Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (HINI) 2009 influenza virus
Identifieur interne : 000379 ( PascalFrancis/Checkpoint ); précédent : 000378; suivant : 000380Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (HINI) 2009 influenza virus
Auteurs : A. Pierangeli [Italie] ; C. Scagnolari [Italie] ; C. Selvaggi [Italie] ; K. Monteleone [Italie] ; S. Verzaro [Italie] ; R. Nenna [Italie] ; G. Cangiano [Italie] ; C. Moretti [Italie] ; P. Papoff [Italie] ; G. Antonelli [Italie] ; F. Midulla [Italie]Source :
- Clinical microbiology and infection [ 1198-743X ] ; 2012.
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Abstract
To characterize respiratory virus infections during the first autumn-winter season of pandemic A (HINI) 2009 influenza virus (A/H I N 1/ 2009) circulation, a prospective study in children attending a paediatric emergency department at the Sapienza University hospital, Rome, was conducted from November 2009 to March 2010. By means of both nasal washings and pharyngeal swabs, enrolled children were checked for 14 respiratory viruses. The majority of acute respiratory infections resulted from viral pathogens (135/231, 58%). Overall, the most common was respiratory syncytial virus (RSV), in 64% of positive samples; A/H 1N1/2009 was the only influenza virus found in 16% and rhinovirus (RV) in 15%. Virus-positive children did not differ significantly from virus-negative children in signs and symptoms at presentation; of the virus groups, RSV-infected children were younger and more frequently admitted to intensive-care units than those infected with A/H1N1/2009 and RV. Of the hospitalized children, stratified by age, both infants and children aged >1 year with RSV were most severely affected, whereas A/H1N1/2009 infections were the mildest overall, although with related pulmonary involvement in older children. Children with RV infections, detected in two flares partially overlapping with the A/H IN 1/2009 and RSV peaks, presented with bronchiolitis, wheezing and pneumonia. Leukocytosis occurred more frequently in RV-infected and A/H I N 1/2009-infected children, and numbers of blood eosinophils were significantly elevated in RV-infected infants. Given the fact that clinical and epidemiological criteria are not sufficient to identify viral respiratory infections, a timely virological diagnosis could allow different infections to be managed separately.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (HINI) 2009 influenza virus</title><author><name sortKey="Pierangeli, A" sort="Pierangeli, A" uniqKey="Pierangeli A" first="A." last="Pierangeli">A. Pierangeli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Scagnolari, C" sort="Scagnolari, C" uniqKey="Scagnolari C" first="C." last="Scagnolari">C. Scagnolari</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Selvaggi, C" sort="Selvaggi, C" uniqKey="Selvaggi C" first="C." last="Selvaggi">C. Selvaggi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Monteleone, K" sort="Monteleone, K" uniqKey="Monteleone K" first="K." last="Monteleone">K. Monteleone</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Verzaro, S" sort="Verzaro, S" uniqKey="Verzaro S" first="S." last="Verzaro">S. Verzaro</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Nenna, R" sort="Nenna, R" uniqKey="Nenna R" first="R." last="Nenna">R. Nenna</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cangiano, G" sort="Cangiano, G" uniqKey="Cangiano G" first="G." last="Cangiano">G. Cangiano</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Moretti, C" sort="Moretti, C" uniqKey="Moretti C" first="C." last="Moretti">C. Moretti</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Papoff, P" sort="Papoff, P" uniqKey="Papoff P" first="P." last="Papoff">P. Papoff</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Antonelli, G" sort="Antonelli, G" uniqKey="Antonelli G" first="G." last="Antonelli">G. Antonelli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Midulla, F" sort="Midulla, F" uniqKey="Midulla F" first="F." last="Midulla">F. Midulla</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">12-0159747</idno><date when="2012">2012</date><idno type="stanalyst">PASCAL 12-0159747 INIST</idno><idno type="RBID">Pascal:12-0159747</idno><idno type="wicri:Area/PascalFrancis/Corpus">000732</idno><idno type="wicri:Area/PascalFrancis/Curation">001704</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000379</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000379</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (HINI) 2009 influenza virus</title><author><name sortKey="Pierangeli, A" sort="Pierangeli, A" uniqKey="Pierangeli A" first="A." last="Pierangeli">A. Pierangeli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Scagnolari, C" sort="Scagnolari, C" uniqKey="Scagnolari C" first="C." last="Scagnolari">C. Scagnolari</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Selvaggi, C" sort="Selvaggi, C" uniqKey="Selvaggi C" first="C." last="Selvaggi">C. Selvaggi</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Monteleone, K" sort="Monteleone, K" uniqKey="Monteleone K" first="K." last="Monteleone">K. Monteleone</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Verzaro, S" sort="Verzaro, S" uniqKey="Verzaro S" first="S." last="Verzaro">S. Verzaro</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Nenna, R" sort="Nenna, R" uniqKey="Nenna R" first="R." last="Nenna">R. Nenna</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Cangiano, G" sort="Cangiano, G" uniqKey="Cangiano G" first="G." last="Cangiano">G. Cangiano</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Moretti, C" sort="Moretti, C" uniqKey="Moretti C" first="C." last="Moretti">C. Moretti</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Papoff, P" sort="Papoff, P" uniqKey="Papoff P" first="P." last="Papoff">P. Papoff</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Antonelli, G" sort="Antonelli, G" uniqKey="Antonelli G" first="G." last="Antonelli">G. Antonelli</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Midulla, F" sort="Midulla, F" uniqKey="Midulla F" first="F." last="Midulla">F. Midulla</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Clinical microbiology and infection</title><title level="j" type="abbreviated">Clin. microbiol. infect.</title><idno type="ISSN">1198-743X</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical microbiology and infection</title><title level="j" type="abbreviated">Clin. microbiol. infect.</title><idno type="ISSN">1198-743X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Diagnosis</term><term>Emergency department</term><term>Flulike syndrome</term><term>Human respiratory syncytial virus</term><term>Influenza A</term><term>Respiratory disease</term><term>Respiratory tract</term><term>Rhinovirus</term><term>Winter</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Grippe A</term><term>Voie respiratoire</term><term>Service urgence</term><term>Hiver</term><term>Enfant</term><term>Virus respiratoire syncytial humain</term><term>Rhinovirus</term><term>Diagnostic</term><term>Pathologie de l'appareil respiratoire</term><term>Pandémie</term><term>Syndrome pseudogrippal</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To characterize respiratory virus infections during the first autumn-winter season of pandemic A (HINI) 2009 influenza virus (A/H I N 1/ 2009) circulation, a prospective study in children attending a paediatric emergency department at the Sapienza University hospital, Rome, was conducted from November 2009 to March 2010. By means of both nasal washings and pharyngeal swabs, enrolled children were checked for 14 respiratory viruses. The majority of acute respiratory infections resulted from viral pathogens (135/231, 58%). Overall, the most common was respiratory syncytial virus (RSV), in 64% of positive samples; A/H 1N1/2009 was the only influenza virus found in 16% and rhinovirus (RV) in 15%. Virus-positive children did not differ significantly from virus-negative children in signs and symptoms at presentation; of the virus groups, RSV-infected children were younger and more frequently admitted to intensive-care units than those infected with A/H1N1/2009 and RV. Of the hospitalized children, stratified by age, both infants and children aged >1 year with RSV were most severely affected, whereas A/H1N1/2009 infections were the mildest overall, although with related pulmonary involvement in older children. Children with RV infections, detected in two flares partially overlapping with the A/H IN 1/2009 and RSV peaks, presented with bronchiolitis, wheezing and pneumonia. Leukocytosis occurred more frequently in RV-infected and A/H I N 1/2009-infected children, and numbers of blood eosinophils were significantly elevated in RV-infected infants. Given the fact that clinical and epidemiological criteria are not sufficient to identify viral respiratory infections, a timely virological diagnosis could allow different infections to be managed separately.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1198-743X</s0></fA01><fA03 i2="1"><s0>Clin. microbiol. infect.</s0></fA03><fA05><s2>18</s2></fA05><fA06><s2>4</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Virological and clinical characterization of respiratory infections in children attending an emergency department during the first autumn-winter circulation of pandemic A (HINI) 2009 influenza virus</s1></fA08><fA11 i1="01" i2="1"><s1>PIERANGELI (A.)</s1></fA11><fA11 i1="02" i2="1"><s1>SCAGNOLARI (C.)</s1></fA11><fA11 i1="03" i2="1"><s1>SELVAGGI (C.)</s1></fA11><fA11 i1="04" i2="1"><s1>MONTELEONE (K.)</s1></fA11><fA11 i1="05" i2="1"><s1>VERZARO (S.)</s1></fA11><fA11 i1="06" i2="1"><s1>NENNA (R.)</s1></fA11><fA11 i1="07" i2="1"><s1>CANGIANO (G.)</s1></fA11><fA11 i1="08" i2="1"><s1>MORETTI (C.)</s1></fA11><fA11 i1="09" i2="1"><s1>PAPOFF (P.)</s1></fA11><fA11 i1="10" i2="1"><s1>ANTONELLI (G.)</s1></fA11><fA11 i1="11" i2="1"><s1>MIDULLA (F.)</s1></fA11><fA14 i1="01"><s1>Virology laboratory, Department of Molecular Medicine and 2) Department of Paediatrics, Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA20><s1>366-373</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>26593</s2><s5>354000508497110080</s5></fA43><fA44><s0>0000</s0><s1>© 2012 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>28 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>12-0159747</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Clinical microbiology and infection</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>To characterize respiratory virus infections during the first autumn-winter season of pandemic A (HINI) 2009 influenza virus (A/H I N 1/ 2009) circulation, a prospective study in children attending a paediatric emergency department at the Sapienza University hospital, Rome, was conducted from November 2009 to March 2010. By means of both nasal washings and pharyngeal swabs, enrolled children were checked for 14 respiratory viruses. The majority of acute respiratory infections resulted from viral pathogens (135/231, 58%). Overall, the most common was respiratory syncytial virus (RSV), in 64% of positive samples; A/H 1N1/2009 was the only influenza virus found in 16% and rhinovirus (RV) in 15%. Virus-positive children did not differ significantly from virus-negative children in signs and symptoms at presentation; of the virus groups, RSV-infected children were younger and more frequently admitted to intensive-care units than those infected with A/H1N1/2009 and RV. Of the hospitalized children, stratified by age, both infants and children aged >1 year with RSV were most severely affected, whereas A/H1N1/2009 infections were the mildest overall, although with related pulmonary involvement in older children. Children with RV infections, detected in two flares partially overlapping with the A/H IN 1/2009 and RSV peaks, presented with bronchiolitis, wheezing and pneumonia. Leukocytosis occurred more frequently in RV-infected and A/H I N 1/2009-infected children, and numbers of blood eosinophils were significantly elevated in RV-infected infants. Given the fact that clinical and epidemiological criteria are not sufficient to identify viral respiratory infections, a timely virological diagnosis could allow different infections to be managed separately.</s0></fC01><fC02 i1="01" i2="X"><s0>002B05C02C</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Grippe A</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Influenza A</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Gripe A</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Voie respiratoire</s0><s5>07</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Respiratory tract</s0><s5>07</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Vía respiratoria</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Service urgence</s0><s5>08</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Emergency department</s0><s5>08</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Servicio urgencia</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Hiver</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Winter</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Invierno</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Enfant</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Child</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Niño</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Virus respiratoire syncytial humain</s0><s2>NW</s2><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Human respiratory syncytial virus</s0><s2>NW</s2><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Human respiratory syncytial virus</s0><s2>NW</s2><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Rhinovirus</s0><s2>NW</s2><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Rhinovirus</s0><s2>NW</s2><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Rhinovirus</s0><s2>NW</s2><s5>12</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Diagnostic</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Diagnosis</s0><s5>13</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Diagnóstico</s0><s5>13</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Pathologie de l'appareil respiratoire</s0><s5>30</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Respiratory disease</s0><s5>30</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Aparato respiratorio patología</s0><s5>30</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Pandémie</s0><s4>INC</s4><s5>86</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Syndrome pseudogrippal</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Flulike syndrome</s0><s4>CD</s4><s5>96</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Hombre</s0></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pneumovirus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Pneumovirus</s0><s2>NW</s2></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Pneumovirus</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Pneumovirinae</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Pneumovirinae</s0><s2>NW</s2></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Pneumovirinae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Paramyxoviridae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Paramyxoviridae</s0><s2>NW</s2></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Paramyxoviridae</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Mononegavirales</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Mononegavirales</s0><s2>NW</s2></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Mononegavirales</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Virus</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Picornaviridae</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Picornaviridae</s0><s2>NW</s2></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Picornaviridae</s0><s2>NW</s2></fC07><fN21><s1>122</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Pierangeli, A" sort="Pierangeli, A" uniqKey="Pierangeli A" first="A." last="Pierangeli">A. Pierangeli</name></region><name sortKey="Antonelli, G" sort="Antonelli, G" uniqKey="Antonelli G" first="G." last="Antonelli">G. Antonelli</name><name sortKey="Cangiano, G" sort="Cangiano, G" uniqKey="Cangiano G" first="G." last="Cangiano">G. Cangiano</name><name sortKey="Midulla, F" sort="Midulla, F" uniqKey="Midulla F" first="F." last="Midulla">F. Midulla</name><name sortKey="Monteleone, K" sort="Monteleone, K" uniqKey="Monteleone K" first="K." last="Monteleone">K. Monteleone</name><name sortKey="Moretti, C" sort="Moretti, C" uniqKey="Moretti C" first="C." last="Moretti">C. Moretti</name><name sortKey="Nenna, R" sort="Nenna, R" uniqKey="Nenna R" first="R." last="Nenna">R. Nenna</name><name sortKey="Papoff, P" sort="Papoff, P" uniqKey="Papoff P" first="P." last="Papoff">P. Papoff</name><name sortKey="Scagnolari, C" sort="Scagnolari, C" uniqKey="Scagnolari C" first="C." last="Scagnolari">C. Scagnolari</name><name sortKey="Selvaggi, C" sort="Selvaggi, C" uniqKey="Selvaggi C" first="C." last="Selvaggi">C. Selvaggi</name><name sortKey="Verzaro, S" sort="Verzaro, S" uniqKey="Verzaro S" first="S." last="Verzaro">S. Verzaro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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