Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada
Identifieur interne : 001D87 ( Ncbi/Merge ); précédent : 001D86; suivant : 001D88Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada
Auteurs : David Champredon ; Marek Laskowski ; Nathalie Charland [Canada] ; Seyed M. MoghadasSource :
- Scientific Reports [ 2045-2322 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Vaccins antigrippaux.
- immunologie : Vaccins antigrippaux.
- ressources et distribution : Vaccins antigrippaux.
- épidémiologie : Grippe humaine, Ontario.
- Humains, Pandémies, Programmes de vaccination, Simulation numérique, Vaccination.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Influenza Vaccines.
- chemical , immunology : Influenza Vaccines.
- geographic , epidemiology : Ontario.
- epidemiology : Influenza, Human.
- methods : Immunization Programs.
- prevention & control : Pandemics.
- chemical , supply & distribution : Influenza Vaccines.
- Computer Simulation, Humans, Vaccination.
Abstract
New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vaccination roll-out. Various scenarios corresponding to the transmissibility of a pandemic strain and vaccine prioritization strategies were simulated using an agent-based model of disease spread in Ontario, the largest Canadian province. We found that the relative reduction of the CAR reached 60% (90%CI: 44–100%) in a best-case scenario, in which the pandemic strain was moderately transmissible, vaccination started 4 weeks before the first imported case, the vaccine administration rate was 4 times higher than its average for seasonal influenza, and the vaccine efficacy was up to 90%. But the relative reductions in the CAR decreased significantly when the vaccination campaign was delayed or the administration rate reduced. In urban settings with similar characteristics to our population study, early availability and high rates of vaccine administration has the potential to substantially reduce the number of influenza cases. Low rates of vaccine administration or uptake can potentially offset the benefits of early vaccination.
Url:
DOI: 10.1038/s41598-018-24764-7
PubMed: 29691450
PubMed Central: 5915538
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000277
- to stream Pmc, to step Curation: 000277
- to stream Pmc, to step Checkpoint: 000177
- to stream PubMed, to step Corpus: 000304
- to stream PubMed, to step Curation: 000304
- to stream PubMed, to step Checkpoint: 000320
Links to Exploration step
PMC:5915538Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada</title><author><name sortKey="Champredon, David" sort="Champredon, David" uniqKey="Champredon D" first="David" last="Champredon">David Champredon</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Laskowski, Marek" sort="Laskowski, Marek" uniqKey="Laskowski M" first="Marek" last="Laskowski">Marek Laskowski</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Charland, Nathalie" sort="Charland, Nathalie" uniqKey="Charland N" first="Nathalie" last="Charland">Nathalie Charland</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0635 0044</institution-id><institution-id institution-id-type="GRID">grid.421219.d</institution-id><institution>Medicago Inc., 1020 Route de l’Eglise, Quebec,</institution></institution-wrap>G1V 3V9 Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>G1V 3V9 Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Moghadas, Seyed M" sort="Moghadas, Seyed M" uniqKey="Moghadas S" first="Seyed M." last="Moghadas">Seyed M. Moghadas</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29691450</idno><idno type="pmc">5915538</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915538</idno><idno type="RBID">PMC:5915538</idno><idno type="doi">10.1038/s41598-018-24764-7</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000277</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000277</idno><idno type="wicri:Area/Pmc/Curation">000277</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000277</idno><idno type="wicri:Area/Pmc/Checkpoint">000177</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000177</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:29691450</idno><idno type="wicri:Area/PubMed/Corpus">000304</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000304</idno><idno type="wicri:Area/PubMed/Curation">000304</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000304</idno><idno type="wicri:Area/PubMed/Checkpoint">000320</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000320</idno><idno type="wicri:Area/Ncbi/Merge">001D87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada</title><author><name sortKey="Champredon, David" sort="Champredon, David" uniqKey="Champredon D" first="David" last="Champredon">David Champredon</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Laskowski, Marek" sort="Laskowski, Marek" uniqKey="Laskowski M" first="Marek" last="Laskowski">Marek Laskowski</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Charland, Nathalie" sort="Charland, Nathalie" uniqKey="Charland N" first="Nathalie" last="Charland">Nathalie Charland</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0635 0044</institution-id><institution-id institution-id-type="GRID">grid.421219.d</institution-id><institution>Medicago Inc., 1020 Route de l’Eglise, Quebec,</institution></institution-wrap>G1V 3V9 Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>G1V 3V9 Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Moghadas, Seyed M" sort="Moghadas, Seyed M" uniqKey="Moghadas S" first="Seyed M." last="Moghadas">Seyed M. Moghadas</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term><term>Humans</term><term>Immunization Programs (methods)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (supply & distribution)</term><term>Influenza, Human (epidemiology)</term><term>Ontario (epidemiology)</term><term>Pandemics (prevention & control)</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Ontario (épidémiologie)</term><term>Pandémies ()</term><term>Programmes de vaccination ()</term><term>Simulation numérique</term><term>Vaccination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (ressources et distribution)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization Programs</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="ressources et distribution" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="supply & distribution" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Ontario</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Humans</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Pandémies</term><term>Programmes de vaccination</term><term>Simulation numérique</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vaccination roll-out. Various scenarios corresponding to the transmissibility of a pandemic strain and vaccine prioritization strategies were simulated using an agent-based model of disease spread in Ontario, the largest Canadian province. We found that the relative reduction of the CAR reached 60% (90%CI: 44–100%) in a best-case scenario, in which the pandemic strain was moderately transmissible, vaccination started 4 weeks before the first imported case, the vaccine administration rate was 4 times higher than its average for seasonal influenza, and the vaccine efficacy was up to 90%. But the relative reductions in the CAR decreased significantly when the vaccination campaign was delayed or the administration rate reduced. In urban settings with similar characteristics to our population study, early availability and high rates of vaccine administration has the potential to substantially reduce the number of influenza cases. Low rates of vaccine administration or uptake can potentially offset the benefits of early vaccination.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Poland, Ga" uniqKey="Poland G">GA Poland</name></author><author><name sortKey="Jacobson, Rm" uniqKey="Jacobson R">RM Jacobson</name></author><author><name sortKey="Ovsyannikova, Ig" uniqKey="Ovsyannikova I">IG Ovsyannikova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conway, Jm" uniqKey="Conway J">JM Conway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biggerstaff, M" uniqKey="Biggerstaff M">M Biggerstaff</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soema, Pc" uniqKey="Soema P">PC Soema</name></author><author><name sortKey="Kompier, R" uniqKey="Kompier R">R Kompier</name></author><author><name sortKey="Amorij, J P" uniqKey="Amorij J">J-P Amorij</name></author><author><name sortKey="Kersten, Gfa" uniqKey="Kersten G">GFA Kersten</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mylius, Sd" uniqKey="Mylius S">SD Mylius</name></author><author><name sortKey="Hagenaars, Tj" uniqKey="Hagenaars T">TJ Hagenaars</name></author><author><name sortKey="Lugner, Ak" uniqKey="Lugner A">AK Lugnér</name></author><author><name sortKey="Wallinga, J" uniqKey="Wallinga J">J Wallinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuite, Ar" uniqKey="Tuite A">AR Tuite</name></author><author><name sortKey="Fisman, Dn" uniqKey="Fisman D">DN Fisman</name></author><author><name sortKey="Kwong, Jc" uniqKey="Kwong J">JC Kwong</name></author><author><name sortKey="Greer, Al" uniqKey="Greer A">AL Greer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowman, C" uniqKey="Bowman C">C Bowman</name></author><author><name sortKey="Arino, J" uniqKey="Arino J">J Arino</name></author><author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaberi Douraki, M" uniqKey="Jaberi Douraki M">M Jaberi-Douraki</name></author><author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Nhl" uniqKey="Leung N">NHL Leung</name></author><author><name sortKey="Xu, C" uniqKey="Xu C">C Xu</name></author><author><name sortKey="Ip, Dkm" uniqKey="Ip D">DKM Ip</name></author><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cori, A" uniqKey="Cori A">A Cori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Llh" uniqKey="Lau L">LLH Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beest, Te" uniqKey="Beest T">te Beest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name></author><author><name sortKey="Schreiber, Sj" uniqKey="Schreiber S">SJ Schreiber</name></author><author><name sortKey="Kopp, Pe" uniqKey="Kopp P">PE Kopp</name></author><author><name sortKey="Getz, Wm" uniqKey="Getz W">WM Getz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schanzer, D" uniqKey="Schanzer D">D Schanzer</name></author><author><name sortKey="Vachon, J" uniqKey="Vachon J">J Vachon</name></author><author><name sortKey="Pelletier, L" uniqKey="Pelletier L">L Pelletier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stehle, J" uniqKey="Stehle J">J Stehlé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genois, M" uniqKey="Genois M">M Génois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biggerstaff, M" uniqKey="Biggerstaff M">M Biggerstaff</name></author><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name></author><author><name sortKey="Gambhir, M" uniqKey="Gambhir M">M Gambhir</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Van Kerckhove, K" uniqKey="Van Kerckhove K">K Van Kerckhove</name></author><author><name sortKey="Hens, N" uniqKey="Hens N">N Hens</name></author><author><name sortKey="Edmunds, Wj" uniqKey="Edmunds W">WJ Edmunds</name></author><author><name sortKey="Eames, Ktd" uniqKey="Eames K">KTD Eames</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldstein, E" uniqKey="Goldstein E">E Goldstein</name></author><author><name sortKey="Miller, Jc" uniqKey="Miller J">JC Miller</name></author><author><name sortKey="O Agan, Jj" uniqKey="O Agan J">JJ O’Hagan</name></author><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lansbury, Le" uniqKey="Lansbury L">LE Lansbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, Mt" uniqKey="Osterholm M">MT Osterholm</name></author><author><name sortKey="Kelley, Ns" uniqKey="Kelley N">NS Kelley</name></author><author><name sortKey="Sommer, A" uniqKey="Sommer A">A Sommer</name></author><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Jk" uniqKey="Yin J">JK Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zost, Sj" uniqKey="Zost S">SJ Zost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castilla, J" uniqKey="Castilla J">J Castilla</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="29691450"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada</title><author><name sortKey="Champredon, David" sort="Champredon, David" uniqKey="Champredon D" first="David" last="Champredon">David Champredon</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Laskowski, Marek" sort="Laskowski, Marek" uniqKey="Laskowski M" first="Marek" last="Laskowski">Marek Laskowski</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Charland, Nathalie" sort="Charland, Nathalie" uniqKey="Charland N" first="Nathalie" last="Charland">Nathalie Charland</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0635 0044</institution-id><institution-id institution-id-type="GRID">grid.421219.d</institution-id><institution>Medicago Inc., 1020 Route de l’Eglise, Quebec,</institution></institution-wrap>G1V 3V9 Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>G1V 3V9 Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Moghadas, Seyed M" sort="Moghadas, Seyed M" uniqKey="Moghadas S" first="Seyed M." last="Moghadas">Seyed M. Moghadas</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29691450</idno><idno type="pmc">5915538</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915538</idno><idno type="RBID">PMC:5915538</idno><idno type="doi">10.1038/s41598-018-24764-7</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000277</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000277</idno><idno type="wicri:Area/Pmc/Curation">000277</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000277</idno><idno type="wicri:Area/Pmc/Checkpoint">000177</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000177</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada</title><author><name sortKey="Champredon, David" sort="Champredon, David" uniqKey="Champredon D" first="David" last="Champredon">David Champredon</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Laskowski, Marek" sort="Laskowski, Marek" uniqKey="Laskowski M" first="Marek" last="Laskowski">Marek Laskowski</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author><author><name sortKey="Charland, Nathalie" sort="Charland, Nathalie" uniqKey="Charland N" first="Nathalie" last="Charland">Nathalie Charland</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0635 0044</institution-id><institution-id institution-id-type="GRID">grid.421219.d</institution-id><institution>Medicago Inc., 1020 Route de l’Eglise, Quebec,</institution></institution-wrap>G1V 3V9 Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>G1V 3V9 Quebec</wicri:regionArea></affiliation></author><author><name sortKey="Moghadas, Seyed M" sort="Moghadas, Seyed M" uniqKey="Moghadas S" first="Seyed M." last="Moghadas">Seyed M. Moghadas</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9430</institution-id><institution-id institution-id-type="GRID">grid.21100.32</institution-id><institution>Agent-Based Modelling Laboratory,</institution><institution>York University,</institution></institution-wrap>Toronto, M3J 1P3 Ontario Canada</nlm:aff><wicri:noCountry code="subfield">M3J 1P3 Ontario Canada</wicri:noCountry></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vaccination roll-out. Various scenarios corresponding to the transmissibility of a pandemic strain and vaccine prioritization strategies were simulated using an agent-based model of disease spread in Ontario, the largest Canadian province. We found that the relative reduction of the CAR reached 60% (90%CI: 44–100%) in a best-case scenario, in which the pandemic strain was moderately transmissible, vaccination started 4 weeks before the first imported case, the vaccine administration rate was 4 times higher than its average for seasonal influenza, and the vaccine efficacy was up to 90%. But the relative reductions in the CAR decreased significantly when the vaccination campaign was delayed or the administration rate reduced. In urban settings with similar characteristics to our population study, early availability and high rates of vaccine administration has the potential to substantially reduce the number of influenza cases. Low rates of vaccine administration or uptake can potentially offset the benefits of early vaccination.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Poland, Ga" uniqKey="Poland G">GA Poland</name></author><author><name sortKey="Jacobson, Rm" uniqKey="Jacobson R">RM Jacobson</name></author><author><name sortKey="Ovsyannikova, Ig" uniqKey="Ovsyannikova I">IG Ovsyannikova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Conway, Jm" uniqKey="Conway J">JM Conway</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biggerstaff, M" uniqKey="Biggerstaff M">M Biggerstaff</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Ss" uniqKey="Wong S">SS Wong</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soema, Pc" uniqKey="Soema P">PC Soema</name></author><author><name sortKey="Kompier, R" uniqKey="Kompier R">R Kompier</name></author><author><name sortKey="Amorij, J P" uniqKey="Amorij J">J-P Amorij</name></author><author><name sortKey="Kersten, Gfa" uniqKey="Kersten G">GFA Kersten</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mylius, Sd" uniqKey="Mylius S">SD Mylius</name></author><author><name sortKey="Hagenaars, Tj" uniqKey="Hagenaars T">TJ Hagenaars</name></author><author><name sortKey="Lugner, Ak" uniqKey="Lugner A">AK Lugnér</name></author><author><name sortKey="Wallinga, J" uniqKey="Wallinga J">J Wallinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tuite, Ar" uniqKey="Tuite A">AR Tuite</name></author><author><name sortKey="Fisman, Dn" uniqKey="Fisman D">DN Fisman</name></author><author><name sortKey="Kwong, Jc" uniqKey="Kwong J">JC Kwong</name></author><author><name sortKey="Greer, Al" uniqKey="Greer A">AL Greer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bowman, C" uniqKey="Bowman C">C Bowman</name></author><author><name sortKey="Arino, J" uniqKey="Arino J">J Arino</name></author><author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaberi Douraki, M" uniqKey="Jaberi Douraki M">M Jaberi-Douraki</name></author><author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Nhl" uniqKey="Leung N">NHL Leung</name></author><author><name sortKey="Xu, C" uniqKey="Xu C">C Xu</name></author><author><name sortKey="Ip, Dkm" uniqKey="Ip D">DKM Ip</name></author><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Simonsen, L" uniqKey="Simonsen L">L Simonsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cori, A" uniqKey="Cori A">A Cori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Llh" uniqKey="Lau L">LLH Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beest, Te" uniqKey="Beest T">te Beest</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name></author><author><name sortKey="Schreiber, Sj" uniqKey="Schreiber S">SJ Schreiber</name></author><author><name sortKey="Kopp, Pe" uniqKey="Kopp P">PE Kopp</name></author><author><name sortKey="Getz, Wm" uniqKey="Getz W">WM Getz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schanzer, D" uniqKey="Schanzer D">D Schanzer</name></author><author><name sortKey="Vachon, J" uniqKey="Vachon J">J Vachon</name></author><author><name sortKey="Pelletier, L" uniqKey="Pelletier L">L Pelletier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stehle, J" uniqKey="Stehle J">J Stehlé</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genois, M" uniqKey="Genois M">M Génois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biggerstaff, M" uniqKey="Biggerstaff M">M Biggerstaff</name></author><author><name sortKey="Cauchemez, S" uniqKey="Cauchemez S">S Cauchemez</name></author><author><name sortKey="Reed, C" uniqKey="Reed C">C Reed</name></author><author><name sortKey="Gambhir, M" uniqKey="Gambhir M">M Gambhir</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Van Kerckhove, K" uniqKey="Van Kerckhove K">K Van Kerckhove</name></author><author><name sortKey="Hens, N" uniqKey="Hens N">N Hens</name></author><author><name sortKey="Edmunds, Wj" uniqKey="Edmunds W">WJ Edmunds</name></author><author><name sortKey="Eames, Ktd" uniqKey="Eames K">KTD Eames</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldstein, E" uniqKey="Goldstein E">E Goldstein</name></author><author><name sortKey="Miller, Jc" uniqKey="Miller J">JC Miller</name></author><author><name sortKey="O Agan, Jj" uniqKey="O Agan J">JJ O’Hagan</name></author><author><name sortKey="Lipsitch, M" uniqKey="Lipsitch M">M Lipsitch</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lansbury, Le" uniqKey="Lansbury L">LE Lansbury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterholm, Mt" uniqKey="Osterholm M">MT Osterholm</name></author><author><name sortKey="Kelley, Ns" uniqKey="Kelley N">NS Kelley</name></author><author><name sortKey="Sommer, A" uniqKey="Sommer A">A Sommer</name></author><author><name sortKey="Belongia, Ea" uniqKey="Belongia E">EA Belongia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, Jk" uniqKey="Yin J">JK Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zost, Sj" uniqKey="Zost S">SJ Zost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Castilla, J" uniqKey="Castilla J">J Castilla</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Earn, Djd" uniqKey="Earn D">DJD Earn</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada.</title><author><name sortKey="Champredon, David" sort="Champredon, David" uniqKey="Champredon D" first="David" last="Champredon">David Champredon</name><affiliation wicri:level="1"><nlm:affiliation>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario, Canada. david.champredon@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Laskowski, Marek" sort="Laskowski, Marek" uniqKey="Laskowski M" first="Marek" last="Laskowski">Marek Laskowski</name><affiliation wicri:level="1"><nlm:affiliation>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Charland, Nathalie" sort="Charland, Nathalie" uniqKey="Charland N" first="Nathalie" last="Charland">Nathalie Charland</name><affiliation wicri:level="1"><nlm:affiliation>Medicago Inc., 1020 Route de l'Eglise, Quebec, G1V 3V9, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Medicago Inc., 1020 Route de l'Eglise, Quebec, G1V 3V9, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Moghadas, Seyed M" sort="Moghadas, Seyed M" uniqKey="Moghadas S" first="Seyed M" last="Moghadas">Seyed M. Moghadas</name><affiliation wicri:level="1"><nlm:affiliation>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29691450</idno><idno type="pmid">29691450</idno><idno type="doi">10.1038/s41598-018-24764-7</idno><idno type="wicri:Area/PubMed/Corpus">000304</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000304</idno><idno type="wicri:Area/PubMed/Curation">000304</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000304</idno><idno type="wicri:Area/PubMed/Checkpoint">000320</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000320</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada.</title><author><name sortKey="Champredon, David" sort="Champredon, David" uniqKey="Champredon D" first="David" last="Champredon">David Champredon</name><affiliation wicri:level="1"><nlm:affiliation>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario, Canada. david.champredon@gmail.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Laskowski, Marek" sort="Laskowski, Marek" uniqKey="Laskowski M" first="Marek" last="Laskowski">Marek Laskowski</name><affiliation wicri:level="1"><nlm:affiliation>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Charland, Nathalie" sort="Charland, Nathalie" uniqKey="Charland N" first="Nathalie" last="Charland">Nathalie Charland</name><affiliation wicri:level="1"><nlm:affiliation>Medicago Inc., 1020 Route de l'Eglise, Quebec, G1V 3V9, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Medicago Inc., 1020 Route de l'Eglise, Quebec, G1V 3V9, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Moghadas, Seyed M" sort="Moghadas, Seyed M" uniqKey="Moghadas S" first="Seyed M" last="Moghadas">Seyed M. Moghadas</name><affiliation wicri:level="1"><nlm:affiliation>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Agent-Based Modelling Laboratory, York University, Toronto, M3J 1P3, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term><term>Humans</term><term>Immunization Programs (methods)</term><term>Influenza Vaccines (administration & dosage)</term><term>Influenza Vaccines (immunology)</term><term>Influenza Vaccines (supply & distribution)</term><term>Influenza, Human (epidemiology)</term><term>Ontario (epidemiology)</term><term>Pandemics (prevention & control)</term><term>Vaccination</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Grippe humaine (épidémiologie)</term><term>Humains</term><term>Ontario (épidémiologie)</term><term>Pandémies ()</term><term>Programmes de vaccination ()</term><term>Simulation numérique</term><term>Vaccination</term><term>Vaccins antigrippaux (administration et posologie)</term><term>Vaccins antigrippaux (immunologie)</term><term>Vaccins antigrippaux (ressources et distribution)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization Programs</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="ressources et distribution" xml:lang="fr"><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" type="chemical" qualifier="supply & distribution" xml:lang="en"><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Ontario</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Humans</term><term>Vaccination</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Pandémies</term><term>Programmes de vaccination</term><term>Simulation numérique</term><term>Vaccination</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">New vaccine production technologies can significantly shorten the timelines for availability of a strain-specific vaccine in the event of an influenza pandemic. We sought to evaluate the potential benefits of early vaccination in reducing the clinical attack rate (CAR), taking into account the timing and speed of vaccination roll-out. Various scenarios corresponding to the transmissibility of a pandemic strain and vaccine prioritization strategies were simulated using an agent-based model of disease spread in Ontario, the largest Canadian province. We found that the relative reduction of the CAR reached 60% (90%CI: 44-100%) in a best-case scenario, in which the pandemic strain was moderately transmissible, vaccination started 4 weeks before the first imported case, the vaccine administration rate was 4 times higher than its average for seasonal influenza, and the vaccine efficacy was up to 90%. But the relative reductions in the CAR decreased significantly when the vaccination campaign was delayed or the administration rate reduced. In urban settings with similar characteristics to our population study, early availability and high rates of vaccine administration has the potential to substantially reduce the number of influenza cases. Low rates of vaccine administration or uptake can potentially offset the benefits of early vaccination.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001D87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= PandemieGrippaleV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5915538
|texte= Assessing the benefits of early pandemic influenza vaccine availability: a case study for Ontario, Canada
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:29691450" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a PandemieGrippaleV1
| This area was generated with Dilib version V0.6.34. |  |