Antiviral Therapy for the Next Influenza Pandemic
Identifieur interne : 001F41 ( Ncbi/Merge ); précédent : 001F40; suivant : 001F42Antiviral Therapy for the Next Influenza Pandemic
Auteurs : Aeron C. Hurt [Australie]Source :
- Tropical Medicine and Infectious Disease [ 2414-6366 ] ; 2019.
Abstract
Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual countries. However, data gaps remain regarding the effectiveness of new and existing antivirals in severely ill patients, and regarding which monotherapy or combinations of antivirals may yield the greatest improvement in outcomes. Regardless of the drug being used, influenza antivirals are most effective when treatment is initiated early in the course of infection, and therefore in a pandemic, effective strategies which enable rapid diagnosis and prompt delivery will yield the greatest benefits.
Url:
DOI: 10.3390/tropicalmed4020067
PubMed: 31003518
PubMed Central: 6630704
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiviral Therapy for the Next Influenza Pandemic</title><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name><affiliation><nlm:aff id="af1-tropicalmed-04-00067">WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;<email>Aeron.Hurt@influenzacentre.org</email>; Tel.: +613-9342-9314</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-tropicalmed-04-00067">Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31003518</idno><idno type="pmc">6630704</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630704</idno><idno type="RBID">PMC:6630704</idno><idno type="doi">10.3390/tropicalmed4020067</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000467</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000467</idno><idno type="wicri:Area/Pmc/Curation">000467</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000467</idno><idno type="wicri:Area/Pmc/Checkpoint">000094</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000094</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:31003518</idno><idno type="wicri:Area/PubMed/Corpus">000153</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000153</idno><idno type="wicri:Area/PubMed/Curation">000153</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000153</idno><idno type="wicri:Area/PubMed/Checkpoint">000175</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000175</idno><idno type="wicri:Area/Ncbi/Merge">001F41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiviral Therapy for the Next Influenza Pandemic</title><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name><affiliation><nlm:aff id="af1-tropicalmed-04-00067">WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;<email>Aeron.Hurt@influenzacentre.org</email>; Tel.: +613-9342-9314</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-tropicalmed-04-00067">Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Tropical Medicine and Infectious Disease</title><idno type="eISSN">2414-6366</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual countries. However, data gaps remain regarding the effectiveness of new and existing antivirals in severely ill patients, and regarding which monotherapy or combinations of antivirals may yield the greatest improvement in outcomes. Regardless of the drug being used, influenza antivirals are most effective when treatment is initiated early in the course of infection, and therefore in a pandemic, effective strategies which enable rapid diagnosis and prompt delivery will yield the greatest benefits.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shanks, G D" uniqKey="Shanks G">G.D. Shanks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luke, T C" uniqKey="Luke T">T.C. 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McVernon</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="31003518"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiviral Therapy for the Next Influenza Pandemic</title><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name><affiliation><nlm:aff id="af1-tropicalmed-04-00067">WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;<email>Aeron.Hurt@influenzacentre.org</email>; Tel.: +613-9342-9314</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-tropicalmed-04-00067">Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31003518</idno><idno type="pmc">6630704</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630704</idno><idno type="RBID">PMC:6630704</idno><idno type="doi">10.3390/tropicalmed4020067</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000467</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000467</idno><idno type="wicri:Area/Pmc/Curation">000467</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000467</idno><idno type="wicri:Area/Pmc/Checkpoint">000094</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000094</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antiviral Therapy for the Next Influenza Pandemic</title><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C." last="Hurt">Aeron C. Hurt</name><affiliation><nlm:aff id="af1-tropicalmed-04-00067">WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia;<email>Aeron.Hurt@influenzacentre.org</email>; Tel.: +613-9342-9314</nlm:aff></affiliation><affiliation wicri:level="4"><nlm:aff id="af2-tropicalmed-04-00067">Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Microbiology and Immunology, University of Melbourne, Parkville, VIC 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Tropical Medicine and Infectious Disease</title><idno type="eISSN">2414-6366</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual countries. However, data gaps remain regarding the effectiveness of new and existing antivirals in severely ill patients, and regarding which monotherapy or combinations of antivirals may yield the greatest improvement in outcomes. Regardless of the drug being used, influenza antivirals are most effective when treatment is initiated early in the course of infection, and therefore in a pandemic, effective strategies which enable rapid diagnosis and prompt delivery will yield the greatest benefits.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shanks, G D" uniqKey="Shanks G">G.D. Shanks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luke, T C" uniqKey="Luke T">T.C. 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McVernon</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antiviral Therapy for the Next Influenza Pandemic.</title><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C" last="Hurt">Aeron C. Hurt</name><affiliation wicri:level="1"><nlm:affiliation>WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Aeron.Hurt@influenzacentre.org.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000</wicri:regionArea><wicri:noRegion>VIC 3000</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31003518</idno><idno type="pmid">31003518</idno><idno type="doi">10.3390/tropicalmed4020067</idno><idno type="wicri:Area/PubMed/Corpus">000153</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000153</idno><idno type="wicri:Area/PubMed/Curation">000153</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000153</idno><idno type="wicri:Area/PubMed/Checkpoint">000175</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000175</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antiviral Therapy for the Next Influenza Pandemic.</title><author><name sortKey="Hurt, Aeron C" sort="Hurt, Aeron C" uniqKey="Hurt A" first="Aeron C" last="Hurt">Aeron C. Hurt</name><affiliation wicri:level="1"><nlm:affiliation>WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia. Aeron.Hurt@influenzacentre.org.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>WHO Collaborating Centre for Reference and Research on Influenza, VIDRL, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000</wicri:regionArea><wicri:noRegion>VIC 3000</wicri:noRegion></affiliation></author></analytic><series><title level="j">Tropical medicine and infectious disease</title><idno type="eISSN">2414-6366</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Influenza antivirals will play a critical role in the treatment of outpatients and hospitalised patients in the next pandemic. In the past decade, a number of new influenza antivirals have been licensed for seasonal influenza, which can now be considered for inclusion into antiviral stockpiles held by the World Health Organization (WHO) and individual countries. However, data gaps remain regarding the effectiveness of new and existing antivirals in severely ill patients, and regarding which monotherapy or combinations of antivirals may yield the greatest improvement in outcomes. Regardless of the drug being used, influenza antivirals are most effective when treatment is initiated early in the course of infection, and therefore in a pandemic, effective strategies which enable rapid diagnosis and prompt delivery will yield the greatest benefits.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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