Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)
Identifieur interne : 000234 ( PascalFrancis/Corpus ); précédent : 000233; suivant : 000235Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)
Auteurs : Manoj Gambhir ; David L. Swerdlow ; Lyn Finelli ; Maria D. Van Kerkhove ; Matthew Biggerstaff ; Simon Cauchemez ; Neil M. FergusonSource :
- Clinical infectious diseases [ 1058-4838 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults. Methods. We construct a mathematical transmission model of influenza transmission that allows for external zoonotic exposure to infection and show how exposure and susceptibility-related factors contribute to the observed case distribution. Results and Conclusions. Age-dependent susceptibility to infection strongly influences epidemic dynamics. The result is that the risk of an outbreak in a highly susceptible age group may be substantially higher than in an older age group with less susceptibility, but exposure-related factors must also be accounted for when interpreting case data.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
|
---|
Format Inist (serveur)
NO : | PASCAL 13-0281409 INIST |
---|---|
ET : | Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v) |
AU : | GAMBHIR (Manoj); SWERDLOW (David L.); FINELLI (Lyn); VAN KERKHOVE (Maria D.); BIGGERSTAFF (Matthew); CAUCHEMEZ (Simon); FERGUSON (Neil M.); SWERDLOW (David L.); FINELLI (Lyn) |
AF : | Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (1 aut., 2 aut.); MRC Centre for Outbreak Analysis and Modelling, Imperial College London/Royaume-Uni (1 aut., 4 aut., 6 aut., 7 aut.); Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (3 aut., 5 aut.); National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (1 aut.); Influenza Division, National Center for Immunization and Respiratory Diseases/Atlanta, Georgia/Etats-Unis (2 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2013; Vol. 57; No. SUP1; S23-S27; Bibl. 24 ref. |
LA : | Anglais |
EA : | Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults. Methods. We construct a mathematical transmission model of influenza transmission that allows for external zoonotic exposure to infection and show how exposure and susceptibility-related factors contribute to the observed case distribution. Results and Conclusions. Age-dependent susceptibility to infection strongly influences epidemic dynamics. The result is that the risk of an outbreak in a highly susceptible age group may be substantially higher than in an older age group with less susceptibility, but exposure-related factors must also be accounted for when interpreting case data. |
CC : | 002B05C02C |
FD : | Grippe A; Multiple; Classe âge; Etude cas; Modélisation; Homme |
FG : | Virose; Infection |
ED : | Influenza A; Multiple; Age distribution; Case study; Modeling; Human |
EG : | Viral disease; Infection |
SD : | Gripe A; Múltiple; Clase edad; Estudio caso; Modelización; Hombre |
LO : | INIST-18407.354000503881080050 |
ID : | 13-0281409 |
Links to Exploration step
Pascal:13-0281409Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)</title>
<author><name sortKey="Gambhir, Manoj" sort="Gambhir, Manoj" uniqKey="Gambhir M" first="Manoj" last="Gambhir">Manoj Gambhir</name>
<affiliation><inist:fA14 i1="01"><s1>Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Swerdlow, David L" sort="Swerdlow, David L" uniqKey="Swerdlow D" first="David L." last="Swerdlow">David L. Swerdlow</name>
<affiliation><inist:fA14 i1="01"><s1>Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Finelli, Lyn" sort="Finelli, Lyn" uniqKey="Finelli L" first="Lyn" last="Finelli">Lyn Finelli</name>
<affiliation><inist:fA14 i1="03"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Biggerstaff, Matthew" sort="Biggerstaff, Matthew" uniqKey="Biggerstaff M" first="Matthew" last="Biggerstaff">Matthew Biggerstaff</name>
<affiliation><inist:fA14 i1="03"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cauchemez, Simon" sort="Cauchemez, Simon" uniqKey="Cauchemez S" first="Simon" last="Cauchemez">Simon Cauchemez</name>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ferguson, Neil M" sort="Ferguson, Neil M" uniqKey="Ferguson N" first="Neil M." last="Ferguson">Neil M. Ferguson</name>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">13-0281409</idno>
<date when="2013">2013</date>
<idno type="stanalyst">PASCAL 13-0281409 INIST</idno>
<idno type="RBID">Pascal:13-0281409</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000234</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)</title>
<author><name sortKey="Gambhir, Manoj" sort="Gambhir, Manoj" uniqKey="Gambhir M" first="Manoj" last="Gambhir">Manoj Gambhir</name>
<affiliation><inist:fA14 i1="01"><s1>Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Swerdlow, David L" sort="Swerdlow, David L" uniqKey="Swerdlow D" first="David L." last="Swerdlow">David L. Swerdlow</name>
<affiliation><inist:fA14 i1="01"><s1>Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Finelli, Lyn" sort="Finelli, Lyn" uniqKey="Finelli L" first="Lyn" last="Finelli">Lyn Finelli</name>
<affiliation><inist:fA14 i1="03"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Van Kerkhove, Maria D" sort="Van Kerkhove, Maria D" uniqKey="Van Kerkhove M" first="Maria D." last="Van Kerkhove">Maria D. Van Kerkhove</name>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Biggerstaff, Matthew" sort="Biggerstaff, Matthew" uniqKey="Biggerstaff M" first="Matthew" last="Biggerstaff">Matthew Biggerstaff</name>
<affiliation><inist:fA14 i1="03"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cauchemez, Simon" sort="Cauchemez, Simon" uniqKey="Cauchemez S" first="Simon" last="Cauchemez">Simon Cauchemez</name>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ferguson, Neil M" sort="Ferguson, Neil M" uniqKey="Ferguson N" first="Neil M." last="Ferguson">Neil M. Ferguson</name>
<affiliation><inist:fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Clinical infectious diseases</title>
<title level="j" type="abbreviated">Clin. infect. dis.</title>
<idno type="ISSN">1058-4838</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age distribution</term>
<term>Case study</term>
<term>Human</term>
<term>Influenza A</term>
<term>Modeling</term>
<term>Multiple</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Grippe A</term>
<term>Multiple</term>
<term>Classe âge</term>
<term>Etude cas</term>
<term>Modélisation</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults. Methods. We construct a mathematical transmission model of influenza transmission that allows for external zoonotic exposure to infection and show how exposure and susceptibility-related factors contribute to the observed case distribution. Results and Conclusions. Age-dependent susceptibility to infection strongly influences epidemic dynamics. The result is that the risk of an outbreak in a highly susceptible age group may be substantially higher than in an older age group with less susceptibility, but exposure-related factors must also be accounted for when interpreting case data.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1058-4838</s0>
</fA01>
<fA02 i1="01"><s0>CIDIEL</s0>
</fA02>
<fA03 i2="1"><s0>Clin. infect. dis.</s0>
</fA03>
<fA05><s2>57</s2>
</fA05>
<fA06><s3>SUP1</s3>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)</s1>
</fA08>
<fA09 i1="01" i2="1" l="ENG"><s1>The Emergence of Influenza A (H3N2)v Virus: What We Learned From the First Wave, July 2011-April 2012</s1>
</fA09>
<fA11 i1="01" i2="1"><s1>GAMBHIR (Manoj)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SWERDLOW (David L.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>FINELLI (Lyn)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>VAN KERKHOVE (Maria D.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>BIGGERSTAFF (Matthew)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>CAUCHEMEZ (Simon)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>FERGUSON (Neil M.)</s1>
</fA11>
<fA12 i1="01" i2="1"><s1>SWERDLOW (David L.)</s1>
<s9>ed.</s9>
</fA12>
<fA12 i1="02" i2="1"><s1>FINELLI (Lyn)</s1>
<s9>ed.</s9>
</fA12>
<fA14 i1="01"><s1>Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>MRC Centre for Outbreak Analysis and Modelling, Imperial College London</s1>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA15 i1="01"><s1>National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</fA15>
<fA15 i1="02"><s1>Influenza Division, National Center for Immunization and Respiratory Diseases</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</fA15>
<fA20><s2>S23-S27</s2>
</fA20>
<fA21><s1>2013</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>18407</s2>
<s5>354000503881080050</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2013 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>24 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>13-0281409</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Clinical infectious diseases</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults. Methods. We construct a mathematical transmission model of influenza transmission that allows for external zoonotic exposure to infection and show how exposure and susceptibility-related factors contribute to the observed case distribution. Results and Conclusions. Age-dependent susceptibility to infection strongly influences epidemic dynamics. The result is that the risk of an outbreak in a highly susceptible age group may be substantially higher than in an older age group with less susceptibility, but exposure-related factors must also be accounted for when interpreting case data.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B05C02C</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Grippe A</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Influenza A</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Gripe A</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Multiple</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Multiple</s0>
<s5>07</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Múltiple</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Classe âge</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Age distribution</s0>
<s5>08</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Clase edad</s0>
<s5>08</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Etude cas</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Case study</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Estudio caso</s0>
<s5>09</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Modélisation</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Modeling</s0>
<s5>13</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Modelización</s0>
<s5>13</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Homme</s0>
<s5>30</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Human</s0>
<s5>30</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Hombre</s0>
<s5>30</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>266</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 13-0281409 INIST</NO>
<ET>Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v)</ET>
<AU>GAMBHIR (Manoj); SWERDLOW (David L.); FINELLI (Lyn); VAN KERKHOVE (Maria D.); BIGGERSTAFF (Matthew); CAUCHEMEZ (Simon); FERGUSON (Neil M.); SWERDLOW (David L.); FINELLI (Lyn)</AU>
<AF>Modeling Unit, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (1 aut., 2 aut.); MRC Centre for Outbreak Analysis and Modelling, Imperial College London/Royaume-Uni (1 aut., 4 aut., 6 aut., 7 aut.); Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (3 aut., 5 aut.); National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention/Atlanta, Georgia/Etats-Unis (1 aut.); Influenza Division, National Center for Immunization and Respiratory Diseases/Atlanta, Georgia/Etats-Unis (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Clinical infectious diseases; ISSN 1058-4838; Coden CIDIEL; Royaume-Uni; Da. 2013; Vol. 57; No. SUP1; S23-S27; Bibl. 24 ref.</SO>
<LA>Anglais</LA>
<EA>Background. In late 2011 and early 2012, 13 cases of human influenza resulted from infection with a novel triple reassortant swine-origin influenza virus, influenza A (H3N2) variant. This variant was notable for its inclusion of the matrix gene from the 2009 influenza A(H1N1) pandemic virus. While most of these confirmed cases were among children, the transmission potential and likely age-dependent susceptibility to the virus was unknown. Preliminary serologic studies indicated that very young children have less protection than older children and adults. Methods. We construct a mathematical transmission model of influenza transmission that allows for external zoonotic exposure to infection and show how exposure and susceptibility-related factors contribute to the observed case distribution. Results and Conclusions. Age-dependent susceptibility to infection strongly influences epidemic dynamics. The result is that the risk of an outbreak in a highly susceptible age group may be substantially higher than in an older age group with less susceptibility, but exposure-related factors must also be accounted for when interpreting case data.</EA>
<CC>002B05C02C</CC>
<FD>Grippe A; Multiple; Classe âge; Etude cas; Modélisation; Homme</FD>
<FG>Virose; Infection</FG>
<ED>Influenza A; Multiple; Age distribution; Case study; Modeling; Human</ED>
<EG>Viral disease; Infection</EG>
<SD>Gripe A; Múltiple; Clase edad; Estudio caso; Modelización; Hombre</SD>
<LO>INIST-18407.354000503881080050</LO>
<ID>13-0281409</ID>
</server>
</inist>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/PascalFrancis/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000234 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Corpus/biblio.hfd -nk 000234 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= PascalFrancis |étape= Corpus |type= RBID |clé= Pascal:13-0281409 |texte= Multiple Contributory Factors to the Age Distribution of Disease Cases: A Modeling Study in the Context of Influenza A(H3N2v) }}
![]() | This area was generated with Dilib version V0.6.34. | ![]() |