PandemieGrippaleV1, PascalFrancis, Checkpoint, bibRecord, 001A52

Cell culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses

Identifieur interne : 001A52 ( PascalFrancis/Checkpoint ); précédent : 001A51; suivant : 001A53

Cell culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses

Auteurs : Otfried Kistner [Autriche] ; M. Keith Howard [Autriche] ; Martin Spruth [Autriche] ; Walter Wodal [Autriche] ; Peter Brühl [Autriche] ; Marijan Gerencer [Autriche] ; Brian A. Crowe [Autriche] ; Helga Savidis-Dacho [Autriche] ; Ian Livey [Autriche] ; Manfred Reiter [Autriche] ; Ines Mayerhofer [Autriche] ; Christa Tauer [Autriche] ; Leopold Grillberger [Autriche] ; Wolfgang Mundt [Autriche] ; Falko G. Falkner [Autriche] ; P. Noel Barrett [Autriche]

Source :

Vaccine [ 0264-410X ] ; 2007.

RBID : Pascal:07-0388587

Descripteurs français

Pascal (Inist)
- Virus, Culture cellulaire, Vaccin, Souche, Immunoprotection, Grippe aviaire.
Wicri :
- topic : Vaccin.

English descriptors

KwdEn :
- Avian influenza, Cell culture, Immunoprotection, Strain, Vaccine, Virus.

Abstract

The rapid spread and the transmission to humans of avian influenza virus (H5N1) have induced world-wide fears of a new pandemic and raised concerns over the ability of standard influenza vaccine production methods to rapidly supply sufficient amounts of an effective vaccine. We report here on a robust and flexible strategy which uses wild-type virus grown in a continuous cell culture (Vero) system to produce an inactivated whole virus vaccine. Candidate vaccines based on clade 1 and clade 2 influenza H5N1 strains were developed and demonstrated to be highly immunogenic in animal models. The vaccines induce cross-neutralising antibodies, highly cross-reactive T-cell responses and are protective in a mouse challenge model not only against the homologous virus but also against other H5N1 strains, including those from another clade. These data indicate that cell culture-grown whole virus vaccines, based on the wild-type virus, allow the rapid high yield production of a candidate pandemic vaccine.

Affiliations:

Autriche

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Pascal:07-0388587

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cell culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses</title>
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<author><name sortKey="Livey, Ian" sort="Livey, Ian" uniqKey="Livey I" first="Ian" last="Livey">Ian Livey</name>
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<author><name sortKey="Tauer, Christa" sort="Tauer, Christa" uniqKey="Tauer C" first="Christa" last="Tauer">Christa Tauer</name>
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<author><name sortKey="Grillberger, Leopold" sort="Grillberger, Leopold" uniqKey="Grillberger L" first="Leopold" last="Grillberger">Leopold Grillberger</name>
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<author><name sortKey="Mundt, Wolfgang" sort="Mundt, Wolfgang" uniqKey="Mundt W" first="Wolfgang" last="Mundt">Wolfgang Mundt</name>
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<author><name sortKey="Falkner, Falko G" sort="Falkner, Falko G" uniqKey="Falkner F" first="Falko G." last="Falkner">Falko G. Falkner</name>
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<author><name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P. Noel" last="Barrett">P. Noel Barrett</name>
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<series><title level="j" type="main">Vaccine</title>
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<front><div type="abstract" xml:lang="en">The rapid spread and the transmission to humans of avian influenza virus (H5N1) have induced world-wide fears of a new pandemic and raised concerns over the ability of standard influenza vaccine production methods to rapidly supply sufficient amounts of an effective vaccine. We report here on a robust and flexible strategy which uses wild-type virus grown in a continuous cell culture (Vero) system to produce an inactivated whole virus vaccine. Candidate vaccines based on clade 1 and clade 2 influenza H5N1 strains were developed and demonstrated to be highly immunogenic in animal models. The vaccines induce cross-neutralising antibodies, highly cross-reactive T-cell responses and are protective in a mouse challenge model not only against the homologous virus but also against other H5N1 strains, including those from another clade. These data indicate that cell culture-grown whole virus vaccines, based on the wild-type virus, allow the rapid high yield production of a candidate pandemic vaccine.</div>
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<fC07 i1="01" i2="X" l="SPA"><s0>Infección</s0>
<s5>13</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Virose</s0>
<s5>16</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Viral disease</s0>
<s5>16</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Virosis</s0>
<s5>16</s5>
</fC07>
<fN21><s1>253</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Autriche</li>
</country>
</list>
<tree><country name="Autriche"><noRegion><name sortKey="Kistner, Otfried" sort="Kistner, Otfried" uniqKey="Kistner O" first="Otfried" last="Kistner">Otfried Kistner</name>
</noRegion>
<name sortKey="Barrett, P Noel" sort="Barrett, P Noel" uniqKey="Barrett P" first="P. Noel" last="Barrett">P. Noel Barrett</name>
<name sortKey="Bruhl, Peter" sort="Bruhl, Peter" uniqKey="Bruhl P" first="Peter" last="Brühl">Peter Brühl</name>
<name sortKey="Crowe, Brian A" sort="Crowe, Brian A" uniqKey="Crowe B" first="Brian A." last="Crowe">Brian A. Crowe</name>
<name sortKey="Falkner, Falko G" sort="Falkner, Falko G" uniqKey="Falkner F" first="Falko G." last="Falkner">Falko G. Falkner</name>
<name sortKey="Gerencer, Marijan" sort="Gerencer, Marijan" uniqKey="Gerencer M" first="Marijan" last="Gerencer">Marijan Gerencer</name>
<name sortKey="Grillberger, Leopold" sort="Grillberger, Leopold" uniqKey="Grillberger L" first="Leopold" last="Grillberger">Leopold Grillberger</name>
<name sortKey="Howard, M Keith" sort="Howard, M Keith" uniqKey="Howard M" first="M. Keith" last="Howard">M. Keith Howard</name>
<name sortKey="Livey, Ian" sort="Livey, Ian" uniqKey="Livey I" first="Ian" last="Livey">Ian Livey</name>
<name sortKey="Mayerhofer, Ines" sort="Mayerhofer, Ines" uniqKey="Mayerhofer I" first="Ines" last="Mayerhofer">Ines Mayerhofer</name>
<name sortKey="Mundt, Wolfgang" sort="Mundt, Wolfgang" uniqKey="Mundt W" first="Wolfgang" last="Mundt">Wolfgang Mundt</name>
<name sortKey="Reiter, Manfred" sort="Reiter, Manfred" uniqKey="Reiter M" first="Manfred" last="Reiter">Manfred Reiter</name>
<name sortKey="Savidis Dacho, Helga" sort="Savidis Dacho, Helga" uniqKey="Savidis Dacho H" first="Helga" last="Savidis-Dacho">Helga Savidis-Dacho</name>
<name sortKey="Spruth, Martin" sort="Spruth, Martin" uniqKey="Spruth M" first="Martin" last="Spruth">Martin Spruth</name>
<name sortKey="Tauer, Christa" sort="Tauer, Christa" uniqKey="Tauer C" first="Christa" last="Tauer">Christa Tauer</name>
<name sortKey="Wodal, Walter" sort="Wodal, Walter" uniqKey="Wodal W" first="Walter" last="Wodal">Walter Wodal</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Cell culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses
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Cell culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses

Cell culture (Vero) derived whole virus (H5N1) vaccine based on wild-type virus strain induces cross-protective immune responses

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