PandemieGrippaleV1, PascalFrancis, Checkpoint, bibRecord, 000247

Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England

Identifieur interne : 000247 ( PascalFrancis/Checkpoint ); précédent : 000246; suivant : 000248

Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England

Auteurs : Ilaria Dorigatti [Royaume-Uni] ; Simon Cauchemez [Royaume-Uni] ; Neil M. Ferguson [Royaume-Uni]

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2013.

RBID : Pascal:14-0095175

Descripteurs français

Pascal (Inist)
- Grippe, Transmission homme homme, 2009, Angleterre, Homme, Epidémiologie, Influenzavirus A(H1N1).
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- 2009, England, Epidemiology, Human, Influenza, Transmission from man to man.

Abstract

In the 2009 H1N1 pandemic, the United Kingdom experienced two waves of infection, the first in the late spring and the second in the autumn. Given the low level of susceptibility to the pandemic virus expected to be remaining in the population after the second wave, it was a surprise that a substantial third epidemic occurred in the UK population between November 2010 and February 2011, despite no evidence for any significant antigenic evolution of the pandemic virus. Here, we use a mathematical model of influenza transmission embedded within a Bayesian synthesis inferential framework to jointly analyze syndromic, virological, and serological surveillance data collected in England in 2009-2011 and thereby assess epidemiological mechanisms which might have generated the third wave. We find that substantially increased transmissibility of the H1N1pdm09 virus is required to reproduce the third wave, suggesting that the virus evolved and increased fitness in the human host by the end of 2010, or that the very cold weather experienced in the United Kingdom at that time enhanced transmission rates. We also find some evidence that the preexisting heterologous immunity which reduced attack rates in adults during 2009 had substantially decayed by the winter of 2010, thus increasing the susceptibility of the adult population to infection. Finally, our analysis suggests that a pandemic vaccination campaign targeting adults and school-age children could have mitigated or prevented the third wave even at moderate levels of coverage.

Affiliations:

Royaume-Uni

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Le document en format XML

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Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England

Increased transmissibility explains the third wave of infection by the 2009 H1N1 pandemic virus in England

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri