Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
Identifieur interne : 001F18 ( Ncbi/Merge ); précédent : 001F17; suivant : 001F19Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant Staphylococcus aureus
Auteurs : Michaela E. Nickol ; Justine Ciric ; Shane D. Falcinelli ; Daniel S. Chertow [États-Unis] ; Jason KindrachukSource :
- Viruses [ 1999-4915 ] ; 2019.
Descripteurs français
- KwdFr :
- Analyse par réseau de protéines, Barrière alvéolocapillaire (physiopathologie), Cellules A549, Co-infection (microbiologie), Co-infection (virologie), Facteurs de virulence, Grippe humaine (microbiologie), Grippe humaine (physiopathologie), Humains, Infections à staphylocoques (physiopathologie), Infections à staphylocoques (virologie), Pneumocytes (microbiologie), Pneumocytes (virologie), Poumon (anatomopathologie), Réplication virale, Sous-type H1N1 du virus de la grippe A, Staphylococcus aureus résistant à la méticilline.
- MESH :
- anatomopathologie : Poumon.
- microbiologie : Co-infection, Grippe humaine, Pneumocytes.
- physiopathologie : Barrière alvéolocapillaire, Grippe humaine, Infections à staphylocoques.
- virologie : Co-infection, Infections à staphylocoques, Pneumocytes.
- Analyse par réseau de protéines, Cellules A549, Facteurs de virulence, Humains, Réplication virale, Sous-type H1N1 du virus de la grippe A, Staphylococcus aureus résistant à la méticilline.
English descriptors
- KwdEn :
- A549 Cells, Alveolar Epithelial Cells (microbiology), Alveolar Epithelial Cells (virology), Blood-Air Barrier (physiopathology), Coinfection (microbiology), Coinfection (virology), Humans, Influenza A Virus, H1N1 Subtype, Influenza, Human (microbiology), Influenza, Human (physiopathology), Lung (pathology), Methicillin-Resistant Staphylococcus aureus, Protein Array Analysis, Staphylococcal Infections (physiopathology), Staphylococcal Infections (virology), Virulence Factors, Virus Replication.
- MESH :
- chemical : Virulence Factors.
- microbiology : Alveolar Epithelial Cells, Coinfection, Influenza, Human.
- pathology : Lung.
- physiopathology : Blood-Air Barrier, Influenza, Human, Staphylococcal Infections.
- virology : Alveolar Epithelial Cells, Coinfection, Staphylococcal Infections.
- A549 Cells, Humans, Influenza A Virus, H1N1 Subtype, Methicillin-Resistant Staphylococcus aureus, Protein Array Analysis, Virus Replication.
Abstract
Influenza viruses are a threat to global public health resulting in ~500,000 deaths each year. Despite an intensive vaccination program, influenza infections remain a recurrent, yet unsolved public health problem. Secondary bacterial infections frequently complicate influenza infections during seasonal outbreaks and pandemics, resulting in increased morbidity and mortality.
Url:
DOI: 10.3390/v11020116
PubMed: 30699912
PubMed Central: 6409999
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PMC:6409999Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant <italic>Staphylococcus aureus</italic>
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<author><name sortKey="Nickol, Michaela E" sort="Nickol, Michaela E" uniqKey="Nickol M" first="Michaela E." last="Nickol">Michaela E. Nickol</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
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<author><name sortKey="Ciric, Justine" sort="Ciric, Justine" uniqKey="Ciric J" first="Justine" last="Ciric">Justine Ciric</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
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<author><name sortKey="Falcinelli, Shane D" sort="Falcinelli, Shane D" uniqKey="Falcinelli S" first="Shane D." last="Falcinelli">Shane D. Falcinelli</name>
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<author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S." last="Chertow">Daniel S. Chertow</name>
<affiliation><nlm:aff id="af3-viruses-11-00116">Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;<email>chertowd@cc.nih.gov</email>
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<placeName><region type="state">Maryland</region>
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(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
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<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2019">2019</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term>
<term>Alveolar Epithelial Cells (microbiology)</term>
<term>Alveolar Epithelial Cells (virology)</term>
<term>Blood-Air Barrier (physiopathology)</term>
<term>Coinfection (microbiology)</term>
<term>Coinfection (virology)</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human (microbiology)</term>
<term>Influenza, Human (physiopathology)</term>
<term>Lung (pathology)</term>
<term>Methicillin-Resistant Staphylococcus aureus</term>
<term>Protein Array Analysis</term>
<term>Staphylococcal Infections (physiopathology)</term>
<term>Staphylococcal Infections (virology)</term>
<term>Virulence Factors</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse par réseau de protéines</term>
<term>Barrière alvéolocapillaire (physiopathologie)</term>
<term>Cellules A549</term>
<term>Co-infection (microbiologie)</term>
<term>Co-infection (virologie)</term>
<term>Facteurs de virulence</term>
<term>Grippe humaine (microbiologie)</term>
<term>Grippe humaine (physiopathologie)</term>
<term>Humains</term>
<term>Infections à staphylocoques (physiopathologie)</term>
<term>Infections à staphylocoques (virologie)</term>
<term>Pneumocytes (microbiologie)</term>
<term>Pneumocytes (virologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Réplication virale</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Staphylococcus aureus résistant à la méticilline</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Co-infection</term>
<term>Grippe humaine</term>
<term>Pneumocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Alveolar Epithelial Cells</term>
<term>Coinfection</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Barrière alvéolocapillaire</term>
<term>Grippe humaine</term>
<term>Infections à staphylocoques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blood-Air Barrier</term>
<term>Influenza, Human</term>
<term>Staphylococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Co-infection</term>
<term>Infections à staphylocoques</term>
<term>Pneumocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Alveolar Epithelial Cells</term>
<term>Coinfection</term>
<term>Staphylococcal Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Methicillin-Resistant Staphylococcus aureus</term>
<term>Protein Array Analysis</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse par réseau de protéines</term>
<term>Cellules A549</term>
<term>Facteurs de virulence</term>
<term>Humains</term>
<term>Réplication virale</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Staphylococcus aureus résistant à la méticilline</term>
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<front><div type="abstract" xml:lang="en"><p>Influenza viruses are a threat to global public health resulting in ~500,000 deaths each year. Despite an intensive vaccination program, influenza infections remain a recurrent, yet unsolved public health problem. Secondary bacterial infections frequently complicate influenza infections during seasonal outbreaks and pandemics, resulting in increased morbidity and mortality. <italic>Staphylococcus aureus</italic>
, including methicillin-resistant <italic>S. aureus</italic>
(MRSA), is frequently associated with these co-infections, including the 2009 influenza pandemic. Damage to alveolar epithelium is a major contributor to severe influenza-bacterial co-infections and can result in gas exchange abnormalities, fluid leakage, and respiratory insufficiency. These deleterious manifestations likely involve both pathogen- and host-mediated mechanisms. However, there is a paucity of information regarding the mechanisms (pathogen- and/or host-mediated) underlying influenza-bacterial co-infection pathogenesis. To address this, we characterized the contributions of viral-, bacterial-, and host-mediated factors to the altered structure and function of alveolar epithelial cells during co-infection with a focus on the 2009 pandemic influenza (pdm2009) and MRSA. Here, we characterized pdm2009 and MRSA replication kinetics, temporal host kinome responses, modulation of MRSA virulence factors, and disruption of alveolar barrier integrity in response to pdm2009-MRSA co-infection. Our results suggest that alveolar barrier disruption during co-infection is mediated primarily through host response dysregulation, resulting in loss of alveolar barrier integrity.</p>
</div>
</front>
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</listBibl>
</div1>
</back>
</TEI>
<double pmid="30699912"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant <italic>Staphylococcus aureus</italic>
</title>
<author><name sortKey="Nickol, Michaela E" sort="Nickol, Michaela E" uniqKey="Nickol M" first="Michaela E." last="Nickol">Michaela E. Nickol</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciric, Justine" sort="Ciric, Justine" uniqKey="Ciric J" first="Justine" last="Ciric">Justine Ciric</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Falcinelli, Shane D" sort="Falcinelli, Shane D" uniqKey="Falcinelli S" first="Shane D." last="Falcinelli">Shane D. Falcinelli</name>
<affiliation><nlm:aff id="af2-viruses-11-00116">Department of Microbiology and Immunology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;<email>shane_falcinelli@med.unc.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S." last="Chertow">Daniel S. Chertow</name>
<affiliation><nlm:aff id="af3-viruses-11-00116">Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;<email>chertowd@cc.nih.gov</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="af4-viruses-11-00116">Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30699912</idno>
<idno type="pmc">6409999</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409999</idno>
<idno type="RBID">PMC:6409999</idno>
<idno type="doi">10.3390/v11020116</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000E45</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E45</idno>
<idno type="wicri:Area/Pmc/Curation">000E45</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E45</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000087</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000087</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant <italic>Staphylococcus aureus</italic>
</title>
<author><name sortKey="Nickol, Michaela E" sort="Nickol, Michaela E" uniqKey="Nickol M" first="Michaela E." last="Nickol">Michaela E. Nickol</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciric, Justine" sort="Ciric, Justine" uniqKey="Ciric J" first="Justine" last="Ciric">Justine Ciric</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Falcinelli, Shane D" sort="Falcinelli, Shane D" uniqKey="Falcinelli S" first="Shane D." last="Falcinelli">Shane D. Falcinelli</name>
<affiliation><nlm:aff id="af2-viruses-11-00116">Department of Microbiology and Immunology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA;<email>shane_falcinelli@med.unc.edu</email>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S." last="Chertow">Daniel S. Chertow</name>
<affiliation><nlm:aff id="af3-viruses-11-00116">Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA;<email>chertowd@cc.nih.gov</email>
</nlm:aff>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="af4-viruses-11-00116">Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD 20892, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name>
<affiliation><nlm:aff id="af1-viruses-11-00116">Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada;<email>nickolm@myumanitoba.ca</email>
(M.E.N.);<email>ciricj@myumanitoba.ca</email>
(J.C.)</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Influenza viruses are a threat to global public health resulting in ~500,000 deaths each year. Despite an intensive vaccination program, influenza infections remain a recurrent, yet unsolved public health problem. Secondary bacterial infections frequently complicate influenza infections during seasonal outbreaks and pandemics, resulting in increased morbidity and mortality. <italic>Staphylococcus aureus</italic>
, including methicillin-resistant <italic>S. aureus</italic>
(MRSA), is frequently associated with these co-infections, including the 2009 influenza pandemic. Damage to alveolar epithelium is a major contributor to severe influenza-bacterial co-infections and can result in gas exchange abnormalities, fluid leakage, and respiratory insufficiency. These deleterious manifestations likely involve both pathogen- and host-mediated mechanisms. However, there is a paucity of information regarding the mechanisms (pathogen- and/or host-mediated) underlying influenza-bacterial co-infection pathogenesis. To address this, we characterized the contributions of viral-, bacterial-, and host-mediated factors to the altered structure and function of alveolar epithelial cells during co-infection with a focus on the 2009 pandemic influenza (pdm2009) and MRSA. Here, we characterized pdm2009 and MRSA replication kinetics, temporal host kinome responses, modulation of MRSA virulence factors, and disruption of alveolar barrier integrity in response to pdm2009-MRSA co-infection. Our results suggest that alveolar barrier disruption during co-infection is mediated primarily through host response dysregulation, resulting in loss of alveolar barrier integrity.</p>
</div>
</front>
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</div1>
</back>
</TEI>
</pmc>
<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant <i>Staphylococcus aureus</i>
.</title>
<author><name sortKey="Nickol, Michaela E" sort="Nickol, Michaela E" uniqKey="Nickol M" first="Michaela E" last="Nickol">Michaela E. Nickol</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. nickolm@myumanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ciric, Justine" sort="Ciric, Justine" uniqKey="Ciric J" first="Justine" last="Ciric">Justine Ciric</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. ciricj@myumanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falcinelli, Shane D" sort="Falcinelli, Shane D" uniqKey="Falcinelli S" first="Shane D" last="Falcinelli">Shane D. Falcinelli</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. shane_falcinelli@med.unc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S" last="Chertow">Daniel S. Chertow</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. chertowd@cc.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Jason.Kindrachuk@umanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:30699912</idno>
<idno type="pmid">30699912</idno>
<idno type="doi">10.3390/v11020116</idno>
<idno type="wicri:Area/PubMed/Corpus">000176</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Characterization of Host and Bacterial Contributions to Lung Barrier Dysfunction Following Co-infection with 2009 Pandemic Influenza and Methicillin Resistant <i>Staphylococcus aureus</i>
.</title>
<author><name sortKey="Nickol, Michaela E" sort="Nickol, Michaela E" uniqKey="Nickol M" first="Michaela E" last="Nickol">Michaela E. Nickol</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. nickolm@myumanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ciric, Justine" sort="Ciric, Justine" uniqKey="Ciric J" first="Justine" last="Ciric">Justine Ciric</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. ciricj@myumanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Falcinelli, Shane D" sort="Falcinelli, Shane D" uniqKey="Falcinelli S" first="Shane D" last="Falcinelli">Shane D. Falcinelli</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA. shane_falcinelli@med.unc.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology and Immunology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chertow, Daniel S" sort="Chertow, Daniel S" uniqKey="Chertow D" first="Daniel S" last="Chertow">Daniel S. Chertow</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. chertowd@cc.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kindrachuk, Jason" sort="Kindrachuk, Jason" uniqKey="Kindrachuk J" first="Jason" last="Kindrachuk">Jason Kindrachuk</name>
<affiliation wicri:level="4"><nlm:affiliation>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada. Jason.Kindrachuk@umanitoba.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9</wicri:regionArea>
<orgName type="university">Université du Manitoba</orgName>
<placeName><settlement type="city">Winnipeg</settlement>
<region type="state">Manitoba</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term>
<term>Alveolar Epithelial Cells (microbiology)</term>
<term>Alveolar Epithelial Cells (virology)</term>
<term>Blood-Air Barrier (physiopathology)</term>
<term>Coinfection (microbiology)</term>
<term>Coinfection (virology)</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza, Human (microbiology)</term>
<term>Influenza, Human (physiopathology)</term>
<term>Lung (pathology)</term>
<term>Methicillin-Resistant Staphylococcus aureus</term>
<term>Protein Array Analysis</term>
<term>Staphylococcal Infections (physiopathology)</term>
<term>Staphylococcal Infections (virology)</term>
<term>Virulence Factors</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Analyse par réseau de protéines</term>
<term>Barrière alvéolocapillaire (physiopathologie)</term>
<term>Cellules A549</term>
<term>Co-infection (microbiologie)</term>
<term>Co-infection (virologie)</term>
<term>Facteurs de virulence</term>
<term>Grippe humaine (microbiologie)</term>
<term>Grippe humaine (physiopathologie)</term>
<term>Humains</term>
<term>Infections à staphylocoques (physiopathologie)</term>
<term>Infections à staphylocoques (virologie)</term>
<term>Pneumocytes (microbiologie)</term>
<term>Pneumocytes (virologie)</term>
<term>Poumon (anatomopathologie)</term>
<term>Réplication virale</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Staphylococcus aureus résistant à la méticilline</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Co-infection</term>
<term>Grippe humaine</term>
<term>Pneumocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Alveolar Epithelial Cells</term>
<term>Coinfection</term>
<term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Barrière alvéolocapillaire</term>
<term>Grippe humaine</term>
<term>Infections à staphylocoques</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Blood-Air Barrier</term>
<term>Influenza, Human</term>
<term>Staphylococcal Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Co-infection</term>
<term>Infections à staphylocoques</term>
<term>Pneumocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Alveolar Epithelial Cells</term>
<term>Coinfection</term>
<term>Staphylococcal Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Methicillin-Resistant Staphylococcus aureus</term>
<term>Protein Array Analysis</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Analyse par réseau de protéines</term>
<term>Cellules A549</term>
<term>Facteurs de virulence</term>
<term>Humains</term>
<term>Réplication virale</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Staphylococcus aureus résistant à la méticilline</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Influenza viruses are a threat to global public health resulting in ~500,000 deaths each year. Despite an intensive vaccination program, influenza infections remain a recurrent, yet unsolved public health problem. Secondary bacterial infections frequently complicate influenza infections during seasonal outbreaks and pandemics, resulting in increased morbidity and mortality. <i>Staphylococcus aureus</i>
, including methicillin-resistant <i>S. aureus</i>
(MRSA), is frequently associated with these co-infections, including the 2009 influenza pandemic. Damage to alveolar epithelium is a major contributor to severe influenza-bacterial co-infections and can result in gas exchange abnormalities, fluid leakage, and respiratory insufficiency. These deleterious manifestations likely involve both pathogen- and host-mediated mechanisms. However, there is a paucity of information regarding the mechanisms (pathogen- and/or host-mediated) underlying influenza-bacterial co-infection pathogenesis. To address this, we characterized the contributions of viral-, bacterial-, and host-mediated factors to the altered structure and function of alveolar epithelial cells during co-infection with a focus on the 2009 pandemic influenza (pdm2009) and MRSA. Here, we characterized pdm2009 and MRSA replication kinetics, temporal host kinome responses, modulation of MRSA virulence factors, and disruption of alveolar barrier integrity in response to pdm2009-MRSA co-infection. Our results suggest that alveolar barrier disruption during co-infection is mediated primarily through host response dysregulation, resulting in loss of alveolar barrier integrity.</div>
</front>
</TEI>
</pubmed>
</double>
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