PandemieGrippaleV1, PascalFrancis, Checkpoint, bibRecord, 001A50

Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease

Identifieur interne : 001A50 ( PascalFrancis/Checkpoint ); précédent : 001A49; suivant : 001A51

Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease

Auteurs : Loranee E. Braun [États-Unis] ; Deena E. Sutter [États-Unis] ; Maryna C. Eichelberger [États-Unis] ; Lioubov Pletneva [États-Unis] ; John F. Kokai-Kun [États-Unis] ; Jorge C. G. Blanco [États-Unis] ; Gregory A. Prince [États-Unis] ; Martin G. Ottolini [États-Unis]

Source :

Microbial pathogenesis [ 0882-4010 ] ; 2007.

RBID : Pascal:07-0480553

Descripteurs français

Pascal (Inist)
- Gossypium hirsutum, Rat, Sigmodon hispidus, Staphylococcus aureus, Virus grippal A, Infection mixte, Grippe.

English descriptors

KwdEn :
- Gossypium hirsutum, Influenza, Influenza A virus, Mixed infection, Rat, Sigmodon hispidus, Staphylococcus aureus.

Abstract

Bacterial super-infection of influenza patients is the primary cause of excess mortality during influenza pandemics, with Staphylococcus aureus (S. aureus) having the highest fatality rate. The cotton rat (Sigmodon hispidus) is an excellent model for both influenza and S. aureus pathogenesis, and therefore a potential tool to model co-infection. We compared physiologic and pathologic changes in cotton rats infected with both S. aureus and influenza A/Wuhan/359/95 (H3N2), with animals infected with each pathogen alone. Co-infected cotton rats demonstrated significantly higher mortality, lower temperatures on 2 and 3 days post-inoculation (p.i.), higher levels of bacteremia and pulmonary bacterial load 4 days p.i., and worse pathology 7 days p.i. Early indicators of exacerbated disease coincided with higher pulmonary mRNA levels for IL-1β, IL-6, IL-10 and IFNy, supporting the idea that these may contribute to disease severity. Our results demonstrate that the cotton rat is a good model of influenza and S. aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001A82
to stream PascalFrancis, to step Curation: 000418

Links to Exploration step

Pascal:07-0480553

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease</title>
<author><name sortKey="Braun, Loranee E" sort="Braun, Loranee E" uniqKey="Braun L" first="Loranee E." last="Braun">Loranee E. Braun</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sutter, Deena E" sort="Sutter, Deena E" uniqKey="Sutter D" first="Deena E." last="Sutter">Deena E. Sutter</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pletneva, Lioubov" sort="Pletneva, Lioubov" uniqKey="Pletneva L" first="Lioubov" last="Pletneva">Lioubov Pletneva</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kokai Kun, John F" sort="Kokai Kun, John F" uniqKey="Kokai Kun J" first="John F." last="Kokai-Kun">John F. Kokai-Kun</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Biosynexus, Inc</s1>
<s2>Gaithersburg, MD</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanco, Jorge C G" sort="Blanco, Jorge C G" uniqKey="Blanco J" first="Jorge C. G." last="Blanco">Jorge C. G. Blanco</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prince, Gregory A" sort="Prince, Gregory A" uniqKey="Prince G" first="Gregory A." last="Prince">Gregory A. Prince</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ottolini, Martin G" sort="Ottolini, Martin G" uniqKey="Ottolini M" first="Martin G." last="Ottolini">Martin G. Ottolini</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">07-0480553</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0480553 INIST</idno>
<idno type="RBID">Pascal:07-0480553</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001A82</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000418</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A50</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001A50</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease</title>
<author><name sortKey="Braun, Loranee E" sort="Braun, Loranee E" uniqKey="Braun L" first="Loranee E." last="Braun">Loranee E. Braun</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sutter, Deena E" sort="Sutter, Deena E" uniqKey="Sutter D" first="Deena E." last="Sutter">Deena E. Sutter</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pletneva, Lioubov" sort="Pletneva, Lioubov" uniqKey="Pletneva L" first="Lioubov" last="Pletneva">Lioubov Pletneva</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kokai Kun, John F" sort="Kokai Kun, John F" uniqKey="Kokai Kun J" first="John F." last="Kokai-Kun">John F. Kokai-Kun</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Biosynexus, Inc</s1>
<s2>Gaithersburg, MD</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanco, Jorge C G" sort="Blanco, Jorge C G" uniqKey="Blanco J" first="Jorge C. G." last="Blanco">Jorge C. G. Blanco</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prince, Gregory A" sort="Prince, Gregory A" uniqKey="Prince G" first="Gregory A." last="Prince">Gregory A. Prince</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ottolini, Martin G" sort="Ottolini, Martin G" uniqKey="Ottolini M" first="Martin G." last="Ottolini">Martin G. Ottolini</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Microbial pathogenesis</title>
<title level="j" type="abbreviated">Microb. pathog.</title>
<idno type="ISSN">0882-4010</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Microbial pathogenesis</title>
<title level="j" type="abbreviated">Microb. pathog.</title>
<idno type="ISSN">0882-4010</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Gossypium hirsutum</term>
<term>Influenza</term>
<term>Influenza A virus</term>
<term>Mixed infection</term>
<term>Rat</term>
<term>Sigmodon hispidus</term>
<term>Staphylococcus aureus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Gossypium hirsutum</term>
<term>Rat</term>
<term>Sigmodon hispidus</term>
<term>Staphylococcus aureus</term>
<term>Virus grippal A</term>
<term>Infection mixte</term>
<term>Grippe</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Bacterial super-infection of influenza patients is the primary cause of excess mortality during influenza pandemics, with Staphylococcus aureus (S. aureus) having the highest fatality rate. The cotton rat (Sigmodon hispidus) is an excellent model for both influenza and S. aureus pathogenesis, and therefore a potential tool to model co-infection. We compared physiologic and pathologic changes in cotton rats infected with both S. aureus and influenza A/Wuhan/359/95 (H3N2), with animals infected with each pathogen alone. Co-infected cotton rats demonstrated significantly higher mortality, lower temperatures on 2 and 3 days post-inoculation (p.i.), higher levels of bacteremia and pulmonary bacterial load 4 days p.i., and worse pathology 7 days p.i. Early indicators of exacerbated disease coincided with higher pulmonary mRNA levels for IL-1β, IL-6, IL-10 and IFNy, supporting the idea that these may contribute to disease severity. Our results demonstrate that the cotton rat is a good model of influenza and S. aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0882-4010</s0>
</fA01>
<fA02 i1="01"><s0>MIPAEV</s0>
</fA02>
<fA03 i2="1"><s0>Microb. pathog.</s0>
</fA03>
<fA05><s2>43</s2>
</fA05>
<fA06><s2>5-6</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>BRAUN (Loranee E.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>SUTTER (Deena E.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>EICHELBERGER (Maryna C.)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>PLETNEVA (Lioubov)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>KOKAI-KUN (John F.)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>BLANCO (Jorge C. G.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>PRINCE (Gregory A.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>OTTOLINI (Martin G.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Pediatrics, F. Edward Hebert School of Medicine of the Uniformed Services University of the Health Sciences</s1>
<s2>Bethesda, MD 20814</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Virion Systems, Inc</s1>
<s2>Rockville, MD 20850</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Biosynexus, Inc</s1>
<s2>Gaithersburg, MD</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>208-216</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20952</s2>
<s5>354000149822850050</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>32 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0480553</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Microbial pathogenesis</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Bacterial super-infection of influenza patients is the primary cause of excess mortality during influenza pandemics, with Staphylococcus aureus (S. aureus) having the highest fatality rate. The cotton rat (Sigmodon hispidus) is an excellent model for both influenza and S. aureus pathogenesis, and therefore a potential tool to model co-infection. We compared physiologic and pathologic changes in cotton rats infected with both S. aureus and influenza A/Wuhan/359/95 (H3N2), with animals infected with each pathogen alone. Co-infected cotton rats demonstrated significantly higher mortality, lower temperatures on 2 and 3 days post-inoculation (p.i.), higher levels of bacteremia and pulmonary bacterial load 4 days p.i., and worse pathology 7 days p.i. Early indicators of exacerbated disease coincided with higher pulmonary mRNA levels for IL-1β, IL-6, IL-10 and IFNy, supporting the idea that these may contribute to disease severity. Our results demonstrate that the cotton rat is a good model of influenza and S. aureus co-infection, with increased mortality and hypothermia as well as prolonged bacterial duration indicative of synergistic disease that may be the result of increased induction of both pro- and anti-inflammatory cytokines.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002A05B15</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002A05C10</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Gossypium hirsutum</s0>
<s2>NS</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Gossypium hirsutum</s0>
<s2>NS</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Gossypium hirsutum</s0>
<s2>NS</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Rat</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Rat</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Rata</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Sigmodon hispidus</s0>
<s2>NS</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Sigmodon hispidus</s0>
<s2>NS</s2>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sigmodon hispidus</s0>
<s2>NS</s2>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Staphylococcus aureus</s0>
<s2>NS</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Staphylococcus aureus</s0>
<s2>NS</s2>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Staphylococcus aureus</s0>
<s2>NS</s2>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Virus grippal A</s0>
<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Influenza A virus</s0>
<s2>NW</s2>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Infection mixte</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Mixed infection</s0>
<s5>14</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Infección mixta</s0>
<s5>14</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Grippe</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Influenza</s0>
<s5>15</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Gripe</s0>
<s5>15</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Malvaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Malvaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Malvaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Dicotyledones</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Angiospermae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Spermatophyta</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Micrococcaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Micrococcaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Micrococcaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Micrococcales</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Micrococcales</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Micrococcales</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Bactérie</s0>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Bacteria</s0>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Bacteria</s0>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Influenzavirus A</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Orthomyxoviridae</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Virus</s0>
<s2>NW</s2>
</fC07>
<fC07 i1="14" i2="X" l="FRE"><s0>Plante à fibres</s0>
<s5>13</s5>
</fC07>
<fC07 i1="14" i2="X" l="ENG"><s0>Fiber crop</s0>
<s5>13</s5>
</fC07>
<fC07 i1="14" i2="X" l="SPA"><s0>Planta de fibras</s0>
<s5>13</s5>
</fC07>
<fC07 i1="15" i2="X" l="FRE"><s0>Virose</s0>
</fC07>
<fC07 i1="15" i2="X" l="ENG"><s0>Viral disease</s0>
</fC07>
<fC07 i1="15" i2="X" l="SPA"><s0>Virosis</s0>
</fC07>
<fC07 i1="16" i2="X" l="FRE"><s0>Infection</s0>
</fC07>
<fC07 i1="16" i2="X" l="ENG"><s0>Infection</s0>
</fC07>
<fC07 i1="16" i2="X" l="SPA"><s0>Infección</s0>
</fC07>
<fN21><s1>316</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Maryland</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Maryland"><name sortKey="Braun, Loranee E" sort="Braun, Loranee E" uniqKey="Braun L" first="Loranee E." last="Braun">Loranee E. Braun</name>
</region>
<name sortKey="Blanco, Jorge C G" sort="Blanco, Jorge C G" uniqKey="Blanco J" first="Jorge C. G." last="Blanco">Jorge C. G. Blanco</name>
<name sortKey="Eichelberger, Maryna C" sort="Eichelberger, Maryna C" uniqKey="Eichelberger M" first="Maryna C." last="Eichelberger">Maryna C. Eichelberger</name>
<name sortKey="Kokai Kun, John F" sort="Kokai Kun, John F" uniqKey="Kokai Kun J" first="John F." last="Kokai-Kun">John F. Kokai-Kun</name>
<name sortKey="Ottolini, Martin G" sort="Ottolini, Martin G" uniqKey="Ottolini M" first="Martin G." last="Ottolini">Martin G. Ottolini</name>
<name sortKey="Pletneva, Lioubov" sort="Pletneva, Lioubov" uniqKey="Pletneva L" first="Lioubov" last="Pletneva">Lioubov Pletneva</name>
<name sortKey="Prince, Gregory A" sort="Prince, Gregory A" uniqKey="Prince G" first="Gregory A." last="Prince">Gregory A. Prince</name>
<name sortKey="Sutter, Deena E" sort="Sutter, Deena E" uniqKey="Sutter D" first="Deena E." last="Sutter">Deena E. Sutter</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/PascalFrancis/Checkpoint

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A50 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 001A50 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    PascalFrancis
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Pascal:07-0480553
   |texte=   Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease
}}

This area was generated with Dilib version V0.6.34.
Data generation: Wed Jun 10 11:04:28 2020. Site generation: Sun Mar 28 09:10:28 2021

	Serveur d'exploration sur les pandémies grippales
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les pandémies grippales

Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease

Co-infection of the cotton rat (Sigmodon hispidus) with Staphylococcus aureus and influenza A virus results in synergistic disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri