Viable influenza A virus in airborne particles expelled during coughs versus exhalations
Identifieur interne : 001B47 ( Ncbi/Merge ); précédent : 001B46; suivant : 001B48Viable influenza A virus in airborne particles expelled during coughs versus exhalations
Auteurs : William G. Lindsley ; Francoise M. Blachere ; Donald H. Beezhold ; Robert E. Thewlis ; Bahar Noorbakhsh ; Sreekumar Othumpangat ; William T. Goldsmith ; Cynthia M. Mcmillen ; Michael E. Andrew ; Carmen N. Burrell ; John D. NotiSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2016.
Descripteurs français
- KwdFr :
- ARN viral, Adulte, Aérosols (analyse), Expiration, Femelle, Grippe humaine (), Grippe humaine (transmission), Grippe humaine (virologie), Humains, Jeune adulte, Microbiologie de l'air, Mâle, Pandémies (), Réplication virale, Spirométrie, Toux (virologie), Viabilité microbienne, Virus de la grippe A (physiologie).
- MESH :
- analyse : Aérosols.
- physiologie : Virus de la grippe A.
- virologie : Grippe humaine, Toux.
- ARN viral, Adulte, Expiration, Femelle, Grippe humaine, Humains, Jeune adulte, Microbiologie de l'air, Mâle, Pandémies, Réplication virale, Spirométrie, Viabilité microbienne.
English descriptors
- KwdEn :
- Adult, Aerosols (analysis), Air Microbiology, Cough (virology), Exhalation, Female, Humans, Influenza A virus (physiology), Influenza, Human (prevention & control), Influenza, Human (transmission), Influenza, Human (virology), Male, Microbial Viability, Pandemics (prevention & control), RNA, Viral, Spirometry, Virus Replication, Young Adult.
- MESH :
- chemical , analysis : Aerosols.
- physiology : Influenza A virus.
- prevention & control : Influenza, Human, Pandemics.
- transmission : Influenza, Human.
- virology : Cough, Influenza, Human.
- Adult, Air Microbiology, Exhalation, Female, Humans, Male, Microbial Viability, RNA, Viral, Spirometry, Virus Replication, Young Adult.
Abstract
To prepare for a possible influenza pandemic, a better understanding of the potential for the airborne transmission of influenza from person to person is needed.
The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations.
Sixty‐one adult volunteer outpatients with influenza‐like symptoms were asked to cough and exhale three times into a spirometer. Aerosol particles produced during coughing and exhalation were collected into liquid media using aerosol samplers. The samples were tested for the presence of viable influenza virus using a viral replication assay (
Fifty‐three test subjects tested positive for influenza A virus. Of these, 28 (53%) produced aerosol particles containing viable influenza A virus during coughing, and 22 (42%) produced aerosols with viable virus during exhalation. Thirteen subjects had both cough aerosol and exhalation aerosol samples that contained viable virus, 15 had positive cough aerosol samples but negative exhalation samples, and 9 had positive exhalation samples but negative cough samples.
Viable influenza A virus was detected more often in cough aerosol particles than in exhalation aerosol particles, but the difference was not large. Because individuals breathe much more often than they cough, these results suggest that breathing may generate more airborne infectious material than coughing over time. However, both respiratory activities could be important in airborne influenza transmission. Our results are also consistent with the theory that much of the aerosol containing viable influenza originates deep in the lungs.
Url:
DOI: 10.1111/irv.12390
PubMed: 26991074
PubMed Central: 4947941
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PMC:4947941Le document en format XML
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Lindsley</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Blachere, Francoise M" sort="Blachere, Francoise M" uniqKey="Blachere F" first="Francoise M." last="Blachere">Francoise M. Blachere</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Beezhold, Donald H" sort="Beezhold, Donald H" uniqKey="Beezhold D" first="Donald H." last="Beezhold">Donald H. Beezhold</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Thewlis, Robert E" sort="Thewlis, Robert E" uniqKey="Thewlis R" first="Robert E." last="Thewlis">Robert E. Thewlis</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Noorbakhsh, Bahar" sort="Noorbakhsh, Bahar" uniqKey="Noorbakhsh B" first="Bahar" last="Noorbakhsh">Bahar Noorbakhsh</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Othumpangat, Sreekumar" sort="Othumpangat, Sreekumar" uniqKey="Othumpangat S" first="Sreekumar" last="Othumpangat">Sreekumar Othumpangat</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Goldsmith, William T" sort="Goldsmith, William T" uniqKey="Goldsmith W" first="William T." last="Goldsmith">William T. Goldsmith</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Mcmillen, Cynthia M" sort="Mcmillen, Cynthia M" uniqKey="Mcmillen C" first="Cynthia M." last="Mcmillen">Cynthia M. Mcmillen</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Andrew, Michael E" sort="Andrew, Michael E" uniqKey="Andrew M" first="Michael E." last="Andrew">Michael E. Andrew</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Burrell, Carmen N" sort="Burrell, Carmen N" uniqKey="Burrell C" first="Carmen N." last="Burrell">Carmen N. Burrell</name><affiliation><nlm:aff id="irv12390-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Noti, John D" sort="Noti, John D" uniqKey="Noti J" first="John D." last="Noti">John D. Noti</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aerosols (analysis)</term><term>Air Microbiology</term><term>Cough (virology)</term><term>Exhalation</term><term>Female</term><term>Humans</term><term>Influenza A virus (physiology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (transmission)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Microbial Viability</term><term>Pandemics (prevention & control)</term><term>RNA, Viral</term><term>Spirometry</term><term>Virus Replication</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral</term><term>Adulte</term><term>Aérosols (analyse)</term><term>Expiration</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Jeune adulte</term><term>Microbiologie de l'air</term><term>Mâle</term><term>Pandémies ()</term><term>Réplication virale</term><term>Spirométrie</term><term>Toux (virologie)</term><term>Viabilité microbienne</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Aerosols</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Aérosols</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cough</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Air Microbiology</term><term>Exhalation</term><term>Female</term><term>Humans</term><term>Male</term><term>Microbial Viability</term><term>RNA, Viral</term><term>Spirometry</term><term>Virus Replication</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Adulte</term><term>Expiration</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Microbiologie de l'air</term><term>Mâle</term><term>Pandémies</term><term>Réplication virale</term><term>Spirométrie</term><term>Viabilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="irv12390-sec-0001"><title>Background</title><p>To prepare for a possible influenza pandemic, a better understanding of the potential for the airborne transmission of influenza from person to person is needed.</p></sec><sec id="irv12390-sec-0002"><title>Objectives</title><p>The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations.</p></sec><sec id="irv12390-sec-0003"><title>Methods</title><p>Sixty‐one adult volunteer outpatients with influenza‐like symptoms were asked to cough and exhale three times into a spirometer. Aerosol particles produced during coughing and exhalation were collected into liquid media using aerosol samplers. The samples were tested for the presence of viable influenza virus using a viral replication assay (<styled-content style="fixed-case">VRA</styled-content>).</p></sec><sec id="irv12390-sec-0004"><title>Results</title><p>Fifty‐three test subjects tested positive for influenza A virus. Of these, 28 (53%) produced aerosol particles containing viable influenza A virus during coughing, and 22 (42%) produced aerosols with viable virus during exhalation. Thirteen subjects had both cough aerosol and exhalation aerosol samples that contained viable virus, 15 had positive cough aerosol samples but negative exhalation samples, and 9 had positive exhalation samples but negative cough samples.</p></sec><sec id="irv12390-sec-0005"><title>Conclusions</title><p>Viable influenza A virus was detected more often in cough aerosol particles than in exhalation aerosol particles, but the difference was not large. Because individuals breathe much more often than they cough, these results suggest that breathing may generate more airborne infectious material than coughing over time. However, both respiratory activities could be important in airborne influenza transmission. Our results are also consistent with the theory that much of the aerosol containing viable influenza originates deep in the lungs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Larson, El" uniqKey="Larson E">EL Larson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="26991074"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viable influenza A virus in airborne particles expelled during coughs versus exhalations</title><author><name sortKey="Lindsley, William G" sort="Lindsley, William G" uniqKey="Lindsley W" first="William G." last="Lindsley">William G. Lindsley</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Blachere, Francoise M" sort="Blachere, Francoise M" uniqKey="Blachere F" first="Francoise M." last="Blachere">Francoise M. Blachere</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Beezhold, Donald H" sort="Beezhold, Donald H" uniqKey="Beezhold D" first="Donald H." last="Beezhold">Donald H. Beezhold</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Thewlis, Robert E" sort="Thewlis, Robert E" uniqKey="Thewlis R" first="Robert E." last="Thewlis">Robert E. Thewlis</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Noorbakhsh, Bahar" sort="Noorbakhsh, Bahar" uniqKey="Noorbakhsh B" first="Bahar" last="Noorbakhsh">Bahar Noorbakhsh</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Othumpangat, Sreekumar" sort="Othumpangat, Sreekumar" uniqKey="Othumpangat S" first="Sreekumar" last="Othumpangat">Sreekumar Othumpangat</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Goldsmith, William T" sort="Goldsmith, William T" uniqKey="Goldsmith W" first="William T." last="Goldsmith">William T. Goldsmith</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Mcmillen, Cynthia M" sort="Mcmillen, Cynthia M" uniqKey="Mcmillen C" first="Cynthia M." last="Mcmillen">Cynthia M. Mcmillen</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Andrew, Michael E" sort="Andrew, Michael E" uniqKey="Andrew M" first="Michael E." last="Andrew">Michael E. Andrew</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Burrell, Carmen N" sort="Burrell, Carmen N" uniqKey="Burrell C" first="Carmen N." last="Burrell">Carmen N. Burrell</name><affiliation><nlm:aff id="irv12390-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Noti, John D" sort="Noti, John D" uniqKey="Noti J" first="John D." last="Noti">John D. Noti</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26991074</idno><idno type="pmc">4947941</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947941</idno><idno type="RBID">PMC:4947941</idno><idno type="doi">10.1111/irv.12390</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000A74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A74</idno><idno type="wicri:Area/Pmc/Curation">000A74</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A74</idno><idno type="wicri:Area/Pmc/Checkpoint">000271</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000271</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Viable influenza A virus in airborne particles expelled during coughs versus exhalations</title><author><name sortKey="Lindsley, William G" sort="Lindsley, William G" uniqKey="Lindsley W" first="William G." last="Lindsley">William G. Lindsley</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Blachere, Francoise M" sort="Blachere, Francoise M" uniqKey="Blachere F" first="Francoise M." last="Blachere">Francoise M. Blachere</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Beezhold, Donald H" sort="Beezhold, Donald H" uniqKey="Beezhold D" first="Donald H." last="Beezhold">Donald H. Beezhold</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Thewlis, Robert E" sort="Thewlis, Robert E" uniqKey="Thewlis R" first="Robert E." last="Thewlis">Robert E. Thewlis</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Noorbakhsh, Bahar" sort="Noorbakhsh, Bahar" uniqKey="Noorbakhsh B" first="Bahar" last="Noorbakhsh">Bahar Noorbakhsh</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Othumpangat, Sreekumar" sort="Othumpangat, Sreekumar" uniqKey="Othumpangat S" first="Sreekumar" last="Othumpangat">Sreekumar Othumpangat</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Goldsmith, William T" sort="Goldsmith, William T" uniqKey="Goldsmith W" first="William T." last="Goldsmith">William T. Goldsmith</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Mcmillen, Cynthia M" sort="Mcmillen, Cynthia M" uniqKey="Mcmillen C" first="Cynthia M." last="Mcmillen">Cynthia M. Mcmillen</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Andrew, Michael E" sort="Andrew, Michael E" uniqKey="Andrew M" first="Michael E." last="Andrew">Michael E. Andrew</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Burrell, Carmen N" sort="Burrell, Carmen N" uniqKey="Burrell C" first="Carmen N." last="Burrell">Carmen N. Burrell</name><affiliation><nlm:aff id="irv12390-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Noti, John D" sort="Noti, John D" uniqKey="Noti J" first="John D." last="Noti">John D. Noti</name><affiliation><nlm:aff id="irv12390-aff-0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="irv12390-sec-0001"><title>Background</title><p>To prepare for a possible influenza pandemic, a better understanding of the potential for the airborne transmission of influenza from person to person is needed.</p></sec><sec id="irv12390-sec-0002"><title>Objectives</title><p>The objective of this study was to directly compare the generation of aerosol particles containing viable influenza virus during coughs and exhalations.</p></sec><sec id="irv12390-sec-0003"><title>Methods</title><p>Sixty‐one adult volunteer outpatients with influenza‐like symptoms were asked to cough and exhale three times into a spirometer. Aerosol particles produced during coughing and exhalation were collected into liquid media using aerosol samplers. The samples were tested for the presence of viable influenza virus using a viral replication assay (<styled-content style="fixed-case">VRA</styled-content>).</p></sec><sec id="irv12390-sec-0004"><title>Results</title><p>Fifty‐three test subjects tested positive for influenza A virus. Of these, 28 (53%) produced aerosol particles containing viable influenza A virus during coughing, and 22 (42%) produced aerosols with viable virus during exhalation. Thirteen subjects had both cough aerosol and exhalation aerosol samples that contained viable virus, 15 had positive cough aerosol samples but negative exhalation samples, and 9 had positive exhalation samples but negative cough samples.</p></sec><sec id="irv12390-sec-0005"><title>Conclusions</title><p>Viable influenza A virus was detected more often in cough aerosol particles than in exhalation aerosol particles, but the difference was not large. Because individuals breathe much more often than they cough, these results suggest that breathing may generate more airborne infectious material than coughing over time. However, both respiratory activities could be important in airborne influenza transmission. Our results are also consistent with the theory that much of the aerosol containing viable influenza originates deep in the lungs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Larson, El" uniqKey="Larson E">EL Larson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viable influenza A virus in airborne particles expelled during coughs versus exhalations.</title><author><name sortKey="Lindsley, William G" sort="Lindsley, William G" uniqKey="Lindsley W" first="William G" last="Lindsley">William G. Lindsley</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Blachere, Francoise M" sort="Blachere, Francoise M" uniqKey="Blachere F" first="Francoise M" last="Blachere">Francoise M. Blachere</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Beezhold, Donald H" sort="Beezhold, Donald H" uniqKey="Beezhold D" first="Donald H" last="Beezhold">Donald H. Beezhold</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Thewlis, Robert E" sort="Thewlis, Robert E" uniqKey="Thewlis R" first="Robert E" last="Thewlis">Robert E. Thewlis</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Noorbakhsh, Bahar" sort="Noorbakhsh, Bahar" uniqKey="Noorbakhsh B" first="Bahar" last="Noorbakhsh">Bahar Noorbakhsh</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Othumpangat, Sreekumar" sort="Othumpangat, Sreekumar" uniqKey="Othumpangat S" first="Sreekumar" last="Othumpangat">Sreekumar Othumpangat</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Goldsmith, William T" sort="Goldsmith, William T" uniqKey="Goldsmith W" first="William T" last="Goldsmith">William T. Goldsmith</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Mcmillen, Cynthia M" sort="Mcmillen, Cynthia M" uniqKey="Mcmillen C" first="Cynthia M" last="Mcmillen">Cynthia M. Mcmillen</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Andrew, Michael E" sort="Andrew, Michael E" uniqKey="Andrew M" first="Michael E" last="Andrew">Michael E. Andrew</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Burrell, Carmen N" sort="Burrell, Carmen N" uniqKey="Burrell C" first="Carmen N" last="Burrell">Carmen N. Burrell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, West Virginia University, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Emergency Medicine, West Virginia University, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Noti, John D" sort="Noti, John D" uniqKey="Noti J" first="John D" last="Noti">John D. Noti</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26991074</idno><idno type="pmid">26991074</idno><idno type="doi">10.1111/irv.12390</idno><idno type="wicri:Area/PubMed/Corpus">000544</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000544</idno><idno type="wicri:Area/PubMed/Curation">000544</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000544</idno><idno type="wicri:Area/PubMed/Checkpoint">000456</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000456</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Viable influenza A virus in airborne particles expelled during coughs versus exhalations.</title><author><name sortKey="Lindsley, William G" sort="Lindsley, William G" uniqKey="Lindsley W" first="William G" last="Lindsley">William G. Lindsley</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Blachere, Francoise M" sort="Blachere, Francoise M" uniqKey="Blachere F" first="Francoise M" last="Blachere">Francoise M. Blachere</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Beezhold, Donald H" sort="Beezhold, Donald H" uniqKey="Beezhold D" first="Donald H" last="Beezhold">Donald H. Beezhold</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Thewlis, Robert E" sort="Thewlis, Robert E" uniqKey="Thewlis R" first="Robert E" last="Thewlis">Robert E. Thewlis</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Noorbakhsh, Bahar" sort="Noorbakhsh, Bahar" uniqKey="Noorbakhsh B" first="Bahar" last="Noorbakhsh">Bahar Noorbakhsh</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Othumpangat, Sreekumar" sort="Othumpangat, Sreekumar" uniqKey="Othumpangat S" first="Sreekumar" last="Othumpangat">Sreekumar Othumpangat</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Goldsmith, William T" sort="Goldsmith, William T" uniqKey="Goldsmith W" first="William T" last="Goldsmith">William T. Goldsmith</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Mcmillen, Cynthia M" sort="Mcmillen, Cynthia M" uniqKey="Mcmillen C" first="Cynthia M" last="Mcmillen">Cynthia M. Mcmillen</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Andrew, Michael E" sort="Andrew, Michael E" uniqKey="Andrew M" first="Michael E" last="Andrew">Michael E. Andrew</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Burrell, Carmen N" sort="Burrell, Carmen N" uniqKey="Burrell C" first="Carmen N" last="Burrell">Carmen N. Burrell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Emergency Medicine, West Virginia University, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Emergency Medicine, West Virginia University, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author><author><name sortKey="Noti, John D" sort="Noti, John D" uniqKey="Noti J" first="John D" last="Noti">John D. Noti</name><affiliation wicri:level="2"><nlm:affiliation>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV</wicri:regionArea><placeName><region type="state">Virginie-Occidentale</region></placeName></affiliation></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aerosols (analysis)</term><term>Air Microbiology</term><term>Cough (virology)</term><term>Exhalation</term><term>Female</term><term>Humans</term><term>Influenza A virus (physiology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (transmission)</term><term>Influenza, Human (virology)</term><term>Male</term><term>Microbial Viability</term><term>Pandemics (prevention & control)</term><term>RNA, Viral</term><term>Spirometry</term><term>Virus Replication</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral</term><term>Adulte</term><term>Aérosols (analyse)</term><term>Expiration</term><term>Femelle</term><term>Grippe humaine ()</term><term>Grippe humaine (transmission)</term><term>Grippe humaine (virologie)</term><term>Humains</term><term>Jeune adulte</term><term>Microbiologie de l'air</term><term>Mâle</term><term>Pandémies ()</term><term>Réplication virale</term><term>Spirométrie</term><term>Toux (virologie)</term><term>Viabilité microbienne</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Aerosols</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Aérosols</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term><term>Toux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cough</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Air Microbiology</term><term>Exhalation</term><term>Female</term><term>Humans</term><term>Male</term><term>Microbial Viability</term><term>RNA, Viral</term><term>Spirometry</term><term>Virus Replication</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>ARN viral</term><term>Adulte</term><term>Expiration</term><term>Femelle</term><term>Grippe humaine</term><term>Humains</term><term>Jeune adulte</term><term>Microbiologie de l'air</term><term>Mâle</term><term>Pandémies</term><term>Réplication virale</term><term>Spirométrie</term><term>Viabilité microbienne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To prepare for a possible influenza pandemic, a better understanding of the potential for the airborne transmission of influenza from person to person is needed.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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