.1 g (95% CI, 1.8-88.3). There was no significant association between maternal H1N1 influenza immunization and LBW or SGA. Conclusions. Pregnant women who received H1N1 influenza vaccine were less likely to give birth preterm, and gave birth to heavier infants. The findings support US vaccine policy choices to prioritize pregnant women during the 2009 influenza A (H1N1) pandemic.
CC : 002B05C02C; 002B20F02
FD : Hypotrophie foetale; Poids de naissance faible; Nouveau né; Pronostic; Immunisation; Vaccination; Prématurité; Accouchement prématuré; Poids naissance; Naissance; Infection; Pandémie; Grippe H1N1
FG : Homme; Pathologie de l'appareil respiratoire; Virose; Prévention; Pathologie de la gestation; Pathologie du foetus; Pathologie du nouveau né
ED : Intrauterine growth retardation; Low birth weight; Newborn; Prognosis; Immunization; Vaccination; Prematurity; Premature delivery; Birth weight; Birth; Infection; H1N1 influenza
EG : Human; Respiratory disease; Viral disease; Prevention; Pregnancy disorders; Fetal diseases; Newborn diseases
SD : Hipotrofia fetal; Peso nacimiento bajo; Recién nacido; Pronóstico; Inmunización; Vacunación; Prematuridad; Parto prematuro; Peso nacimiento; Nacimiento; Infección; Gripe H1N1
LO : INIST-18407.354000500660760040
ID : 13-0157683

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Le document en format XML

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<title xml:lang="en" level="a">Neonatal Outcomes After Antenatal Influenza Immunization During the 2009 H1N1 Influenza Pandemic: Impact on Preterm Birth, Birth Weight, and Small for Gestational Age Birth</title>
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<name sortKey="Adjaye Gbewonyo, Dzifa" sort="Adjaye Gbewonyo, Dzifa" uniqKey="Adjaye Gbewonyo D" first="Dzifa" last="Adjaye-Gbewonyo">Dzifa Adjaye-Gbewonyo</name>
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<name sortKey="Orenstein, Walter" sort="Orenstein, Walter" uniqKey="Orenstein W" first="Walter" last="Orenstein">Walter Orenstein</name>
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<name sortKey="Davis, Robert L" sort="Davis, Robert L" uniqKey="Davis R" first="Robert L." last="Davis">Robert L. Davis</name>
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<name sortKey="Omer, Saad B" sort="Omer, Saad B" uniqKey="Omer S" first="Saad B." last="Omer">Saad B. Omer</name>
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<title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
<imprint>
<date when="2013">2013</date>
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<title level="j" type="main">Clinical infectious diseases</title>
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<profileDesc>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Birth</term>
<term>Birth weight</term>
<term>H1N1 influenza</term>
<term>Immunization</term>
<term>Infection</term>
<term>Intrauterine growth retardation</term>
<term>Low birth weight</term>
<term>Newborn</term>
<term>Premature delivery</term>
<term>Prematurity</term>
<term>Prognosis</term>
<term>Vaccination</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Hypotrophie foetale</term>
<term>Poids de naissance faible</term>
<term>Nouveau né</term>
<term>Pronostic</term>
<term>Immunisation</term>
<term>Vaccination</term>
<term>Prématurité</term>
<term>Accouchement prématuré</term>
<term>Poids naissance</term>
<term>Naissance</term>
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<front>
<div type="abstract" xml:lang="en">Background. Influenza infection during pregnancy is associated with adverse fetal outcomes such as preterm birth and small for gestational age (SGA). Maternal influenza immunization may prevent these adverse infant outcomes during periods of influenza circulation. Methods. We conducted a retrospective cohort study of live births within Kaiser Permanente (KP) Georgia and Mid-Atlantic States (n = 3327) during the period of 2009 influenza A (H1N1) virus circulation. Primary outcomes were third-trimester preterm birth (27-36 weeks), birth weight, low birth weight (LBW, <2500 g), and SGA. Results. There were 327 (9.8%) preterm, 236 (7.4%) LBW, and 267 (8.4%) SGA births. Among H1N1-vaccinated mothers (n = 1125), there were 86 (7.6%) preterm, 68 (6.4%) LBW, and 99 (9.3%) SGA births, and the mean birth weight was 3308.5 g (95% confidence interval [CI], 3276.6-3340.4). Among unvaccinated mothers (n = 1581), there were 191 (12.1%) preterm, 132 (8.8%) LBW, and 123 (8.2%) SGA births, and the mean birth weight was 3245.3 g (95% CI, 3216.5-3274.2). Infants of H1N1-vaccinated mothers had 37% lower odds of being born preterm than infants of unvaccinated mothers (adjusted odds ratio, 0.63 [95% CI, .47-.84]). The mean birth weight difference between infants of H1N1-vaccinated mothers and infants of unvaccinated mothers was 45.1 g (95% CI, 1.8-88.3). There was no significant association between maternal H1N1 influenza immunization and LBW or SGA. Conclusions. Pregnant women who received H1N1 influenza vaccine were less likely to give birth preterm, and gave birth to heavier infants. The findings support US vaccine policy choices to prioritize pregnant women during the 2009 influenza A (H1N1) pandemic.</div>
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<s5>15</s5>
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<s5>16</s5>
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<s5>16</s5>
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<s5>16</s5>
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<s5>17</s5>
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<s5>17</s5>
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<s0>Nacimiento</s0>
<s5>17</s5>
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<s0>Infection</s0>
<s5>18</s5>
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<fC03 i1="11" i2="X" l="ENG">
<s0>Infection</s0>
<s5>18</s5>
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<s5>18</s5>
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<s4>INC</s4>
<s5>86</s5>
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<s5>96</s5>
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<s4>CD</s4>
<s5>96</s5>
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<s0>Gripe H1N1</s0>
<s4>CD</s4>
<s5>96</s5>
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<s0>Pathologie de l'appareil respiratoire</s0>
<s5>37</s5>
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<fC07 i1="02" i2="X" l="ENG">
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<fC07 i1="03" i2="X" l="ENG">
<s0>Viral disease</s0>
<s5>38</s5>
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<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Prévention</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Prevention</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Prevención</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Pathologie de la gestation</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Pregnancy disorders</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Gestación patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Pathologie du foetus</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Fetal diseases</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Feto patología</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Pathologie du nouveau né</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Newborn diseases</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Recién nacido patología</s0>
<s5>42</s5>
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<fN21>
<s1>140</s1>
</fN21>
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<s1>OTO</s1>
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<NO>PASCAL 13-0157683 INIST</NO>
<ET>Neonatal Outcomes After Antenatal Influenza Immunization During the 2009 H1N1 Influenza Pandemic: Impact on Preterm Birth, Birth Weight, and Small for Gestational Age Birth</ET>
<AU>RICHARDS (Jennifer L.); HANSEN (Craig); BREDFELDT (Christine); BEDNARCZYK (Robert A.); STEINHOFF (Mark C.); ADJAYE-GBEWONYO (Dzifa); AULT (Kevin); GALLAGHER (Mia); ORENSTEIN (Walter); DAVIS (Robert L.); OMER (Saad B.)</AU>
<AF>Center for Health Research-Southeast, Kaiser Permanente/Etats-Unis (1 aut., 2 aut., 4 aut., 6 aut., 8 aut., 9 aut., 10 aut., 11 aut.); Rollins School of Public Health, Emory University/Atlanta, Georgia/Etats-Unis (1 aut., 4 aut., 7 aut., 11 aut.); Mid-Atlantic Permanente Research Institute, Kaiser Permanente Mid-Atlantic States/Rockville, Maryland/Etats-Unis (3 aut.); Cincinnati Children's Hospital Medical Center/Cincinnati, Ohio/Etats-Unis (5 aut.); Bloomberg School of Public Health, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); School of Medicine, Emory University/Atlanta, Georgia/Etats-Unis (7 aut., 11 aut.); Emory Vaccine Center, Emory University/Atlanta, Georgia/Etats-Unis (7 aut., 9 aut., 11 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2013; Vol. 56; No. 9; Pp. 1216-1222; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Background. Influenza infection during pregnancy is associated with adverse fetal outcomes such as preterm birth and small for gestational age (SGA). Maternal influenza immunization may prevent these adverse infant outcomes during periods of influenza circulation. Methods. We conducted a retrospective cohort study of live births within Kaiser Permanente (KP) Georgia and Mid-Atlantic States (n = 3327) during the period of 2009 influenza A (H1N1) virus circulation. Primary outcomes were third-trimester preterm birth (27-36 weeks), birth weight, low birth weight (LBW, <2500 g), and SGA. Results. There were 327 (9.8%) preterm, 236 (7.4%) LBW, and 267 (8.4%) SGA births. Among H1N1-vaccinated mothers (n = 1125), there were 86 (7.6%) preterm, 68 (6.4%) LBW, and 99 (9.3%) SGA births, and the mean birth weight was 3308.5 g (95% confidence interval [CI], 3276.6-3340.4). Among unvaccinated mothers (n = 1581), there were 191 (12.1%) preterm, 132 (8.8%) LBW, and 123 (8.2%) SGA births, and the mean birth weight was 3245.3 g (95% CI, 3216.5-3274.2). Infants of H1N1-vaccinated mothers had 37% lower odds of being born preterm than infants of unvaccinated mothers (adjusted odds ratio, 0.63 [95% CI, .47-.84]). The mean birth weight difference between infants of H1N1-vaccinated mothers and infants of unvaccinated mothers was 45.1 g (95% CI, 1.8-88.3). There was no significant association between maternal H1N1 influenza immunization and LBW or SGA. Conclusions. Pregnant women who received H1N1 influenza vaccine were less likely to give birth preterm, and gave birth to heavier infants. The findings support US vaccine policy choices to prioritize pregnant women during the 2009 influenza A (H1N1) pandemic.</EA>
<CC>002B05C02C; 002B20F02</CC>
<FD>Hypotrophie foetale; Poids de naissance faible; Nouveau né; Pronostic; Immunisation; Vaccination; Prématurité; Accouchement prématuré; Poids naissance; Naissance; Infection; Pandémie; Grippe H1N1</FD>
<FG>Homme; Pathologie de l'appareil respiratoire; Virose; Prévention; Pathologie de la gestation; Pathologie du foetus; Pathologie du nouveau né</FG>
<ED>Intrauterine growth retardation; Low birth weight; Newborn; Prognosis; Immunization; Vaccination; Prematurity; Premature delivery; Birth weight; Birth; Infection; H1N1 influenza</ED>
<EG>Human; Respiratory disease; Viral disease; Prevention; Pregnancy disorders; Fetal diseases; Newborn diseases</EG>
<SD>Hipotrofia fetal; Peso nacimiento bajo; Recién nacido; Pronóstico; Inmunización; Vacunación; Prematuridad; Parto prematuro; Peso nacimiento; Nacimiento; Infección; Gripe H1N1</SD>
<LO>INIST-18407.354000500660760040</LO>
<ID>13-0157683</ID>
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